Author results

2AQX
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CRYSTAL STRUCTURE OF THE CATALYTIC AND CAM-BINDING DOMAINS OF INOSITOL 1,4,5-TRISPHOSPHATE 3-KINASE B
Descriptor:PREDICTED: inositol 1,4,5-trisphosphate 3-kinase B, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE
Authors:Chamberlain, P.P., Sandberg, M.L., Sauer, K., Cooke, M.P., Lesley, S.A., Spraggon, G.
Deposit date:2005-08-18
Release date:2005-12-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural insights into enzyme regulation for inositol 1,4,5-trisphosphate 3-kinase B
Biochemistry, 44, 2005
2Q7D
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CRYSTAL STRUCTURE OF HUMAN INOSITOL 1,3,4-TRISPHOSPHATE 5/6-KINASE (ITPK1) IN COMPLEX WITH AMPPNP AND MN2+
Descriptor:Inositol-tetrakisphosphate 1-kinase, MANGANESE (II) ION, SULFATE ION, ...
Authors:Chamberlain, P.P., Lesley, S.A., Spraggon, G.
Deposit date:2007-06-06
Release date:2007-07-03
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Integration of inositol phosphate signaling pathways via human ITPK1.
J.Biol.Chem., 282, 2007
2QB5
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CRYSTAL STRUCTURE OF HUMAN INOSITOL 1,3,4-TRISPHOSPHATE 5/6-KINASE (ITPK1) IN COMPLEX WITH ADP AND MN2+
Descriptor:Inositol-tetrakisphosphate 1-kinase, SULFATE ION, MANGANESE (II) ION, ...
Authors:Chamberlain, P.P., Lesley, S.A., Spraggon, G.
Deposit date:2007-06-15
Release date:2007-07-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Integration of inositol phosphate signaling pathways via human ITPK1.
J.Biol.Chem., 282, 2007
4TZ4
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CRYSTAL STRUCTURE OF HUMAN CEREBLON IN COMPLEX WITH DDB1 AND LENALIDOMIDE
Descriptor:DNA damage-binding protein 1, Protein cereblon, ZINC ION, ...
Authors:Chamberlain, P.P., Pagarigan, B., Delker, S., Leon, B., Riley, M.
Deposit date:2014-07-09
Release date:2014-08-06
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex
To Be Published
4TZC
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CRYSTAL STRUCTURE OF MURINE CEREBLON IN COMPLEX WITH THALIDOMIDE
Descriptor:Protein cereblon, ZINC ION, S-Thalidomide, ...
Authors:Chamberlain, P.P., Pagarigan, B., Delker, S., Leon, B.
Deposit date:2014-07-10
Release date:2014-08-06
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex
to be published
4TZU
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CRYSTAL STRUCTURE OF MURINE CEREBLON IN COMPLEX WITH POMALIDOMIDE
Descriptor:Protein cereblon, SULFATE ION, ZINC ION, ...
Authors:Chamberlain, P.P., Pagarigan, B., Delker, S., Leon, B.
Deposit date:2014-07-10
Release date:2014-08-06
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex
to be published
1LW0
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CRYSTAL STRUCTURE OF T215Y MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE
Descriptor:HIV-1 REVERSE TRANSCRIPTASE, PHOSPHATE ION, 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE
Authors:Ren, J., Chamberlain, P.P., Nichols, C.E., Douglas, L., Stuart, D.I., Stammers, D.K.
Deposit date:2002-05-30
Release date:2002-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215.
J.Virol., 76, 2002
1LW2
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CRYSTAL STRUCTURE OF T215Y MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH 1051U91
Descriptor:HIV-1 REVERSE TRANSCRIPTASE, PHOSPHATE ION, 6,11-DIHYDRO-11-ETHYL-6-METHYL-9-NITRO-5H-PYRIDO[2,3-B][1,5]BENZODIAZEPIN-5-ONE
Authors:Ren, J., Chamberlain, P.P., Nichols, C.E., Douglas, L., Stuart, D.I., Stammers, D.K.
Deposit date:2002-05-30
Release date:2002-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215.
J.Virol., 76, 2002
1LWC
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CRYSTAL STRUCTURE OF M184V MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE
Descriptor:HIV-1 REVERSE TRANSCRIPTASE, PHOSPHATE ION, 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE
Authors:Ren, J., Chamberlain, P.P., Nichols, C.E., Douglas, L., Stuart, D.I., Stammers, D.K.
Deposit date:2002-05-31
Release date:2002-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Crystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215.
J.Virol., 76, 2002
1LWE
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CRYSTAL STRUCTURE OF M41L/T215Y MUTANT HIV-1 REVERSE TRANSCRIPTASE (RTMN) IN COMPLEX WITH NEVIRAPINE
Descriptor:HIV-1 REVERSE TRANSCRIPTASE, PHOSPHATE ION, 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE
Authors:Ren, J., Chamberlain, P.P., Nichols, C.E., Douglas, L., Stuart, D.I., Stammers, D.K.
Deposit date:2002-05-31
Release date:2002-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Crystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215.
J.Virol., 76, 2002
1LWF
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CRYSTAL STRUCTURE OF A MUTANT HIV-1 REVERSE TRANSCRIPTASE (RTMQ+M184V: M41L/D67N/K70R/M184V/T215Y) IN COMPLEX WITH NEVIRAPINE
Descriptor:HIV-1 REVERSE TRANSCRIPTASE, 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE
Authors:Ren, J., Chamberlain, P.P., Nichols, C.E., Douglas, L., Stuart, D.I., Stammers, D.K.
Deposit date:2002-05-31
Release date:2002-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215.
J.Virol., 76, 2002
3DOK
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CRYSTAL STRUCTURE OF K103N MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW678248.
Descriptor:Reverse transcriptase/ribonuclease H, p51 RT, PHOSPHATE ION, ...
Authors:Chamberlain, P.P., Ren, J., Stammers, D.K.
Deposit date:2008-07-04
Release date:2008-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for the improved drug resistance profile of new generation benzophenone non-nucleoside HIV-1 reverse transcriptase inhibitors.
J.Med.Chem., 51, 2008
3DOL
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CRYSTAL STRUCTURE OF L100I MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW695634.
Descriptor:Reverse transcriptase/ribonuclease H, p66 RT, PHOSPHATE ION, ...
Authors:Chamberlain, P.P., Ren, J., Stammers, D.K.
Deposit date:2008-07-04
Release date:2008-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for the improved drug resistance profile of new generation benzophenone non-nucleoside HIV-1 reverse transcriptase inhibitors.
J.Med.Chem., 51, 2008
5HXB
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CEREBLON IN COMPLEX WITH DDB1, CC-885, AND GSPT1
Descriptor:Eukaryotic peptide chain release factor GTP-binding subunit ERF3A, DNA damage-binding protein 1, Protein cereblon, ...
Authors:Chamberlain, P.P., Matyskiela, M., Pagarigan, B.
Deposit date:2016-01-30
Release date:2016-06-29
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase.
Nature, 535, 2016
1S1T
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CRYSTAL STRUCTURE OF L100I MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH UC-781
Descriptor:Reverse transcriptase, PHOSPHATE ION, 2-METHYL-FURAN-3-CARBOTHIOIC ACID [4-CHLORO-3-(3-METHYL-BUT-2-ENYLOXY)-PHENYL]-AMIDE
Authors:Ren, J., Nichols, C.E., Chamberlain, P.P., Stammers, D.K.
Deposit date:2004-01-07
Release date:2004-06-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors
J.Mol.Biol., 336, 2004
1S1U
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CRYSTAL STRUCTURE OF L100I MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE
Descriptor:Reverse transcriptase, 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE
Authors:Ren, J., Nichols, C.E., Chamberlain, P.P., Stammers, D.K.
Deposit date:2004-01-07
Release date:2004-06-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors
J.Mol.Biol., 336, 2004
1S1V
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CRYSTAL STRUCTURE OF L100I MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH TNK-651
Descriptor:Reverse transcriptase, 6-BENZYL-1-BENZYLOXYMETHYL-5-ISOPROPYL URACIL
Authors:Ren, J., Nichols, C.E., Chamberlain, P.P., Stammers, D.K.
Deposit date:2004-01-07
Release date:2004-06-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors
J.Mol.Biol., 336, 2004
1S1W
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CRYSTAL STRUCTURE OF V106A MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH UC-781
Descriptor:Reverse transcriptase, 2-METHYL-FURAN-3-CARBOTHIOIC ACID [4-CHLORO-3-(3-METHYL-BUT-2-ENYLOXY)-PHENYL]-AMIDE
Authors:Ren, J., Nichols, C.E., Chamberlain, P.P., Stammers, D.K.
Deposit date:2004-01-07
Release date:2004-06-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors
J.Mol.Biol., 336, 2004
1S1X
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CRYSTAL STRUCTURE OF V108I MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE
Descriptor:Reverse transcriptase, 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE
Authors:Ren, J., Nichols, C.E., Chamberlain, P.P., Stammers, D.K.
Deposit date:2004-01-07
Release date:2004-06-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors
J.Mol.Biol., 336, 2004
1MU2
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CRYSTAL STRUCTURE OF HIV-2 REVERSE TRANSCRIPTASE
Descriptor:HIV-2 RT, SULFATE ION, GLYCEROL
Authors:Ren, J., Bird, L.E., Chamberlain, P.P., Stewart-Jones, G.B., Stuart, D.I., Stammers, D.K.
Deposit date:2002-09-23
Release date:2002-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structure of HIV-2 reverse transcriptase at 2.35-A resolution and the mechanism of resistance to non-nucleoside inhibitors
Proc.Natl.Acad.Sci.USA, 99, 2002
2HND
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CRYSTAL STRUCTURE OF K101E MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE
Descriptor:Reverse transcriptase/ribonuclease H, PHOSPHATE ION, MAGNESIUM ION, ...
Authors:Ren, J., Nichols, C.E., Stamp, A., Chamberlain, P.P., Stammers, D.K.
Deposit date:2006-07-12
Release date:2006-09-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural insights into mechanisms of non-nucleoside drug resistance for HIV-1 reverse transcriptases mutated at codons 101 or 138.
Febs J., 273, 2006
2HNY
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CRYSTAL STRUCTURE OF E138K MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE
Descriptor:Reverse transcriptase/ribonuclease H, PHOSPHATE ION, MAGNESIUM ION, ...
Authors:Ren, J., Nichols, C.E., Stamp, A., Chamberlain, P.P., Stammers, D.K.
Deposit date:2006-07-13
Release date:2006-09-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural insights into mechanisms of non-nucleoside drug resistance for HIV-1 reverse transcriptases mutated at codons 101 or 138.
Febs J., 273, 2006
2HNZ
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CRYSTAL STRUCTURE OF E138K MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH PETT-2
Descriptor:Reverse transcriptase/ribonuclease H, PHOSPHATE ION, 1-[2-(4-ETHOXY-3-FLUOROPYRIDIN-2-YL)ETHYL]-3-(5-METHYLPYRIDIN-2-YL)THIOUREA
Authors:Ren, J., Nichols, C.E., Stamp, A., Chamberlain, P.P., Stammers, D.K.
Deposit date:2006-07-13
Release date:2006-09-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural insights into mechanisms of non-nucleoside drug resistance for HIV-1 reverse transcriptases mutated at codons 101 or 138.
Febs J., 273, 2006
2OPP
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CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW420867X.
Descriptor:Reverse transcriptase/ribonuclease H, p51 RT, PHOSPHATE ION, ...
Authors:Ren, J., Nichols, C.E., Chamberlain, P.P., Weaver, K.L., Chan, S.J.H., Kleim, J., Stammers, D.K.
Deposit date:2007-01-30
Release date:2007-05-22
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Relationship of Potency and Resilience to Drug Resistant Mutations for GW420867X Revealed by Crystal Structures of Inhibitor Complexes for Wild-Type, Leu100Ile, Lys101Glu, and Tyr188Cys Mutant HIV-1 Reverse Transcriptases.
J.Med.Chem., 50, 2007
2OPQ
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CRYSTAL STRUCTURE OF L100I MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW420867X.
Descriptor:Reverse transcriptase/ribonuclease H, p51 RT, PHOSPHATE ION, ...
Authors:Ren, J., Nichols, C.E., Chamberlain, P.P., Weaver, K.L., Short, S.A., Chan, J.H., Kleim, J., Stammers, D.K.
Deposit date:2007-01-30
Release date:2007-05-22
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Relationship of Potency and Resilience to Drug Resistant Mutations for GW420867X Revealed by Crystal Structures of Inhibitor Complexes for Wild-Type, Leu100Ile, Lys101Glu, and Tyr188Cys Mutant HIV-1 Reverse Transcriptases.
J.Med.Chem., 50, 2007
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