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5FBW
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BU of 5fbw by Molmil
PI4KB in complex with Rab11 and the MI369 Inhibitor
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Phosphatidylinositol 4-kinase beta,Phosphatidylinositol 4-kinase beta, Ras-related protein Rab-11A, ...
Authors:Chalupska, D, Mejdrova, I, Nencka, R, Boura, E.
Deposit date:2015-12-14
Release date:2016-12-28
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.487 Å)
Cite:PI4KB in complex with Rab11 and the MI369 Inhibitor
To Be Published
5FBQ
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BU of 5fbq by Molmil
PI4KB in complex with Rab11 and the MI358 Inhibitor
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Phosphatidylinositol 4-kinase beta,Phosphatidylinositol 4-kinase beta, Ras-related protein Rab-11A, ...
Authors:Chalupska, D, Mejdrova, I, Nencka, R, Boura, E.
Deposit date:2015-12-14
Release date:2016-12-28
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.789 Å)
Cite:PI4KB in complex with Rab11 and the MI358 Inhibitor
To Be Published
5FBL
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BU of 5fbl by Molmil
PI4KB in complex with Rab11 and the MI356 Inhibitor
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Phosphatidylinositol 4-kinase beta,Phosphatidylinositol 4-kinase beta, Ras-related protein Rab-11A, ...
Authors:Chalupska, D, Mejdrova, I, Nencka, R, Boura, E.
Deposit date:2015-12-14
Release date:2016-12-28
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.372 Å)
Cite:PI4KB in complex with Rab11 and the MI356 Inhibitor
To Be Published
5FBV
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BU of 5fbv by Molmil
PI4KB in complex with Rab11 and the MI364 Inhibitor
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Phosphatidylinositol 4-kinase beta,Phosphatidylinositol 4-kinase beta, Ras-related protein Rab-11A, ...
Authors:Chalupska, D, Mejdrova, I, Nencka, R, Boura, E.
Deposit date:2015-12-14
Release date:2016-12-28
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.285 Å)
Cite:PI4KB in complex with Rab11 and the MI364 Inhibitor
To Be Published
5FBR
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BU of 5fbr by Molmil
PI4KB in complex with Rab11 and the MI359 Inhibitor
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Phosphatidylinositol 4-kinase beta,Phosphatidylinositol 4-kinase beta, Ras-related protein Rab-11A, ...
Authors:Chalupska, D, Mejdrova, I, Nencka, R, Boura, E.
Deposit date:2015-12-14
Release date:2016-12-28
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.28 Å)
Cite:PI4KB in complex with Rab11 and the MI359 Inhibitor
To Be Published
4WAE
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BU of 4wae by Molmil
Phosphatidylinositol 4-kinase III beta crystallized with ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Phosphatidylinositol 4-kinase beta,Phosphatidylinositol 4-kinase beta
Authors:Chalupska, D, Boura, E.
Deposit date:2014-08-29
Release date:2015-05-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.318 Å)
Cite:Highly Selective Phosphatidylinositol 4-Kinase III beta Inhibitors and Structural Insight into Their Mode of Action.
J.Med.Chem., 58, 2015
4WAG
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BU of 4wag by Molmil
Phosphatidylinositol 4-kinase III beta crystallized with MI103 inhibitor
Descriptor: 6-chloro-3-(3,4-dimethoxyphenyl)-2-methylimidazo[1,2-b]pyridazin-8-amine, Phosphatidylinositol 4-kinase beta,Phosphatidylinositol 4-kinase beta
Authors:Chalupska, D, Boura, E.
Deposit date:2014-08-29
Release date:2015-05-20
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (3.407 Å)
Cite:Highly Selective Phosphatidylinositol 4-Kinase III beta Inhibitors and Structural Insight into Their Mode of Action.
J.Med.Chem., 58, 2015
4WTV
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BU of 4wtv by Molmil
Crystal structure of the phosphatidylinositol 4-kinase IIbeta
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Phosphatidylinositol 4-kinase type 2-beta,Endolysin,Phosphatidylinositol 4-kinase type 2-beta
Authors:Klima, M, Baumlova, A, Chalupska, D, Boura, E.
Deposit date:2014-10-30
Release date:2015-07-15
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The high-resolution crystal structure of phosphatidylinositol 4-kinase II beta and the crystal structure of phosphatidylinositol 4-kinase II alpha containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor design.
Acta Crystallogr.,Sect.D, 71, 2015
4PLA
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BU of 4pla by Molmil
Crystal structure of phosphatidyl inositol 4-kinase II alpha in complex with ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Chimera protein of Phosphatidylinositol 4-kinase type 2-alpha and Lysozyme
Authors:Baumlova, A, Chalupska, D, Boura, E.
Deposit date:2014-05-16
Release date:2014-09-10
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.771 Å)
Cite:The crystal structure of the phosphatidylinositol 4-kinase II alpha.
Embo Rep., 15, 2014
8OIV
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BU of 8oiv by Molmil
Monkeypox virus VP39 in complex with SAH and cap0
Descriptor: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Skvara, P, Chalupska, D, Silhan, J, Klima, M, Boura, E.
Deposit date:2023-03-23
Release date:2023-08-23
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Structural basis for RNA-cap recognition and methylation by the mpox methyltransferase VP39.
Antiviral Res., 216, 2023
8A5X
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BU of 8a5x by Molmil
Crystal structure of phosphatidyl inositol 4-kinase II beta in complex with MM1373
Descriptor: 4-azanyl-7-[3-(hydroxymethyl)phenyl]quinazoline-6-carboxamide, Phosphatidylinositol 4-kinase type 2-beta,Endolysin
Authors:Klima, M, Boura, E.
Deposit date:2022-06-16
Release date:2022-10-05
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure-based design and modular synthesis of novel PI4K class II inhibitors bearing a 4-aminoquinazoline scaffold.
Bioorg.Med.Chem.Lett., 76, 2022
4YC4
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BU of 4yc4 by Molmil
Crystal structure of phosphatidyl inositol 4-kinase II alpha in complex with nucleotide analog
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Phosphatidylinositol 4-kinase type 2-alpha,Lysozyme,Phosphatidylinositol 4-kinase type 2-alpha, [(1S,3S,4S)-3-(6-amino-9H-purin-9-yl)bicyclo[2.2.1]hept-1-yl]methanol
Authors:Klima, M, Boura, E.
Deposit date:2015-02-19
Release date:2015-07-15
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:The high-resolution crystal structure of phosphatidylinositol 4-kinase II beta and the crystal structure of phosphatidylinositol 4-kinase II alpha containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor design.
Acta Crystallogr.,Sect.D, 71, 2015
5I14
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BU of 5i14 by Molmil
Truncated and mutated T4 lysozyme
Descriptor: NICKEL (II) ION, mutated and truncated T4 lysozyme
Authors:Klima, M, Boura, E.
Deposit date:2016-02-05
Release date:2016-02-17
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.745 Å)
Cite:Metal ions-binding T4 lysozyme as an intramolecular protein purification tag compatible with X-ray crystallography.
Protein Sci., 26, 2017
6YI3
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BU of 6yi3 by Molmil
The N-terminal RNA-binding domain of the SARS-CoV-2 nucleocapsid phosphoprotein
Descriptor: Nucleoprotein
Authors:Veverka, V, Boura, E.
Deposit date:2020-03-31
Release date:2020-04-08
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural basis of RNA recognition by the SARS-CoV-2 nucleocapsid phosphoprotein.
Plos Pathog., 16, 2020
3N7Z
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BU of 3n7z by Molmil
Crystal structure of acetyltransferase from Bacillus anthracis
Descriptor: Acetyltransferase, GNAT family, SODIUM ION
Authors:Chang, C, Wu, R, Gornicki, P, Zhang, R, Joachimiak, A, Midwest Center for Structural Genomics (MCSG)
Deposit date:2010-05-27
Release date:2010-06-16
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Biochemical and Structural Analysis of an Eis Family Aminoglycoside Acetyltransferase from Bacillus anthracis.
Biochemistry, 54, 2015
7ACT
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BU of 7act by Molmil
The SARS-CoV-2 nucleocapsid phosphoprotein N-terminal domain in complex with 10mer ssRNA
Descriptor: Nucleoprotein, ssRNA
Authors:Veverka, V.
Deposit date:2020-09-11
Release date:2020-10-28
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural basis of RNA recognition by the SARS-CoV-2 nucleocapsid phosphoprotein.
Plos Pathog., 16, 2020
7ACS
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BU of 7acs by Molmil
The SARS-CoV-2 nucleocapsid phosphoprotein N-terminal domain in complex with 7mer dsRNA
Descriptor: Nucleoprotein, RNA (5'-R(P*CP*AP*CP*UP*GP*AP*C)-3'), RNA (5'-R(P*GP*UP*CP*AP*GP*UP*G)-3')
Authors:Veverka, V.
Deposit date:2020-09-11
Release date:2020-11-04
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural basis of RNA recognition by the SARS-CoV-2 nucleocapsid phosphoprotein.
Plos Pathog., 16, 2020
2N72
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BU of 2n72 by Molmil
Solution structure of the Q domain from ACBD3
Descriptor: Golgi resident protein GCP60
Authors:Veverka, V, Hexnerova, R.
Deposit date:2015-09-02
Release date:2016-07-20
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural insights and in vitro reconstitution of membrane targeting and activation of human PI4KB by the ACBD3 protein.
Sci Rep, 6, 2016
2N73
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BU of 2n73 by Molmil
Solution structure of the ACBD3:PI4KB complex
Descriptor: Golgi resident protein GCP60, Phosphatidylinositol 4-kinase beta
Authors:Veverka, V, Hexnerova, R.
Deposit date:2015-09-02
Release date:2016-07-20
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural insights and in vitro reconstitution of membrane targeting and activation of human PI4KB by the ACBD3 protein.
Sci Rep, 6, 2016
5LZ3
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BU of 5lz3 by Molmil
Crystal structure of human ACBD3 GOLD domain in complex with 3A protein of Aichivirus A
Descriptor: 3A, Golgi resident protein GCP60
Authors:Klima, M, Boura, E.
Deposit date:2016-09-29
Release date:2016-12-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3 Å)
Cite:Kobuviral Non-structural 3A Proteins Act as Molecular Harnesses to Hijack the Host ACBD3 Protein.
Structure, 25, 2017
5LZ6
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BU of 5lz6 by Molmil
Crystal structure of human ACBD3 GOLD domain in complex with 3A protein of Aichivirus B
Descriptor: 3A, Golgi resident protein GCP60, beta-D-glucopyranose
Authors:Klima, M, Boura, E.
Deposit date:2016-09-29
Release date:2016-12-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Kobuviral Non-structural 3A Proteins Act as Molecular Harnesses to Hijack the Host ACBD3 Protein.
Structure, 25, 2017
5LZ1
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BU of 5lz1 by Molmil
Crystal structure of human ACBD3 GOLD domain
Descriptor: Golgi resident protein GCP60
Authors:Klima, M, Boura, E.
Deposit date:2016-09-29
Release date:2016-12-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Kobuviral Non-structural 3A Proteins Act as Molecular Harnesses to Hijack the Host ACBD3 Protein.
Structure, 25, 2017
8ORW
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BU of 8orw by Molmil
Crystal structure of human STING in complex with the agonist MD1203
Descriptor: 9-[(1~{S},6~{R},8~{R},9~{R},10~{R},15~{R},17~{R},18~{R})-8-(6-aminopurin-9-yl)-9,18-bis(fluoranyl)-3,12-bis(oxidanyl)-3,12-bis(oxidanylidene)-2,4,7,11,13-pentaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecan-17-yl]-1~{H}-purin-6-one, Stimulator of interferon protein
Authors:Klima, M, Boura, E.
Deposit date:2023-04-17
Release date:2023-12-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Fluorinated cGAMP analogs, which act as STING agonists and are not cleavable by poxins: Structural basis of their function.
Structure, 2024
8ORV
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BU of 8orv by Molmil
Crystal structure of monkeypox virus poxin in complex with the STING agonist MD1203
Descriptor: 9-[(1~{S},6~{R},8~{R},9~{R},10~{R},15~{R},17~{R},18~{R})-8-(6-aminopurin-9-yl)-9,18-bis(fluoranyl)-3,12-bis(oxidanyl)-3,12-bis(oxidanylidene)-2,4,7,11,13-pentaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecan-17-yl]-1~{H}-purin-6-one, MPXVgp165
Authors:Duchoslav, V, Klima, M, Boura, E.
Deposit date:2023-04-17
Release date:2023-12-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Fluorinated cGAMP analogs, which act as STING agonists and are not cleavable by poxins: Structural basis of their function.
Structure, 2024
8P45
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BU of 8p45 by Molmil
Crystal structure of human STING in complex with the agonist MD1202D
Descriptor: 9-[(1~{S},3~{R},6~{R},8~{R},9~{R},10~{R},12~{R},15~{R},17~{R},18~{R})-8-(6-aminopurin-9-yl)-9,18-bis(fluoranyl)-3,12-bis(oxidanylidene)-3,12-bis(sulfanyl)-2,4,7,11,13-pentaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecan-17-yl]-1~{H}-purin-6-one, Stimulator of interferon genes protein
Authors:Klima, M, Boura, E.
Deposit date:2023-05-19
Release date:2023-12-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.23 Å)
Cite:Fluorinated cGAMP analogs, which act as STING agonists and are not cleavable by poxins: Structural basis of their function.
Structure, 2024

 

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PDB entries from 2024-03-27

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