Author results

1AJE
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CDC42 FROM HUMAN, NMR, 20 STRUCTURES
Descriptor:CDC42HS
Authors:Feltham, J.L., Dotsch, V., Raza, S., Manor, D., Cerione, R.A., Sutcliffe, M.J., Wagner, G., Oswald, R.E.
Deposit date:1997-05-02
Release date:1997-11-12
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Definition of the switch surface in the solution structure of Cdc42Hs.
Biochemistry, 36, 1997
1AJW
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STRUCTURE OF RHOGDI: A C-TERMINAL BINDING DOMAIN TARGETS AN N-TERMINAL INHIBITORY PEPTIDE TO GTPASES, NMR, 20 STRUCTURES
Descriptor:RHOGDI
Authors:Rosen, M.K., Gosser, Y.Q.
Deposit date:1997-05-11
Release date:1997-11-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:C-terminal binding domain of Rho GDP-dissociation inhibitor directs N-terminal inhibitory peptide to GTPases.
Nature, 387, 1997
1GDF
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STRUCTURE OF RHOGDI: A C-TERMINAL BINDING DOMAIN TARGETS AN N-TERMINAL INHIBITORY PEPTIDE TO GTPASES, NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor:RHOGDI
Authors:Rosen, M.K., Gosser, Y.Q.
Deposit date:1997-05-11
Release date:1997-11-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:C-terminal binding domain of Rho GDP-dissociation inhibitor directs N-terminal inhibitory peptide to GTPases.
Nature, 387, 1997
2NGR
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TRANSITION STATE COMPLEX FOR GTP HYDROLYSIS BY CDC42: COMPARISONS OF THE HIGH RESOLUTION STRUCTURES FOR CDC42 BOUND TO THE ACTIVE AND CATALYTICALLY COMPROMISED FORMS OF THE CDC42-GAP.
Descriptor:PROTEIN (GTP BINDING PROTEIN (G25K)), PROTEIN (GTPASE ACTIVATING PROTEIN (RHG)), MAGNESIUM ION, ...
Authors:Nassar, N., Hoffman, G., Clardy, J., Cerione, R.
Deposit date:1998-07-31
Release date:1999-01-06
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP.
Nat.Struct.Biol., 5, 1998
1AN0
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CDC42HS-GDP COMPLEX
Descriptor:CDC42HS-GDP, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
Authors:Kongsaeree, P., Cerione, R., Clardy, J.
Deposit date:1997-06-26
Release date:1999-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The Structure Determination of Cdc42Hs and Gdp Complex
To be Published
1GRN
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CRYSTAL STRUCTURE OF THE CDC42/CDC42GAP/ALF3 COMPLEX.
Descriptor:PROTEIN (GTP BINDING PROTEIN), PROTEIN (RHO GTPASE ACTIVATING PROTEIN), MAGNESIUM ION, ...
Authors:Nassar, N., Hoffman, G.R., Clardy, J.C., Cerione, R.A.
Deposit date:1998-07-30
Release date:1999-12-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP.
Nat.Struct.Biol., 5, 1998
1CC0
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CRYSTAL STRUCTURE OF THE RHOA.GDP-RHOGDI COMPLEX
Descriptor:transforming protein rhoA, rho GDP dissociation inhibitor alpha, MAGNESIUM ION, ...
Authors:Longenecker, K.L., Read, P., Derewenda, U., Dauter, Z., Garrard, S., Walker, L., Somlyo, A.V., Somlyo, A.P., Nakamoto, R.K., Derewenda, Z.S.
Deposit date:1999-03-03
Release date:2000-01-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (5 Å)
Cite:How RhoGDI binds Rho.
Acta Crystallogr.,Sect.D, 55, 1999
1DOA
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STRUCTURE OF THE RHO FAMILY GTP-BINDING PROTEIN CDC42 IN COMPLEX WITH THE MULTIFUNCTIONAL REGULATOR RHOGDI
Descriptor:PROTEIN (GTP-BINDING PROTEIN), PROTEIN (GDP-DISSOCIATION INHIBITOR 1), MAGNESIUM ION, ...
Authors:Hoffman, G.R., Nassar, N., Cerione, R.C.
Deposit date:1999-12-20
Release date:2000-02-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI.
Cell(Cambridge,Mass.), 100, 2000
1EES
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SOLUTION STRUCTURE OF CDC42HS COMPLEXED WITH A PEPTIDE DERIVED FROM P-21 ACTIVATED KINASE, NMR, 20 STRUCTURES
Descriptor:GTP-BINDING PROTEIN, P21-ACTIVATED KINASE
Authors:Gizachew, D., Guo, W., Chohan, K.C., Sutcliffe, M.J., Oswald, R.E.
Deposit date:2000-02-02
Release date:2000-03-29
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of the complex of Cdc42Hs with a peptide derived from P-21 activated kinase.
Biochemistry, 39, 2000
1KV3
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HUMAN TISSUE TRANSGLUTAMINASE IN GDP BOUND FORM
Descriptor:Protein-glutamine gamma-glutamyltransferase, GUANOSINE-5'-DIPHOSPHATE
Authors:Liu, S., Cerione, R.A., Clardy, J.
Deposit date:2002-01-24
Release date:2002-03-13
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for the guanine nucleotide-binding activity of tissue transglutaminase and its regulation of transamidation activity.
Proc.Natl.Acad.Sci.USA, 99, 2002
1NI2
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STRUCTURE OF THE ACTIVE FERM DOMAIN OF EZRIN
Descriptor:Ezrin
Authors:Smith, W.J., Nassar, N., Bretscher, A.P., Cerione, R.A., Karplus, P.A.
Deposit date:2002-12-20
Release date:2003-02-25
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the Active N-terminal Domain of Ezrin. CONFORMATIONAL AND MOBILITY CHANGES IDENTIFY KEYSTONE INTERACTIONS.
J.Biol.Chem., 278, 2003
1PZD
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STRUCTURAL IDENTIFICATION OF A CONSERVED APPENDAGE DOMAIN IN THE CARBOXYL-TERMINUS OF THE COPI GAMMA-SUBUNIT.
Descriptor:Coatomer gamma subunit, SULFATE ION
Authors:Hoffman, G.R., Rahl, P.B., Collins, R.N., Cerione, R.A.
Deposit date:2003-07-10
Release date:2003-10-14
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Conserved Structural Motifs in Intracellular Trafficking Pathways. Structure of the gammaCOP Appendage Domain.
Mol.Cell, 12, 2003
2GCN
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CRYSTAL STRUCTURE OF THE HUMAN RHOC-GDP COMPLEX
Descriptor:Rho-related GTP-binding protein RhoC, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Dias, S.M.G., Cerione, R.A.
Deposit date:2006-03-14
Release date:2007-03-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:X-ray Crystal Structures Reveal Two Activated States for RhoC.
Biochemistry, 46, 2007
2GCO
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CRYSTAL STRUCTURE OF THE HUMAN RHOC-GPPNHP COMPLEX
Descriptor:Rho-related GTP-binding protein RhoC, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Dias, S.M.G., Cerione, R.A.
Deposit date:2006-03-14
Release date:2007-03-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:X-ray Crystal Structures Reveal Two Activated States for RhoC.
Biochemistry, 46, 2007
2GCP
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CRYSTAL STRUCTURE OF THE HUMAN RHOC-GSP COMPLEX
Descriptor:Rho-related GTP-binding protein RhoC, MAGNESIUM ION, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ...
Authors:Dias, S.M.G., Cerione, R.A.
Deposit date:2006-03-14
Release date:2007-03-27
Last modified:2011-08-31
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:X-ray Crystal Structures Reveal Two Activated States for RhoC.
Biochemistry, 46, 2007
2QRZ
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CDC42 BOUND TO GMP-PCP: INDUCED FIT BY EFFECTOR IS REQUIRED
Descriptor:Cell division control protein 42 homolog precursor, MAGNESIUM ION, SULFATE ION, ...
Authors:Phillips, M.J., Calero, G., Chan, B., Cerione, R.A.
Deposit date:2007-07-30
Release date:2008-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Effector Proteins Exert an Important Influence on the Signaling-active State of the Small GTPase Cdc42.
J.Biol.Chem., 283, 2008
3FEX
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CRYSTAL STRUCTURE OF THE CBC-IMPORTIN ALPHA COMPLEX.
Descriptor:Nuclear cap-binding protein subunit 1, Nuclear cap-binding protein subunit 2, Importin subunit alpha-2
Authors:Dias, S.M.G., Ambrosio, A.L.B., Cerione, R.A.
Deposit date:2008-12-01
Release date:2009-08-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.549 Å)
Cite:The molecular basis for the regulation of the cap-binding complex by the importins.
Nat.Struct.Mol.Biol., 16, 2009
3FEY
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CRYSTAL STRUCTURE OF THE CBC-IMPORTIN ALPHA COMPLEX.
Descriptor:Nuclear cap-binding protein subunit 1, Nuclear cap-binding protein subunit 2, Importin subunit alpha-2
Authors:Dias, S.M.G., Ambrosio, A.L.B., Cerione, R.A.
Deposit date:2008-12-01
Release date:2009-08-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The molecular basis for the regulation of the cap-binding complex by the importins.
Nat.Struct.Mol.Biol., 16, 2009
3RIG
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SIRT5 IS AN NAD-DEPENDENT PROTEIN LYSINE DEMALONYLASE AND DESUCCINYLASE
Descriptor:NAD-dependent deacetylase sirtuin-5, peptide of histone 3 thioacetyl-lysine 9, ZINC ION, ...
Authors:Zhou, Y.
Deposit date:2011-04-13
Release date:2011-11-23
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase
Science, 334, 2011
3RIY
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SIRT5 IS AN NAD-DEPENDENT PROTEIN LYSINE DEMALONYLASE AND DESUCCINYLASE
Descriptor:NAD-dependent deacetylase sirtuin-5, peptide of histone 3 N-succinyl lysine 9, ZINC ION, ...
Authors:Zhou, Y., Hao, Q.
Deposit date:2011-04-14
Release date:2011-11-23
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase
Science, 334, 2011
3SS3
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CRYSTAL STRUCTURE OF MOUSE GLUTAMINASE C, LIGAND-FREE FORM
Descriptor:Glutaminase C, CHLORIDE ION
Authors:Ambrosio, A.L.B., Dias, S.M.G., Cerione, R.A.
Deposit date:2011-07-07
Release date:2012-01-11
Last modified:2012-04-04
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism.
Proc.Natl.Acad.Sci.USA, 109, 2012
3SS4
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CRYSTAL STRUCTURE OF MOUSE GLUTAMINASE C, PHOSPHATE-BOUND FORM
Descriptor:Glutaminase C, PHOSPHATE ION
Authors:Ambrosio, A.L.B., Dias, S.M.G., Cerione, R.A.
Deposit date:2011-07-07
Release date:2012-01-11
Last modified:2012-04-04
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism.
Proc.Natl.Acad.Sci.USA, 109, 2012
3SS5
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CRYSTAL STRUCTURE OF MOUSE GLUTAMINASE C, L-GLUTAMATE-BOUND FORM
Descriptor:Glutaminase C, GLUTAMIC ACID
Authors:Ambrosio, A.L.B., Dias, S.M.G., Cerione, R.A.
Deposit date:2011-07-07
Release date:2012-01-11
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism.
Proc.Natl.Acad.Sci.USA, 109, 2012
3V00
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STUDIES OF A CONSTITUTIVELY ACTIVE G-ALPHA SUBUNIT PROVIDE INSIGHTS INTO THE MECHANISM OF G PROTEIN ACTIVATION.
Descriptor:Guanine nucleotide-binding protein G(t) subunit alpha-1/ Guanine nucleotide-binding protein G(i) subunit alpha-1 chimeric protein, GUANOSINE-5'-DIPHOSPHATE
Authors:Singh, G., Cerione, R.A.
Deposit date:2011-12-07
Release date:2012-04-18
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A constitutively active G-alpha subunit provide insights into the mechanism of G protein activation
Biochemistry, 51, 2012
4F4U
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THE BICYCLIC INTERMEDIATE STRUCTURE PROVIDES INSIGHTS INTO THE DESUCCINYLATION MECHANISM OF SIRT5
Descriptor:NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial, peptide from Histone H3.1, ...
Authors:Zhou, Y., Hao, Q.
Deposit date:2012-05-11
Release date:2012-06-20
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Bicyclic Intermediate Structure Provides Insights into the Desuccinylation Mechanism of Human Sirtuin 5 (SIRT5)
J.Biol.Chem., 287, 2012
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