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6D7A
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BU of 6d7a by Molmil
Structure of T. gondii PLP1 beta-rich domain
Descriptor: Perforin-like protein 1, SODIUM ION
Authors:Guerra, A.J, Koropatkin, N.M, Wawrzak, Z, Bahr, C.M.E, Carruthers, V.B.
Deposit date:2018-04-24
Release date:2018-05-16
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (1.13 Å)
Cite:Structural basis of Toxoplasma gondii perforin-like protein 1 membrane interaction and activity during egress.
PLoS Pathog., 14, 2018
2LU2
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BU of 2lu2 by Molmil
MIC5 regulates the activity of Toxoplasma subtilisin 1 by mimicking a subtilisin prodomain
Descriptor: Microneme TgMIC5 protein
Authors:Saouros, S, Dou, Z, Henry, M, Marchant, J, Carruthers, V.B, Matthews, S.
Deposit date:2012-06-07
Release date:2012-08-22
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Microneme protein 5 regulates the activity of toxoplasma subtilisin 1 by mimicking a subtilisin prodomain.
J.Biol.Chem., 287, 2012
3F75
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BU of 3f75 by Molmil
Activated Toxoplasma gondii cathepsin L (TgCPL) in complex with its propeptide
Descriptor: 1,2-ETHANEDIOL, BROMIDE ION, CHLORIDE ION, ...
Authors:Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2008-11-07
Release date:2008-11-25
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Toxoplasma gondii cathepsin L is the primary target of the invasion-inhibitory compound morpholinurea-leucyl-homophenyl-vinyl sulfone phenyl.
J.Biol.Chem., 284, 2009
6BFA
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BU of 6bfa by Molmil
Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1553
Descriptor: 1-{4-amino-3-[6-(cyclopropyloxy)naphthalen-2-yl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-2-methylpropan-2-ol, Calmodulin-domain protein kinase 1
Authors:Merritt, E.A.
Deposit date:2017-10-26
Release date:2017-12-06
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis.
J. Med. Chem., 59, 2016
2MPO
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BU of 2mpo by Molmil
Structural basis of Toxoplasma gondii MIC2-Associated Protein interaction with MIC2
Descriptor: MIC2-associated protein
Authors:Liu, B, Matthews, S.
Deposit date:2014-05-29
Release date:2014-11-26
Method:SOLUTION NMR
Cite:Structural basis of Toxoplasma gondii MIC2-Associated Protein interaction with MIC2
To Be Published
4TZR
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BU of 4tzr by Molmil
Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1561
Descriptor: 1-{4-amino-3-[2-(cyclopropyloxy)quinolin-6-yl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-2-methylpropan-2-ol, Calmodulin-domain protein kinase 1
Authors:Merritt, E.A.
Deposit date:2014-07-10
Release date:2014-08-27
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis.
J. Med. Chem., 59, 2016

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PDB entries from 2024-03-27

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