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2LU2
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MIC5 REGULATES THE ACTIVITY OF TOXOPLASMA SUBTILISIN 1 BY MIMICKING A SUBTILISIN PRODOMAIN
Descriptor:Microneme TgMIC5 protein
Authors:Saouros, S., Dou, Z., Henry, M., Marchant, J., Carruthers, V.B., Matthews, S.
Deposit date:2012-06-07
Release date:2012-08-22
Last modified:2012-11-14
Method:SOLUTION NMR
Cite:Microneme protein 5 regulates the activity of toxoplasma subtilisin 1 by mimicking a subtilisin prodomain.
J.Biol.Chem., 287, 2012
6D7A
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STRUCTURE OF T. GONDII PLP1 BETA-RICH DOMAIN
Descriptor:Perforin-like protein 1, SODIUM ION
Authors:Guerra, A.J., Koropatkin, N.M., Wawrzak, Z., Bahr, C.M.E., Carruthers, V.B.
Deposit date:2018-04-24
Release date:2018-05-16
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (1.13 Å)
Cite:Structural basis of Toxoplasma gondii perforin-like protein 1 membrane interaction and activity during egress.
PLoS Pathog., 14, 2018
2MPO
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STRUCTURAL BASIS OF TOXOPLASMA GONDII MIC2-ASSOCIATED PROTEIN INTERACTION WITH MIC2
Descriptor:MIC2-associated protein
Authors:Liu, B., Matthews, S.
Deposit date:2014-05-29
Release date:2014-11-26
Method:SOLUTION NMR
Cite:Structural basis of Toxoplasma gondii MIC2-Associated Protein interaction with MIC2
To Be Published
3F75
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ACTIVATED TOXOPLASMA GONDII CATHEPSIN L (TGCPL) IN COMPLEX WITH ITS PROPEPTIDE
Descriptor:Cathepsin L Protease, Cathepsin L Propeptide, CHLORIDE ION, ...
Authors:Larson, E.T., Merritt, E.A., Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2008-11-07
Release date:2008-11-25
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Toxoplasma gondii cathepsin L is the primary target of the invasion-inhibitory compound morpholinurea-leucyl-homophenyl-vinyl sulfone phenyl.
J.Biol.Chem., 284, 2009
4TZR
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CALCIUM-DEPENDENT PROTEIN KINASE 1 FROM TOXOPLASMA GONDII (TGCDPK1) IN COMPLEX WITH INHIBITOR UW1561
Descriptor:Calmodulin-domain protein kinase 1, 1-{4-amino-3-[2-(cyclopropyloxy)quinolin-6-yl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-2-methylpropan-2-ol
Authors:Merritt, E.A.
Deposit date:2014-07-10
Release date:2014-08-27
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis.
J. Med. Chem., 59, 2016
6BFA
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CALCIUM-DEPENDENT PROTEIN KINASE 1 FROM TOXOPLASMA GONDII (TGCDPK1) IN COMPLEX WITH INHIBITOR UW1553
Descriptor:Calmodulin-domain protein kinase 1, 1-{4-amino-3-[6-(cyclopropyloxy)naphthalen-2-yl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-2-methylpropan-2-ol
Authors:Merritt, E.A.
Deposit date:2017-10-26
Release date:2017-12-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis.
J. Med. Chem., 59, 2016