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4AZE
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HUMAN DYRK1A IN COMPLEX WITH LEUCETTINE L41
Descriptor:DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 1A, 5-(1,3-benzodioxol-5-ylmethyl)-2-(phenylamino)-4H-imidazol-4-one
Authors:Elkins, J.M., Soundararajan, M., Muniz, J.R.C., Tahtouh, T., Burgy, G., Durieu, E., Lozach, O., Cochet, C., Schmid, R.S., Lo, D.C., Delhommel, F., Carreaux, F., Bazureau, J.P., Meijer, L., Edwards, A., Bountra, C., Knapp, S.
Deposit date:2012-06-25
Release date:2012-09-05
Last modified:2012-11-21
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Selectivity, Co-Crystal Structures and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B.
J.Med.Chem., 55, 2012
4AZF
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HUMAN DYRK2 IN COMPLEX WITH LEUCETTINE L41
Descriptor:DYRK2 DUAL-SPECIFICITY TYROSINE-PHOSPHORYLATION REGULATED KINASE 2, 5-(1,3-benzodioxol-5-ylmethyl)-2-(phenylamino)-4H-imidazol-4-one, 1,2-ETHANEDIOL, ...
Authors:Elkins, J.M., Soundararajan, M., Muniz, J.R.C., Tahtouh, T., Burgy, G., Durieu, E., Lozach, O., Cochet, C., Schmid, R.S., Lo, D.C., Delhommel, F., Carreaux, F., Bazureau, J.P., Meijer, L., Edwards, A., Bountra, C., Knapp, S.
Deposit date:2012-06-25
Release date:2012-09-05
Last modified:2012-11-21
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Selectivity, Co-Crystal Structures and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B.
J.Med.Chem., 55, 2012
3RAW
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CRYSTAL STRUCTURE OF HUMAN CDC-LIKE KINASE 3 ISOFORM IN COMPLEX WITH LEUCETTINE L41
Descriptor:Dual specificity protein kinase CLK3, 5-(1,3-benzodioxol-5-ylmethyl)-2-(phenylamino)-4H-imidazol-4-one
Authors:Filippakopoulos, P., Fedorov, O., King, O., Debdab, M., Carreaux, F., Renault, S., Bullock, A., Muniz, J.R.C., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Meijer, L., Bazureau, J.P., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2011-03-28
Release date:2011-05-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Crystal Structure of human CDC-like kinase 3 isoform with a benzo-dioxol ligand
To be Published
4GW8
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HUMAN PROTO-ONCOGENE SERINE THREONINE KINASE (PIM1) IN COMPLEX WITH A CONSENSUS PEPTIDE AND LEUCETTINE L41
Descriptor:Serine/threonine-protein kinase pim-1, Consensus peptide (Pimtide), 5-(1,3-benzodioxol-5-ylmethyl)-2-(phenylamino)-4H-imidazol-4-one, ...
Authors:Filippakopoulos, P., Bullock, A., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A., Meijer, L., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2012-09-01
Release date:2012-10-03
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B.
J.Med.Chem., 55, 2012
4B7T
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GLYCOGEN SYNTHASE KINASE 3 BETA COMPLEXED WITH AXIN PEPTIDE AND LEUCETTINE L4
Descriptor:GLYCOGEN SYNTHASE KINASE-3 BETA, AXIN-1, (5Z)-5-(1,3-benzodioxol-5-ylmethylidene)-3-methyl-2-(propan-2-ylamino)imidazol-4-one
Authors:Oberholzer, A.E., Pearl, L.H.
Deposit date:2012-08-22
Release date:2013-01-30
Method:X-RAY DIFFRACTION (2.772 Å)
Cite:Selectivity, Cocrystal Structures, and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B.
J.Med.Chem., 55, 2012