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7BO7
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BU of 7bo7 by Molmil
CRYSTAL STRUCTURE OF THE HUMAN PRMT5:MEP50 COMPLEX with JNJB44355437
Descriptor: (2~{R},3~{R},4~{S},5~{R})-2-[(4~{a}~{S},7~{a}~{S})-4-azanyl-1,4,4~{a},7~{a}-tetrahydropyrrolo[2,3-d]pyrimidin-7-yl]-5-(quinolin-7-yloxymethyl)oxolane-3,4-diol, 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Brown, D, Robinson, C, Carr, K.H, Pande, V.
Deposit date:2021-01-24
Release date:2022-03-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.83 Å)
Cite:CRYSTAL STRUCTURE OF THE HUMAN PRMT5:MEP50 COMPLEX with JNJB44355437
To Be Published
3RFE
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BU of 3rfe by Molmil
Crystal structure of glycoprotein GPIb ectodomain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, Platelet glycoprotein Ib beta chain, ...
Authors:McEwan, P.A, Yang, W, Carr, K.H, Mo, X, Zheng, X, Li, R, Emsley, J.
Deposit date:2011-04-06
Release date:2011-12-21
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.245 Å)
Cite:Quaternary organization of GPIb-IX complex and insights into Bernard-Soulier syndrome revealed by the structures of GPIbbeta and a GPIbbeta/GPIX chimer
Blood, 118, 2011
3REZ
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BU of 3rez by Molmil
glycoprotein GPIb variant
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, Platelet glycoprotein Ib beta chain, ...
Authors:McEwan, P.A, Yang, W, Carr, K.H, Mo, X, Zheng, X, Li, R, Emsley, J.
Deposit date:2011-04-05
Release date:2012-02-15
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Quaternary organization of GPIb-IX complex and insights into Bernard-Soulier syndrome revealed by the structures of GPIb beta and a GPIb beta/GPIX chimera
Blood, 118, 2011
5M53
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BU of 5m53 by Molmil
Nek2 bound to arylaminopurine inhibitor 11
Descriptor: 1,2-ETHANEDIOL, 3-[[6-(cyclohexylmethoxy)-7~{H}-purin-2-yl]amino]-~{N},~{N}-dimethyl-benzamide, DI(HYDROXYETHYL)ETHER, ...
Authors:Bayliss, R, Carr, K.H.
Deposit date:2016-10-20
Release date:2016-11-09
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-guided design of purine-based probes for selective Nek2 inhibition.
Oncotarget, 8, 2017
6S73
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BU of 6s73 by Molmil
Crystal structure of Nek7 SRS mutant bound to compound 51
Descriptor: 3-[[6-(cyclohexylmethoxy)-7~{H}-purin-2-yl]amino]-~{N}-[3-(dimethylamino)propyl]benzenesulfonamide, Serine/threonine-protein kinase Nek7
Authors:Nasir, N, Byrne, M.J, Bhatia, C, Bayliss, R.
Deposit date:2019-07-04
Release date:2020-06-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Nek7 conformational flexibility and inhibitor binding probed through protein engineering of the R-spine.
Biochem.J., 477, 2020
6S75
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BU of 6s75 by Molmil
Crystal structure of Nek7 bound to compound 51
Descriptor: 3-[[6-(cyclohexylmethoxy)-7~{H}-purin-2-yl]amino]-~{N}-[3-(dimethylamino)propyl]benzenesulfonamide, Serine/threonine-protein kinase Nek7
Authors:Nasir, N, Bayliss, R.
Deposit date:2019-07-04
Release date:2020-06-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Nek7 conformational flexibility and inhibitor binding probed through protein engineering of the R-spine.
Biochem.J., 477, 2020
6S76
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BU of 6s76 by Molmil
Crystal structure of human Nek7
Descriptor: DI(HYDROXYETHYL)ETHER, Serine/threonine-protein kinase Nek7
Authors:Nasir, N, Bayliss, R.
Deposit date:2019-07-04
Release date:2020-06-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.38 Å)
Cite:Nek7 conformational flexibility and inhibitor binding probed through protein engineering of the R-spine.
Biochem.J., 477, 2020
6SK9
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BU of 6sk9 by Molmil
Nek2 bound to purine compound 51
Descriptor: 3-[[6-(cyclohexylmethoxy)-7~{H}-purin-2-yl]amino]-~{N}-[3-(dimethylamino)propyl]benzenesulfonamide, GLYCEROL, Serine/threonine-protein kinase Nek2
Authors:Bayliss, R, Byrne, M.J, Mas-Droux, C.
Deposit date:2019-08-15
Release date:2020-06-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Nek7 conformational flexibility and inhibitor binding probed through protein engineering of the R-spine.
Biochem.J., 477, 2020
5M55
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BU of 5m55 by Molmil
Nek2 bound to arylaminopurine 71
Descriptor: 6-[(~{Z})-2-(diethylamino)ethenyl]-~{N}-phenyl-7~{H}-purin-2-amine, CHLORIDE ION, SULFATE ION, ...
Authors:Bayliss, R.
Deposit date:2016-10-20
Release date:2016-11-02
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure-guided design of purine-based probes for selective Nek2 inhibition.
Oncotarget, 8, 2017
5M51
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BU of 5m51 by Molmil
Nek2 bound to arylaminopurine compound 8
Descriptor: 3-[[6-(cyclohexylmethoxy)-9~{H}-purin-2-yl]amino]benzamide, Serine/threonine-protein kinase Nek2
Authors:Bayliss, R, Yeoh, S.
Deposit date:2016-10-20
Release date:2016-11-09
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.899 Å)
Cite:Structure-guided design of purine-based probes for selective Nek2 inhibition.
Oncotarget, 8, 2017
5M57
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BU of 5m57 by Molmil
Nek2 bound to arylaminopurine 6
Descriptor: O6-CYCLOHEXYLMETHOXY-2-(4'-SULPHAMOYLANILINO) PURINE, Serine/threonine-protein kinase Nek2
Authors:Bayliss, R.
Deposit date:2016-10-20
Release date:2016-11-23
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure-guided design of purine-based probes for selective Nek2 inhibition.
Oncotarget, 8, 2017

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