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3RSN
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CRYSTAL STRUCTURE OF THE N-TERMINAL REGION OF HUMAN ASH2L
分子名称:Set1/Ash2 histone methyltransferase complex subunit ASH2, ZINC ION
著者Chen, Y., Wan, B., Wang, K.C., Cao, F., Yang, Y., Protacio, A., Dou, Y., Chang, H.Y., Lei, M.
登録日2011-05-02
公開日2011-06-22
最終更新日2011-12-14
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding.
Embo Rep., 12, 2011
3TOJ
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STRUCTURE OF THE SPRY DOMAIN OF HUMAN ASH2L
分子名称:Set1/Ash2 histone methyltransferase complex subunit ASH2
著者Chen, Y., Cao, F., Wan, B., Dou, Y., Lei, M.
登録日2011-09-05
公開日2012-01-25
最終更新日2017-08-23
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献Structure of the SPRY domain of human Ash2L and its interactions with RbBP5 and DPY30.
Cell Res., 22, 2012
3VRL
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CRYSTAL STRUCTURE OF BMJ4 P24 CAPSID PROTEIN IN COMPLEX WITH A10F9 FAB
分子名称:A10F9 Fab heavy chain, A10F9 Fab light chain, Gag protein
著者Gu, Y., Cao, F., Li, S., Yuan, Y.A., Xia, N.
登録日2012-04-12
公開日2013-04-17
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structure of the HIV-1 capsid protein p24 in complex with the broad-spectrum antibody A10F9
To be Published
4GM3
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CRYSTAL STRUCTURE OF HUMAN WD REPEAT DOMAIN 5 WITH COMPOUND MM-101
分子名称:WD repeat-containing protein 5, MM-101
著者Karatas, H., Townsend, E.C., Chen, Y., Bernard, D., Cao, F., Liu, L., Lei, M., Dou, Y., Wang, S.
登録日2012-08-15
公開日2013-07-31
実験手法X-RAY DIFFRACTION (3.393 Å)
主引用文献High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction.
J.Am.Chem.Soc., 135, 2013
4GM8
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CRYSTAL STRUCTURE OF HUMAN WD REPEAT DOMAIN 5 WITH COMPOUND MM-102
分子名称:WD repeat-containing protein 5, MM-102
著者Karatas, H., Townsend, E.C., Chen, Y., Bernard, D., Cao, F., Liu, L., Lei, M., Dou, Y., Wang, S.
登録日2012-08-15
公開日2013-07-31
実験手法X-RAY DIFFRACTION (2.601 Å)
主引用文献High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction.
J.Am.Chem.Soc., 135, 2013
4GMB
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CRYSTAL STRUCTURE OF HUMAN WD REPEAT DOMAIN 5 WITH COMPOUND MM-402
分子名称:WD repeat-containing protein 5, MM-402
著者Karatas, H., Townsend, E.C., Chen, Y., Bernard, D., Cao, F., Liu, L., Lei, M., Dou, Y., Wang, S.
登録日2012-08-15
公開日2014-02-19
最終更新日2017-06-28
実験手法X-RAY DIFFRACTION (2.781 Å)
主引用文献Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction.
J. Med. Chem., 2017
5F59
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THE CRYSTAL STRUCTURE OF MLL3 SET DOMAIN
分子名称:Histone-lysine N-methyltransferase 2C, ZINC ION, S-ADENOSYL-L-HOMOCYSTEINE
著者Li, Y., Lei, M., Chen, Y.
登録日2015-12-04
公開日2016-02-24
最終更新日2016-04-20
実験手法X-RAY DIFFRACTION (2.801 Å)
主引用文献Structural basis for activity regulation of MLL family methyltransferases.
Nature, 530, 2016
5F5E
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THE CRYSTAL STRUCTURE OF MLL1 SET DOMAIN WITH N3816I/Q3867L MUTATION
分子名称:Histone-lysine N-methyltransferase 2A, ZINC ION, S-ADENOSYL-L-HOMOCYSTEINE
著者Li, Y., Lei, M., Chen, Y.
登録日2015-12-04
公開日2016-02-24
最終更新日2016-04-20
実験手法X-RAY DIFFRACTION (1.802 Å)
主引用文献Structural basis for activity regulation of MLL family methyltransferases.
Nature, 530, 2016
5F6K
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CRYSTAL STRUCTURE OF THE MLL3-ASH2L-RBBP5 COMPLEX
分子名称:Set1/Ash2 histone methyltransferase complex subunit ASH2,Set1/Ash2 histone methyltransferase complex subunit ASH2, Histone-lysine N-methyltransferase 2C, Retinoblastoma-binding protein 5, ...
著者Li, Y., Lei, M., Chen, Y.
登録日2015-12-06
公開日2016-02-24
最終更新日2016-04-20
実験手法X-RAY DIFFRACTION (2.411 Å)
主引用文献Structural basis for activity regulation of MLL family methyltransferases.
Nature, 530, 2016
5F6L
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THE CRYSTAL STRUCTURE OF MLL1 (N3861I/Q3867L) IN COMPLEX WITH RBBP5 AND ASH2L
分子名称:Retinoblastoma-binding protein 5, Set1/Ash2 histone methyltransferase complex subunit ASH2, Histone-lysine N-methyltransferase 2A, ...
著者Li, Y., Lei, M., Chen, Y.
登録日2015-12-06
公開日2016-02-24
最終更新日2016-04-20
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural basis for activity regulation of MLL family methyltransferases.
Nature, 530, 2016
5VFC
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WDR5 BOUND TO INHIBITOR MM-589
分子名称:WD repeat-containing protein 5, N-{(3R,6S,9S,12R)-6-ethyl-12-methyl-9-[3-(N'-methylcarbamimidamido)propyl]-2,5,8,11-tetraoxo-3-phenyl-1,4,7,10-tetraazacyclotetradecan-12-yl}-2-methylpropanamide, SULFATE ION, ...
著者Stuckey, J.A.
登録日2017-04-07
公開日2017-06-28
最終更新日2017-09-20
実験手法X-RAY DIFFRACTION (1.64 Å)
主引用文献Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction.
J. Med. Chem., 60, 2017