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2IF7
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BU of 2if7 by Molmil
Crystal Structure of NTB-A
Descriptor: CALCIUM ION, CHLORIDE ION, SLAM family member 6
Authors:Cao, E, Ramagopal, U.A, Fedorov, A.A, Fedorov, E.V, Nathenson, S.G, Almo, S.C.
Deposit date:2006-09-20
Release date:2006-10-17
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3 Å)
Cite:NTB-A Receptor Crystal Structure: Insights into Homophilic Interactions in the Signaling Lymphocytic Activation Molecule Receptor Family.
Immunity, 25, 2006
2OYP
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BU of 2oyp by Molmil
T Cell Immunoglobulin Mucin-3 Crystal Structure Revealed a Galectin-9-independent Binding Surface
Descriptor: Hepatitis A virus cellular receptor 2, SULFATE ION
Authors:Cao, E, Ramagopal, U.A, Fedorov, A.A, Fedorov, E.V, Nathenson, S.G, Almo, S.C.
Deposit date:2007-02-22
Release date:2007-04-10
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.952 Å)
Cite:T cell immunoglobulin mucin-3 crystal structure reveals a galectin-9-independent ligand-binding surface
Immunity, 26, 2007
6WB8
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BU of 6wb8 by Molmil
Cryo-EM structure of PKD2 C331S disease variant
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Polycystin-2
Authors:Cao, E, Wang, J, Decaen, P.G.
Deposit date:2020-03-26
Release date:2020-04-22
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.24 Å)
Cite:Molecular dysregulation of ciliary polycystin-2 channels caused by variants in the TOP domain.
Proc.Natl.Acad.Sci.USA, 117, 2020
6PZT
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BU of 6pzt by Molmil
cryo-EM structure of human NKCC1
Descriptor: Solute carrier family 12 member 2
Authors:Cao, E, Wang, Q, Yang, X.
Deposit date:2019-08-01
Release date:2020-03-25
Method:ELECTRON MICROSCOPY (3.46 Å)
Cite:Structure of the human cation-chloride cotransporter NKCC1 determined by single-particle electron cryo-microscopy.
Nat Commun, 11, 2020
3J5Q
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BU of 3j5q by Molmil
Structure of TRPV1 ion channel in complex with DkTx and RTX determined by single particle electron cryo-microscopy
Descriptor: Kappa-theraphotoxin-Cg1a 1, Transient receptor potential cation channel subfamily V member 1
Authors:Liao, M, Cao, E, Julius, D, Cheng, Y.
Deposit date:2013-10-28
Release date:2013-12-04
Last modified:2022-11-02
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:TRPV1 structures in distinct conformations reveal activation mechanisms.
Nature, 504, 2013
3J5R
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BU of 3j5r by Molmil
Reconstruction of TRPV1 ion channel in complex with capsaicin by single particle cryo-microscopy
Descriptor: Transient receptor potential cation channel subfamily V member 1
Authors:Liao, M, Cao, E, Julius, D, Cheng, Y.
Deposit date:2013-10-28
Release date:2013-12-04
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:TRPV1 structures in distinct conformations reveal activation mechanisms.
Nature, 504, 2013
6D1W
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BU of 6d1w by Molmil
human PKD2 F604P mutant
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Polycystin-2
Authors:Zheng, W, Yang, X, Bulkley, D, Chen, X.Z, Cao, E.
Deposit date:2018-04-12
Release date:2018-06-27
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.54 Å)
Cite:Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels.
Nat Commun, 9, 2018
1NPU
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BU of 1npu by Molmil
CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF MURINE PD-1
Descriptor: Programmed cell death protein 1
Authors:Zhang, X, Schwartz, J.-C.D, Guo, X, Cao, E, Chen, L, Zhang, Z.-Y, Nathenson, S.G, Almo, S.C, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2003-01-20
Release date:2004-03-23
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and functional analysis of the costimulatory receptor programmed death-1.
Immunity, 20, 2004
5T4D
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BU of 5t4d by Molmil
Cryo-EM structure of Polycystic Kidney Disease protein 2 (PKD2), residues 198-703
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, hPKD:198-703, Polycystin-2
Authors:Shen, P.S, Yang, X, DeCaen, P.G, Liu, X, Bulkley, D, Clapham, D.E, Cao, E.
Deposit date:2016-08-29
Release date:2016-11-02
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3 Å)
Cite:The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs.
Cell, 167, 2016
3BP5
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BU of 3bp5 by Molmil
Crystal structure of the mouse PD-1 and PD-L2 complex
Descriptor: GLYCEROL, Programmed cell death 1 ligand 2, Programmed cell death protein 1
Authors:Yan, Q, Lazar-Molnar, E, Cao, E, Ramagopal, U.A, Toro, R, Nathenson, S.G, Almo, S.C.
Deposit date:2007-12-18
Release date:2008-07-15
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the complex between programmed death-1 (PD-1) and its ligand PD-L2.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3BP6
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BU of 3bp6 by Molmil
Crystal structure of the mouse PD-1 Mutant and PD-L2 complex
Descriptor: GLYCEROL, Programmed cell death 1 ligand 2, Programmed cell death protein 1
Authors:Yan, Q, Lazar-Molnar, E, Cao, E, Ramagopal, U.A, Toro, R, Nathenson, S.G, Almo, S.C.
Deposit date:2007-12-18
Release date:2009-02-24
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of the mouse PD-1 A99L and PD-L2 complex
To be published
3BOV
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BU of 3bov by Molmil
Crystal structure of the receptor binding domain of mouse PD-L2
Descriptor: FORMIC ACID, Programmed cell death 1 ligand 2, SODIUM ION
Authors:Lazar-Molnar, E, Ramagopal, U, Cao, E, Toro, R, Nathenson, S.G, Almo, S.C.
Deposit date:2007-12-17
Release date:2008-07-15
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Crystal structure of the complex between programmed death-1 (PD-1) and its ligand PD-L2.
Proc.Natl.Acad.Sci.USA, 105, 2008
3RNK
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BU of 3rnk by Molmil
Crystal structure of the complex between mouse PD-1 mutant and PD-L2 IgV domain
Descriptor: Programmed cell death 1 ligand 2, Programmed cell death protein 1
Authors:Lazar-Molnar, E, Ramagopal, U.A, Cao, E, Nathenson, S.G, Almo, S.C.
Deposit date:2011-04-22
Release date:2011-06-01
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Crystal structure of the complex between mouse PD-1 mutant and PD-L2 IgV domain
To be Published
3J5P
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BU of 3j5p by Molmil
Structure of TRPV1 ion channel determined by single particle electron cryo-microscopy
Descriptor: Transient receptor potential cation channel subfamily V member 1
Authors:Liao, M, Cao, E, Julius, D, Cheng, Y.
Deposit date:2013-10-28
Release date:2013-12-04
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (3.275 Å)
Cite:Structure of the TRPV1 ion channel determined by electron cryo-microscopy.
Nature, 504, 2013
3SBW
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BU of 3sbw by Molmil
Crystal structure of the complex between the extracellular domains of mouse PD-1 mutant and human PD-L1
Descriptor: Programmed cell death 1 ligand 1, Programmed cell death protein 1
Authors:Lazar-Molnar, E, Ramagopal, U.A, Cao, E, Nathenson, S.G, Almo, S.C.
Deposit date:2011-06-06
Release date:2011-07-13
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Crystal structure of the complex between the extracellular domains of mouse PD-1 mutant and human PD-L1
To be published
2PKD
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BU of 2pkd by Molmil
Crystal structure of CD84: Insite into SLAM family function
Descriptor: CHLORIDE ION, SLAM family member 5
Authors:Yan, Q, Malashkevich, V.N, Fedorov, A, Cao, E, Lary, J.W, Cole, J.L, Nathenson, S.G, Almo, S.C.
Deposit date:2007-04-17
Release date:2007-06-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.043 Å)
Cite:Structure of CD84 provides insight into SLAM family function.
Proc.Natl.Acad.Sci.Usa, 104, 2007
5IS0
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BU of 5is0 by Molmil
Structure of TRPV1 in complex with capsazepine, determined in lipid nanodisc
Descriptor: Transient receptor potential cation channel subfamily V member 1, capsazepine
Authors:Gao, Y, Cao, E, Julius, D, Cheng, Y.
Deposit date:2016-03-15
Release date:2016-05-25
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.43 Å)
Cite:TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action.
Nature, 534, 2016
5IRX
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BU of 5irx by Molmil
Structure of TRPV1 in complex with DkTx and RTX, determined in lipid nanodisc
Descriptor: (2S)-2-(acetyloxy)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}propyl pentanoate, (2S)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(hexanoyloxy)propyl hexanoate, (4R,7S)-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-7-[(pentanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphatetradecan-1-aminium, ...
Authors:Gao, Y, Cao, E, Julius, D, Cheng, Y.
Deposit date:2016-03-14
Release date:2016-05-25
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (2.95 Å)
Cite:TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action.
Nature, 534, 2016
5IRZ
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BU of 5irz by Molmil
Structure of TRPV1 determined in lipid nanodisc
Descriptor: (2S)-1-{[(R)-hydroxy{[(1R,2R,3S,4S,5S,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-3-(pentanoyloxy)propan-2-yl decanoate, (2S)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(hexanoyloxy)propyl hexanoate, (4R,7S)-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-7-[(pentanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphatetradecan-1-aminium, ...
Authors:Gao, Y, Cao, E, Julius, D, Cheng, Y.
Deposit date:2016-03-15
Release date:2016-05-25
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.28 Å)
Cite:TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action.
Nature, 534, 2016
7TTI
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BU of 7tti by Molmil
Human KCC1 bound with VU0463271 In an outward-open state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-cyclopropyl-N-(4-methyl-1,3-thiazol-2-yl)-2-[(6-phenylpyridazin-3-yl)sulfanyl]acetamide, Solute carrier family 12 member 4
Authors:Zhao, Y.X, Cao, E.H.
Deposit date:2022-02-01
Release date:2022-06-29
Last modified:2022-07-13
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure of the human cation-chloride cotransport KCC1 in an outward-open state.
Proc.Natl.Acad.Sci.USA, 119, 2022
7TTH
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BU of 7tth by Molmil
Human potassium-chloride cotransporter 1 in inward-open state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, POTASSIUM ION, Solute carrier family 12 member 4
Authors:Zhao, Y.X, Cao, E.H.
Deposit date:2022-02-01
Release date:2022-06-29
Last modified:2022-07-13
Method:ELECTRON MICROSCOPY (3.25 Å)
Cite:Structure of the human cation-chloride cotransport KCC1 in an outward-open state.
Proc.Natl.Acad.Sci.USA, 119, 2022
7S1Z
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BU of 7s1z by Molmil
Cryo-EM structure of Human NKCC1 K289NA492EL671C
Descriptor: Solute carrier family 12 member 2
Authors:Zhao, Y.X, Cao, E.H.
Deposit date:2021-09-02
Release date:2022-05-25
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide
Nat Commun, 13, 2022
7S1X
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BU of 7s1x by Molmil
Cryo-EM structure of human NKCC1 K289NA492EL671C bound with bumetanide
Descriptor: 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid, CHLORIDE ION, POTASSIUM ION, ...
Authors:Zhao, Y.X, Cao, E.H.
Deposit date:2021-09-02
Release date:2022-05-25
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide
Nat Commun, 13, 2022
7S1Y
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BU of 7s1y by Molmil
Cryo-EM structure of human NKCC1 K289NA492E bound with bumetanide
Descriptor: 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid, CHLORIDE ION, POTASSIUM ION, ...
Authors:Zhao, Y.X, Cao, E.h.
Deposit date:2021-09-02
Release date:2022-05-25
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide
Nat Commun, 13, 2022
3J9J
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BU of 3j9j by Molmil
Structure of the capsaicin receptor, TRPV1, determined by single particle electron cryo-microscopy
Descriptor: Transient receptor potential cation channel subfamily V member 1
Authors:Wang, R.Y.-R, Barad, B.A, Fraser, J.S, DiMaio, F.
Deposit date:2015-02-02
Release date:2015-09-02
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (3.275 Å)
Cite:EMRinger: side chain-directed model and map validation for 3D cryo-electron microscopy.
Nat.Methods, 12, 2015

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PDB entries from 2024-03-27

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