Author results

5BTR
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CRYSTAL STRUCTURE OF SIRT1 IN COMPLEX WITH RESVERATROL AND AN AMC-CONTAINING PEPTIDE
Descriptor:NAD-dependent protein deacetylase sirtuin-1, AMC-containing peptide, ZINC ION, ...
Authors:Cao, D., Wang, M., Qiu, X., Liu, D., Jiang, H., Yang, N., Xu, R.M.
Deposit date:2015-06-03
Release date:2015-07-08
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol
Genes Dev., 29, 2015
5X58
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PREFUSION STRUCTURE OF SARS-COV SPIKE GLYCOPROTEIN, CONFORMATION 1
Descriptor:Spike glycoprotein, N-ACETYL-D-GLUCOSAMINE
Authors:Yuan, Y., Cao, D., Zhang, Y., Ma, J., Qi, J., Wang, Q., Lu, G., Wu, Y., Yan, J., Shi, Y., Zhang, X., Gao, G.F.
Deposit date:2017-02-15
Release date:2017-05-03
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains
Nat Commun, 8, 2017
5X59
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PREFUSION STRUCTURE OF MERS-COV SPIKE GLYCOPROTEIN, THREE-FOLD SYMMETRY
Descriptor:S protein, N-ACETYL-D-GLUCOSAMINE
Authors:Yuan, Y., Cao, D., Zhang, Y., Ma, J., Qi, J., Wang, Q., Lu, G., Wu, Y., Yan, J., Shi, Y., Zhang, X., Gao, G.F.
Deposit date:2017-02-15
Release date:2017-05-03
Last modified:2017-05-24
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains
Nat Commun, 8, 2017
5X5B
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PREFUSION STRUCTURE OF SARS-COV SPIKE GLYCOPROTEIN, CONFORMATION 2
Descriptor:Spike glycoprotein
Authors:Yuan, Y., Cao, D., Zhang, Y., Ma, J., Qi, J., Wang, Q., Lu, G., Wu, Y., Yan, J., Shi, Y., Zhang, X., Gao, G.F.
Deposit date:2017-02-15
Release date:2017-05-03
Last modified:2017-05-24
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains
Nat Commun, 8, 2017
5X5C
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PREFUSION STRUCTURE OF MERS-COV SPIKE GLYCOPROTEIN, CONFORMATION 1
Descriptor:S protein
Authors:Yuan, Y., Cao, D., Zhang, Y., Ma, J., Qi, J., Wang, Q., Lu, G., Wu, Y., Yan, J., Shi, Y., Zhang, X., Gao, G.F.
Deposit date:2017-02-15
Release date:2017-05-03
Last modified:2017-05-24
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains
Nat Commun, 8, 2017
5X5F
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PREFUSION STRUCTURE OF MERS-COV SPIKE GLYCOPROTEIN, CONFORMATION 2
Descriptor:S protein
Authors:Yuan, Y., Cao, D., Zhang, Y., Ma, J., Qi, J., Wang, Q., Lu, G., Wu, Y., Yan, J., Shi, Y., Zhang, X., Gao, G.F.
Deposit date:2017-02-15
Release date:2017-05-03
Last modified:2017-05-24
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains
Nat Commun, 8, 2017
5XI2
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BRD4 BOUND WITH COMPOUND BDI2
Descriptor:Bromodomain-containing protein 4, (3~{R})-4-cyclopropyl-1,3-dimethyl-6-[[(1~{S})-1-(4-methylphenyl)ethyl]amino]-3~{H}-quinoxalin-2-one
Authors:Xiong, B., Cao, D., Li, Y.
Deposit date:2017-04-25
Release date:2018-05-02
Method:X-RAY DIFFRACTION (1.909 Å)
Cite:BRD4 bound with compound Bdi2
To Be Published
5XI3
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BRD4 BOUND WITH COMPOUND BDI3
Descriptor:Bromodomain-containing protein 4, (3~{R})-4-cyclopropyl-1,3-dimethyl-6-[[(1~{R})-1-phenylethyl]amino]-3~{H}-quinoxalin-2-one
Authors:Xiong, B., Cao, D., Li, Y.
Deposit date:2017-04-25
Release date:2018-05-02
Method:X-RAY DIFFRACTION (1.674 Å)
Cite:BRD4 bound with compound Bdi3
To Be Published
5XI4
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BRD4 BOUND WITH COMPOUND BDI4
Descriptor:Bromodomain-containing protein 4, (3~{S})-4-cyclopropyl-1,3-dimethyl-6-[[(1~{S})-1-(4-methylphenyl)ethyl]amino]-3~{H}-quinoxalin-2-one
Authors:Xiong, B., Cao, D., Li, Y.
Deposit date:2017-04-25
Release date:2018-05-02
Method:X-RAY DIFFRACTION (1.486 Å)
Cite:BRD4 bound with compound Bdi4
To Be Published
4HXK
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BRD4 BROMODOMAIN 1 COMPLEX WITH 6,7-DIHYDROTHIENO[3,2-C]PYRIDIN-5(4H)-YL(1H-IMIDAZOL-1-YL)METHANONE INHIBITOR
Descriptor:Bromodomain-containing protein 4, 6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl(1H-imidazol-1-yl)methanone
Authors:Chen, T.T., Cao, D.Y., Chen, W.Y., Xiong, B., Shen, J.K., Xu, Y.C.
Deposit date:2012-11-12
Release date:2013-04-03
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Fragment-Based Drug Discovery of 2-Thiazolidinones as Inhibitors of the Histone Reader BRD4 Bromodomain.
J.Med.Chem., 56, 2013
4HXL
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BRD4 BROMODOMAIN 1 COMPLEX WITH 3-CYCLOHEXYL-N-{3-(2-OXO-2,3-DIHYDRO-1,3-THIAZOL-4-YL)-5-[(THIOPHEN-2-YLSULFONYL)AMINO]PHENYL}PROPANAMIDE INHIBITOR
Descriptor:Bromodomain-containing protein 4, 3-cyclohexyl-N-{3-(2-oxo-2,3-dihydro-1,3-thiazol-4-yl)-5-[(thiophen-2-ylsulfonyl)amino]phenyl}propanamide
Authors:Chen, T.T., Cao, D.Y., Chen, W.Y., Xiong, B., Shen, J.K., Xu, Y.C.
Deposit date:2012-11-12
Release date:2013-04-03
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Fragment-Based Drug Discovery of 2-Thiazolidinones as Inhibitors of the Histone Reader BRD4 Bromodomain.
J.Med.Chem., 56, 2013
4HXM
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BRD4 BROMODOMAIN 1 COMPLEX WITH N-{3-(2-OXO-2,3-DIHYDRO-1,3-THIAZOL-4-YL)-5-[(THIOPHEN-2-YLSULFONYL)AMINO]PHENYL}BUTANAMIDE INHIBITOR
Descriptor:Bromodomain-containing protein 4, N-{3-(2-oxo-2,3-dihydro-1,3-thiazol-4-yl)-5-[(thiophen-2-ylsulfonyl)amino]phenyl}butanamide
Authors:Chen, T.T., Cao, D.Y., Chen, W.Y., Xiong, B., Shen, J.K., Xu, Y.C.
Deposit date:2012-11-12
Release date:2013-04-03
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Fragment-Based Drug Discovery of 2-Thiazolidinones as Inhibitors of the Histone Reader BRD4 Bromodomain.
J.Med.Chem., 56, 2013
4HXN
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BRD4 BROMODOMAIN 1 COMPLEX WITH 4-(2-FLUOROPHENYL)-1,3-THIAZOL-2(3H)-ONE INHIBITOR
Descriptor:Bromodomain-containing protein 4, 4-(2-fluorophenyl)-1,3-thiazol-2(3H)-one
Authors:Chen, T.T., Cao, D.Y., Chen, W.Y., Xiong, B., Shen, J.K., Xu, Y.C.
Deposit date:2012-11-12
Release date:2013-04-03
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Fragment-Based Drug Discovery of 2-Thiazolidinones as Inhibitors of the Histone Reader BRD4 Bromodomain.
J.Med.Chem., 56, 2013
4HXO
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BRD4 BROMODOMAIN 1 COMPLEX WITH 3-{[(3-METHYL-1,2-OXAZOL-5-YL)METHYL]SULFANYL}[1,2,4]TRIAZOLO[4,3-A]PYRIDINE INHIBITOR
Descriptor:Bromodomain-containing protein 4, 3-{[(3-methyl-1,2-oxazol-5-yl)methyl]sulfanyl}[1,2,4]triazolo[4,3-a]pyridine
Authors:Chen, T.T., Cao, D.Y., Chen, W.Y., Xiong, B., Shen, J.K., Xu, Y.C.
Deposit date:2012-11-12
Release date:2013-04-03
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Fragment-Based Drug Discovery of 2-Thiazolidinones as Inhibitors of the Histone Reader BRD4 Bromodomain.
J.Med.Chem., 56, 2013
4HXP
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BRD4 BROMODOMAIN 1 COMPLEX WITH 4-(2-OXO-1,3-OXAZOLIDIN-3-YL)BENZAMIDE INHIBITOR
Descriptor:Bromodomain-containing protein 4, 4-(2-oxo-1,3-oxazolidin-3-yl)benzamide
Authors:Chen, T.T., Cao, D.Y., Chen, W.Y., Xiong, B., Shen, J.K., Xu, Y.C.
Deposit date:2012-11-12
Release date:2013-04-03
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Fragment-Based Drug Discovery of 2-Thiazolidinones as Inhibitors of the Histone Reader BRD4 Bromodomain.
J.Med.Chem., 56, 2013
4HXR
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BRD4 BROMODOMAIN 1 COMPLEX WITH N-[3-(2-OXO-2,3-DIHYDRO-1,3-THIAZOL-4-YL)PHENYL]THIOPHENE-2-SULFONAMIDE INHIBITOR
Descriptor:Bromodomain-containing protein 4, N-[3-(2-oxo-2,3-dihydro-1,3-thiazol-4-yl)phenyl]thiophene-2-sulfonamide
Authors:Chen, T.T., Cao, D.Y., Chen, W.Y., Xiong, B., Shen, J.K., Xu, Y.C.
Deposit date:2012-11-12
Release date:2013-04-03
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Fragment-Based Drug Discovery of 2-Thiazolidinones as Inhibitors of the Histone Reader BRD4 Bromodomain.
J.Med.Chem., 56, 2013
4HXS
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BRD4 BROMODOMAIN 1 COMPLEX WITH N-[3-(2-OXO-2,3-DIHYDRO-1,3-THIAZOL-4-YL)PHENYL]-1-PHENYLMETHANESULFONAMIDE INHIBITOR
Descriptor:Bromodomain-containing protein 4, N-[3-(2-oxo-2,3-dihydro-1,3-thiazol-4-yl)phenyl]-1-phenylmethanesulfonamide
Authors:Chen, T.T., Cao, D.Y., Chen, W.Y., Xiong, B., Shen, J.K., Xu, Y.C.
Deposit date:2012-11-12
Release date:2013-04-03
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Fragment-Based Drug Discovery of 2-Thiazolidinones as Inhibitors of the Histone Reader BRD4 Bromodomain.
J.Med.Chem., 56, 2013
4WI2
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STRUCTURAL MAPPING OF THE HUMAN IGG1 BINDING SITE FOR FCRN: HU3S193 FC (WILD-TYPE)
Descriptor:Ig gamma-1 chain C region, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Farrugia, W., Burvenich, I.J.G., Scott, A.M., Ramsland, P.A.
Deposit date:2014-09-25
Release date:2015-09-30
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and functional mapping of human IgG1 binding site for FcRn in vivo using human FcRn transgenic mice
To Be Published
4WI3
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STRUCTURAL MAPPING OF THE HUMAN IGG1 BINDING SITE FOR FCRN: HU3S193 FC MUTATION I253A
Descriptor:Ig gamma-1 chain C region, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Farrugia, W., Burvenich, I.J.G., Scott, A.M., Ramsland, P.A.
Deposit date:2014-09-25
Release date:2015-09-30
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.703 Å)
Cite:Structural and functional mapping of human IgG1 binding site for FcRn in vivo using human FcRn transgenic mice
To Be Published
4WI4
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STRUCTURAL MAPPING OF THE HUMAN IGG1 BINDING SITE FOR FCRN: HU3S193 FC MUTATION S254A
Descriptor:Ig gamma-1 chain C region, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Farrugia, W., Burvenich, I.J.G., Scott, A.M., Ramsland, P.A.
Deposit date:2014-09-25
Release date:2015-09-30
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural and functional mapping of human IgG1 binding site for FcRn in vivo using human FcRn transgenic mice
To Be Published
4WI5
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STRUCTURAL MAPPING OF THE HUMAN IGG1 BINDING SITE FOR FCRN: HU3S193 FC MUTATION H310A
Descriptor:Ig gamma-1 chain C region, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Farrugia, W., Burvenich, I.J.G., Scott, A.M., Ramsland, P.A.
Deposit date:2014-09-25
Release date:2015-09-30
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural and functional mapping of human IgG1 binding site for FcRn in vivo using human FcRn transgenic mice
To Be Published
4WI6
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STRUCTURAL MAPPING OF THE HUMAN IGG1 BINDING SITE FOR FCRN: HU3S193 FC MUTATION N434A
Descriptor:Ig gamma-1 chain C region, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Farrugia, W., Burvenich, I.J.G., Scott, A.M., Ramsland, P.A.
Deposit date:2014-09-25
Release date:2015-09-30
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.201 Å)
Cite:Structural and functional mapping of human IgG1 binding site for FcRn in vivo using human FcRn transgenic mice
To Be Published
4WI7
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STRUCTURAL MAPPING OF THE HUMAN IGG1 BINDING SITE FOR FCRN: HU3S193 FC MUTATION H435A
Descriptor:Ig gamma-1 chain C region, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Farrugia, W., Burvenich, I.J.G., Scott, A.M., Ramsland, P.A.
Deposit date:2014-09-25
Release date:2015-09-30
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and functional mapping of human IgG1 binding site for FcRn in vivo using human FcRn transgenic mice
To Be Published
4WI8
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STRUCTURAL MAPPING OF THE HUMAN IGG1 BINDING SITE FOR FCRN: HU3S193 FC MUTATION Y436A
Descriptor:Ig gamma-1 chain C region, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Farrugia, W., Burvenich, I.J.G., Scott, A.M., Ramsland, P.A.
Deposit date:2014-09-25
Release date:2015-09-30
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural and functional mapping of human IgG1 binding site for FcRn in vivo using human FcRn transgenic mice
To Be Published
4WI9
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STRUCTURAL MAPPING OF THE HUMAN IGG1 BINDING SITE FOR FCRN: HU3S193 FC MUTATION I253A/H310A
Descriptor:Ig gamma-1 chain C region, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
Authors:Farrugia, W., Burvenich, I.J.G., Scott, A.M., Ramsland, P.A.
Deposit date:2014-09-25
Release date:2015-09-30
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural and functional mapping of human IgG1 binding site for FcRn in vivo using human FcRn transgenic mice
To Be Published
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