Author results

1PBW
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STRUCTURE OF BCR-HOMOLOGY (BH) DOMAIN
Descriptor:PHOSPHATIDYLINOSITOL 3-KINASE
Authors:Musacchio, A., Cantley, L.C., Harrison, S.C.
Deposit date:1996-10-17
Release date:1997-03-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the breakpoint cluster region-homology domain from phosphoinositide 3-kinase p85 alpha subunit.
Proc.Natl.Acad.Sci.USA, 93, 1996
1QJA
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14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (MODE 2)
Descriptor:14-3-3 PROTEIN ZETA, PHOSPHOPEPTIDE
Authors:Rittinger, K., Budman, J., Xu, J., Volinia, S., Cantley, L.C., Smerdon, S.J., Gamblin, S.J., Yaffe, M.B.
Deposit date:1999-06-23
Release date:1999-09-15
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Analysis of 14-3-3 Phosphopeptide Complexes Identifies a Dual Role for the Nuclear Export Signal of 14-3-3 in Ligand Binding
Mol.Cell, 4, 1999
1QJB
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14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (MODE 1)
Descriptor:14-3-3 PROTEIN ZETA/DELTA, PHOSPHOPEPTIDE
Authors:Rittinger, K., Budman, J., Xu, J., Volinia, S., Cantley, L.C., Smerdon, S.J., Gamblin, S.J., Yaffe, M.B.
Deposit date:1999-06-23
Release date:1999-09-15
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Analysis of 14-3-3 Phosphopeptide Complexes Identifies a Dual Role for the Nuclear Export Signal of 14-3-3 in Ligand Binding
Mol.Cell, 4, 1999
1YRK
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THE C2 DOMAIN OF PKC IS A NEW PHOSPHO-TYROSINE BINDING DOMAIN
Descriptor:Protein kinase C, delta type, 13-residue peptide, ...
Authors:Benes, C.H., Wu, N., Elia, A.E., Dharia, T., Cantley, L.C., Soltoff, S.P.
Deposit date:2005-02-03
Release date:2005-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The C2 domain of PKCdelta is a phosphotyrosine binding domain.
Cell(Cambridge,Mass.), 121, 2005
1D1Z
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CRYSTAL STRUCTURE OF THE XLP PROTEIN SAP
Descriptor:SAP SH2 DOMAIN, SULFATE ION
Authors:Poy, F., Yaffe, M.B., Sayos, J., Saxena, K., Eck, M.J.
Deposit date:1999-09-22
Release date:1999-10-13
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
Mol.Cell, 4, 1999
1D4T
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CRYSTAL STRUCTURE OF THE XLP PROTEIN SAP IN COMPLEX WITH A SLAM PEPTIDE
Descriptor:T CELL SIGNAL TRANSDUCTION MOLECULE SAP, SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE
Authors:Poy, F., Yaffe, M.B., Sayos, J., Saxena, K., Eck, M.J.
Deposit date:1999-10-06
Release date:1999-10-14
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
Mol.Cell, 4, 1999
1D4W
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CRYSTAL STRUCTURE OF THE XLP PROTEIN SAP IN COMPLEX WITH SLAM PHOSPHOPEPTIDE
Descriptor:T CELL SIGNAL TRANSDUCTION MOLECULE SAP, SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE
Authors:Poy, F., Yaffe, M.B., Sayos, J., Saxena, K., Eck, M.J.
Deposit date:1999-10-06
Release date:1999-10-14
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
Mol.Cell, 4, 1999
1PWP
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CRYSTAL STRUCTURE OF THE ANTHRAX LETHAL FACTOR COMPLEXED WITH SMALL MOLECULE INHIBITOR NSC 12155
Descriptor:Lethal factor, ZINC ION, N,N'-BIS(4-AMINO-2-METHYLQUINOLIN-6-YL)UREA
Authors:Wong, T.Y., Schwarzenbacher, R., Liddington, R.C.
Deposit date:2003-07-02
Release date:2004-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Identification of small molecule inhibitors of anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
1PWQ
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CRYSTAL STRUCTURE OF ANTHRAX LETHAL FACTOR COMPLEXED WITH THIOACETYL-TYR-PRO-MET-AMIDE, A METAL-CHELATING PEPTIDYL SMALL MOLECULE INHIBITOR
Descriptor:Lethal factor, ZINC ION, N-(SULFANYLACETYL)TYROSYLPROLYLMETHIONINAMIDE
Authors:Wong, T.Y., Schwarzenbacher, R., Liddington, R.C.
Deposit date:2003-07-02
Release date:2004-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.52 Å)
Cite:The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
1PWU
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CRYSTAL STRUCTURE OF ANTHRAX LETHAL FACTOR COMPLEXED WITH (3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE), A KNOWN SMALL MOLECULE INHIBITOR OF MATRIX METALLOPROTEASES.
Descriptor:Lethal factor, ZINC ION, 3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE
Authors:Wong, T.Y., Schwarzenbacher, R., Liddington, R.C.
Deposit date:2003-07-02
Release date:2004-02-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
1PWV
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CRYSTAL STRUCTURE OF ANTHRAX LETHAL FACTOR WILD-TYPE PROTEIN COMPLEXED WITH AN OPTIMISED PEPTIDE SUBSTRATE.
Descriptor:Lethal factor, LF20
Authors:Wong, T.Y., Schwarzenbacher, R., Liddington, R.C.
Deposit date:2003-07-02
Release date:2004-02-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
1PWW
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CRYSTAL STRUCTURE OF ANTHRAX LETHAL FACTOR ACTIVE SITE MUTANT PROTEIN COMPLEXED WITH AN OPTIMISED PEPTIDE SUBSTRATE IN THE PRESENCE OF ZINC.
Descriptor:Lethal factor, LF20, ZINC ION
Authors:Wong, T.Y., Schwarzenbacher, R., Liddington, R.C.
Deposit date:2003-07-02
Release date:2004-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
3BJF
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PYRUVATE KINASE M2 IS A PHOSPHOTYROSINE BINDING PROTEIN
Descriptor:Pyruvate kinase isozymes M1/M2, BETA-FRUCTOSE-1,6-DIPHOSPHATE, OXALATE ION, ...
Authors:Wu, N.
Deposit date:2007-12-03
Release date:2008-03-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Pyruvate kinase M2 is a phosphotyrosine-binding protein.
Nature, 452, 2008
3BJT
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PYRUVATE KINASE M2 IS A PHOSPHOTYROSINE BINDING PROTEIN
Descriptor:Pyruvate kinase isozymes M1/M2, OXALATE ION, MAGNESIUM ION
Authors:Wu, N.
Deposit date:2007-12-04
Release date:2008-03-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Pyruvate kinase M2 is a phosphotyrosine-binding protein.
Nature, 452, 2008
3E4A
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HUMAN IDE-INHIBITOR COMPLEX AT 2.6 ANGSTROM RESOLUTION
Descriptor:Insulin-degrading enzyme, HYDROXAMATE PEPTIDE II1, ZINC ION, ...
Authors:Malito, E., Leissring, M.A., Choi, S., Cuny, G.D., Tang, W.J.
Deposit date:2008-08-11
Release date:2009-05-19
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin.
Plos One, 5, 2010
3INM
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CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC NADP(+)-DEPENDENT ISOCITRATE DEHYDROGENASE R132H MUTANT IN COMPLEX WITH NADPH, ALPHA-KETOGLUTARATE AND CALCIUM(2+)
Descriptor:Isocitrate dehydrogenase [NADP] cytoplasmic, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-OXOGLUTARIC ACID, ...
Authors:Fontano, E., Brown, R.S., Suto, R.K., Bhyravbhatla, B.
Deposit date:2009-08-12
Release date:2009-11-24
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.
Nature, 462, 2009
3ME3
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ACTIVATOR-BOUND STRUCTURE OF HUMAN PYRUVATE KINASE M2
Descriptor:Pyruvate kinase isozymes M1/M2, 3-{[4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-1,4-diazepan-1-yl]sulfonyl}aniline, BETA-FRUCTOSE-1,6-DIPHOSPHATE, ...
Authors:Hong, B., Dimov, S., Tempel, W., Auld, D., Thomas, C., Boxer, M., Jianq, J.-K., Skoumbourdis, A., Min, S., Southall, N., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Inglese, J., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2010-03-31
Release date:2010-04-28
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.
Nat.Chem.Biol., 8, 2012
3U2Z
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ACTIVATOR-BOUND STRUCTURE OF HUMAN PYRUVATE KINASE M2
Descriptor:Pyruvate kinase isozymes M1/M2, BETA-FRUCTOSE-1,6-DIPHOSPHATE, UNKNOWN ATOM OR ION, ...
Authors:Hong, B., Dimov, S., Tempel, W., Auld, D., Thomas, C., Boxer, M., Jianq, J.-K., Skoumbourdis, A., Min, S., Southall, N., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Inglese, J., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2011-10-04
Release date:2012-09-12
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.
Nat.Chem.Biol., 8, 2012
3WZZ
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CRYSTAL STRUCTURE OF PIP4KIIBETA
Descriptor:Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
Authors:Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang, Y., Kahoud, E.R., Takano, T., Yokota, T., Emerling, B., Asara, J.A., Ishida, T., Shimada, I., Daikoku, T., Cantley, L.C., Senda, T., Sasaki, A.T.
Deposit date:2014-10-08
Release date:2015-10-14
Last modified:2016-02-03
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The Lipid Kinase PI5P4K beta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
Mol.Cell, 61, 2016
3X01
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CRYSTAL STRUCTURE OF PIP4KIIBETA COMPLEX WITH AMP
Descriptor:Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, ADENOSINE MONOPHOSPHATE
Authors:Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang, Y., Kahoud, E.R., Takano, T., Yokota, T., Emerling, B., Asara, J.A., Ishida, T., Shimada, I., Daikoku, T., Cantley, L.C., Senda, T., Sasaki, A.T.
Deposit date:2014-10-09
Release date:2015-10-14
Last modified:2016-02-03
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The Lipid Kinase PI5P4K beta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
Mol.Cell, 61, 2016
3X02
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CRYSTAL STRUCTURE OF PIP4KIIBETA COMPLEX WITH GMP
Descriptor:Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, GUANOSINE-5'-MONOPHOSPHATE
Authors:Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang, Y., Kahoud, E.R., Takano, T., Yokota, T., Emerling, B., Asara, J.A., Ishida, T., Shimada, I., Daikoku, T., Cantley, L.C., Senda, T., Sasaki, A.T.
Deposit date:2014-10-09
Release date:2015-10-14
Last modified:2016-02-03
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:The Lipid Kinase PI5P4K beta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
Mol.Cell, 61, 2016
3X03
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CRYSTAL STRUCTURE OF PIP4KIIBETA COMPLEX WITH AMPPNP
Descriptor:Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang, Y., Kahoud, E.R., Takano, T., Yokota, T., Emerling, B., Asara, J.A., Ishida, T., Shimada, I., Daikoku, T., Cantley, L.C., Senda, T., Sasaki, A.T.
Deposit date:2014-10-09
Release date:2015-10-14
Last modified:2016-02-03
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The Lipid Kinase PI5P4K beta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
Mol.Cell, 61, 2016
3X04
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CRYSTAL STRUCTURE OF PIP4KIIBETA COMPLEX WITH GMPPNP
Descriptor:Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang, Y., Kahoud, E.R., Takano, T., Yokota, T., Emerling, B., Asara, J.A., Ishida, T., Shimada, I., Daikoku, T., Cantley, L.C., Senda, T., Sasaki, A.T.
Deposit date:2014-10-09
Release date:2015-10-14
Last modified:2016-02-03
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The Lipid Kinase PI5P4K beta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
Mol.Cell, 61, 2016
3X05
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CRYSTAL STRUCTURE OF PIP4KIIBETA T201M COMPLEX WITH AMP
Descriptor:Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, ADENOSINE MONOPHOSPHATE
Authors:Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang, Y., Kahoud, E.R., Takano, T., Yokota, T., Emerling, B., Asara, J.A., Ishida, T., Shimada, I., Daikoku, T., Cantley, L.C., Senda, T., Sasaki, A.T.
Deposit date:2014-10-09
Release date:2015-10-14
Last modified:2016-02-03
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The Lipid Kinase PI5P4K beta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
Mol.Cell, 61, 2016
3X06
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CRYSTAL STRUCTURE OF PIP4KIIBETA T201M COMPLEX WITH GMP
Descriptor:Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, GUANOSINE-5'-MONOPHOSPHATE
Authors:Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang, Y., Kahoud, E.R., Takano, T., Yokota, T., Emerling, B., Asara, J.A., Ishida, T., Shimada, I., Daikoku, T., Cantley, L.C., Senda, T., Sasaki, A.T.
Deposit date:2014-10-09
Release date:2015-10-14
Last modified:2016-02-03
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:The Lipid Kinase PI5P4K beta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
Mol.Cell, 61, 2016
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