Author results

1PBW
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STRUCTURE OF BCR-HOMOLOGY (BH) DOMAIN
分子名称:PHOSPHATIDYLINOSITOL 3-KINASE
著者Musacchio, A., Cantley, L.C., Harrison, S.C.
登録日1996-10-17
公開日1997-03-12
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of the breakpoint cluster region-homology domain from phosphoinositide 3-kinase p85 alpha subunit.
Proc.Natl.Acad.Sci.USA, 93, 1996
1QJA
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14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (MODE 2)
分子名称:14-3-3 PROTEIN ZETA, PHOSPHOPEPTIDE
著者Rittinger, K., Budman, J., Xu, J., Volinia, S., Cantley, L.C., Smerdon, S.J., Gamblin, S.J., Yaffe, M.B.
登録日1999-06-23
公開日1999-09-15
最終更新日2018-02-28
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Analysis of 14-3-3 Phosphopeptide Complexes Identifies a Dual Role for the Nuclear Export Signal of 14-3-3 in Ligand Binding
Mol.Cell, 4, 1999
1QJB
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14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (MODE 1)
分子名称:14-3-3 PROTEIN ZETA/DELTA, PHOSPHOPEPTIDE
著者Rittinger, K., Budman, J., Xu, J., Volinia, S., Cantley, L.C., Smerdon, S.J., Gamblin, S.J., Yaffe, M.B.
登録日1999-06-23
公開日1999-09-15
最終更新日2018-02-28
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Analysis of 14-3-3 Phosphopeptide Complexes Identifies a Dual Role for the Nuclear Export Signal of 14-3-3 in Ligand Binding
Mol.Cell, 4, 1999
1YRK
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THE C2 DOMAIN OF PKC IS A NEW PHOSPHO-TYROSINE BINDING DOMAIN
分子名称:Protein kinase C, delta type, 13-residue peptide, ...
著者Benes, C.H., Wu, N., Elia, A.E., Dharia, T., Cantley, L.C., Soltoff, S.P.
登録日2005-02-03
公開日2005-07-26
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献The C2 domain of PKCdelta is a phosphotyrosine binding domain.
Cell(Cambridge,Mass.), 121, 2005
1D1Z
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CRYSTAL STRUCTURE OF THE XLP PROTEIN SAP
分子名称:SAP SH2 DOMAIN, SULFATE ION
著者Poy, F., Yaffe, M.B., Sayos, J., Saxena, K., Eck, M.J.
登録日1999-09-22
公開日1999-10-13
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
Mol.Cell, 4, 1999
1D4T
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CRYSTAL STRUCTURE OF THE XLP PROTEIN SAP IN COMPLEX WITH A SLAM PEPTIDE
分子名称:T CELL SIGNAL TRANSDUCTION MOLECULE SAP, SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE
著者Poy, F., Yaffe, M.B., Sayos, J., Saxena, K., Eck, M.J.
登録日1999-10-06
公開日1999-10-14
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
Mol.Cell, 4, 1999
1D4W
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CRYSTAL STRUCTURE OF THE XLP PROTEIN SAP IN COMPLEX WITH SLAM PHOSPHOPEPTIDE
分子名称:T CELL SIGNAL TRANSDUCTION MOLECULE SAP, SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE
著者Poy, F., Yaffe, M.B., Sayos, J., Saxena, K., Eck, M.J.
登録日1999-10-06
公開日1999-10-14
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
Mol.Cell, 4, 1999
1PWP
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CRYSTAL STRUCTURE OF THE ANTHRAX LETHAL FACTOR COMPLEXED WITH SMALL MOLECULE INHIBITOR NSC 12155
分子名称:Lethal factor, ZINC ION, N,N'-BIS(4-AMINO-2-METHYLQUINOLIN-6-YL)UREA
著者Wong, T.Y., Schwarzenbacher, R., Liddington, R.C.
登録日2003-07-02
公開日2004-01-13
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Identification of small molecule inhibitors of anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
1PWQ
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CRYSTAL STRUCTURE OF ANTHRAX LETHAL FACTOR COMPLEXED WITH THIOACETYL-TYR-PRO-MET-AMIDE, A METAL-CHELATING PEPTIDYL SMALL MOLECULE INHIBITOR
分子名称:Lethal factor, ZINC ION, N-(SULFANYLACETYL)TYROSYLPROLYLMETHIONINAMIDE
著者Wong, T.Y., Schwarzenbacher, R., Liddington, R.C.
登録日2003-07-02
公開日2004-01-13
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.52 Å)
主引用文献The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
1PWU
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CRYSTAL STRUCTURE OF ANTHRAX LETHAL FACTOR COMPLEXED WITH (3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE), A KNOWN SMALL MOLECULE INHIBITOR OF MATRIX METALLOPROTEASES.
分子名称:Lethal factor, ZINC ION, 3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE
著者Wong, T.Y., Schwarzenbacher, R., Liddington, R.C.
登録日2003-07-02
公開日2004-02-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
1PWV
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CRYSTAL STRUCTURE OF ANTHRAX LETHAL FACTOR WILD-TYPE PROTEIN COMPLEXED WITH AN OPTIMISED PEPTIDE SUBSTRATE.
分子名称:Lethal factor, LF20
著者Wong, T.Y., Schwarzenbacher, R., Liddington, R.C.
登録日2003-07-02
公開日2004-02-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
1PWW
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CRYSTAL STRUCTURE OF ANTHRAX LETHAL FACTOR ACTIVE SITE MUTANT PROTEIN COMPLEXED WITH AN OPTIMISED PEPTIDE SUBSTRATE IN THE PRESENCE OF ZINC.
分子名称:Lethal factor, LF20, ZINC ION
著者Wong, T.Y., Schwarzenbacher, R., Liddington, R.C.
登録日2003-07-02
公開日2004-01-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
3BJF
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PYRUVATE KINASE M2 IS A PHOSPHOTYROSINE BINDING PROTEIN
分子名称:Pyruvate kinase isozymes M1/M2, BETA-FRUCTOSE-1,6-DIPHOSPHATE, OXALATE ION, ...
著者Wu, N.
登録日2007-12-03
公開日2008-03-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Pyruvate kinase M2 is a phosphotyrosine-binding protein.
Nature, 452, 2008
3BJT
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PYRUVATE KINASE M2 IS A PHOSPHOTYROSINE BINDING PROTEIN
分子名称:Pyruvate kinase isozymes M1/M2, OXALATE ION, MAGNESIUM ION
著者Wu, N.
登録日2007-12-04
公開日2008-03-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Pyruvate kinase M2 is a phosphotyrosine-binding protein.
Nature, 452, 2008
3E4A
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HUMAN IDE-INHIBITOR COMPLEX AT 2.6 ANGSTROM RESOLUTION
分子名称:Insulin-degrading enzyme, HYDROXAMATE PEPTIDE II1, ZINC ION, ...
著者Malito, E., Leissring, M.A., Choi, S., Cuny, G.D., Tang, W.J.
登録日2008-08-11
公開日2009-05-19
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin.
Plos One, 5, 2010
3INM
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CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC NADP(+)-DEPENDENT ISOCITRATE DEHYDROGENASE R132H MUTANT IN COMPLEX WITH NADPH, ALPHA-KETOGLUTARATE AND CALCIUM(2+)
分子名称:Isocitrate dehydrogenase [NADP] cytoplasmic, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-OXOGLUTARIC ACID, ...
著者Fontano, E., Brown, R.S., Suto, R.K., Bhyravbhatla, B.
登録日2009-08-12
公開日2009-11-24
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.
Nature, 462, 2009
3ME3
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ACTIVATOR-BOUND STRUCTURE OF HUMAN PYRUVATE KINASE M2
分子名称:Pyruvate kinase isozymes M1/M2, 3-{[4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-1,4-diazepan-1-yl]sulfonyl}aniline, BETA-FRUCTOSE-1,6-DIPHOSPHATE, ...
著者Hong, B., Dimov, S., Tempel, W., Auld, D., Thomas, C., Boxer, M., Jianq, J.-K., Skoumbourdis, A., Min, S., Southall, N., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Inglese, J., Park, H., Structural Genomics Consortium (SGC)
登録日2010-03-31
公開日2010-04-28
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.
Nat.Chem.Biol., 8, 2012
3U2Z
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ACTIVATOR-BOUND STRUCTURE OF HUMAN PYRUVATE KINASE M2
分子名称:Pyruvate kinase isozymes M1/M2, BETA-FRUCTOSE-1,6-DIPHOSPHATE, UNKNOWN ATOM OR ION, ...
著者Hong, B., Dimov, S., Tempel, W., Auld, D., Thomas, C., Boxer, M., Jianq, J.-K., Skoumbourdis, A., Min, S., Southall, N., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Inglese, J., Park, H., Structural Genomics Consortium (SGC)
登録日2011-10-04
公開日2012-09-12
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.
Nat.Chem.Biol., 8, 2012
3WZZ
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CRYSTAL STRUCTURE OF PIP4KIIBETA
分子名称:Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
著者Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang, Y., Kahoud, E.R., Takano, T., Yokota, T., Emerling, B., Asara, J.A., Ishida, T., Shimada, I., Daikoku, T., Cantley, L.C., Senda, T., Sasaki, A.T.
登録日2014-10-08
公開日2015-10-14
最終更新日2016-02-03
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献The Lipid Kinase PI5P4K beta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
Mol.Cell, 61, 2016
3X01
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CRYSTAL STRUCTURE OF PIP4KIIBETA COMPLEX WITH AMP
分子名称:Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, ADENOSINE MONOPHOSPHATE
著者Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang, Y., Kahoud, E.R., Takano, T., Yokota, T., Emerling, B., Asara, J.A., Ishida, T., Shimada, I., Daikoku, T., Cantley, L.C., Senda, T., Sasaki, A.T.
登録日2014-10-09
公開日2015-10-14
最終更新日2016-02-03
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献The Lipid Kinase PI5P4K beta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
Mol.Cell, 61, 2016
3X02
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CRYSTAL STRUCTURE OF PIP4KIIBETA COMPLEX WITH GMP
分子名称:Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, GUANOSINE-5'-MONOPHOSPHATE
著者Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang, Y., Kahoud, E.R., Takano, T., Yokota, T., Emerling, B., Asara, J.A., Ishida, T., Shimada, I., Daikoku, T., Cantley, L.C., Senda, T., Sasaki, A.T.
登録日2014-10-09
公開日2015-10-14
最終更新日2016-02-03
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献The Lipid Kinase PI5P4K beta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
Mol.Cell, 61, 2016
3X03
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CRYSTAL STRUCTURE OF PIP4KIIBETA COMPLEX WITH AMPPNP
分子名称:Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
著者Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang, Y., Kahoud, E.R., Takano, T., Yokota, T., Emerling, B., Asara, J.A., Ishida, T., Shimada, I., Daikoku, T., Cantley, L.C., Senda, T., Sasaki, A.T.
登録日2014-10-09
公開日2015-10-14
最終更新日2016-02-03
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献The Lipid Kinase PI5P4K beta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
Mol.Cell, 61, 2016
3X04
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CRYSTAL STRUCTURE OF PIP4KIIBETA COMPLEX WITH GMPPNP
分子名称:Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
著者Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang, Y., Kahoud, E.R., Takano, T., Yokota, T., Emerling, B., Asara, J.A., Ishida, T., Shimada, I., Daikoku, T., Cantley, L.C., Senda, T., Sasaki, A.T.
登録日2014-10-09
公開日2015-10-14
最終更新日2016-02-03
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献The Lipid Kinase PI5P4K beta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
Mol.Cell, 61, 2016
3X05
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CRYSTAL STRUCTURE OF PIP4KIIBETA T201M COMPLEX WITH AMP
分子名称:Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, ADENOSINE MONOPHOSPHATE
著者Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang, Y., Kahoud, E.R., Takano, T., Yokota, T., Emerling, B., Asara, J.A., Ishida, T., Shimada, I., Daikoku, T., Cantley, L.C., Senda, T., Sasaki, A.T.
登録日2014-10-09
公開日2015-10-14
最終更新日2016-02-03
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The Lipid Kinase PI5P4K beta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
Mol.Cell, 61, 2016
3X06
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CRYSTAL STRUCTURE OF PIP4KIIBETA T201M COMPLEX WITH GMP
分子名称:Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, GUANOSINE-5'-MONOPHOSPHATE
著者Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang, Y., Kahoud, E.R., Takano, T., Yokota, T., Emerling, B., Asara, J.A., Ishida, T., Shimada, I., Daikoku, T., Cantley, L.C., Senda, T., Sasaki, A.T.
登録日2014-10-09
公開日2015-10-14
最終更新日2016-02-03
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献The Lipid Kinase PI5P4K beta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
Mol.Cell, 61, 2016
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