Author results

4TQX
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MOLECULAR BASIS OF STREPTOCOCCUS MUTANS SORTASE A INHIBITION BY CHALCONE.
Descriptor:Sortase, TETRAETHYLENE GLYCOL, ACETIC ACID, ...
Authors:Wallock-Richards, D.J., Marles-Wright, J., Clarke, D.J., Maitra, A., Dodds, M., Hanley, B., Campopiano, D.J.
Deposit date:2014-06-12
Release date:2015-05-20
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:Molecular basis of Streptococcus mutans sortase A inhibition by the flavonoid natural product trans-chalcone.
Chem.Commun.(Camb.), 51, 2015
1XC1
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OXO ZIRCONIUM(IV) CLUSTER IN THE FERRIC BINDING PROTEIN (FBP)
Descriptor:periplasmic iron-binding protein, OXO ZIRCONIUM(IV) CLUSTER
Authors:Zhong, W., Alexeev, D., Harvey, I., Guo, M., Hunter, D.J.B., Zhu, H., Campopiano, D.J., Sadler, P.J.
Deposit date:2004-08-31
Release date:2004-09-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:Assembly of an Oxo-Zirconium(IV) Cluster in a Protein Cleft
Angew.Chem.Int.Ed.Engl., 43, 2004
1R1N
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TRI-NUCLEAR OXO-IRON CLUSTERS IN THE FERRIC BINDING PROTEIN FROM N. GONORRHOEAE
Descriptor:Ferric-iron Binding Protein, OXO-IRON CLUSTER 1, OXO-IRON CLUSTER 2, ...
Authors:Zhu, H., Alexeev, D., Hunter, D.J., Campopiano, D.J., Sadler, P.J.
Deposit date:2003-09-24
Release date:2004-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Oxo-iron clusters in a bacterial iron-trafficking protein: new roles for a conserved motif.
Biochem.J., 376, 2003
2XBN
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INHIBITION OF THE PLP-DEPENDENT ENZYME SERINE PALMITOYLTRANSFERASE BY CYCLOSERINE: EVIDENCE FOR A NOVEL DECARBOXYLATIVE MECHANISM OF INACTIVATION
Descriptor:SERINE PALMITOYLTRANSFERASE, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, MAGNESIUM ION
Authors:Lowther, J., Yard, B.A., Johnson, K.A., Carter, L.G., Bhat, V.T., Raman, M.C.C., Clarke, D.J., Ramakers, B., McMahon, S.A., Naismith, J.H., Campopiano, D.J.
Deposit date:2010-04-13
Release date:2010-05-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Inhibition of the Plp-Dependent Enzyme Serine Palmitoyltransferase by Cycloserine: Evidence for a Novel Decarboxylative Mechanism of Inactivation.
Mol.Biosystems, 6, 2010
4BMK
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SERINE PALMITOYLTRANSFERASE K265A FROM S. PAUCIMOBILIS WITH BOUND PLP- MYRIOCIN ALDIMINE
Descriptor:SERINE PALMITOYLTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE, Decarboxylated Myriocin, ...
Authors:Wadsworth, J.M., Clarke, D.J., McMahon, S.A., Beattie, A.E., Lowther, J., Dunn, T.M., Naismith, J.H., Campopiano, D.J.
Deposit date:2013-05-09
Release date:2013-09-04
Last modified:2013-10-09
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:The Chemical Basis of Serine Palmitoyltransferase Inhibition by Myriocin.
J.Am.Chem.Soc., 135, 2013
5DBV
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STRUCTURE OF A C269A MUTANT OF PROPIONALDEHYDE DEHYDROGENASE FROM THE CLOSTRIDIUM PHYTOFERMENTANS FUCOSE UTILISATION BACTERIAL MICROCOMPARTMENT
Descriptor:Aldehyde Dehydrogenase, SULFATE ION, COENZYME A, ...
Authors:Tuck, L.R., Altenbach, K., Ang, T.F., Crawshaw, A.D., Campopiano, D.J., Clarke, D.J., Marles-Wright, J.
Deposit date:2015-08-22
Release date:2016-03-16
Last modified:2018-01-10
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Insight into Coenzyme A cofactor binding and the mechanism of acyl-transfer in an acylating aldehyde dehydrogenase from Clostridium phytofermentans.
Sci Rep, 6, 2016
5DRU
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STRUCTURE OF HIS387ALA MUTANT OF THE PROPIONALDEHYDE DEHYDROGENASE FROM THE CLOSTRIDIUM PHYTOFERMENTANS FUCOSE UTILISATION BACTERIAL MICROCOMPARTMENT
Descriptor:Aldehyde Dehydrogenase, SULFATE ION
Authors:Tuck, L.R., Altenbach, K., Fu, A.T., Crawshaw, A.D., Campopiano, D.J., Clarke, D.J., Marles-Wright, J.
Deposit date:2015-09-16
Release date:2016-03-16
Method:X-RAY DIFFRACTION (2.083 Å)
Cite:Insight into Coenzyme A cofactor binding and the mechanism of acyl-transfer in an acylating aldehyde dehydrogenase from Clostridium phytofermentans.
Sci Rep, 6, 2016
1O7T
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METAL NANOCLUSTERS BOUND TO THE FERRIC BINDING PROTEIN FROM NEISSERIA GONORRHOEAE.
Descriptor:IRON BINDING PROTEIN, HF OXO CLUSTER HF5, SMALLEST HF-OXO-PHOSPHATE CLUSTER HF3, ...
Authors:Alexeev, D., Zu, H., Guo, M., Zhong, W., Hunter, D.J.B., Yang, W., Campopiano, D.J., Sadler, P.J.
Deposit date:2002-11-12
Release date:2003-02-27
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:A novel protein-mineral interface.
Nat. Struct. Biol., 10, 2003
2X8U
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SPHINGOMONAS WITTICHII SERINE PALMITOYLTRANSFERASE
Descriptor:SERINE PALMITOYLTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE
Authors:Raman, M.C.C., Johnson, K.A., Campopiano, D.J., Naismith, J.H.
Deposit date:2010-03-12
Release date:2010-03-23
Last modified:2015-11-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Serine Palmitoyltransferase from Sphingomonas Wittichii Rw1 an Interesting Link to an Unusual Acyl Carrier Protein
Biopolymers, 93, 2010
3EFR
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BIOTIN PROTEIN LIGASE R40G MUTANT FROM AQUIFEX AEOLICUS IN COMPLEX WITH BIOTIN
Descriptor:Biotin [acetyl-CoA-carboxylase] ligase, BIOTIN, SULFATE ION
Authors:Tron, C.M., McNae, I.W., Walkinshaw, M.D., Baxter, R.L., Campopiano, D.J.
Deposit date:2008-09-10
Release date:2009-06-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural and functional studies of the biotin protein ligase from Aquifex aeolicus reveal a critical role for a conserved residue in target specificity
J.Mol.Biol., 387, 2009
3EFS
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BIOTIN PROTEIN LIGASE FROM AQUIFEX AEOLICUS IN COMPLEX WITH BIOTIN AND ATP
Descriptor:Biotin [acetyl-CoA-carboxylase] ligase, ADENOSINE-5'-TRIPHOSPHATE, BIOTIN, ...
Authors:Tron, C.M., McNae, I.W., Walkinshaw, M.D., Baxter, R.L., Campopiano, D.J.
Deposit date:2008-09-10
Release date:2009-06-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and functional studies of the biotin protein ligase from Aquifex aeolicus reveal a critical role for a conserved residue in target specificity
J.Mol.Biol., 387, 2009
3FJP
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APO STRUCTURE OF BIOTIN PROTEIN LIGASE FROM AQUIFEX AEOLICUS
Descriptor:Biotin [acetyl-CoA-carboxylase] ligase, SULFATE ION
Authors:McNae, I.W., Tron, C.M., Baxter, R.L., Walkinshaw, M.D., Campopiano, D.J.
Deposit date:2008-12-15
Release date:2009-06-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and functional studies of the biotin protein ligase from Aquifex aeolicus reveal a critical role for a conserved residue in target specificity
J.Mol.Biol., 387, 2009
5K1R
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STRUCTURE OF BURKHOLDERIA PSEUDOMALLEI K96243 SPHINGOSINE-1-PHOSPHATE LYASE BPSS2021
Descriptor:Burkholderia pseudomallei sphingosine-1-phosphate lyase Bpss2021, PYRIDOXAL-5'-PHOSPHATE
Authors:Mclean, C.J., Campopiano, D.J., Marles-Wright, J.
Deposit date:2016-05-18
Release date:2016-11-02
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (2.104 Å)
Cite:Characterization of homologous sphingosine-1-phosphate lyase isoforms in the bacterial pathogen Burkholderia pseudomallei.
J. Lipid Res., 58, 2017
1BS0
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PLP-DEPENDENT ACYL-COA SYNTHASE
Descriptor:PROTEIN (8-AMINO-7-OXONANOATE SYNTHASE), SULFATE ION
Authors:Alexeev, D., Alexeeva, M., Baxter, R.L., Campopiano, D.J., Webster, S.P., Sawyer, L.
Deposit date:1998-08-31
Release date:1999-08-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The crystal structure of 8-amino-7-oxononanoate synthase: a bacterial PLP-dependent, acyl-CoA-condensing enzyme.
J.Mol.Biol., 284, 1998
1DJ9
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CRYSTAL STRUCTURE OF 8-AMINO-7-OXONANOATE SYNTHASE (OR 7-KETO-8AMINIPELARGONATE OR KAPA SYNTHASE) COMPLEXED WITH PLP AND THE PRODUCT 8(S)-AMINO-7-OXONANONOATE (OR KAPA). THE ENZYME OF BIOTIN BIOSYNTHETIC PATHWAY.
Descriptor:8-AMINO-7-OXONONANOATE SYNTHASE, SULFATE ION, MAGNESIUM ION, ...
Authors:Webster, S.P., Alexeev, D., Campopiano, D.J., Watt, R.M., Alexeeva, M., Sawyer, L., Baxter, R.L.
Deposit date:1999-12-02
Release date:2000-12-06
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Mechanism of 8-amino-7-oxononanoate synthase: spectroscopic, kinetic, and crystallographic studies.
Biochemistry, 39, 2000
1DJE
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CRYSTAL STRUCTURE OF THE PLP-BOUND FORM OF 8-AMINO-7-OXONANOATE SYNTHASE
Descriptor:8-AMINO-7-OXONANOATE SYNTHASE, SULFATE ION, PYRIDOXAL-5'-PHOSPHATE
Authors:Webster, S.P., Alexeev, D., Campopiano, D.J., Watt, R.M., Alexeeva, M., Sawyer, L., Baxter, R.L.
Deposit date:1999-12-02
Release date:2000-12-04
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Mechanism of 8-amino-7-oxononanoate synthase: spectroscopic, kinetic, and crystallographic studies.
Biochemistry, 39, 2000
2JG2
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HIGH RESOLUTION STRUCTURE OF SPT WITH PLP INTERNAL ALDIMINE
Descriptor:SERINE PALMITOYLTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE, MAGNESIUM ION
Authors:Yard, B.A., Carter, L.G., Johnson, K.A., Overton, I.M., Mcmahon, S.A., Dorward, M., Liu, H., Puech, D., Oke, M., Barton, G.J., Naismith, J.H., Campopiano, D.J.
Deposit date:2007-02-07
Release date:2007-05-01
Last modified:2015-11-11
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:The Structure of Serine Palmitoyltransferase; Gateway to Sphingolipid Biosynthesis.
J.Mol.Biol., 370, 2007
2JGT
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LOW RESOLUTION STRUCTURE OF SPT
Descriptor:SERINE PALMITOYLTRANSFERASE
Authors:Yard, B.A., Carter, L.G., Johnson, K.A., Overton, I.M., Mcmahon, S.A., Dorward, M., Liu, H., Puech, D., Oke, M., Barton, G.J., Naismith, J.H., Campopiano, D.J.
Deposit date:2007-02-14
Release date:2007-05-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:The Structure of Serine Palmitoyltransferase; Gateway to Sphingolipid Biosynthesis.
J.Mol.Biol., 370, 2007
2W8J
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SPT WITH PLP-SER
Descriptor:SERINE PALMITOYLTRANSFERASE, [3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-SERINE
Authors:Carter, L.G., Raman, M.C.C., Johnson, K.A., Campopiano, D.J., Naismith, J.H.
Deposit date:2009-01-16
Release date:2009-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The External-Aldimine Form of Serine Palmitoyltranserase; Structural, Kinetic and Spectroscopic Analysis of the Wild-Type Enzyme and Hsan1 Mutant Mimics.
J.Biol.Chem., 284, 2009
2W8T
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SPT WITH PLP, N100C
Descriptor:SERINE PALMITOYLTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE
Authors:Raman, M.C.C., Johnson, K.A., Campopiano, D.J., Naismith, J.H.
Deposit date:2009-01-19
Release date:2009-01-27
Last modified:2015-11-18
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:The External-Aldimine Form of Serine Palmitoyltranserase; Structural, Kinetic and Spectroscopic Analysis of the Wild-Type Enzyme and Hsan1 Mutant Mimics.
J.Biol.Chem., 284, 2009
2W8U
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SPT WITH PLP, N100Y
Descriptor:SERINE PALMITOYLTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE
Authors:Raman, M.C.C., Johnson, K.A., Campopiano, D.J., Naismith, J.H.
Deposit date:2009-01-19
Release date:2009-01-27
Last modified:2015-11-18
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The External-Aldimine Form of Serine Palmitoyltranserase; Structural, Kinetic and Spectroscopic Analysis of the Wild-Type Enzyme and Hsan1 Mutant Mimics.
J.Biol.Chem., 284, 2009
2W8V
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SPT WITH PLP, N100W
Descriptor:SERINE PALMITOYLTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE
Authors:Raman, M.C.C., Johnson, K.A., Campopiano, D.J., Naismith, J.H.
Deposit date:2009-01-19
Release date:2009-01-27
Last modified:2015-11-18
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:The External-Aldimine Form of Serine Palmitoyltranserase; Structural, Kinetic and Spectroscopic Analysis of the Wild-Type Enzyme and Hsan1 Mutant Mimics.
J.Biol.Chem., 284, 2009
2W8W
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N100Y SPT WITH PLP-SER
Descriptor:SERINE PALMITOYLTRANSFERASE, [3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-SERINE
Authors:Raman, M.C.C., Johnson, K.A., Campopiano, D.J., Naismith, J.H.
Deposit date:2009-01-19
Release date:2009-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:The External-Aldimine Form of Serine Palmitoyltranserase; Structural, Kinetic and Spectroscopic Analysis of the Wild-Type Enzyme and Hsan1 Mutant Mimics.
J.Biol.Chem., 284, 2009
4A6G
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N-ACYL AMINO ACID RACEMASE FROM AMYCALOTOPSIS SP. TS-1-60: G291D- F323Y MUTANT IN COMPLEX WITH N-ACETYL METHIONINE
Descriptor:N-ACYLAMINO ACID RACEMASE, N-ACETYLMETHIONINE, MAGNESIUM ION
Authors:Baxter, S., Royer, S., Grogan, G., Holt-Tiffin, K.E., Taylor, I.N., Fotheringham, I.G., Campopiano, D.J.
Deposit date:2011-11-02
Release date:2012-11-14
Last modified:2012-12-19
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:An Improved Racemase/Acylase Biotransformation for the Preparation of Enantiomerically Pure Amino Acids.
J.Am.Chem.Soc., 134, 2012
5FLG
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CRYSTAL STRUCTURE OF THE 6-CARBOXYHEXANOATE-COA LIGASE (BIOW)FROM BACILLUS SUBTILIS IN COMPLEX WITH AMPPNP
Descriptor:6-CARBOXYHEXANOATE--COA LIGASE, PIMELIC ACID, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Moynie, L., Wang, M., Campopiano, D.J., Naismith, J.H.
Deposit date:2015-10-26
Release date:2016-11-16
Last modified:2017-05-24
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Using the pimeloyl-CoA synthetase adenylation fold to synthesize fatty acid thioesters.
Nat. Chem. Biol., 13, 2017
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