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2UZT
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BU of 2uzt by Molmil
PKA structures of AKT, indazole-pyridine inhibitors
Descriptor: (2S)-1-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}-3-PHENYLPROPAN-2-AMINE, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA, CAMP-DEPENDENT PROTEIN KINASE, ...
Authors:Zhu, G.D, Gandhi, V.B, Gong, J, Thomas, S, Woods, K.W, Song, X, Li, T, Diebold, R.B, Luo, Y, Liu, X, Guan, R, Klinghofer, V, Johnson, E.F, Bouska, J, Olson, A, Marsh, K.C, Stoll, V.S, Mamo, M, Polakowski, J, Campbell, T.J, Penning, T.D, Li, Q, Rosenberg, S.H, Giranda, V.L.
Deposit date:2007-05-01
Release date:2007-06-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Syntheses of Potent, Selective, and Orally Bioavailable Indazole-Pyridine Series of Protein Kinase B/Akt Inhibitors with Reduced Hypotension.
J.Med.Chem., 50, 2007
2UZU
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BU of 2uzu by Molmil
PKA structures of indazole-pyridine series of AKT inhibitors
Descriptor: (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA, CAMP-DEPENDENT PROTEIN KINASE, ...
Authors:Zhu, G.D, Gandhi, V.B, Gong, J, Thomas, S, Woods, K.W, Song, X, Li, T, Diebold, R.B, Luo, Y, Liu, X, Guan, R, Klinghofer, V, Johnson, E.F, Bouska, J, Olson, A, Marsh, K.C, Stoll, V.S, Mamo, M, Polakowski, J, Campbell, T.J, Penning, T.D, Li, Q, Rosenberg, S.H, Giranda, V.L.
Deposit date:2007-05-01
Release date:2007-06-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Syntheses of Potent, Selective, and Orally Bioavailable Indazole-Pyridine Series of Protein Kinase B/Akt Inhibitors with Reduced Hypotension.
J.Med.Chem., 50, 2007
2UZV
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BU of 2uzv by Molmil
PKA structures of indazole-pyridine series of AKT inhibitors
Descriptor: (2S)-1-[3-(CYCLOHEXYLMETHOXY)PHENYL]-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA,, CAMP-DEPENDENT PROTEIN KINASE, ...
Authors:Zhu, G.D, Gandhi, V.B, Gong, J, Thomas, S, Woods, K.W, Song, X, Li, T, Diebold, R.B, Luo, Y, Liu, X, Guan, R, Klinghofer, V, Johnson, E.F, Bouska, J, Olson, A, Marsh, K.C, Stoll, V.S, Mamo, M, Polakowski, J, Campbell, T.J, Penning, T.D, Li, Q, Rosenberg, S.H, Giranda, V.L.
Deposit date:2007-05-01
Release date:2007-06-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Syntheses of Potent, Selective, and Orally Bioavailable Indazole-Pyridine Series of Protein Kinase B/Akt Inhibitors with Reduced Hypotension.
J.Med.Chem., 50, 2007
2UZW
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BU of 2uzw by Molmil
PKA structures of indazole-pyridine series of AKT inhibitors
Descriptor: 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.] PYRAZOLE, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA, CAMP-DEPENDENT PROTEIN KINASE, ...
Authors:Zhu, G.D, Gandhi, V.B, Gong, J, Thomas, S, Woods, K.W, Song, X, Li, T, Diebold, R.B, Luo, Y, Liu, X, Guan, R, Klinghofer, V, Johnson, E.F, Bouska, J, Olson, A, Marsh, K.C, Stoll, V.S, Mamo, M, Polakowski, J, Campbell, T.J, Penning, T.D, Li, Q, Rosenberg, S.H, Giranda, V.L.
Deposit date:2007-05-01
Release date:2007-06-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Syntheses of Potent, Selective, and Orally Bioavailable Indazole-Pyridine Series of Protein Kinase B/Akt Inhibitors with Reduced Hypotension.
J.Med.Chem., 50, 2007
1K0O
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BU of 1k0o by Molmil
Crystal structure of a soluble form of CLIC1. An intracellular chloride ion channel
Descriptor: CHLORIDE INTRACELLULAR CHANNEL PROTEIN 1
Authors:Harrop, S.J, DeMaere, M.Z, Fairlie, W.D, Reztsova, T, Valenzuela, S.M, Mazzanti, M, Tonini, R, Qiu, M.R, Jankova, L, Warton, K, Bauskin, A.R, Wu, W.M, Pankhurst, S, Campbell, T.J, Breit, S.N, Curmi, P.M.G.
Deposit date:2001-09-19
Release date:2001-12-12
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structure of a soluble form of the intracellular chloride ion channel CLIC1 (NCC27) at 1.4-A resolution.
J.Biol.Chem., 276, 2001
1K0N
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BU of 1k0n by Molmil
Chloride Intracellular Channel 1 (CLIC1) complexed with glutathione
Descriptor: CHLORIDE INTRACELLULAR CHANNEL PROTEIN 1, GLUTATHIONE
Authors:Harrop, S.J, DeMaere, M.Z, Fairlie, W.D, Reztsova, T, Valenzuela, S.M, Mazzanti, M, Tonini, R, Qiu, M.R, Jankova, L, Warton, K, Bauskin, A.R, Wu, W.M, Pankhurst, S, Campbell, T.J, Breit, S.N, Curmi, P.M.G.
Deposit date:2001-09-19
Release date:2001-12-12
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of a soluble form of the intracellular chloride ion channel CLIC1 (NCC27) at 1.4-A resolution.
J.Biol.Chem., 276, 2001
1K0M
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BU of 1k0m by Molmil
Crystal structure of a soluble monomeric form of CLIC1 at 1.4 angstroms
Descriptor: CHLORIDE INTRACELLULAR CHANNEL PROTEIN 1
Authors:Harrop, S.J, DeMaere, M.Z, Fairlie, W.D, Reztsova, T, Valenzuela, S.M, Mazzanti, M, Tonini, R, Qiu, M.R, Jankova, L, Warton, K, Bauskin, A.R, Wu, W.M, Pankhurst, S, Campbell, T.J, Breit, S.N, Curmi, P.M.G.
Deposit date:2001-09-19
Release date:2001-12-12
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structure of a soluble form of the intracellular chloride ion channel CLIC1 (NCC27) at 1.4-A resolution.
J.Biol.Chem., 276, 2001
1UJL
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BU of 1ujl by Molmil
Solution Structure of the HERG K+ channel S5-P extracellular linker
Descriptor: Potassium voltage-gated channel subfamily H member 2
Authors:Torres, A.M, Bansal, P.S, Sunde, M, Clarke, C.E, Bursill, J.A, Smith, D.J, Bauskin, A, Breit, S.N, Campbell, T.J, Alewood, P.F, Kuchel, P.W, Vandenberg, J.I.
Deposit date:2003-08-05
Release date:2003-11-04
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Structure of the HERG K+ channel S5P extracellular linker: role of an amphipathic alpha-helix in C-type inactivation.
J.Biol.Chem., 278, 2003
1RK4
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BU of 1rk4 by Molmil
Crystal Structure of a Soluble Dimeric Form of Oxidised CLIC1
Descriptor: CHLORIDE INTRACELLULAR CHANNEL PROTEIN 1
Authors:Littler, D.R, Harrop, S.J, Fairlie, W.D, Brown, L.J, Pankhurst, G.J, Pankhurst, S, DeMaere, M.Z, Campbell, T.J, Bauskin, A.R, Tonini, R, Mazzanti, M, Breit, S.N, Curmi, P.M.
Deposit date:2003-11-20
Release date:2003-12-02
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.792 Å)
Cite:The Intracellular Chloride Ion Channel Protein CLIC1 Undergoes a Redox-controlled Structural Transition
J.Biol.Chem., 279, 2004

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