Author results

3NRX
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INSIGHTS INTO ANTI-PARALLEL MICROTUBULE CROSSLINKING BY PRC1, A CONSERVED NON-MOTOR MICROTUBULE BINDING PROTEIN
Descriptor:Protein regulator of cytokinesis 1
Authors:Kapoor, T.M., Subramanian, R., Wilson-Kubalek, E.M., Arthur, C.P., Bick, M.J., Campbell, E.A., Darst, S.A., Milligan, R.A.
Deposit date:2010-06-30
Release date:2010-08-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Insights into Antiparallel Microtubule Crosslinking by PRC1, a Conserved Nonmotor Microtubule Binding Protein.
Cell(Cambridge,Mass.), 142, 2010
1KU3
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CRYSTAL STRUCTURE OF THERMUS AQUATICUS RNA POLYMERASE SIGMA SUBUNIT FRAGMENT, REGION 4
Descriptor:sigma factor sigA
Authors:Campbell, E.A., Muzzin, O., Chlenov, M., Sun, J.L., Olson, C.A., Weinman, O., Trester-Zedlitz, M.L., Darst, S.A.
Deposit date:2002-01-21
Release date:2002-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of the bacterial RNA polymerase promoter specificity sigma subunit.
Mol.Cell, 9, 2002
1OR7
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CRYSTAL STRUCTURE OF ESCHERICHIA COLI SIGMAE WITH THE CYTOPLASMIC DOMAIN OF ITS ANTI-SIGMA RSEA
Descriptor:RNA polymerase sigma-E factor, Sigma-E factor negative regulatory protein
Authors:Campbell, E.A., Tupy, J.L., Gruber, T.M., Wang, S., Sharp, M.M., Gross, C.A., Darst, S.A.
Deposit date:2003-03-12
Release date:2003-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of Escherichia coli sigmaE with the cytoplasmic domain of its anti-sigma RseA.
Mol.Cell, 11, 2003
3NRY
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INSIGHTS INTO ANTI-PARALLEL MICROTUBULE CROSSLINKING BY PRC1, A CONSERVED MICROTUBULE BINDING PROTEIN
Descriptor:Protein regulator of cytokinesis 1
Authors:Kapoor, T.M., Subramanian, R., Wilson-Kubalek, E.M., Arthur, C.P., Bick, M.J., Campbell, E.A., Darst, S.A., Milligan, R.A.
Deposit date:2010-07-01
Release date:2010-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insights into Antiparallel Microtubule Crosslinking by PRC1, a Conserved Nonmotor Microtubule Binding Protein.
Cell(Cambridge,Mass.), 142, 2010
4X8K
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MYCOBACTERIUM TUBERCULOSIS RBPA-SID IN COMPLEX WITH SIGMAA DOMAIN 2
Descriptor:RNA polymerase sigma factor SigA, RNA polymerase-binding protein RbpA, SULFATE ION, ...
Authors:Hubin, E.A., Flack, J.E., Tabib-Salazar, A., Paget, M.S., Darst, S.A., Campbell, E.A.
Deposit date:2014-12-10
Release date:2015-06-03
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.202 Å)
Cite:Structural, functional, and genetic analyses of the actinobacterial transcription factor RbpA.
Proc.Natl.Acad.Sci.USA, 112, 2015
3GFK
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CRYSTAL STRUCTURE OF BACILLUS SUBTILIS SPX/RNA POLYMERASE ALPHA SUBUNIT C-TERMINAL DOMAIN COMPLEX
Descriptor:Regulatory protein spx, DNA-directed RNA polymerase subunit alpha
Authors:Lamour, V., Westblade, L.F., Campbell, E.A., Darst, S.A.
Deposit date:2009-02-27
Release date:2009-03-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the in vivo-assembled Bacillus subtilis Spx/RNA polymerase alpha subunit C-terminal domain complex
J.Struct.Biol., 168, 2009
4L5G
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CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS CARD
Descriptor:CarD
Authors:Srivastava, D.B., Westblade, L.F., Campbell, E.A., Darst, S.A.
Deposit date:2013-06-11
Release date:2013-07-31
Last modified:2013-08-21
Method:X-RAY DIFFRACTION (2.3902 Å)
Cite:Structure and function of CarD, an essential mycobacterial transcription factor.
Proc.Natl.Acad.Sci.USA, 110, 2013
1KU7
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CRYSTAL STRUCTURE OF THERMUS AQUATICS RNA POLYMERASE SIGMAA SUBUNIT REGION 4 BOUND TO-35 ELEMENT DNA
Descriptor:5'-D(*CP*CP*TP*TP*GP*AP*CP*AP*AP*AP*G)-3', 5'-D(*CP*CP*TP*TP*TP*GP*TP*CP*AP*AP*G)-3', sigma factor sigA
Authors:Campbell, E.A., Muzzin, O., Chlenov, M., Sun, J.L., Olson, C.A., Weinman, O., Trester-Zedlitz, M.L., Darst, S.A.
Deposit date:2002-01-21
Release date:2002-03-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of the bacterial RNA polymerase promoter specificity sigma subunit.
Mol.Cell, 9, 2002
1TH8
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CRYSTAL STRUCTURES OF THE ADP AND ATP BOUND FORMS OF THE BACILLUS ANTI-SIGMA FACTOR SPOIIAB IN COMPLEX WITH THE ANTI-ANTI-SIGMA SPOIIAA: INHIBITORY COMPLEX WITH ADP, CRYSTAL FORM II
Descriptor:Anti-sigma F factor, Anti-sigma F factor antagonist, MAGNESIUM ION, ...
Authors:Masuda, S., Murakami, K.S., Wang, S., Olson, C.A., Donigian, J., Leon, F., Darst, S.A., Campbell, E.A.
Deposit date:2004-06-01
Release date:2004-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structures of the ADP and ATP Bound Forms of the Bacillus Anti-sigma Factor SpoIIAB in Complex with the Anti-anti-sigma SpoIIAA.
J.Mol.Biol., 340, 2004
2Q1Z
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CRYSTAL STRUCTURE OF RHODOBACTER SPHAEROIDES SIGE IN COMPLEX WITH THE ANTI-SIGMA CHRR
Descriptor:RpoE, ECF SigE, Anti-Sigma factor ChrR, ...
Authors:Campbell, E.A., Darst, S.A.
Deposit date:2007-05-25
Release date:2007-09-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A conserved structural module regulates transcriptional responses to diverse stress signals in bacteria.
Mol.Cell, 27, 2007
4XAX
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CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS CARD IN COMPLEX WITH THE THERMUS AQUATICUS RNA POLYMERASE BETA1 DOMAIN
Descriptor:DNA-directed RNA polymerase subunit beta domain 1, CarD, 1,2-ETHANEDIOL
Authors:Chen, J., Bae, B., Campbell, E.A., Darst, S.A.
Deposit date:2014-12-15
Release date:2015-09-16
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.404 Å)
Cite:CarD uses a minor groove wedge mechanism to stabilize the RNA polymerase open promoter complex.
Elife, 4, 2015
1THN
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CRYSTAL STRUCTURES OF THE ADP AND ATP BOUND FORMS OF THE BACILLUS ANTI-SIGMA FACTOR SPOIIAB IN COMPLEX WITH THE ANTI-ANTI-SIGMA SPOIIAA: INHIBITORY COMPLEX WITH ADP, CRYSTAL FORM I
Descriptor:Anti-sigma F factor, Anti-sigma F factor antagonist, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Masuda, S., Murakami, K.S., Wang, S., Olson, C.A., Donigan, J., Leon, F., Darst, S.A., Campbell, E.A.
Deposit date:2004-06-01
Release date:2004-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structures of the ADP and ATP Bound Forms of the Bacillus Anti-sigma Factor SpoIIAB in Complex with the Anti-anti-sigma SpoIIAA.
J.Mol.Biol., 340, 2004
1TID
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CRYSTAL STRUCTURES OF THE ADP AND ATP BOUND FORMS OF THE BACILLUS ANTI-SIGMA FACTOR SPOIIAB IN COMPLEX WITH THE ANTI-ANTI-SIGMA SPOIIAA: POISED FOR PHOSPHORYLATION COMPLEX WITH ATP, CRYSTAL FORM I
Descriptor:Anti-sigma F factor, Anti-sigma F factor antagonist, MAGNESIUM ION, ...
Authors:Masuda, S., Murakami, K.S., Wang, S., Olson, C.A., Donigan, J., Leon, F., Darst, S.A., Campbell, E.A.
Deposit date:2004-06-02
Release date:2004-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structures of the ADP and ATP Bound Forms of the Bacillus Anti-sigma Factor SpoIIAB in Complex with the Anti-anti-sigma SpoIIAA.
J.Mol.Biol., 340, 2004
2P7V
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CRYSTAL STRUCTURE OF THE ESCHERICHIA COLI REGULATOR OF SIGMA 70, RSD, IN COMPLEX WITH SIGMA 70 DOMAIN 4
Descriptor:Regulator of sigma D, RNA polymerase sigma factor rpoD, MAGNESIUM ION
Authors:Patikoglou, G.A., Westblade, L.F., Campbell, E.A., Lamour, V., Lane, W.J., Darst, S.A.
Deposit date:2007-03-20
Release date:2007-08-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of the Escherichia coli regulator of sigma70, Rsd, in complex with sigma70 domain 4.
J.Mol.Biol., 372, 2007
1TIL
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CRYSTAL STRUCTURES OF THE ADP AND ATP BOUND FORMS OF THE BACILLUS ANTI-SIGMA FACTOR SPOIIAB IN COMPLEX WITH THE ANTI-ANTI-SIGMA SPOIIAA:POISED FOR PHOSPHORYLATION COMPLEX WITH ATP, CRYSTAL FORM II
Descriptor:Anti-sigma F factor, Anti-sigma F factor antagonist, MAGNESIUM ION, ...
Authors:Masuda, S., Murakami, K.S., Wang, S., Olson, C.A., Donigan, J., Leon, F., Darst, S.A., Campbell, E.A.
Deposit date:2004-06-02
Release date:2004-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structures of the ADP and ATP Bound Forms of the Bacillus Anti-sigma Factor SpoIIAB in Complex with the Anti-anti-sigma SpoIIAA.
J.Mol.Biol., 340, 2004
2Z2S
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CRYSTAL STRUCTURE OF RHODOBACTER SPHAEROIDES SIGE IN COMPLEX WITH THE ANTI-SIGMA CHRR
Descriptor:RpoE, ECF SigE, Anti-Sigma factor ChrR, ...
Authors:Darst, S.A., Campbell, E.A.
Deposit date:2007-05-26
Release date:2008-02-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A conserved structural module regulates transcriptional responses to diverse stress signals in bacteria.
Mol.Cell, 27, 2007
5TW1
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CRYSTAL STRUCTURE OF A MYCOBACTERIUM SMEGMATIS TRANSCRIPTION INITIATION COMPLEX WITH RBPA
Descriptor:RNA polymerase-binding protein RbpA, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Hubin, E.A., Darst, S.A., Campbell, E.A.
Deposit date:2016-11-10
Release date:2017-01-18
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Structure and function of the mycobacterial transcription initiation complex with the essential regulator RbpA.
Elife, 6, 2017
5VI8
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STRUCTURE OF A MYCOBACTERIUM SMEGMATIS TRANSCRIPTION INITIATION COMPLEX WITH AN UPSTREAM-FORK PROMOTER FRAGMENT
Descriptor:RNA polymerase-binding protein RbpA, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Hubin, E.A., Campbell, E.A., Darst, S.A.
Deposit date:2017-04-14
Release date:2017-04-26
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Structural insights into the mycobacteria transcription initiation complex from analysis of X-ray crystal structures.
Nat Commun, 8, 2017
1KU2
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CRYSTAL STRUCTURE OF THERMUS AQUATICUS RNA POLYMERASE SIGMA SUBUNIT FRAGMENT CONTAINING REGIONS 1.2 TO 3.1
Descriptor:sigma factor sigA, SULFATE ION
Authors:Campbell, E.A., Muzzin, O., Chlenov, M., Sun, J.L., Olson, C.A., Weinman, O., Trester-Zedlitz, M.L., Darst, S.A.
Deposit date:2002-01-21
Release date:2002-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of the bacterial RNA polymerase promoter specificity sigma subunit.
Mol.Cell, 9, 2002
1L0O
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CRYSTAL STRUCTURE OF THE BACILLUS STEAROTHERMOPHILUS ANTI-SIGMA FACTOR SPOIIAB WITH THE SPORULATION SIGMA FACTOR SIGMAF
Descriptor:Anti-sigma F factor, sigma factor, MAGNESIUM ION, ...
Authors:Campbell, E.A., Masuda, S., Sun, J.L., Muzzin, O., Olson, C.A., Wang, S., Darst, S.A.
Deposit date:2002-02-12
Release date:2002-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of the Bacillus stearothermophilus anti-sigma factor SpoIIAB with the sporulation sigma factor sigmaF.
Cell(Cambridge,Mass.), 108, 2002
3MLQ
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS TRANSCRIPTION-REPAIR COUPLING FACTOR RNA POLYMERASE INTERACTING DOMAIN WITH THE THERMUS AQUATICUS RNA POLYMERASE BETA1 DOMAIN
Descriptor:DNA-directed RNA polymerase subunit beta, Transcription-repair coupling factor, PHOSPHATE ION
Authors:Darst, S.A., Westblade, L.F., Campbell, E.A.
Deposit date:2010-04-18
Release date:2010-10-13
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Structural basis for the bacterial transcription-repair coupling factor/RNA polymerase interaction.
Nucleic Acids Res., 38, 2010
3TBI
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CRYSTAL STRUCTURE OF T4 GP33 BOUND TO E. COLI RNAP BETA-FLAP DOMAIN
Descriptor:RNA polymerase-associated protein Gp33, DNA-directed RNA polymerase subunit beta
Authors:Twist, K.A.F., Campbell, E.A., Darst, S.A.
Deposit date:2011-08-06
Release date:2011-11-23
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of T4 gp33 bound to E. coli RNAP beta-flap domain
To be Published
6CCE
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CRYSTAL STRUCTURE OF A MYCOBACTERIUM SMEGMATIS RNA POLYMERASE TRANSCRIPTION INITIATION COMPLEX WITH INHIBITOR KANGLEMYCIN A
Descriptor:RNA polymerase-binding protein RbpA, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Lilic, M., Darst, S.A., Campbell, E.A.
Deposit date:2018-02-07
Release date:2018-08-15
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism.
Nat Commun, 9, 2018
6CCV
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CRYSTAL STRUCTURE OF A MYCOBACTERIUM SMEGMATIS RNA POLYMERASE TRANSCRIPTION INITIATION COMPLEX WITH INHIBITOR RIFAMPICIN
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Lilic, M., Darst, S.A., Campbell, E.A.
Deposit date:2018-02-07
Release date:2018-08-15
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism.
Nat Commun, 9, 2018
5VI5
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STRUCTURE OF MYCOBACTERIUM SMEGMATIS TRANSCRIPTION INITIATION COMPLEX WITH A FULL TRANSCRIPTION BUBBLE
Descriptor:DNA (49-MER), DNA (44-MER), RNA (5'-R(*UP*CP*GP*A)-3'), ...
Authors:Darst, S.A., Campbell, E.A., Lilic, M.
Deposit date:2017-04-14
Release date:2017-07-26
Method:X-RAY DIFFRACTION (3.196 Å)
Cite:Structural insights into the mycobacteria transcription initiation complex from analysis of X-ray crystal structures.
Nat Commun, 8, 2017
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