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6HMO
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BU of 6hmo by Molmil
Solution structure of the RNA duplex formed by the 5'-end of U1snRNA and the 5'-splice site of SMN2 exon7 in complex with the SMN-C5 splicing modifier
Descriptor: 2-(8-fluoranyl-2-methyl-imidazo[1,2-a]pyridin-6-yl)-7-(4-methylpiperazin-1-yl)pyrido[1,2-a]pyrimidin-4-one, RNA (5'-R(*AP*UP*AP*CP*(PSU)P*(PSU)P*AP*CP*CP*UP*G)-3'), RNA (5'-R(*GP*GP*AP*GP*UP*AP*AP*GP*UP*CP*U)-3')
Authors:Campagne, S, Allain, F.H.
Deposit date:2018-09-12
Release date:2019-08-14
Last modified:2020-02-26
Method:SOLUTION NMR
Cite:Structural basis of a small molecule targeting RNA for a specific splicing correction.
Nat.Chem.Biol., 15, 2019
6HMI
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BU of 6hmi by Molmil
Solution structure of the RNA duplex formed by the 5'-end of U1snRNA and the 5'-splice site of SMN2 exon7
Descriptor: RNA (5'-R(*AP*UP*AP*CP*(PSU)P*(PSU)P*AP*CP*CP*UP*G)-3'), RNA (5'-R(*GP*GP*AP*GP*UP*AP*AP*GP*UP*CP*U)-3')
Authors:Campagne, S, Allain, F.H.
Deposit date:2018-09-12
Release date:2019-08-14
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural basis of a small molecule targeting RNA for a specific splicing correction.
Nat.Chem.Biol., 15, 2019
5IEJ
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BU of 5iej by Molmil
Solution structure of the BeF3-activated conformation of SdrG from Pseudomonas melonis Fr1
Descriptor: SdrG
Authors:Campagne, S, Vorholt, J.A, Allain, F.H.-T.
Deposit date:2016-02-25
Release date:2016-07-20
Last modified:2019-05-08
Method:SOLUTION NMR
Cite:Role of the PFXFATG[G/Y] Motif in the Activation of SdrG, a Response Regulator Involved in the Alphaproteobacterial General Stress Response.
Structure, 24, 2016
5IEB
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BU of 5ieb by Molmil
Solution structure of SdrG from Sphingomonas melonis Fr1
Descriptor: Sensory transduction regulatory protein
Authors:Campagne, S, Vorholt, J.A, Allain, F.H.-T.
Deposit date:2016-02-25
Release date:2016-07-20
Last modified:2019-11-06
Method:SOLUTION NMR
Cite:Role of the PFXFATG[G/Y] Motif in the Activation of SdrG, a Response Regulator Involved in the Alphaproteobacterial General Stress Response.
Structure, 24, 2016
5OR5
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BU of 5or5 by Molmil
NMR structure of the complex formed by an engineered region 2 of sigmaE in complex with GTAAAA
Descriptor: DNA (5'-D(*GP*TP*AP*AP*AP*A)-3'), ECF RNA polymerase sigma-E factor,ECF RNA polymerase sigma factor SigW,ECF RNA polymerase sigma-E factor
Authors:Campagne, S, Vorholt, J.A, Allain, F.H.
Deposit date:2017-08-15
Release date:2018-06-27
Last modified:2019-07-10
Method:SOLUTION NMR
Cite:Engineered promoter selectivity of an ECF sigma factor
Not published
7AEP
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BU of 7aep by Molmil
Solution structure of U1-A RRM2 (190-282)
Descriptor: U1 small nuclear ribonucleoprotein A
Authors:Campagne, S, Allain, F.H.
Deposit date:2020-09-18
Release date:2021-02-03
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:An in vitro reconstituted U1 snRNP allows the study of the disordered regions of the particle and the interactions with proteins and ligands.
Nucleic Acids Res., 49, 2021
7ZAP
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BU of 7zap by Molmil
Solution structure of RBM39 RRM1 bound to U1 snRNA stem loop 3
Descriptor: RNA-binding protein 39, U1 snRNA SL3
Authors:Campagne, S, Allain, F.H.
Deposit date:2022-03-22
Release date:2023-03-29
Last modified:2023-09-20
Method:SOLUTION NMR
Cite:Molecular basis of RNA-binding and autoregulation by the cancer-associated splicing factor RBM39.
Nat Commun, 14, 2023
7Q33
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BU of 7q33 by Molmil
Solution structure of RBM39 RRM2 bound to 5'-AGCUUUG-3
Descriptor: RNA (5'-R(*AP*GP*CP*UP*UP*UP*G)-3'), RNA-binding protein 39
Authors:Campagne, S, Allain, F.H.
Deposit date:2021-10-26
Release date:2023-02-08
Last modified:2023-09-20
Method:SOLUTION NMR
Cite:Molecular basis of RNA-binding and autoregulation by the cancer-associated splicing factor RBM39.
Nat Commun, 14, 2023
4LUP
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BU of 4lup by Molmil
Crystal structure of the complex formed by region of E. coli sigmaE bound to its -10 element non template strand
Descriptor: 1,2-ETHANEDIOL, RNA polymerase sigma factor, region 2 of sigmaE of E. coli
Authors:Campagne, S, Marsh, M.E, Vorholt, J.A.V, Allain, F.H.-T, Capitani, G.
Deposit date:2013-07-25
Release date:2014-02-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structural basis for -10 promoter element melting by environmentally induced sigma factors.
Nat.Struct.Mol.Biol., 21, 2014
2KO0
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BU of 2ko0 by Molmil
Solution structure of the THAP zinc finger of THAP1 in complex with its DNA target
Descriptor: RRM1, THAP domain-containing protein 1, ZINC ION
Authors:Campagne, S, Gervais, V, Saurel, O, Milon, A.
Deposit date:2009-09-08
Release date:2010-01-19
Last modified:2021-11-10
Method:SOLUTION NMR
Cite:Structural determinants of specific DNA-recognition by the THAP zinc finger
Nucleic Acids Res., 2010
2L1G
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BU of 2l1g by Molmil
RDC refined solution structure of the THAP zinc finger of THAP1 in complex with its 16bp RRM1 DNA target
Descriptor: DNA (5'-D(*GP*CP*TP*TP*GP*TP*GP*TP*GP*GP*GP*CP*AP*GP*CP*G)-3'), DNA (5'-D(P*CP*GP*CP*TP*GP*CP*CP*CP*AP*CP*AP*CP*AP*AP*GP*C)-3'), THAP domain-containing protein 1, ...
Authors:Campagne, S, Gervais, V, Saurel, O, Milon, A.
Deposit date:2010-07-28
Release date:2010-09-08
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:RDC refined solution structure of the THAP zinc finger of THAP1 in complex with its 16bp RRM1 DNA target
To be published
2LFW
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BU of 2lfw by Molmil
NMR structure of the PhyRSL-NepR complex from Sphingomonas sp. Fr1
Descriptor: NepR anti sigma factor, PhyR sigma-like domain
Authors:Campagne, S, Damberger, F.F, Vorholt, J.A, Allain, F.H.-T.
Deposit date:2011-07-18
Release date:2012-04-25
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural basis for sigma factor mimicry in the general stress response of Alphaproteobacteria.
Proc.Natl.Acad.Sci.USA, 109, 2012
2MAP
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BU of 2map by Molmil
Solution structure of the complex formed by the region 2 of E. coli sigmaE and its cognate -10 promoter element non template strand TGTCAAA.
Descriptor: DNA, RNA polymerase sigma factor
Authors:Campagne, S, Vorholt, J.A, Allain, F.H.-T.
Deposit date:2013-07-16
Release date:2014-02-19
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural basis for -10 promoter element melting by environmentally induced sigma factors.
Nat.Struct.Mol.Biol., 21, 2014
2MAO
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BU of 2mao by Molmil
NMR structure of region 2 of E. coli sigmaE
Descriptor: RNA polymerase sigma factor
Authors:Campagne, S, Vorholt, J.A, Allain, F.H.-T.
Deposit date:2013-07-16
Release date:2014-02-19
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural basis for -10 promoter element melting by environmentally induced sigma factors.
Nat.Struct.Mol.Biol., 21, 2014
6SNJ
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BU of 6snj by Molmil
Solution structure of the FUS/TLS RNA recognition motif in complex with U1 snRNA stem loop III
Descriptor: RNA-binding protein FUS, U1 snRNA stem loop III, RNA (28-MER)
Authors:Campagne, S, Allain, F.H.
Deposit date:2019-08-26
Release date:2020-10-28
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis.
Nat Commun, 11, 2020
5OR0
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BU of 5or0 by Molmil
NMR derived model of the 5'-splice site of SMN2 in complex with the 5'-end of U1 snRNA
Descriptor: RNA (5'-R(P*AP*UP*AP*CP*(PSU)P*(PSU)P*AP*CP*CP*UP*G)-3'), RNA (5'-R(P*GP*GP*AP*GP*UP*AP*AP*GP*UP*CP*U)-3')
Authors:Campagne, S, Clery, A, Allain, F.H.
Deposit date:2017-08-14
Release date:2017-08-30
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers.
Nat Commun, 8, 2017
2NB9
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BU of 2nb9 by Molmil
Solution structure of ZitP zinc finger
Descriptor: Uncharacterized protein, ZINC ION
Authors:Campagne, S, Berge, M, Viollier, P.H, Allain, F.H.-T.
Deposit date:2016-02-01
Release date:2016-12-14
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Modularity and determinants of a (bi-)polarization control system from free-living and obligate intracellular bacteria.
Elife, 5, 2016
8CF2
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BU of 8cf2 by Molmil
Solution structure of the RNA helix formed by the 5'-end of U1 snRNA and an A-1 bulged 5'-splice site in complex with SMN-CY
Descriptor: 4-[(3~{S})-3-ethylpiperazin-1-yl]-2-fluoranyl-~{N}-(2-methylimidazo[1,2-a]pyrazin-6-yl)benzamide, RNA (5'-R(P*AP*UP*AP*CP*(PSU)P*(PSU)P*AP*CP*CP*UP*G)-3'), RNA (5'-R(P*GP*GP*AP*GP*UP*AP*AP*GP*UP*CP*U)-3')
Authors:Malard, F, Marquevielle, J, Campagne, S.
Deposit date:2023-02-02
Release date:2024-02-21
Last modified:2024-04-10
Method:SOLUTION NMR
Cite:The diversity of splicing modifiers acting on A-1 bulged 5'-splice sites reveals rules for rational drug design.
Nucleic Acids Res., 2024
8R62
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BU of 8r62 by Molmil
Solution structure of Risdiplam bound to the RNA duplex formed upon 5'-splice site recognition
Descriptor: 7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-1~{H}-pyrido[1,2-a]pyrimidin-4-one, RNA (5'-R(*AP*UP*AP*CP*(PSU)P*(PSU)P*AP*CP*CP*UP*G)-3'), RNA (5'-R(P*GP*GP*AP*GP*UP*AP*AP*GP*UP*CP*U)-3')
Authors:Malard, F, Campagne, S.
Deposit date:2023-11-20
Release date:2024-03-06
Last modified:2024-04-10
Method:SOLUTION NMR
Cite:The diversity of splicing modifiers acting on A-1 bulged 5'-splice sites reveals rules for rational drug design.
Nucleic Acids Res., 2024
8R8P
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BU of 8r8p by Molmil
Solution structure of SMN-CX bound to the RNA helix formed upon SMN2 exon7 5'-splice site recognition
Descriptor: 2-(8-fluoranyl-2-methyl-imidazo[1,2-a]pyridin-6-yl)-6-(4-methylpiperazin-1-yl)quinazoline, RNA (5'-R(*AP*UP*AP*CP*(PSU)P*(PSU)P*AP*CP*CP*UP*G)-3'), RNA (5'-R(P*GP*GP*AP*GP*UP*AP*AP*GP*UP*CP*U)-3')
Authors:Malard, F, Campagne, S.
Deposit date:2023-11-29
Release date:2024-03-06
Last modified:2024-04-10
Method:SOLID-STATE NMR
Cite:The diversity of splicing modifiers acting on A-1 bulged 5'-splice sites reveals rules for rational drug design.
Nucleic Acids Res., 2024
8R63
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BU of 8r63 by Molmil
Solution structure of branaplam bound to the RNA duplex formed upon 5'-splice site recognition
Descriptor: 5-(1~{H}-pyrazol-4-yl)-2-[6-(2,2,6,6-tetramethylpiperidin-4-yl)oxypyridazin-3-yl]phenol, RNA (5'-R(*AP*UP*AP*CP*(PSU)P*(PSU)P*AP*CP*CP*UP*G)-3'), RNA (5'-R(P*GP*GP*AP*GP*UP*AP*AP*GP*UP*CP*U)-3')
Authors:Malard, F, Campagne, S.
Deposit date:2023-11-20
Release date:2024-03-06
Last modified:2024-04-10
Method:SOLUTION NMR
Cite:The diversity of splicing modifiers acting on A-1 bulged 5'-splice sites reveals rules for rational drug design.
Nucleic Acids Res., 2024
7P08
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BU of 7p08 by Molmil
Solution structure of the human SF3A1 ubiquitin-like domain
Descriptor: Isoform 1 of Splicing factor 3A subunit 1
Authors:de Vries, T, Campagne, S, Allain, F.H.T.
Deposit date:2021-06-29
Release date:2022-02-09
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:Sequence-specific RNA recognition by an RGG motif connects U1 and U2 snRNP for spliceosome assembly.
Proc.Natl.Acad.Sci.USA, 119, 2022
2JTG
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BU of 2jtg by Molmil
Solution structure of the THAP-zinc finger of THAP1
Descriptor: THAP domain-containing protein 1, ZINC ION
Authors:Bessiere, D, Campagne, S, Milon, A, Gervais, V.
Deposit date:2007-07-31
Release date:2007-12-11
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Structure-function analysis of the THAP zinc finger of THAP1, a large C2CH DNA-binding module linked to Rb/E2F pathways
J.Biol.Chem., 283, 2008
2LAU
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BU of 2lau by Molmil
Solution structure of the THAP-zinc finger domain 1-81 from the cell growth suppressor human THAP11 protein
Descriptor: THAP domain-containing protein 11, ZINC ION
Authors:Durand, J, Campagne, S, Milon, A, Gervais, V.
Deposit date:2011-03-21
Release date:2012-09-26
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Solution structure of the THAP domain from the cell growth suppressor human THAP11
To be Published
7QDD
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BU of 7qdd by Molmil
NMR structure of Npl3 RRM1 bound to the AUCCAA RNA
Descriptor: Nucleolar protein 3, RNA (5'-R(*AP*UP*CP*CP*AP*A)-3')
Authors:Clery, A, Allain, F.H.-T, Moursy, A.
Deposit date:2021-11-26
Release date:2022-10-26
Last modified:2024-01-10
Method:SOLUTION NMR
Cite:RNA recognition by Npl3p reveals U2 snRNA-binding compatible with a chaperone role during splicing.
Nat Commun, 14, 2023

 

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