Author results

2F3K
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SUBSTRATE ENVELOPE AND DRUG RESISTANCE: CRYSTAL STRUCTURE OF R01 IN COMPLEX WITH WILD-TYPE HIV-1 PROTEASE
分子名称:Protease, PHOSPHATE ION, (3S,4AS,8AS)-N-(TERT-BUTYL)-2-[(3S)-3-({3-(METHYLSULFONYL)-N-[(PYRIDIN-3-YLOXY)ACETYL]-L-VALYL}AMINO)-2-OXO-4-PHENYLBUTYL]DECAHYDROISOQUINOLINE-3-CARBOXAMIDE
著者Prabu-Jeyabalan, M., King, N.M., Nalivaika, E.A., Heilek-Snyder, G., Cammack, N., Schiffer, C.A.
登録日2005-11-21
公開日2006-11-21
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (1.599 Å)
主引用文献Substrate envelope and drug resistance: crystal structure of RO1 in complex with wild-type human immunodeficiency virus type 1 protease.
Antimicrob.Agents Chemother., 50, 2006
2GIQ
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HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE NS5B WITH NNI-2 INHIBITOR
分子名称:RNA-directed RNA polymerase, 1-(2-CYCLOPROPYLETHYL)-3-(1,1-DIOXIDO-2H-1,2,4-BENZOTHIADIAZIN-3-YL)-6-FLUORO-4-HYDROXYQUINOLIN-2(1H)-ONE
著者Harris, S.F.
登録日2006-03-29
公開日2007-04-03
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Selection and characterization of replicon variants dually resistant to thumb- and palm-binding nonnucleoside polymerase inhibitors of the hepatitis C virus.
J.Virol., 80, 2006
2GIR
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HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE NS5B WITH NNI-1 INHIBITOR
分子名称:RNA-directed RNA polymerase, 3-{ISOPROPYL[(TRANS-4-METHYLCYCLOHEXYL)CARBONYL]AMINO}-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID
著者Harris, S.F.
登録日2006-03-29
公開日2007-04-03
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Selection and characterization of replicon variants dually resistant to thumb- and palm-binding nonnucleoside polymerase inhibitors of the hepatitis C virus.
J.Virol., 80, 2006
2OT5
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CRYSTAL STRUCTURE OF THE HIV GP41 CORE WITH THE ENFUVIRTIDE RESISTANCE MUTATION N43D
分子名称:HIV-1 gp41 glycoprotein
著者Bai, X., Seedorff, J.E., Green, J., Dwyer, J.J.
登録日2007-02-07
公開日2008-06-17
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Impact of the enfuvirtide resistance mutation N43D and the associated baseline polymorphism E137K on peptide sensitivity and six-helix bundle structure.
Biochemistry, 47, 2008
3CP1
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STRUCTURE OF A LONGER THERMALSTABLE CORE DOMAIN OF HIV-1 GP41 CONTAINING THE ENFUVIRTIDE RESISTANCE MUTATION N43D
分子名称:Transmembrane Protein
著者Wang, Z.M., Dwyer, J.J.
登録日2008-03-30
公開日2008-06-17
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Impact of the enfuvirtide resistance mutation N43D and the associated baseline polymorphism E137K on peptide sensitivity and six-helix bundle structure.
Biochemistry, 47, 2008
3CYO
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STRUCTURE OF A LONGER THERMALSTABLE CORE DOMAIN OF HIV-1 GP41 CONTAINING THE ENFUVIRTIDE RESISTANCE MUTATION N43D AND COMPLEMENTARY MUTATION E137K
分子名称:Transmembrane protein
著者Wang, Z.M., Dwyer, J.J.
登録日2008-04-25
公開日2008-06-17
最終更新日2017-08-16
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Impact of the enfuvirtide resistance mutation N43D and the associated baseline polymorphism E137K on peptide sensitivity and six-helix bundle structure.
Biochemistry, 47, 2008
3FQK
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HEPATITIS C VIRUS POLYMERASE NS5B (BK 1-570) WITH HCV-796 INHIBITOR
分子名称:RNA-directed RNA polymerase, 5-cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsulfonyl)amino]-N-methyl-1-benzofuran-3-carboxamide
著者Harris, S.F., Wong, A.
登録日2009-01-07
公開日2009-02-24
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Slow binding inhibition and mechanism of resistance of non-nucleoside polymerase inhibitors of hepatitis C virus.
J.Biol.Chem., 284, 2009
3FQL
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HEPATITIS C VIRUS POLYMERASE NS5B (CON1 1-570) WITH HCV-796 INHIBITOR
分子名称:RNA-directed RNA polymerase, 5-cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsulfonyl)amino]-N-methyl-1-benzofuran-3-carboxamide, GLYCEROL
著者Harris, S.F., Wong, A.
登録日2009-01-07
公開日2009-02-24
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Slow binding inhibition and mechanism of resistance of non-nucleoside polymerase inhibitors of hepatitis C virus.
J.Biol.Chem., 284, 2009