Author results

1FRO
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HUMAN GLYOXALASE I WITH BENZYL-GLUTATHIONE INHIBITOR
Descriptor:LACTOYLGLUTATHIONE LYASE, ZINC ION, S-BENZYL-GLUTATHIONE
Authors:Cameron, A.D., Jones, T.A.
Deposit date:1997-02-25
Release date:1997-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of human glyoxalase I--evidence for gene duplication and 3D domain swapping.
EMBO J., 16, 1997
1GSE
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GLUTATHIONE TRANSFERASE A1-1 COMPLEXED WITH AN ETHACRYNIC ACID GLUTATHIONE CONJUGATE (MUTANT R15K)
Descriptor:GLUTATHIONE TRANSFERASE, GLUTATHIONE, ETHACRYNIC ACID, ...
Authors:Cameron, A.D., Jones, T.A.
Deposit date:1995-06-09
Release date:1995-09-15
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural analysis of human alpha-class glutathione transferase A1-1 in the apo-form and in complexes with ethacrynic acid and its glutathione conjugate.
Structure, 3, 1995
1QH3
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HUMAN GLYOXALASE II WITH CACODYLATE AND ACETATE IONS PRESENT IN THE ACTIVE SITE
Descriptor:PROTEIN (HYDROXYACYLGLUTATHIONE HYDROLASE), ZINC ION, CACODYLATE ION, ...
Authors:Cameron, A.D., Ridderstrom, M., Olin, B., Mannervik, B.
Deposit date:1999-05-10
Release date:1999-09-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of human glyoxalase II and its complex with a glutathione thiolester substrate analogue.
Structure Fold.Des., 7, 1999
1QH5
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HUMAN GLYOXALASE II WITH S-(N-HYDROXY-N-BROMOPHENYLCARBAMOYL)GLUTATHIONE
Descriptor:PROTEIN (HYDROXYACYLGLUTATHIONE HYDROLASE), ZINC ION, GLUTATHIONE, ...
Authors:Cameron, A.D., Ridderstrom, M., Olin, B., Mannervik, B.
Deposit date:1999-05-11
Release date:1999-09-24
Last modified:2011-12-14
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Crystal structure of human glyoxalase II and its complex with a glutathione thiolester substrate analogue.
Structure Fold.Des., 7, 1999
1QIN
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HUMAN GLYOXALASE I COMPLEXED WITH S-(N-HYDROXY-N-P-IODOPHENYLCARBAMOYL) GLUTATHIONE
Descriptor:PROTEIN (LACTOYLGLUTATHIONE LYASE), ZINC ION, S-(N-HYDROXY-N-IODOPHENYLCARBAMOYL)GLUTATHIONE
Authors:Cameron, A.D., Ridderstrom, M., Olin, B., Mannervik, B.
Deposit date:1999-06-14
Release date:1999-11-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue.
Biochemistry, 38, 1999
1QIP
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HUMAN GLYOXALASE I COMPLEXED WITH S-P-NITROBENZYLOXYCARBONYLGLUTATHIONE
Descriptor:PROTEIN (LACTOYLGLUTATHIONE LYASE), ZINC ION, S-P-NITROBENZYLOXYCARBONYLGLUTATHIONE, ...
Authors:Cameron, A.D., Ridderstrom, M., Olin, B., Mannervik, B.
Deposit date:1999-06-14
Release date:1999-11-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue.
Biochemistry, 38, 1999
1YCA
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DISTAL POCKET POLARITY IN LIGAND BINDING TO MYOGLOBIN: DEOXY AND CARBONMONOXY FORMS OF A THREONINE68 (E11) MUTANT INVESTIGATED BY X-RAY CRYSTALLOGRAPHY AND INFRARED SPECTROSCOPY
Descriptor:MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE, CARBON MONOXIDE
Authors:Cameron, A.D., Smerdon, S.J., Wilkinson, A.J., Habash, J., Helliwell, J.R.
Deposit date:1993-08-10
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Distal pocket polarity in ligand binding to myoglobin: deoxy and carbonmonoxy forms of a threonine68(E11) mutant investigated by X-ray crystallography and infrared spectroscopy.
Biochemistry, 32, 1993
1YCB
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DISTAL POCKET POLARITY IN LIGAND BINDING TO MYOGLOBIN: DEOXY AND CARBONMONOXY FORMS OF A THREONINE68 (E11) MUTANT INVESTIGATED BY X-RAY CRYSTALLOGRAPHY AND INFRARED SPECTROSCOPY
Descriptor:MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE
Authors:Cameron, A.D., Smerdon, S.J., Wilkinson, A.J., Habash, J., Helliwell, J.R.
Deposit date:1993-08-10
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Distal pocket polarity in ligand binding to myoglobin: deoxy and carbonmonoxy forms of a threonine68(E11) mutant investigated by X-ray crystallography and infrared spectroscopy.
Biochemistry, 32, 1993
1BH5
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HUMAN GLYOXALASE I Q33E, E172Q DOUBLE MUTANT
Descriptor:LACTOYLGLUTATHIONE LYASE, ZINC ION, S-HEXYLGLUTATHIONE
Authors:Cameron, A.D., Jones, T.A.
Deposit date:1998-06-13
Release date:1998-11-04
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Involvement of an active-site Zn2+ ligand in the catalytic mechanism of human glyoxalase I.
J.Biol.Chem., 273, 1998
1GSD
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GLUTATHIONE TRANSFERASE A1-1 IN UNLIGANDED FORM
Descriptor:GLUTATHIONE TRANSFERASE A1-1
Authors:L'Hermite, G., Sinning, I., Cameron, A.D., Jones, T.A.
Deposit date:1995-06-09
Release date:1995-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural analysis of human alpha-class glutathione transferase A1-1 in the apo-form and in complexes with ethacrynic acid and its glutathione conjugate.
Structure, 3, 1995
1GSF
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GLUTATHIONE TRANSFERASE A1-1 COMPLEXED WITH ETHACRYNIC ACID
Descriptor:GLUTATHIONE TRANSFERASE A1-1, ETHACRYNIC ACID
Authors:L'Hermite, G., Sinning, I., Cameron, A.D., Jones, T.A.
Deposit date:1995-06-09
Release date:1995-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural analysis of human alpha-class glutathione transferase A1-1 in the apo-form and in complexes with ethacrynic acid and its glutathione conjugate.
Structure, 3, 1995
2J50
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STRUCTURE OF AURORA-2 IN COMPLEX WITH PHA-739358
Descriptor:SERINE/THREONINE-PROTEIN KINASE 6, N-[(3E)-5-[(2R)-2-METHOXY-2-PHENYLACETYL]PYRROLO[3,4-C]PYRAZOL-3(5H)-YLIDENE]-4-(4-METHYLPIPERAZIN-1-YL)BENZAMIDE, SULFATE ION
Authors:Cameron, A.D., Izzo, G., Storici, P., Rusconi, L., Fancelli, D., Varasi, M., Berta, D., Bindi, S., Forte, B., Severino, D., Tonani, R., Vianello, P.
Deposit date:2006-09-08
Release date:2006-11-06
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (3 Å)
Cite:1,4,5,6-Tetrahydropyrrolo[3,4-C]Pyrazoles: Identification of a Potent Aurora Kinase Inhibitor with a Favorable Antitumor Kinase Inhibition Profile.
J.Med.Chem., 49, 2006
2JGB
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STRUCTURE OF HUMAN EIF4E HOMOLOGOUS PROTEIN 4EHP WITH M7GTP
Descriptor:EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 2, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1, 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE
Authors:Cameron, A.D., Rosettani, P., Knapp, S., Vismara, M.G., Rusconi, L.
Deposit date:2007-02-12
Release date:2007-02-27
Last modified:2018-03-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structures of the human eIF4E homologous protein, h4EHP, in its m7GTP-bound and unliganded forms.
J. Mol. Biol., 368, 2007
2JGC
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STRUCTURE OF THE HUMAN EIF4E HOMOLOGOUS PROTEIN, 4EHP WITHOUT LIGAND BOUND
Descriptor:EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 2, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1
Authors:Cameron, A.D., Rosettani, P., Knapp, S., Vismara, M.G., Rusconi, L.
Deposit date:2007-02-12
Release date:2007-02-27
Last modified:2018-03-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of the human eIF4E homologous protein, h4EHP, in its m7GTP-bound and unliganded forms.
J. Mol. Biol., 368, 2007
6H7A
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STRUCTURE OF LEISHMANIA PABP1 (DOMAIN J).
Descriptor:PABP1 domain J
Authors:Cameron, A.D., Firczuk, H., dos Santos Rodrigues, F.H., McCarthy, J.E.G.
Deposit date:2018-07-31
Release date:2018-12-12
Last modified:2019-07-03
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:The Leishmania PABP1-eIF4E4 interface: a novel 5'-3' interaction architecture for trans-spliced mRNAs.
Nucleic Acids Res., 47, 2019
6H7B
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STRUCTURE OF LEISHMANIA PABP1 (DOMAIN J) COMPLEXED WITH A PEPTIDE CONTAINING THE PAM2 MOTIF OF EIF4E4.
Descriptor:Polyadenylate-binding protein, HIS-HIS-MET-ASN-PRO-ASN-ALA-THR-GLU-PHE-MET-PRO
Authors:Cameron, A.D., Firczuk, H., dos Santos Rodrigues, F.H., McCarthy, J.E.G.
Deposit date:2018-07-31
Release date:2018-12-12
Last modified:2019-07-03
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:The Leishmania PABP1-eIF4E4 interface: a novel 5'-3' interaction architecture for trans-spliced mRNAs.
Nucleic Acids Res., 47, 2019
1RK2
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E. COLI RIBOKINASE COMPLEXED WITH RIBOSE AND ADP, SOLVED IN SPACE GROUP P212121
Descriptor:RIBOKINASE, RIBOSE, TETRAFLUOROALUMINATE ION, ...
Authors:Sigrell, J.A., Cameron, A.D., Mowbray, S.L.
Deposit date:1999-05-20
Release date:1999-09-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Induced fit on sugar binding activates ribokinase.
J.Mol.Biol., 290, 1999
1RKA
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THE APO FORM OF E. COLI RIBOKINASE
Descriptor:PROTEIN (RIBOKINASE)
Authors:Sigrell, J.A., Cameron, A.D., Mowbray, S.L.
Deposit date:1999-03-22
Release date:1999-08-31
Last modified:2019-11-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Induced fit on sugar binding activates ribokinase.
J.Mol.Biol., 290, 1999
1RKS
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E. COLI RIBOKINASE IN COMPLEX WITH D-RIBOSE
Descriptor:PROTEIN (RIBOKINASE), RIBOSE, PHOSPHATE ION
Authors:Sigrell, J.A., Cameron, A.D., Mowbray, S.L.
Deposit date:1999-05-17
Release date:1999-08-31
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Induced fit on sugar binding activates ribokinase.
J.Mol.Biol., 290, 1999
1RKD
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E. COLI RIBOKINASE COMPLEXED WITH RIBOSE AND ADP
Descriptor:RIBOKINASE, RIBOSE, PHOSPHATE ION, ...
Authors:Sigrell, J.A., Cameron, A.D., Jones, T.A., Mowbray, S.L.
Deposit date:1997-11-29
Release date:1998-03-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Structure of Escherichia coli ribokinase in complex with ribose and dinucleotide determined to 1.8 A resolution: insights into a new family of kinase structures.
Structure, 6, 1998
1H8V
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THE X-RAY CRYSTAL STRUCTURE OF THE TRICHODERMA REESEI FAMILY 12 ENDOGLUCANASE 3, CEL12A, AT 1.9 A RESOLUTION
Descriptor:ENDO-BETA-1,4-GLUCANASE, N-ACETYL-D-GLUCOSAMINE
Authors:Sandgren, M., Shaw, A., Ropp, T.H., Wu, S., Bott, R., Cameron, A.D., Stahlberg, J., Mitchinson, C., Jones, T.A.
Deposit date:2001-02-16
Release date:2001-04-24
Last modified:2011-12-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The X-Ray Crystal Structure of the Trichoderma Reesei Family 12 Endoglucanase 3, Cel12A, at 1.9 A Resolution
J.Mol.Biol., 308, 2001
2JLN
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STRUCTURE OF MHP1, A NUCLEOBASE-CATION-SYMPORT-1 FAMILY TRANSPORTER
Descriptor:MHP1, SODIUM ION, MERCURY (II) ION
Authors:Weyand, S., Shimamura, T., Yajima, S., Suzuki, S., Mirza, O., Krusong, K., Carpenter, E.P., Rutherford, N.G., Hadden, J.M., O'Reilly, J., Ma, P., Saidijam, M., Patching, S.G., Hope, R.J., Norbertczak, H.T., Roach, P.C.J., Iwata, S., Henderson, P.J.F., Cameron, A.D.
Deposit date:2008-09-11
Release date:2008-10-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structure and Molecular Mechanism of a Nucleobase-Cation-Symport-1 Family Transporter.
Science, 322, 2008
2V7A
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CRYSTAL STRUCTURE OF THE T315I ABL MUTANT IN COMPLEX WITH THE INHIBITOR PHA-739358
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1, N-[(3E)-5-[(2R)-2-METHOXY-2-PHENYLACETYL]PYRROLO[3,4-C]PYRAZOL-3(5H)-YLIDENE]-4-(4-METHYLPIPERAZIN-1-YL)BENZAMIDE, MAGNESIUM ION
Authors:Modugno, M., Casale, E., Soncini, C., Rosettani, P., Colombo, R., Lupi, R., Rusconi, L., Fancelli, D., Carpinelli, P., Cameron, A.D., Isacchi, A., Moll, J.
Deposit date:2007-07-27
Release date:2007-09-18
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of the T315I Abl Mutant in Complex with the Aurora Kinases Inhibitor Pha-739358.
Cancer Res., 67, 2007
2WIH
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STRUCTURE OF CDK2-CYCLIN A WITH PHA-848125
Descriptor:CELL DIVISION PROTEIN KINASE 2, CYCLIN-A2, N,1,4,4-TETRAMETHYL-8-{[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]AMINO}-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE, ...
Authors:Brasca, M.G., Amboldi, N., Ballinari, D., Cameron, A.D., Casale, E., Cervi, G., Colombo, M., Colotta, F., Croci, V., Dalessio, R., Fiorentini, F., Isacchi, A., Mercurio, C., Moretti, W., Panzeri, A., Pastori, W., Pevarello, P., Quartieri, F., Roletto, F., Traquandi, G., Vianello, P., Vulpetti, A., Ciomei, M.
Deposit date:2009-05-13
Release date:2009-07-28
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Identification of N,1,4,4-Tetramethyl-8-{[4-(4-Methylpiperazin-1-Yl)Phenyl]Amino}-4,5-Dihydro-1H-Pyrazolo[4,3-H]Quinazoline-3-Carboxamide (Pha-848125), a Potent, Orally Available Cyclin Dependent Kinase Inhibitor.
J.Med.Chem., 52, 2009
2X79
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INWARD FACING CONFORMATION OF MHP1
Descriptor:HYDANTOIN TRANSPORT PROTEIN
Authors:Shimamura, T., Weyand, S., Beckstein, O., Rutherford, N.G., Hadden, J.M., Sharples, D., Sansom, M.S.P., Iwata, S., Henderson, P.J.F., Cameron, A.D.
Deposit date:2010-02-25
Release date:2010-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Molecular Basis of Alternating Access Membrane Transport by the Sodium-Hydantoin Transporter Mhp1.
Science, 328, 2010
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