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6D8C
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CRYO-EM STRUCTURE OF FLNAABD E254K BOUND TO PHALLOIDIN-STABILIZED F-ACTIN
Descriptor:Filamin-A, Actin, alpha skeletal muscle, ...
Authors:Iwamoto, D.V., Huehn, A.R., Simon, B., Huet-Calderwood, C., Baldassarre, M., Sindelar, C.V., Calderwood, D.A.
Deposit date:2018-04-26
Release date:2018-09-19
Last modified:2018-10-17
Method:ELECTRON MICROSCOPY (3.54 Å)
Cite:Structural basis of the filamin A actin-binding domain interaction with F-actin.
Nat. Struct. Mol. Biol., 25, 2018
1MIX
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CRYSTAL STRUCTURE OF A FERM DOMAIN OF TALIN
Descriptor:Talin
Authors:Garcia-Alvarez, B., de Pereda, J.M., Calderwood, D.A., Ulmer, T.S., Critchley, D., Campbell, I.D., Ginsberg, M.H., Liddington, R.C.
Deposit date:2002-08-23
Release date:2003-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural determinants of integrin recognition by talin
Mol.Cell, 11, 2003
1MIZ
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CRYSTAL STRUCTURE OF AN INTEGRIN BETA3-TALIN CHIMERA
Descriptor:integrin beta3, TALIN
Authors:Garcia-Alvarez, B., de Pereda, J.M., Calderwood, D.A., Ulmer, T.S., Critchley, D., Campbell, I.D., Ginsberg, M.H., Liddington, R.C.
Deposit date:2002-08-23
Release date:2003-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural determinants of integrin recognition by talin
Mol.Cell, 11, 2003
1MK7
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CRYSTAL STRUCTURE OF AN INTEGRIN BETA3-TALIN CHIMERA
Descriptor:Integrin Beta3, TALIN
Authors:Garcia-Alvarez, B., De Pereda, J.M., Calderwood, D.A., Ulmer, T.S., Critchley, D., Campbell, I.D., Ginsberg, M.H., Liddington, R.C.
Deposit date:2002-08-28
Release date:2003-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Determinants of Integrin Recognition by Talin
Mol.Cell, 11, 2003
1MK9
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CRYSTAL STRUCTURE OF AN INTEGRIN BETA3-TALIN CHIMERA
Descriptor:Integrin Beta3, TALIN
Authors:Garcia-Alvarez, B., De Pereda, J.M., Calderwood, D.A., Ulmer, T.S., Critchley, D., Campbell, I.D., Ginsberg, M.H., Liddington, R.C.
Deposit date:2002-08-28
Release date:2003-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Determinants of Integrin Recognition by Talin
Mol.Cell, 11, 2003
3F6Q
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CRYSTAL STRUCTURE OF INTEGRIN-LINKED KINASE ANKYRIN REPEAT DOMAIN IN COMPLEX WITH PINCH1 LIM1 DOMAIN
Descriptor:Integrin-linked protein kinase, LIM and senescent cell antigen-like-containing domain protein 1, IODIDE ION, ...
Authors:Chiswell, B.P., Calderwood, D.A., Boggon, T.J.
Deposit date:2008-11-06
Release date:2008-12-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The structural basis of integrin-linked kinase-PINCH interactions.
Proc.Natl.Acad.Sci.USA, 105, 2008
3IXE
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STRUCTURAL BASIS OF COMPETITION BETWEEN PINCH1 AND PINCH2 FOR BINDING TO THE ANKYRIN REPEAT DOMAIN OF INTEGRIN-LINKED KINASE
Descriptor:Integrin-linked protein kinase, LIM and senescent cell antigen-like-containing domain protein 2, ZINC ION
Authors:Chiswell, B.P., Stiegler, A.L., Boggon, T.J., Calderwood, D.A.
Deposit date:2009-09-03
Release date:2009-12-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain of integrin-linked kinase.
J.Struct.Biol., 170, 2010
4BBK
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STRUCTURAL AND FUNCTIONAL CHARACTERISATION OF THE KINDLIN-1 PLECKSTRIN HOMOLOGY DOMAIN
Descriptor:FERMITIN FAMILY HOMOLOG 1, GLYCEROL
Authors:Yates, L.A., Lumb, C.N., Brahme, N.N., Zalyte, R., Bird, L.E., De Colibus, L., Owens, R.J., Calderwood, D.A., Sansom, M.S.P., Gilbert, R.J.C.
Deposit date:2012-09-25
Release date:2012-11-14
Last modified:2013-01-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and Functional Characterisation of the Kindlin-1 Pleckstrin Homology Domain
J.Biol.Chem., 287, 2012
4DX8
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ICAP1 IN COMPLEX WITH KRIT1 N-TERMINUS
Descriptor:Integrin beta-1-binding protein 1, Krev interaction trapped protein 1, BROMIDE ION
Authors:Liu, W., Draheim, K., Zhang, R., Calderwood, D.A., Boggon, T.J.
Deposit date:2012-02-27
Release date:2013-01-09
Last modified:2013-03-13
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Mechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin Activation.
Mol.Cell, 49, 2013
4DX9
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ICAP1 IN COMPLEX WITH INTEGRIN BETA 1 CYTOPLASMIC TAIL
Descriptor:Integrin beta-1-binding protein 1, Integrin beta-1
Authors:Liu, W., Draheim, K., Zhang, R., Calderwood, D.A., Boggon, T.J.
Deposit date:2012-02-27
Release date:2013-01-09
Last modified:2013-03-13
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:Mechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin Activation.
Mol.Cell, 49, 2013
4EDL
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CRYSTAL STRUCTURE OF BETA-PARVIN CH2 DOMAIN
Descriptor:Beta-parvin, 1,2-ETHANEDIOL
Authors:Stiegler, A.L., Draheim, K.M., Li, X., Chayen, N.E., Calderwood, D.A., Boggon, T.J.
Deposit date:2012-03-27
Release date:2012-08-08
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for paxillin binding and focal adhesion targeting of beta-parvin.
J.Biol.Chem., 287, 2012
4EDM
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CRYSTAL STRUCTURE OF BETA-PARVIN CH2 DOMAIN
Descriptor:Beta-parvin, 1,2-ETHANEDIOL
Authors:Stiegler, A.L., Draheim, K.M., Li, X., Chayen, N.E., Calderwood, D.A., Boggon, T.J.
Deposit date:2012-03-27
Release date:2012-08-08
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for paxillin binding and focal adhesion targeting of beta-parvin.
J.Biol.Chem., 287, 2012
4EDN
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CRYSTAL STRUCTURE OF BETA-PARVIN CH2 DOMAIN IN COMPLEX WITH PAXILLIN LD1 MOTIF
Descriptor:Beta-parvin, Paxillin, SULFATE ION
Authors:Stiegler, A.L., Draheim, K.M., Li, X., Chayen, N.E., Calderwood, D.A., Boggon, T.J.
Deposit date:2012-03-27
Release date:2012-08-08
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for paxillin binding and focal adhesion targeting of beta-parvin.
J.Biol.Chem., 287, 2012
4HI8
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STRUCTURE OF INTEGRIN-LINKED KINASE ANKYRIN REPEAT DOMAIN IN COMPLEX WITH PINCH1 LIM1 DOMAIN COLLECTED AT HIGH ENERGY, WAVELENGTH 0.32800
Descriptor:Integrin-linked protein kinase, LIM and senescent cell antigen-like-containing domain protein 1, PHOSPHATE ION, ...
Authors:Stiegler, A.L., Jakoncic, J., Stojanoff, V., Chiswell, B.P., Calderwood, D.A., Boggon, T.J.
Deposit date:2012-10-11
Release date:2013-12-11
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.203 Å)
Cite:Structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain collected at high energy, wavelength 0.32800
To be Published
4HI9
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1.2 STRUCTURE OF INTEGRIN-LINKED KINASE ANKYRIN REPEAT DOMAIN IN COMPLEX WITH PINCH1 LIM1 DOMAIN COLLECTED AT WAVELENGTH 0.91974
Descriptor:Integrin-linked protein kinase, LIM and senescent cell antigen-like-containing domain protein 1, PHOSPHATE ION, ...
Authors:Stiegler, A.L., Jakoncic, J., Stojanoff, V., Chiswell, B.P., Calderwood, D.A., Boggon, T.J.
Deposit date:2012-10-11
Release date:2013-12-11
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.203 Å)
Cite:1.2 structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain collected at wavelength 0.91974
To be Published
2BRQ
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CRYSTAL STRUCTURE OF THE FILAMIN A REPEAT 21 COMPLEXED WITH THE INTEGRIN BETA7 CYTOPLASMIC TAIL PEPTIDE
Descriptor:FILAMIN A, INTEGRIN BETA-7 SUBUNIT, GLUTATHIONE, ...
Authors:Kiema, T.-R., Ylanne, J.
Deposit date:2005-05-11
Release date:2006-02-07
Last modified:2012-02-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Molecular Basis of Filamin Binding to Integrins and Competition with Talin.
Mol.Cell, 21, 2006
2J3S
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CRYSTAL STRUCTURE OF THE HUMAN FILAMIN A IG DOMAINS 19 TO 21
Descriptor:FILAMIN-A, BROMIDE ION, 1,4-DIETHYLENE DIOXIDE, ...
Authors:Kiema, T.-R., Ylanne, J.
Deposit date:2006-08-23
Release date:2007-10-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of Three Tandem Filamin Domains Reveals Auto-Inhibition of Ligand-Binding.
Embo J., 26, 2007
2KC1
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NMR STRUCTURE OF THE F0 DOMAIN (RESIDUES 0-85) OF THE TALIN FERM DOMAIN
Descriptor:MKIAA1027 protein
Authors:Goult, B.T., Elliott, P.R., Roberts, G.C.K., Critchley, D.R., Barsukov, I.L.
Deposit date:2008-12-13
Release date:2010-01-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation.
Embo J., 29, 2010
2KC2
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NMR STRUCTURE OF THE F1 DOMAIN (RESIDUES 86-202) OF THE TALIN
Descriptor:Talin-1
Authors:Goult, B.T., Elliott, P.R., Roberts, G.C.K., Critchely, D.R., Barsukov, I.L.
Deposit date:2008-12-13
Release date:2010-01-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation.
Embo J., 29, 2010
2KMA
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NMR STRUCTURE OF THE F0F1 DOUBLE DOMAIN (RESIDUES 1-202) OF THE TALIN FERM DOMAIN
Descriptor:Talin 1
Authors:Goult, B.T., Elliott, P.R., Bate, N., Roberts, G.C., Critchley, D.R., Barsukov, I.L.
Deposit date:2009-07-25
Release date:2010-03-02
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation.
Embo J., 2010
2KMC
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SOLUTION STRUCTURE OF THE N-TERMINAL DOMAIN OF KINDLIN-1
Descriptor:Fermitin family homolog 1
Authors:Goult, B.T., Bate, N., Roberts, G.C., Barsukov, I.L., Critchley, D.R.
Deposit date:2009-07-27
Release date:2009-10-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The Structure of the N-Terminus of Kindlin-1: A Domain Important for alphaIIbbeta3 Integrin Activation
J.Mol.Biol., 394, 2009
2W0P
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CRYSTAL STRUCTURE OF THE FILAMIN A REPEAT 21 COMPLEXED WITH THE MIGFILIN PEPTIDE
Descriptor:FILAMIN-A, FILAMIN-BINDING LIM PROTEIN 1, SULFATE ION
Authors:Ruskamo, S., Ylanne, J.
Deposit date:2008-08-20
Release date:2008-09-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Basis of the Migfilin-Filamin Interaction and Competition with Integrin {Beta} Tails.
J.Biol.Chem., 283, 2008
4DXA
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CO-CRYSTAL STRUCTURE OF RAP1 IN COMPLEX WITH KRIT1
Descriptor:Ras-related protein Rap-1b, Krev interaction trapped protein 1, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ...
Authors:Li, X., Zhang, R., Boggon, T.J.
Deposit date:2012-02-27
Release date:2012-05-16
Last modified:2012-07-25
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural Basis for Small G Protein Effector Interaction of Ras-related Protein 1 (Rap1) and Adaptor Protein Krev Interaction Trapped 1 (KRIT1).
J.Biol.Chem., 287, 2012
4KS7
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PAK6 KINASE DOMAIN IN COMPLEX WITH PF-3758309
Descriptor:Serine/threonine-protein kinase PAK 6, ISOPROPYL ALCOHOL, PF-3758309
Authors:Gao, J., Boggon, T.J.
Deposit date:2013-05-17
Release date:2013-09-11
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Substrate and Inhibitor Specificity of the Type II p21-Activated Kinase, PAK6.
Plos One, 8, 2013
4KS8
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PAK6 KINASE DOMAIN IN COMPLEX WITH SUNITINIB
Descriptor:Serine/threonine-protein kinase PAK 6, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
Authors:Gao, J., Boggon, T.J.
Deposit date:2013-05-17
Release date:2013-09-11
Last modified:2013-12-04
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Substrate and Inhibitor Specificity of the Type II p21-Activated Kinase, PAK6.
Plos One, 8, 2013
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