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6D8C
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BU of 6d8c by Molmil
Cryo-EM structure of FLNaABD E254K bound to phalloidin-stabilized F-actin
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ...
Authors:Iwamoto, D.V, Huehn, A.R, Simon, B, Huet-Calderwood, C, Baldassarre, M, Sindelar, C.V, Calderwood, D.A.
Deposit date:2018-04-26
Release date:2018-09-19
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.54 Å)
Cite:Structural basis of the filamin A actin-binding domain interaction with F-actin.
Nat. Struct. Mol. Biol., 25, 2018
3F6Q
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BU of 3f6q by Molmil
Crystal structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain
Descriptor: IODIDE ION, Integrin-linked protein kinase, LIM and senescent cell antigen-like-containing domain protein 1, ...
Authors:Chiswell, B.P, Calderwood, D.A, Boggon, T.J.
Deposit date:2008-11-06
Release date:2008-12-02
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The structural basis of integrin-linked kinase-PINCH interactions.
Proc.Natl.Acad.Sci.USA, 105, 2008
4EDM
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BU of 4edm by Molmil
Crystal structure of beta-parvin CH2 domain
Descriptor: 1,2-ETHANEDIOL, Beta-parvin
Authors:Stiegler, A.L, Draheim, K.M, Li, X, Chayen, N.E, Calderwood, D.A, Boggon, T.J.
Deposit date:2012-03-27
Release date:2012-08-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for paxillin binding and focal adhesion targeting of beta-parvin.
J.Biol.Chem., 287, 2012
4HI9
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BU of 4hi9 by Molmil
1.2 structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain collected at wavelength 0.91974
Descriptor: IODIDE ION, Integrin-linked protein kinase, LIM and senescent cell antigen-like-containing domain protein 1, ...
Authors:Stiegler, A.L, Jakoncic, J, Stojanoff, V, Chiswell, B.P, Calderwood, D.A, Boggon, T.J.
Deposit date:2012-10-11
Release date:2013-12-11
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.203 Å)
Cite:1.2 structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain collected at wavelength 0.91974
To be Published
4HI8
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BU of 4hi8 by Molmil
Structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain collected at high energy, wavelength 0.32800
Descriptor: Integrin-linked protein kinase, LIM and senescent cell antigen-like-containing domain protein 1, PHOSPHATE ION, ...
Authors:Stiegler, A.L, Jakoncic, J, Stojanoff, V, Chiswell, B.P, Calderwood, D.A, Boggon, T.J.
Deposit date:2012-10-11
Release date:2013-12-11
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.203 Å)
Cite:Structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain collected at high energy, wavelength 0.32800
To be Published
3IXE
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BU of 3ixe by Molmil
Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain of integrin-linked kinase
Descriptor: Integrin-linked protein kinase, LIM and senescent cell antigen-like-containing domain protein 2, ZINC ION
Authors:Chiswell, B.P, Stiegler, A.L, Boggon, T.J, Calderwood, D.A.
Deposit date:2009-09-03
Release date:2009-12-15
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain of integrin-linked kinase.
J.Struct.Biol., 170, 2010
4BBK
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BU of 4bbk by Molmil
Structural and functional characterisation of the kindlin-1 pleckstrin homology domain
Descriptor: FERMITIN FAMILY HOMOLOG 1, GLYCEROL
Authors:Yates, L.A, Lumb, C.N, Brahme, N.N, Zalyte, R, Bird, L.E, De Colibus, L, Owens, R.J, Calderwood, D.A, Sansom, M.S.P, Gilbert, R.J.C.
Deposit date:2012-09-25
Release date:2012-11-14
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and Functional Characterisation of the Kindlin-1 Pleckstrin Homology Domain
J.Biol.Chem., 287, 2012
4DX9
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BU of 4dx9 by Molmil
ICAP1 in complex with integrin beta 1 cytoplasmic tail
Descriptor: Integrin beta-1, Integrin beta-1-binding protein 1
Authors:Liu, W, Draheim, K, Zhang, R, Calderwood, D.A, Boggon, T.J.
Deposit date:2012-02-27
Release date:2013-01-09
Last modified:2020-09-02
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:Mechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin Activation.
Mol.Cell, 49, 2013
4DX8
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BU of 4dx8 by Molmil
ICAP1 in complex with KRIT1 N-terminus
Descriptor: BROMIDE ION, Integrin beta-1-binding protein 1, Krev interaction trapped protein 1
Authors:Liu, W, Draheim, K, Zhang, R, Calderwood, D.A, Boggon, T.J.
Deposit date:2012-02-27
Release date:2013-01-09
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Mechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin Activation.
Mol.Cell, 49, 2013
4EDL
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BU of 4edl by Molmil
Crystal structure of beta-parvin CH2 domain
Descriptor: 1,2-ETHANEDIOL, Beta-parvin
Authors:Stiegler, A.L, Draheim, K.M, Li, X, Chayen, N.E, Calderwood, D.A, Boggon, T.J.
Deposit date:2012-03-27
Release date:2012-08-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for paxillin binding and focal adhesion targeting of beta-parvin.
J.Biol.Chem., 287, 2012
4EDN
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BU of 4edn by Molmil
Crystal structure of beta-parvin CH2 domain in complex with paxillin LD1 motif
Descriptor: Beta-parvin, Paxillin, SULFATE ION
Authors:Stiegler, A.L, Draheim, K.M, Li, X, Chayen, N.E, Calderwood, D.A, Boggon, T.J.
Deposit date:2012-03-27
Release date:2012-08-08
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for paxillin binding and focal adhesion targeting of beta-parvin.
J.Biol.Chem., 287, 2012
1MK7
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BU of 1mk7 by Molmil
CRYSTAL STRUCTURE OF AN INTEGRIN BETA3-TALIN CHIMERA
Descriptor: Integrin Beta3, TALIN
Authors:Garcia-Alvarez, B, De Pereda, J.M, Calderwood, D.A, Ulmer, T.S, Critchley, D, Campbell, I.D, Ginsberg, M.H, Liddington, R.C.
Deposit date:2002-08-28
Release date:2003-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Determinants of Integrin Recognition by Talin
Mol.Cell, 11, 2003
1MIX
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BU of 1mix by Molmil
Crystal structure of a FERM domain of Talin
Descriptor: Talin
Authors:Garcia-Alvarez, B, de Pereda, J.M, Calderwood, D.A, Ulmer, T.S, Critchley, D, Campbell, I.D, Ginsberg, M.H, Liddington, R.C.
Deposit date:2002-08-23
Release date:2003-01-28
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural determinants of integrin recognition by talin
Mol.Cell, 11, 2003
1MIZ
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BU of 1miz by Molmil
Crystal structure of an integrin beta3-talin chimera
Descriptor: TALIN, integrin beta3
Authors:Garcia-Alvarez, B, de Pereda, J.M, Calderwood, D.A, Ulmer, T.S, Critchley, D, Campbell, I.D, Ginsberg, M.H, Liddington, R.C.
Deposit date:2002-08-23
Release date:2003-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural determinants of integrin recognition by talin
Mol.Cell, 11, 2003
1MK9
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BU of 1mk9 by Molmil
CRYSTAL STRUCTURE OF AN INTEGRIN BETA3-TALIN CHIMERA
Descriptor: Integrin Beta3, TALIN
Authors:Garcia-Alvarez, B, De Pereda, J.M, Calderwood, D.A, Ulmer, T.S, Critchley, D, Campbell, I.D, Ginsberg, M.H, Liddington, R.C.
Deposit date:2002-08-28
Release date:2003-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Determinants of Integrin Recognition by Talin
Mol.Cell, 11, 2003
7LO0
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BU of 7lo0 by Molmil
Structure of human ASF1a in complex with a TLK2 peptide
Descriptor: Histone chaperone ASF1A, Serine/threonine-protein kinase tousled-like 2
Authors:Simon, B, Calderwood, D, Turk, B.E, Boggon, T.J.
Deposit date:2021-02-08
Release date:2022-02-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry.
Nat Commun, 13, 2022
7LNY
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BU of 7lny by Molmil
Apo structure of the Histone chaperone ASF1A residues 1-155
Descriptor: Histone chaperone ASF1A
Authors:Simon, B, Boggon, T.J, Calderwood, D, Turk, B.E.
Deposit date:2021-02-08
Release date:2022-02-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry.
Nat Commun, 13, 2022
2W0P
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BU of 2w0p by Molmil
Crystal structure of the filamin A repeat 21 complexed with the migfilin peptide
Descriptor: FILAMIN-A, FILAMIN-BINDING LIM PROTEIN 1, SULFATE ION
Authors:Ruskamo, S, Ylanne, J.
Deposit date:2008-08-20
Release date:2008-09-30
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Basis of the Migfilin-Filamin Interaction and Competition with Integrin {Beta} Tails.
J.Biol.Chem., 283, 2008
4TVQ
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BU of 4tvq by Molmil
CCM3 in complex with CCM2 LD-like motif
Descriptor: Cerebral cavernous malformations 2 protein, Cerebral cavernous malformations 3 protein
Authors:Li, X, Zhang, R, Fisher, O.S, Boggon, T.J.
Deposit date:2014-06-27
Release date:2015-03-25
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:CCM2-CCM3 interaction stabilizes their protein expression and permits endothelial network formation.
J.Cell Biol., 208, 2015
4KS8
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BU of 4ks8 by Molmil
PAK6 kinase domain in complex with sunitinib
Descriptor: N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carbo xamide, Serine/threonine-protein kinase PAK 6
Authors:Gao, J, Boggon, T.J.
Deposit date:2013-05-17
Release date:2013-09-11
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Substrate and Inhibitor Specificity of the Type II p21-Activated Kinase, PAK6.
Plos One, 8, 2013
4KS7
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BU of 4ks7 by Molmil
PAK6 kinase domain in complex with PF-3758309
Descriptor: ISOPROPYL ALCOHOL, PF-3758309, Serine/threonine-protein kinase PAK 6
Authors:Gao, J, Boggon, T.J.
Deposit date:2013-05-17
Release date:2013-09-11
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Substrate and Inhibitor Specificity of the Type II p21-Activated Kinase, PAK6.
Plos One, 8, 2013
7S46
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BU of 7s46 by Molmil
PAK4cat (D440N/S474E) in complex with Integrin beta5 760-770 peptide
Descriptor: Integrin beta-5, Isoform 2 of Serine/threonine-protein kinase PAK 4, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Ha, B.H, Boggon, T.J.
Deposit date:2021-09-08
Release date:2022-11-09
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Molecular basis for integrin adhesion receptor binding to p21-activated kinase 4 (PAK4)
Commun Biol, 5, 2022
7S47
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BU of 7s47 by Molmil
Integrin beta5(743-774)-linker-PAK4cat(D440N/S474E)
Descriptor: Integrin beta-5, Isoform 2 of Serine/threonine-protein kinase PAK 4 chimera, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Ha, B.H, Boggon, T.J.
Deposit date:2021-09-08
Release date:2022-11-09
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular basis for integrin adhesion receptor binding to p21-activated kinase 4 (PAK4)
Commun Biol, 5, 2022
7S48
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BU of 7s48 by Molmil
PAK4cat in complex with Integrin beta5 760-770 peptide
Descriptor: Integrin beta-5, Serine/threonine-protein kinase PAK 4
Authors:Ha, B.H, Boggon, T.J.
Deposit date:2021-09-08
Release date:2022-11-09
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Molecular basis for integrin adhesion receptor binding to p21-activated kinase 4 (PAK4)
Commun Biol, 5, 2022
2BRQ
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BU of 2brq by Molmil
Crystal structure of the filamin A repeat 21 complexed with the integrin beta7 cytoplasmic tail peptide
Descriptor: FILAMIN A, GLUTATHIONE, GLYCEROL, ...
Authors:Kiema, T.-R, Ylanne, J.
Deposit date:2005-05-11
Release date:2006-02-07
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Molecular Basis of Filamin Binding to Integrins and Competition with Talin.
Mol.Cell, 21, 2006

 

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