Author results

3E2F
  • Download 3e2f
  • View 3e2f
Molmil generated image of 3e2f
CRYSTAL STRUCTURE OF MOUSE KYNURENINE AMINOTRANSFERASE III, PLP-BOUND FORM
Descriptor:Kynurenine-oxoglutarate transaminase 3, GLYCEROL
Authors:Han, Q., Robinson, R., Cai, T., Tagle, D.A., Li, J.
Deposit date:2008-08-05
Release date:2008-12-30
Last modified:2018-08-01
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Correction for Han et al., "Biochemical and Structural Properties of Mouse Kynurenine Aminotransferase III".
Mol. Cell. Biol., 38, 2018
3E2Y
  • Download 3e2y
  • View 3e2y
Molmil generated image of 3e2y
CRYSTAL STRUCTURE OF MOUSE KYNURENINE AMINOTRANSFERASE III IN COMPLEX WITH GLUTAMINE
Descriptor:Kynurenine-oxoglutarate transaminase 3, GLUTAMINE, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, ...
Authors:Han, Q., Robinson, R., Cai, T., Tagle, D.A., Li, J.
Deposit date:2008-08-06
Release date:2008-12-30
Last modified:2018-08-01
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Correction for Han et al., "Biochemical and Structural Properties of Mouse Kynurenine Aminotransferase III".
Mol. Cell. Biol., 38, 2018
3E2Z
  • Download 3e2z
  • View 3e2z
Molmil generated image of 3e2z
CRYSTAL STRUCTURE OF MOUSE KYNURENINE AMINOTRANSFERASE III IN COMPLEX WITH KYNURENINE
Descriptor:Kynurenine-oxoglutarate transaminase 3, (2S)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid, GLYCEROL, ...
Authors:Han, Q., Robinson, R., Cai, T., Tagle, D.A., Li, J.
Deposit date:2008-08-06
Release date:2008-12-30
Last modified:2018-08-01
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Correction for Han et al., "Biochemical and Structural Properties of Mouse Kynurenine Aminotransferase III".
Mol. Cell. Biol., 38, 2018
1LZX
  • Download 1lzx
  • View 1lzx
Molmil generated image of 1lzx
RAT NEURONAL NOS HEME DOMAIN WITH NG-HYDROXY-L-ARGININE BOUND
Descriptor:Nitric-oxide synthase, ACETATE ION, ZINC ION, ...
Authors:Li, H., Shimizu, H., Flinspach, M., Jamal, J., Yang, W., Xian, M., Cai, T., Wen, E.Z., Jia, Q., Wang, P.G., Poulos, T.L.
Deposit date:2002-06-11
Release date:2002-11-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Novel Binding Mode of N-Alkyl-N'-Hydroxyguanidine to Neuronal Nitric Oxide Synthase Provides Mechanistic Insights into NO Biosynthesis
Biochemistry, 41, 2002
1LZZ
  • Download 1lzz
  • View 1lzz
Molmil generated image of 1lzz
RAT NEURONAL NOS HEME DOMAIN WITH N-ISOPROPYL-N'-HYDROXYGUANIDINE BOUND
Descriptor:Nitric-oxide synthase, ACETATE ION, ZINC ION, ...
Authors:Li, H., Shimizu, H., Flinspach, M., Jamal, J., Yang, W., Xian, M., Cai, T., Wen, E.Z., Jia, Q., Wang, P.G., Poulos, T.L.
Deposit date:2002-06-11
Release date:2002-11-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:The Novel Binding Mode of N-Alkyl-N'-Hydroxyguanidine to Neuronal Nitric Oxide Synthase Provides Mechanistic Insights into NO Biosynthesis
Biochemistry, 41, 2002
1M00
  • Download 1m00
  • View 1m00
Molmil generated image of 1m00
RAT NEURONAL NOS HEME DOMAIN WITH N-BUTYL-N'-HYDROXYGUANIDINE BOUND
Descriptor:Nitric-oxide synthase, ACETATE ION, ZINC ION, ...
Authors:Li, H., Shimizu, H., Flinspach, M., Jamal, J., Yang, W., Xian, M., Cai, T., Wen, E.Z., Jia, Q., Wang, P.G., Poulos, T.L.
Deposit date:2002-06-11
Release date:2002-11-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:The Novel Binding Mode of N-Alkyl-N'-Hydroxyguanidine to Neuronal Nitric Oxide Synthase Provides Mechanistic Insights into NO Biosynthesis
Biochemistry, 41, 2002
2P01
  • Download 2p01
  • View 2p01
Molmil generated image of 2p01
THE STRUCTURE OF RECEPTOR-ASSOCIATED PROTEIN(RAP)
Descriptor:Alpha-2-macroglobulin receptor-associated protein
Authors:Lee, D., Walsh, J.D., Migliorini, M., Yu, P., Cai, T., Schwieters, C.D., Krueger, S., Strickland, D.K., Wang, Y.X.
Deposit date:2007-02-28
Release date:2007-08-21
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The structure of receptor-associated protein (RAP).
Protein Sci., 16, 2007
2P03
  • Download 2p03
  • View 2p03
Molmil generated image of 2p03
THE STRUCTURE OF RECEPTOR-ASSOCIATED PROTEIN(RAP)
Descriptor:Alpha-2-macroglobulin receptor-associated protein
Authors:Lee, D., Walsh, J.D., Migliorini, M., Yu, P., Cai, T., Schwieters, C.D., Krueger, S., Strickland, D.K., Wang, Y.X.
Deposit date:2007-02-28
Release date:2007-08-21
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The structure of receptor-associated protein (RAP).
Protein Sci., 16, 2007
2ZJG
  • Download 2zjg
  • View 2zjg
Molmil generated image of 2zjg
CRYSTAL STRUCTURAL OF MOUSE KYNURENINE AMINOTRANSFERASE III
Descriptor:Kynurenine-oxoglutarate transaminase 3, GLYCEROL
Authors:Han, Q., Cai, T., Tagle, D.A., Robinson, H., Li, J.
Deposit date:2008-03-07
Release date:2009-01-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural and functional characterization of mouse kynurenine aminotransferase III
To be Published
3DC1
  • Download 3dc1
  • View 3dc1
Molmil generated image of 3dc1
CRYSTAL STRUCTURE OF KYNURENINE AMINOTRANSFERASE II COMPLEX WITH ALPHA-KETOGLUTARATE
Descriptor:Kynurenine/alpha-aminoadipate aminotransferase mitochondrial, 2-OXOGLUTARIC ACID, GLYCEROL
Authors:Han, Q., Cai, T., Tagle, D.A., Robinson, H., Li, J.
Deposit date:2008-06-03
Release date:2008-07-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Substrate specificity and structure of human aminoadipate aminotransferase/kynurenine aminotransferase II
Biosci.Rep., 28, 2008
3FVS
  • Download 3fvs
  • View 3fvs
Molmil generated image of 3fvs
HUMAN KYNURENINE AMINOTRANSFERASE I IN COMPLEX WITH GLYCEROL
Descriptor:Kynurenine--oxoglutarate transaminase 1, SODIUM ION, GLYCEROL
Authors:Han, Q., Robinson, H., Cai, T., Tagle, D.A., Li, J.
Deposit date:2009-01-16
Release date:2009-05-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K
J.Med.Chem., 52, 2009
3FVU
  • Download 3fvu
  • View 3fvu
Molmil generated image of 3fvu
CRYSTAL STRUCTURE OF HUMAN KYNURENINE AMINOTRANSFERASE I IN COMPLEX WITH INDOLE-3-ACETIC ACID
Descriptor:Kynurenine--oxoglutarate transaminase 1, 1H-INDOL-3-YLACETIC ACID, GLYCEROL, ...
Authors:Han, Q., Robinson, H., Cai, T., Tagle, D.A., Li, J.
Deposit date:2009-01-16
Release date:2009-05-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K
J.Med.Chem., 52, 2009
3FVX
  • Download 3fvx
  • View 3fvx
Molmil generated image of 3fvx
HUMAN KYNURENINE AMINOTRANSFERASE I IN COMPLEX WITH TRIS
Descriptor:Kynurenine--oxoglutarate transaminase 1, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, SODIUM ION
Authors:Han, Q., Robinson, H., Cai, T., Tagle, D.A., Li, J.
Deposit date:2009-01-16
Release date:2009-05-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K
J.Med.Chem., 52, 2009
3PD6
  • Download 3pd6
  • View 3pd6
Molmil generated image of 3pd6
CRYSTAL STRUCTURE OF MOUSE MITOCHONDRIAL ASPARTATE AMINOTRANSFERASE, A NEWLY IDENTIFIED KYNURENINE AMINOTRANSFERASE-IV
Descriptor:Aspartate aminotransferase, mitochondrial, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, ...
Authors:Han, Q., Robinson, H., Cai, T., Tagle, D.A., Li, J.
Deposit date:2010-10-22
Release date:2010-11-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Biochemical and structural characterization of mouse mitochondrial aspartate aminotransferase, a newly identified kynurenine aminotransferase-IV.
Biosci.Rep., 31, 2011
3PDB
  • Download 3pdb
  • View 3pdb
Molmil generated image of 3pdb
CRYSTAL STRUCTURE OF MOUSE MITOCHONDRIAL ASPARTATE AMINOTRANSFERASE IN COMPLEX WITH OXALOACETIC ACID
Descriptor:Aspartate aminotransferase, mitochondrial, BETA-MERCAPTOETHANOL, ...
Authors:Han, Q., Robinson, H., Cai, T., Tagle, D.A., Li, J.
Deposit date:2010-10-22
Release date:2010-11-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Biochemical and structural characterization of mouse mitochondrial aspartate aminotransferase, a newly identified kynurenine aminotransferase-IV.
Biosci.Rep., 31, 2011
4MM0
  • Download 4mm0
  • View 4mm0
Molmil generated image of 4mm0
CRYSTAL STRUCTURE ANALYSIS OF THE PUTATIVE THIOETHER SYNTHASE SGVP INVOLVED IN THE TAILORING STEP OF GRISEOVIRIDIN
Descriptor:P450-like monooxygenase, PROTOPORPHYRIN IX CONTAINING FE
Authors:Zhang, H., Huang, L., Yi, M., Cai, T., Zhang, H.
Deposit date:2013-09-07
Release date:2014-09-17
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Analysis of SgvP: a Putative Thioether Synthase Involved in the Tailoring Step of Griseoviridin
To be Published
3HLM
  • Download 3hlm
  • View 3hlm
Molmil generated image of 3hlm
CRYSTAL STRUCTURE OF MOUSE MITOCHONDRIAL ASPARTATE AMINOTRANSFERASE/KYNURENINE AMINOTRANSFERASE IV
Descriptor:Aspartate aminotransferase, mitochondrial, GLYCEROL
Authors:Han, Q., Robinson, H., Li, J.
Deposit date:2009-05-27
Release date:2010-06-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure, expression, and function of kynurenine aminotransferases in human and rodent brains.
Cell.Mol.Life Sci., 67, 2010
3QAQ
  • Download 3qaq
  • View 3qaq
Molmil generated image of 3qaq
CRYSTAL STRUCTURE OF PI3K-GAMMA IN COMPLEX WITH TRIAZINE-BENZIMIDAZOLE 1
Descriptor:Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, [(4-{2-[(3-hydroxyphenyl)amino]-1H-benzimidazol-1-yl}-1,3,5-triazin-2-yl)amino]acetonitrile
Authors:Whittington, D.A., Tang, J., Yakowec, P.
Deposit date:2011-01-11
Release date:2011-03-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Discovery of triazine-benzimidazoles as selective inhibitors of mTOR.
Bioorg.Med.Chem.Lett., 21, 2011
3QAR
  • Download 3qar
  • View 3qar
Molmil generated image of 3qar
CRYSTAL STRUCTURE OF PI3K-GAMMA IN COMPLEX WITH TRIAZINE-BENZIMIDAZOLE 32
Descriptor:Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, 1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(1H-pyrazol-3-yl)-1H-benzimidazol-2-amine
Authors:Whittington, D.A., Tang, J., Yakowec, P.
Deposit date:2011-01-11
Release date:2011-03-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Discovery of triazine-benzimidazoles as selective inhibitors of mTOR.
Bioorg.Med.Chem.Lett., 21, 2011
4FHJ
  • Download 4fhj
  • View 4fhj
Molmil generated image of 4fhj
CRYSTAL STRUCTURE OF PI3K-GAMMA IN COMPLEX WITH IMIDAZOPYRIDINE 2
Descriptor:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, 3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(1H-pyrazol-5-yl)imidazo[1,2-a]pyridin-2-amine
Authors:Shaffer, P.L., Tang, J., Yakowec, P.
Deposit date:2012-06-06
Release date:2012-07-18
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
4FHK
  • Download 4fhk
  • View 4fhk
Molmil generated image of 4fhk
CRYSTAL STRUCTURE OF PI3K-GAMMA IN COMPLEX WITH IMIDAZOPYRIDAZINE 19E
Descriptor:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, 3-[2-methyl-6-(pyrazin-2-ylamino)pyrimidin-4-yl]-N-(1H-pyrazol-3-yl)imidazo[1,2-b]pyridazin-2-amine
Authors:Shaffer, P.L., Tang, J., Yakowec, P.
Deposit date:2012-06-06
Release date:2013-04-10
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3 Å)
Cite:Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
6A50
  • Download 6a50
  • View 6a50
Molmil generated image of 6a50
STRUCTURE OF BENZOYLFORMATE DECARBOXYLASES IN COMPLEX WITH COFACTOR TPP
Descriptor:benzoylformate decarboxylases, MAGNESIUM ION, THIAMINE DIPHOSPHATE
Authors:Guo, Y., Wang, S., Nie, Y., Li, S.
Deposit date:2018-06-21
Release date:2019-02-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A Synthetic Pathway for Acetyl-Coenzyme A Biosynthesis
Nat Commun, 2019
1P6H
  • Download 1p6h
  • View 1p6h
Molmil generated image of 1p6h
RAT NEURONAL NOS HEME DOMAIN WITH L-N(OMEGA)-NITROARGININE-2,4-L-DIAMINOBUTYRIC AMIDE BOUND
Descriptor:Nitric-oxide synthase, brain, ACETATE ION, ...
Authors:Flinspach, M.L., Li, H., Jamal, J., Yang, W., Huang, H., Hah, J.-M., Gomez-Vidal, J.A., Litzinger, E.A., Silverman, R.B., Poulos, T.L.
Deposit date:2003-04-29
Release date:2004-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase.
Nat.Struct.Mol.Biol., 11, 2004
1P6I
  • Download 1p6i
  • View 1p6i
Molmil generated image of 1p6i
RAT NEURONAL NOS HEME DOMAIN WITH (4S)-N-(4-AMINO-5-[AMINOETHYL]AMINOPENTYL)-N'-NITROGUANIDINE BOUND
Descriptor:Nitric-oxide synthase, brain, ACETATE ION, ...
Authors:Flinspach, M.L., Li, H., Jamal, J., Yang, W., Huang, H., Hah, J.-M., Gomez-Vidal, J.A., Litzinger, E.A., Silverman, R.B., Poulos, T.L.
Deposit date:2003-04-29
Release date:2004-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase.
Nat.Struct.Mol.Biol., 11, 2004
1P6J
  • Download 1p6j
  • View 1p6j
Molmil generated image of 1p6j
RAT NEURONAL NOS HEME DOMAIN WITH L-N(OMEGA)-NITROARGININE-(4R)-AMINO-L-PROLINE AMIDE BOUND
Descriptor:Nitric-oxide synthase, brain, ACETATE ION, ...
Authors:Flinspach, M.L., Li, H., Jamal, J., Yang, W., Huang, H., Hah, J.-M., Gomez-Vidal, J.A., Litzinger, E.A., Silverman, R.B., Poulos, T.L.
Deposit date:2003-04-29
Release date:2004-01-13
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase.
Nat.Struct.Mol.Biol., 11, 2004
<12>