Author results

3A60
  • Download 3a60
  • View 3a60
Molmil generated image of 3a60
CRYSTAL STRUCTURE OF UNPHOSPHORYLATED P70S6K1 (FORM I)
Descriptor:Ribosomal protein S6 kinase beta-1, STAUROSPORINE
Authors:Sunami, T., Byrne, N., Diehl, R.E., Funabashi, K., Hall, D.L., Ikuta, M., Patel, S.B., Shipman, J.M., Smith, R.F., Takahashi, I., Zugay-Murphy, J., Iwasawa, Y., Lumb, K.J., Munshi, S.K., Sharma, S.
Deposit date:2009-08-17
Release date:2009-10-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis of human p70 ribosomal S6 kinase-1 regulation by activation loop phosphorylation.
J.Biol.Chem., 285, 2010
3A61
  • Download 3a61
  • View 3a61
Molmil generated image of 3a61
CRYSTAL STRUCTURE OF UNPHOSPHORYLATED P70S6K1 (FORM II)
Descriptor:Ribosomal protein S6 kinase beta-1, STAUROSPORINE
Authors:Sunami, T., Byrne, N., Diehl, R.E., Funabashi, K., Hall, D.L., Ikuta, M., Patel, S.B., Shipman, J.M., Smith, R.F., Takahashi, I., Zugay-Murphy, J., Iwasawa, Y., Lumb, K.J., Munshi, S.K., Sharma, S.
Deposit date:2009-08-18
Release date:2009-10-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.43 Å)
Cite:Structural basis of human p70 ribosomal S6 kinase-1 regulation by activation loop phosphorylation.
J.Biol.Chem., 285, 2010
3A62
  • Download 3a62
  • View 3a62
Molmil generated image of 3a62
CRYSTAL STRUCTURE OF PHOSPHORYLATED P70S6K1
Descriptor:Ribosomal protein S6 kinase beta-1, STAUROSPORINE, MANGANESE (II) ION
Authors:Sunami, T., Byrne, N., Diehl, R.E., Funabashi, K., Hall, D.L., Ikuta, M., Patel, S.B., Shipman, J.M., Smith, R.F., Takahashi, I., Zugay-Murphy, J., Iwasawa, Y., Lumb, K.J., Munshi, S.K., Sharma, S.
Deposit date:2009-08-18
Release date:2009-10-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural basis of human p70 ribosomal S6 kinase-1 regulation by activation loop phosphorylation.
J.Biol.Chem., 285, 2010
5TZR
  • Download 5tzr
  • View 5tzr
Molmil generated image of 5tzr
GPR40 IN COMPLEX WITH PARTIAL AGONIST MK-8666
Descriptor:Free fatty acid receptor 1,Endolysin,Free fatty acid receptor 1, SODIUM ION, (5aR,6S,6aS)-3-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy][1,1'-biphenyl]-3-yl}methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid, ...
Authors:Lu, J., Byrne, N., Patel, S., Sharma, S., Soisson, S.M.
Deposit date:2016-11-22
Release date:2017-06-07
Last modified:2017-07-19
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40.
Nat. Struct. Mol. Biol., 24, 2017
5TZY
  • Download 5tzy
  • View 5tzy
Molmil generated image of 5tzy
GPR40 IN COMPLEX WITH AGOPAM AP8 AND PARTIAL AGONIST MK-8666
Descriptor:Free fatty acid receptor 1,Endolysin,Free fatty acid receptor 1, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (5aR,6S,6aS)-3-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy][1,1'-biphenyl]-3-yl}methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid, ...
Authors:Lu, J., Byrne, N., Patel, S., Sharma, S., Soisson, S.M.
Deposit date:2016-11-22
Release date:2017-06-07
Last modified:2017-07-19
Method:X-RAY DIFFRACTION (3.22 Å)
Cite:Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40.
Nat. Struct. Mol. Biol., 24, 2017
3CUK
  • Download 3cuk
  • View 3cuk
Molmil generated image of 3cuk
CRYSTAL STRUCTURE OF HUMAN D-AMINO ACID OXIDASE: BOUND TO AN INHIBITOR
Descriptor:D-amino-acid oxidase, FLAVIN-ADENINE DINUCLEOTIDE, 4H-furo[3,2-b]pyrrole-5-carboxylic acid
Authors:Prasad, S., Munshi, S.
Deposit date:2008-04-16
Release date:2008-07-22
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors.
Bioorg.Med.Chem.Lett., 18, 2008
2Z7Q
  • Download 2z7q
  • View 2z7q
Molmil generated image of 2z7q
CRYSTAL STRUCTURE OF THE N-TERMINAL KINASE DOMAIN OF HUMAN RSK-1 BOUND TO AMP-PCP
Descriptor:Ribosomal protein S6 kinase alpha-1, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
Authors:Ikuta, M., Munshi, S.K.
Deposit date:2007-08-28
Release date:2008-05-13
Last modified:2012-02-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of the N-terminal kinase domain of human RSK1 bound to three different ligands: Implications for the design of RSK1 specific inhibitors.
Protein Sci., 16, 2007
2Z7R
  • Download 2z7r
  • View 2z7r
Molmil generated image of 2z7r
CRYSTAL STRUCTURE OF THE N-TERMINAL KINASE DOMAIN OF HUMAN RSK1 BOUND TO STAUROSPORINE
Descriptor:Ribosomal protein S6 kinase alpha-1, STAUROSPORINE
Authors:Ikuta, M., Munshi, S.K.
Deposit date:2007-08-28
Release date:2008-05-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of the N-terminal kinase domain of human RSK1 bound to three different ligands: Implications for the design of RSK1 specific inhibitors.
Protein Sci., 16, 2007
2Z7S
  • Download 2z7s
  • View 2z7s
Molmil generated image of 2z7s
CRYSTAL STRUCTURE OF THE N-TERMINAL KINASE DOMAIN OF HUMAN RSK1 BOUND TO PURVALNOL A
Descriptor:Ribosomal protein S6 kinase alpha-1, 2-({6-[(3-CHLOROPHENYL)AMINO]-9-ISOPROPYL-9H-PURIN-2-YL}AMINO)-3-METHYLBUTAN-1-OL
Authors:Ikuta, M., Munshi, S.K.
Deposit date:2007-08-28
Release date:2008-05-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of the N-terminal kinase domain of human RSK1 bound to three different ligands: Implications for the design of RSK1 specific inhibitors.
Protein Sci., 16, 2007
6U26
  • Download 6u26
  • View 6u26
Molmil generated image of 6u26
PCSK9 IN COMPLEX WITH COMPOUND 16
Descriptor:Proprotein convertase subtilisin/kexin type 9, 4'-{[(1R)-6-{2-[2-({N~5~-[N,N'-bis(tert-butoxycarbonyl)carbamimidoyl]-N~2~-(tert-butoxycarbonyl)-L-ornithyl}amino)ethoxy]ethoxy}-1-methyl-1-{2-oxo-2-[(1,3-thiazol-2-yl)amino]ethyl}-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy}-2'-fluoro[1,1'-biphenyl]-4-carboxylic acid
Authors:Orth, P.
Deposit date:2019-08-19
Release date:2019-11-06
Last modified:2020-01-29
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9.
Cell Chem Biol, 27, 2020
6U2N
  • Download 6u2n
  • View 6u2n
Molmil generated image of 6u2n
PCSK9 IN COMPLEX WITH COMPOUND 4
Descriptor:Proprotein convertase subtilisin/kexin type 9, 4-{[(1R)-6-methoxy-1-methyl-1-{2-oxo-2-[(1,3-thiazol-2-yl)amino]ethyl}-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy}benzoic acid
Authors:Lu, J., Soisson, S.
Deposit date:2019-08-20
Release date:2019-11-06
Last modified:2020-01-29
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9.
Cell Chem Biol, 27, 2020
6U2P
  • Download 6u2p
  • View 6u2p
Molmil generated image of 6u2p
PCSK9 IN COMPLEX WITH COMPOUND 5
Descriptor:Proprotein convertase subtilisin/kexin type 9, 1,2-ETHANEDIOL, 2-fluoro-4-{[(1R)-6-methoxy-1-methyl-1-{2-oxo-2-[(1,3-thiazol-2-yl)amino]ethyl}-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy}benzoic acid
Authors:Lu, J., Soisson, S.
Deposit date:2019-08-20
Release date:2019-11-06
Last modified:2020-01-29
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9.
Cell Chem Biol, 27, 2020
6U36
  • Download 6u36
  • View 6u36
Molmil generated image of 6u36
PCSK9 IN COMPLEX WITH A FAB AND COMPOUND 14
Descriptor:Proprotein convertase subtilisin/kexin type 9, Fab Heavy Chain, Fab Light Chain, ...
Authors:Lu, J., Soisson, S.
Deposit date:2019-08-21
Release date:2019-11-06
Last modified:2020-01-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9.
Cell Chem Biol, 27, 2020
6U38
  • Download 6u38
  • View 6u38
Molmil generated image of 6u38
PCSK9 IN COMPLEX WITH A FAB AND COMPOUND 8
Descriptor:Proprotein convertase subtilisin/kexin type 9, Fab Heavy Chain, Fab Light Chain, ...
Authors:Lu, J., Soisson, S.
Deposit date:2019-08-21
Release date:2019-11-06
Last modified:2020-01-29
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9.
Cell Chem Biol, 27, 2020
6U3X
  • Download 6u3x
  • View 6u3x
Molmil generated image of 6u3x
PCSK9 IN COMPLEX WITH COMPOUND 2
Descriptor:Proprotein convertase subtilisin/kexin type 9, 2-[(1R)-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl]-N-(1,3-thiazol-2-yl)acetamide
Authors:Lu, J., Soisson, S.
Deposit date:2019-08-22
Release date:2019-11-06
Last modified:2020-01-29
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9.
Cell Chem Biol, 27, 2020