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1H3L
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BU of 1h3l by Molmil
N-terminal fragment of SigR from Streptomyces coelicolor
Descriptor: RNA POLYMERASE SIGMA FACTOR
Authors:Li, W, Stevenson, C.E.M, Burton, N, Jakimowicz, P, Paget, M.S.B, Buttner, M.J, Lawson, D.M, Kleanthous, C.
Deposit date:2002-09-10
Release date:2002-10-03
Last modified:2015-09-23
Method:X-RAY DIFFRACTION (2.375 Å)
Cite:Identification and Structure of the Anti-Sigma Factor-Binding Domain of the Disulfide-Stress Regulated Sigma Factor Sigma(R) from Streptomyces Coelicolor
J.Mol.Biol., 323, 2002
2C0Z
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BU of 2c0z by Molmil
The 1.6 A resolution crystal structure of NovW: a 4-keto-6-deoxy sugar epimerase from the novobiocin biosynthetic gene cluster of Streptomyces spheroides
Descriptor: 1,2-ETHANEDIOL, NOVW, SULFATE ION
Authors:Jakimowicz, P, Tello, M, Freel-Meyers, C.L, Walsh, C.T, Buttner, M.J, Field, R.A, Lawson, D.M.
Deposit date:2005-09-09
Release date:2006-01-25
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The 1.6 A Resolution Crystal Structure of Novw: A 4-Keto-6-Deoxy Sugar Epimerase from the Novobiocin Biosynthetic Gene Cluster of Streptomyces Spheroides
Proteins, 63, 2006
2Y3P
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BU of 2y3p by Molmil
Crystal structure of N-terminal domain of GyrA with the antibiotic simocyclinone D8
Descriptor: DNA GYRASE SUBUNIT A, MAGNESIUM ION, SIMOCYCLINONE D8
Authors:Edwards, M.J, Flatman, R.H, Mitchenall, L.A, Stevenson, C.E.M, Le, T.B.K, Clarke, T.A, McKay, A.R, Fiedler, H.-P, Buttner, M.J, Lawson, D.M, Maxwell, A.
Deposit date:2010-12-22
Release date:2010-12-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:A Crystal Structure of the Bifunctional Antibiotic Simocyclinone D8, Bound to DNA Gyrase.
Science, 326, 2009
5L40
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BU of 5l40 by Molmil
polyketide ketoreductase SimC7 - apo crystal form 1
Descriptor: polyketide ketoreductase SimC7
Authors:Schafer, M, Stevenson, C.E.M, Wilkinson, B, Lawson, D.M, Buttner, M.J.
Deposit date:2016-05-24
Release date:2016-10-05
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Substrate-Assisted Catalysis in Polyketide Reduction Proceeds via a Phenolate Intermediate.
Cell Chem Biol, 23, 2016
5L4L
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BU of 5l4l by Molmil
polyketide ketoreductase SimC7 - ternary complex with NADP+ and 7-oxo-SD8
Descriptor: 7-oxo-simocyclinone D8, GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Schafer, M, Stevenson, C.E.M, Wilkinson, B, Lawson, D.M, Buttner, M.J.
Deposit date:2016-05-25
Release date:2016-10-05
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Substrate-Assisted Catalysis in Polyketide Reduction Proceeds via a Phenolate Intermediate.
Cell Chem Biol, 23, 2016
5L3Z
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BU of 5l3z by Molmil
polyketide ketoreductase SimC7 - binary complex with NADP+
Descriptor: NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, polyketide ketoreductase SimC7
Authors:Schafer, M, Stevenson, C.E.M, Wilkinson, B, Lawson, D.M, Buttner, M.J.
Deposit date:2016-05-24
Release date:2016-10-05
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Substrate-Assisted Catalysis in Polyketide Reduction Proceeds via a Phenolate Intermediate.
Cell Chem Biol, 23, 2016
5L45
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BU of 5l45 by Molmil
polyketide ketoreductase SimC7 - apo crystal form 2
Descriptor: GLYCEROL, SimC7, TETRAETHYLENE GLYCOL
Authors:Schafer, M, Stevenson, C.E.M, Wilkinson, B, Lawson, D.M, Buttner, M.J.
Deposit date:2016-05-25
Release date:2016-10-05
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Substrate-Assisted Catalysis in Polyketide Reduction Proceeds via a Phenolate Intermediate.
Cell Chem Biol, 23, 2016
3ZQL
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BU of 3zql by Molmil
DNA-bound form of TetR-like repressor SimR
Descriptor: 5'-D(*DTP*TP*CP*GP*TP*AP*CP*GP*CP*CP*GP*TP*AP*DCP *GP*AP*A)-3', 5'-D(*DTP*TP*CP*GP*TP*AP*CP*GP*GP*CP*GP*TP*AP*DCP *GP*AP*A)-3', PUTATIVE REPRESSOR SIMREG2
Authors:Le, T.B.K, Schumacher, M.A, Lawson, D.M, Brennan, R.G, Buttner, M.J.
Deposit date:2011-06-10
Release date:2011-08-31
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:The Crystal Structure of the Tetr Family Transcriptional Repressor Simr Bound to DNA and the Role of a Flexible N-Terminal Extension in Minor Groove Binding.
Nucleic Acids Res., 39, 2011
2Y30
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BU of 2y30 by Molmil
Simocyclinone D8 bound form of TetR-like repressor SimR
Descriptor: CHLORIDE ION, PUTATIVE REPRESSOR SIMREG2, SIMOCYCLINONE D8
Authors:Le, T.B.K, Stevenson, C.E.M, Fiedler, H.-P, Maxwell, A, Lawson, D.M, Buttner, M.J.
Deposit date:2010-12-17
Release date:2011-03-09
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of the Tetr-Like Simocyclinone Efflux Pump Repressor, Simr, and the Mechanism of Ligand-Mediated Derepression.
J.Mol.Biol., 408, 2011
2Y2Z
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BU of 2y2z by Molmil
ligand-free form of TetR-like repressor SimR
Descriptor: PUTATIVE REPRESSOR SIMREG2
Authors:Le, T.B.K, Stevenson, C.E.M, Fiedler, H.-P, Maxwell, A, Lawson, D.M, Buttner, M.J.
Deposit date:2010-12-17
Release date:2011-03-09
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structures of the Tetr-Like Simocyclinone Efflux Pump Repressor, Simr, and the Mechanism of Ligand-Mediated Derepression.
J.Mol.Biol., 408, 2011
2Y31
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BU of 2y31 by Molmil
Simocyclinone C4 bound form of TetR-like repressor SimR
Descriptor: CALCIUM ION, CHLORIDE ION, PENTAETHYLENE GLYCOL, ...
Authors:Le, T.B.K, Stevenson, C.E.M, Fiedler, H.-P, Maxwell, A, Lawson, D.M, Buttner, M.J.
Deposit date:2010-12-17
Release date:2011-03-09
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of the Tetr-Like Simocyclinone Efflux Pump Repressor, Simr, and the Mechanism of Ligand-Mediated Derepression.
J.Mol.Biol., 408, 2011
6DXO
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BU of 6dxo by Molmil
1.8 A structure of RsbN-BldN complex.
Descriptor: BldN, RNA polymerase ECF-subfamily sigma factor
Authors:Schumacher, M.A.
Deposit date:2018-06-29
Release date:2018-07-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The crystal structure of the RsbN-sigma BldN complex from Streptomyces venezuelae defines a new structural class of anti-sigma factor.
Nucleic Acids Res., 46, 2018
6PFJ
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BU of 6pfj by Molmil
Structure of S. venezuelae RsiG-WhiG-(ci-di-GMP) complex, P64 crystal form
Descriptor: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), AmfC protein, RNA polymerase sigma factor
Authors:Schumacher, M.A.
Deposit date:2019-06-21
Release date:2019-11-13
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:c-di-GMP Arms an Anti-sigma to Control Progression of Multicellular Differentiation in Streptomyces.
Mol.Cell, 77, 2020
6PFV
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BU of 6pfv by Molmil
Structure of S. venezuelae RisG-WhiG-c-di-GMP complex: orthorhombic crystal form
Descriptor: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), AmfC protein, RNA polymerase sigma factor
Authors:Schumacher, M.A.
Deposit date:2019-06-22
Release date:2019-11-13
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3 Å)
Cite:c-di-GMP Arms an Anti-sigma to Control Progression of Multicellular Differentiation in Streptomyces.
Mol.Cell, 77, 2020
8DY7
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BU of 8dy7 by Molmil
Streptomyces venezuelae RNAP transcription open promoter complex with WhiA and WhiB transcription factors
Descriptor: DNA (71-MER), DNA (78-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Lilic, M, Campbell, E.A.
Deposit date:2022-08-03
Release date:2023-03-01
Last modified:2023-03-22
Method:ELECTRON MICROSCOPY (3.18 Å)
Cite:Structural basis of dual activation of cell division by the actinobacterial transcription factors WhiA and WhiB.
Proc.Natl.Acad.Sci.USA, 120, 2023
8DY9
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BU of 8dy9 by Molmil
Streptomyces venezuelae RNAP unconstrained open promoter complex with WhiA and WhiB transcription factors
Descriptor: DNA (38-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Lilic, M, Campbell, E.A.
Deposit date:2022-08-03
Release date:2023-03-01
Last modified:2023-03-22
Method:ELECTRON MICROSCOPY (3.12 Å)
Cite:Structural basis of dual activation of cell division by the actinobacterial transcription factors WhiA and WhiB.
Proc.Natl.Acad.Sci.USA, 120, 2023
6AMK
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BU of 6amk by Molmil
Structure of Streptomyces venezuelae BldC-whiI opt complex
Descriptor: DNA (5'-D(*AP*AP*TP*GP*TP*CP*CP*GP*AP*AP*TP*TP*AP*CP*CP*CP*GP*AP*AP*TP*TP*G)-3'), DNA (5'-D(*TP*TP*CP*AP*AP*TP*TP*CP*GP*GP*GP*TP*AP*AP*TP*TP*CP*GP*GP*GP*CP*A)-3'), Putative DNA-binding protein
Authors:Schumacher, M.A.
Deposit date:2017-08-09
Release date:2018-03-28
Last modified:2018-11-07
Method:X-RAY DIFFRACTION (3.288 Å)
Cite:The MerR-like protein BldC binds DNA direct repeats as cooperative multimers to regulate Streptomyces development.
Nat Commun, 9, 2018
6AMA
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BU of 6ama by Molmil
Structure of S. coelicolor/S. venezuelae BldC-smeA-ssfA complex to 3.09 Angstrom
Descriptor: DNA (99-MER), Putative DNA-binding protein
Authors:Schumacher, M.A.
Deposit date:2017-08-09
Release date:2018-03-28
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.09 Å)
Cite:The MerR-like protein BldC binds DNA direct repeats as cooperative multimers to regulate Streptomyces development.
Nat Commun, 9, 2018
4OB4
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BU of 4ob4 by Molmil
Structure of the S. venezulae BldD DNA-binding domain
Descriptor: Putative DNA-binding protein
Authors:schumacher, M.A, Tschowri, N, Buttner, M, Brennan, R.
Deposit date:2014-01-06
Release date:2014-11-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Tetrameric c-di-GMP mediates effective transcription factor dimerization to control Streptomyces development.
Cell(Cambridge,Mass.), 158, 2014
4OAY
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BU of 4oay by Molmil
BldD CTD-c-di-GMP complex
Descriptor: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), DNA-binding protein
Authors:Schumacher, M.A, Tschowri, N, Buttner, M, Brennan, R.G.
Deposit date:2014-01-06
Release date:2014-11-19
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Tetrameric c-di-GMP mediates effective transcription factor dimerization to control Streptomyces development.
Cell(Cambridge,Mass.), 158, 2014
4OAZ
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BU of 4oaz by Molmil
BldD CTD-c-di-GMP complex
Descriptor: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), Putative DNA-binding protein
Authors:Schumacher, M.A, Tschowri, N, Buttner, M, Brennan, R.G.
Deposit date:2014-01-06
Release date:2014-11-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Tetrameric c-di-GMP mediates effective transcription factor dimerization to control Streptomyces development.
Cell(Cambridge,Mass.), 158, 2014
5TZF
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BU of 5tzf by Molmil
Structure of the BldD CTD(D116A)-(c-di-GMP)2 intermediate, form 1
Descriptor: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), DNA-binding protein
Authors:Schumacher, M.A.
Deposit date:2016-11-21
Release date:2017-04-19
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Streptomyces master regulator BldD binds c-di-GMP sequentially to create a functional BldD2-(c-di-GMP)4 complex.
Nucleic Acids Res., 45, 2017
5TZD
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BU of 5tzd by Molmil
Structure of the WT S. venezulae BldD-(CTD-c-di-GMP)2 assembly intermediate
Descriptor: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), DNA-binding protein
Authors:Schumacher, M.
Deposit date:2016-11-21
Release date:2017-04-19
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.749 Å)
Cite:The Streptomyces master regulator BldD binds c-di-GMP sequentially to create a functional BldD2-(c-di-GMP)4 complex.
Nucleic Acids Res., 45, 2017
5TZG
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BU of 5tzg by Molmil
Structure of the BldD CTD(D116A)-(c-di-GMP)2, form 2
Descriptor: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), DNA-binding protein, ZINC ION
Authors:Schumacher, M.A.
Deposit date:2016-11-21
Release date:2017-04-19
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The Streptomyces master regulator BldD binds c-di-GMP sequentially to create a functional BldD2-(c-di-GMP)4 complex.
Nucleic Acids Res., 45, 2017
5KHD
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BU of 5khd by Molmil
Structure of 1.75 A BldD C-domain-c-di-GMP complex
Descriptor: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), DNA-binding protein
Authors:Schumacher, M.
Deposit date:2016-06-14
Release date:2016-06-29
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.7501 Å)
Cite:Tetrameric c-di-GMP mediates effective transcription factor dimerization to control Streptomyces development.
Cell, 158, 2014

 

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