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4AW0
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BU of 4aw0 by Molmil
Human PDK1 Kinase Domain in Complex with Allosteric Compound PS182 Bound to the PIF-Pocket
Descriptor: 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1, ADENOSINE-5'-TRIPHOSPHATE, DIMETHYL SULFOXIDE, ...
Authors:Schulze, J.O, Busschots, K, Lopez-Garcia, L.A, Lammi, C, Stroba, A, Zeuzem, S, Piiper, A, Alzari, P.M, Neimanis, S, Arencibia, J.M, Engel, M, Biondi, R.M.
Deposit date:2012-05-30
Release date:2012-10-03
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Substrate-Selective Inhibition of Protein Kinase Pdk1 by Small Compounds that Bind to the Pif-Pocket Allosteric Docking Site.
Chem.Biol., 19, 2012
4AW1
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BU of 4aw1 by Molmil
Human PDK1 Kinase Domain in Complex with Allosteric Compound PS210 Bound to the PIF-Pocket
Descriptor: 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1, ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ...
Authors:Schulze, J.O, Busschots, K, Lopez-Garcia, L.A, Lammi, C, Stroba, A, Zeuzem, S, Piiper, A, Alzari, P.M, Neimanis, S, Arencibia, J.M, Engel, M, Biondi, R.M.
Deposit date:2012-05-30
Release date:2012-10-03
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Substrate-Selective Inhibition of Protein Kinase Pdk1 by Small Compounds that Bind to the Pif-Pocket Allosteric Docking Site.
Chem.Biol., 19, 2012
5LVL
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BU of 5lvl by Molmil
Human PDK1 Kinase Domain in Complex with Compound PS653 Bound to the ATP-Binding Site
Descriptor: 2,6-DIHYDROANTHRA/1,9-CD/PYRAZOL-6-ONE, 3-phosphoinositide-dependent protein kinase 1, DIMETHYL SULFOXIDE, ...
Authors:Schulze, J.O, Saladino, G, Busschots, K, Neimanis, S, Suess, E, Odadzic, D, Zeuzem, S, Hindie, V, Herbrand, A.K, Lisa, M.N, Alzari, P.M, Gervasio, F.L, Biondi, R.M.
Deposit date:2016-09-14
Release date:2016-10-19
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase.
Cell Chem Biol, 23, 2016
5LVP
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BU of 5lvp by Molmil
Human PDK1 Kinase Domain in Complex with an HM-Peptide Bound to the PIF-Pocket
Descriptor: 3-phosphoinositide-dependent protein kinase 1, ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ...
Authors:Schulze, J.O, Saladino, G, Busschots, K, Neimanis, S, Suess, E, Odadzic, D, Zeuzem, S, Hindie, V, Herbrand, A.K, Lisa, M.N, Alzari, P.M, Gervasio, F.L, Biondi, R.M.
Deposit date:2016-09-14
Release date:2016-10-19
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase.
Cell Chem Biol, 23, 2016
5LVN
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BU of 5lvn by Molmil
Human PDK1 Kinase Domain in Complex with Adenosine Bound to the ATP-Binding Site
Descriptor: 3-phosphoinositide-dependent protein kinase 1, ADENOSINE, CHLORIDE ION, ...
Authors:Schulze, J.O, Saladino, G, Busschots, K, Neimanis, S, Suess, E, Odadzic, D, Zeuzem, S, Hindie, V, Herbrand, A.K, Lisa, M.N, Alzari, P.M, Gervasio, F.L, Biondi, R.M.
Deposit date:2016-09-14
Release date:2016-10-19
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.379 Å)
Cite:Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase.
Cell Chem Biol, 23, 2016
5LVM
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BU of 5lvm by Molmil
Human PDK1 Kinase Domain in Complex with Adenine Bound to the ATP-Binding Site
Descriptor: 3-phosphoinositide-dependent protein kinase 1, ADENINE, DITHIANE DIOL
Authors:Schulze, J.O, Saladino, G, Busschots, K, Neimanis, S, Suess, E, Odadzic, D, Zeuzem, S, Hindie, V, Herbrand, A.K, Lisa, M.N, Alzari, P.M, Gervasio, F.L, Biondi, R.M.
Deposit date:2016-09-14
Release date:2016-10-19
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.26 Å)
Cite:Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase.
Cell Chem Biol, 23, 2016
5LVO
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BU of 5lvo by Molmil
Human PDK1 Kinase Domain in Complex with Allosteric Compound PSE10 Bound to the PIF-Pocket
Descriptor: 2-oxidanylidenepropyl ~{N}-(2-chloranyl-6-fluoranyl-phenyl)carbonyl-~{N}'-(4-chlorophenyl)carbamimidothioate, 3-phosphoinositide-dependent protein kinase 1, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Schulze, J.O, Saladino, G, Busschots, K, Neimanis, S, Suess, E, Odadzic, D, Zeuzem, S, Hindie, V, Herbrand, A.K, Lisa, M.N, Alzari, P.M, Gervasio, F.L, Biondi, R.M.
Deposit date:2016-09-14
Release date:2016-10-19
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.09 Å)
Cite:Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase.
Cell Chem Biol, 23, 2016
4CT2
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BU of 4ct2 by Molmil
Human PDK1-PKCzeta Kinase Chimera
Descriptor: 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1, ADENOSINE-5'-TRIPHOSPHATE, DITHIANE DIOL, ...
Authors:Schulze, J.O, Zhang, H, Lopez-Garcia, L.A, Biondi, R.M.
Deposit date:2014-03-11
Release date:2014-05-28
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Molecular Mechanism of Regulation of the Atypical Protein Kinase C by N-Terminal Domains and an Allosteric Small Compound.
Chem.Biol., 21, 2014
4CT1
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BU of 4ct1 by Molmil
Human PDK1-PKCzeta Kinase Chimera in Complex with Allosteric Compound PS315 Bound to the PIF-Pocket
Descriptor: (2Z)-3-(biphenyl-4-yl)-5-(4-chlorophenyl)pent-2-enoic acid, 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Schulze, J.O, Zhang, H, Lopez-Garcia, L.A, Biondi, R.M.
Deposit date:2014-03-11
Release date:2014-05-28
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Molecular Mechanism of Regulation of the Atypical Protein Kinase C by N-Terminal Domains and an Allosteric Small Compound.
Chem.Biol., 21, 2014

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