4NYI | | APPROACH FOR TARGETING RAS WITH SMALL MOLECULES THAT ACTIVATE SOS-MEDIATED NUCLEOTIDE EXCHANGE | | Descriptor: | GTPase HRas, Son of sevenless homolog 1, MAGNESIUM ION, ... | | Authors: | Burns, M.C., Sun, Q., Phan, J., Fesik, S.W. | | Deposit date: | 2013-12-10 | | Release date: | 2014-03-12 | | Last modified: | 2014-03-19 | | Method: | X-RAY DIFFRACTION (2.9612 Å) | | Cite: | Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange.
Proc.Natl.Acad.Sci.USA, 111, 2014
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4NYJ | | APPROACH FOR TARGETING RAS WITH SMALL MOLECULES THAT ACTIVATE SOS-MEDIATED NUCLEOTIDE EXCHANGE | | Descriptor: | GTPase HRas, Son of sevenless homolog 1, MAGNESIUM ION, ... | | Authors: | Burns, M.C., Sun, Q., Phan, J., Fesik, S.W. | | Deposit date: | 2013-12-10 | | Release date: | 2014-03-12 | | Last modified: | 2014-03-19 | | Method: | X-RAY DIFFRACTION (2.8522 Å) | | Cite: | Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange.
Proc.Natl.Acad.Sci.USA, 111, 2014
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4NYM | | APPROACH FOR TARGETING RAS WITH SMALL MOLECULES THAT ACTIVATE SOS-MEDIATED NUCLEOTIDE EXCHANGE | | Descriptor: | GTPase HRas, Son of sevenless homolog 1, MAGNESIUM ION, ... | | Authors: | Burns, M.C., Sun, Q., Phan, J., Fesik, S.W. | | Deposit date: | 2013-12-10 | | Release date: | 2014-03-12 | | Last modified: | 2014-03-19 | | Method: | X-RAY DIFFRACTION (3.5529 Å) | | Cite: | Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange.
Proc.Natl.Acad.Sci.USA, 111, 2014
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5WFO | | LIGAND-BOUND RAS:SOS:RAS COMPLEX | | Descriptor: | GTPase HRas, Son of sevenless homolog 1, MAGNESIUM ION, ... | | Authors: | Sun, Q., Phan, J., Burns, M.C., Fesik, S.W. | | Deposit date: | 2017-07-12 | | Release date: | 2018-05-23 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling.
Anal. Biochem., 548, 2018
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5WFP | | LIGAND-BOUND RAS:SOS:RAS COMPLEX | | Descriptor: | GTPase HRas, Son of sevenless homolog 1, MAGNESIUM ION, ... | | Authors: | Sun, Q., Phan, J., Burns, M.C., Fesik, S.W. | | Deposit date: | 2017-07-12 | | Release date: | 2018-05-23 | | Method: | X-RAY DIFFRACTION (2.08 Å) | | Cite: | High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling.
Anal. Biochem., 548, 2018
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5WFQ | | LIGAND-BOUND RAS:SOS:RAS COMPLEX | | Descriptor: | GTPase HRas, Son of sevenless homolog 1, MAGNESIUM ION, ... | | Authors: | Sun, Q., Phan, J., Burns, M.C., Fesik, S.W. | | Deposit date: | 2017-07-12 | | Release date: | 2018-05-23 | | Method: | X-RAY DIFFRACTION (2.26 Å) | | Cite: | High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling.
Anal. Biochem., 548, 2018
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5WFR | | LIGAND-BOUND RAS:SOS:RAS COMPLEX | | Descriptor: | GTPase HRas, Son of sevenless homolog 1, MAGNESIUM ION, ... | | Authors: | Sun, Q., Phan, J., Burns, M.C., Fesik, S.W. | | Deposit date: | 2017-07-12 | | Release date: | 2018-05-23 | | Method: | X-RAY DIFFRACTION (2.46 Å) | | Cite: | High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling.
Anal. Biochem., 548, 2018
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4EPR | | DISCOVERY OF SMALL MOLECULES THAT BIND TO K-RAS AND INHIBIT SOS-MEDIATED ACTIVATION. | | Descriptor: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | | Authors: | Sun, Q., Burke, J.P., Phan, J., Burns, M.C., Olejniczak, E.T., Waterson, A.G., Lee, T., Rossanese, O.W., Fesik, S.W. | | Deposit date: | 2012-04-17 | | Release date: | 2012-05-23 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation.
Angew.Chem.Int.Ed.Engl., 51, 2012
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4EPT | | DISCOVERY OF SMALL MOLECULES THAT BIND TO K-RAS AND INHIBIT SOS-MEDIATED ACTIVATION | | Descriptor: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Sun, Q., Burke, J.P., Phan, J., Burns, M.C., Olejniczak, E.T., Waterson, A.G., Lee, T., Rossanese, O.W., Fesik, S.W. | | Deposit date: | 2012-04-17 | | Release date: | 2012-05-23 | | Last modified: | 2012-07-25 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation.
Angew.Chem.Int.Ed.Engl., 51, 2012
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4EPV | | DISCOVERY OF SMALL MOLECULES THAT BIND TO K-RAS AND INHIBIT SOS-MEDIATED ACTIVATION | | Descriptor: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Sun, Q., Burke, J.P., Phan, J., Burns, M.C., Olejniczak, E.T., Waterson, A.G., Lee, T., Rossanese, O.W., Fesik, S.W. | | Deposit date: | 2012-04-17 | | Release date: | 2012-05-23 | | Last modified: | 2012-07-25 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation.
Angew.Chem.Int.Ed.Engl., 51, 2012
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4EPW | | DISCOVERY OF SMALL MOLECULES THAT BIND TO K-RAS AND INHIBIT SOS-MEDIATED ACTIVATION | | Descriptor: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Sun, Q., Burke, J.P., Phan, J., Burns, M.C., Olejniczak, E.T., Waterson, A.G., Lee, T., Rossanese, O.W., Fesik, S.W. | | Deposit date: | 2012-04-17 | | Release date: | 2012-05-23 | | Last modified: | 2012-07-25 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation.
Angew.Chem.Int.Ed.Engl., 51, 2012
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4EPX | | DISCOVERY OF SMALL MOLECULES THAT BIND TO K-RAS AND INHIBIT SOS-MEDIATED ACTIVATION | | Descriptor: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Sun, Q., Burke, J.P., Phan, J., Burns, M.C., Olejniczak, E.T., Waterson, A.G., Lee, T., Rossanese, O.W., Fesik, S.W. | | Deposit date: | 2012-04-17 | | Release date: | 2012-05-23 | | Last modified: | 2012-07-25 | | Method: | X-RAY DIFFRACTION (1.76 Å) | | Cite: | Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation.
Angew.Chem.Int.Ed.Engl., 51, 2012
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4EPY | | DISCOVERY OF SMALL MOLECULES THAT BIND TO K-RAS AND INHIBIT SOS-MEDIATED ACTIVATION | | Descriptor: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Sun, Q., Burke, J.P., Phan, J., Burns, M.C., Olejniczak, E.T., Waterson, A.G., Lee, T., Rossanese, O.W., Fesik, S.W. | | Deposit date: | 2012-04-17 | | Release date: | 2012-05-23 | | Last modified: | 2012-07-25 | | Method: | X-RAY DIFFRACTION (1.801 Å) | | Cite: | Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation.
Angew.Chem.Int.Ed.Engl., 51, 2012
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6BVI | | RAS:SOS:RAS IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR | | Descriptor: | GTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | | Authors: | Phan, J., Abbott, J., Fesik, S.W. | | Deposit date: | 2017-12-13 | | Release date: | 2018-10-24 | | Method: | X-RAY DIFFRACTION (1.746 Å) | | Cite: | Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling.
J. Med. Chem., 2018
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6BVK | | RAS:SOS:RAS IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR | | Descriptor: | GTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | | Authors: | Phan, J., Abbott, J., Fesik, S.W. | | Deposit date: | 2017-12-13 | | Release date: | 2018-10-24 | | Method: | X-RAY DIFFRACTION (1.799 Å) | | Cite: | Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling.
J. Med. Chem., 2018
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6BVL | |
6BVM | | RAS:SOS:RAS IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR | | Descriptor: | GTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | | Authors: | Phan, J., Abbott, J., Fesik, S.W. | | Deposit date: | 2017-12-13 | | Release date: | 2018-10-24 | | Method: | X-RAY DIFFRACTION (1.796 Å) | | Cite: | Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling.
J. Med. Chem., 2018
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6CUO | | RAS:SOS:RAS IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR | | Descriptor: | GTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | | Authors: | Phan, J., Abbott, J., Fesik, S.W. | | Deposit date: | 2018-03-26 | | Release date: | 2019-02-06 | | Method: | X-RAY DIFFRACTION (1.73 Å) | | Cite: | Discovery of Quinazolines That Activate SOS1-Mediated Nucleotide Exchange on RAS.
ACS Med Chem Lett, 9, 2018
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6CUP | | RAS:SOS:RAS IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR | | Descriptor: | GTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | | Authors: | Phan, J., Abbott, J., Fesik, S.W. | | Deposit date: | 2018-03-26 | | Release date: | 2019-02-06 | | Method: | X-RAY DIFFRACTION (1.833 Å) | | Cite: | Discovery of Quinazolines That Activate SOS1-Mediated Nucleotide Exchange on RAS.
ACS Med Chem Lett, 9, 2018
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6CUR | | RAS:SOS:RAS IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR | | Descriptor: | GTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | | Authors: | Phan, J., Abbott, J., Fesik, S.W. | | Deposit date: | 2018-03-26 | | Release date: | 2019-02-06 | | Method: | X-RAY DIFFRACTION (1.73 Å) | | Cite: | Discovery of Quinazolines That Activate SOS1-Mediated Nucleotide Exchange on RAS.
ACS Med Chem Lett, 9, 2018
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6D55 | | RAS:SOS:RAS IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR | | Descriptor: | GTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | | Authors: | Phan, J., Hodges, T., Fesik, S.W. | | Deposit date: | 2018-04-19 | | Release date: | 2018-09-19 | | Last modified: | 2018-11-07 | | Method: | X-RAY DIFFRACTION (1.68 Å) | | Cite: | Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.
J. Med. Chem., 61, 2018
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6D56 | | RAS:SOS:RAS IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR | | Descriptor: | GTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | | Authors: | Phan, J., Hodges, T., Fesik, S.W. | | Deposit date: | 2018-04-19 | | Release date: | 2018-09-19 | | Last modified: | 2018-11-07 | | Method: | X-RAY DIFFRACTION (1.68 Å) | | Cite: | Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.
J. Med. Chem., 61, 2018
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6D59 | | RAS:SOS:RAS IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR | | Descriptor: | GTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | | Authors: | Phan, J., Hodges, T., Fesik, S.W. | | Deposit date: | 2018-04-19 | | Release date: | 2018-09-19 | | Last modified: | 2018-11-07 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.
J. Med. Chem., 61, 2018
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6D5E | | RAS:SOS:RAS IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR | | Descriptor: | GTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | | Authors: | Phan, J., Hodges, T., Fesik, S.W. | | Deposit date: | 2018-04-19 | | Release date: | 2018-09-19 | | Last modified: | 2018-11-07 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.
J. Med. Chem., 61, 2018
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6D5G | | RAS:SOS:RAS IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR | | Descriptor: | GTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | | Authors: | Phan, J., Hodges, T., Fesik, S.W. | | Deposit date: | 2018-04-19 | | Release date: | 2018-09-19 | | Last modified: | 2018-11-07 | | Method: | X-RAY DIFFRACTION (1.92 Å) | | Cite: | Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.
J. Med. Chem., 61, 2018
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