Author results

1BZH
  • Download 1bzh
  • View 1bzh
Molmil generated image of 1bzh
CYCLIC PEPTIDE INHIBITOR OF HUMAN PTP1B
分子名称:PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE 1B), PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE 1B INHIBITOR)
著者Groves, M.R., Yao, Z.J., Burke Jr., T.R., Barford, D.
登録日1998-10-28
公開日1999-02-16
最終更新日2018-12-26
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics.
Biochemistry, 37, 1998
6D3F
  • Download 6d3f
  • View 6d3f
Molmil generated image of 6d3f
CRYSTAL STRUCTURE OF THE PTP EPSILON D2 DOMAIN
分子名称:Receptor-type tyrosine-protein phosphatase epsilon
著者Lountos, G.T., Raran-Kurussi, S., Zhao, B.M., Dyas, B.K., Austin, B.P., Burke Jr., T.R., Ulrich, R.G., Waugh, D.S.
登録日2018-04-16
公開日2018-10-17
実験手法X-RAY DIFFRACTION (2.271 Å)
主引用文献High-resolution crystal structures of the D1 and D2 domains of protein tyrosine phosphatase epsilon for structure-based drug design.
Acta Crystallogr D Struct Biol, 74, 2018
6D4D
  • Download 6d4d
  • View 6d4d
Molmil generated image of 6d4d
CRYSTAL STRUCTURE OF THE PTP EPSILON D1 DOMAIN
分子名称:Receptor-type tyrosine-protein phosphatase epsilon
著者Lountos, G.T., Raran-Kurussi, S., Zhao, B.M., Dyas, B.K., Austin, B.P., Burke Jr., T.R., Ulrich, R.G., Waugh, D.S.
登録日2018-04-18
公開日2018-10-17
実験手法X-RAY DIFFRACTION (1.765 Å)
主引用文献High-resolution crystal structures of the D1 and D2 domains of protein tyrosine phosphatase epsilon for structure-based drug design.
Acta Crystallogr D Struct Biol, 74, 2018
6D4F
  • Download 6d4f
  • View 6d4f
Molmil generated image of 6d4f
CRYSTAL STRUCTURE OF PTP EPSILON D2 DOMAIN (A455N/V457Y/E597D)
分子名称:Receptor-type tyrosine-protein phosphatase epsilon, PENTAETHYLENE GLYCOL
著者Lountos, G.T., Raran-Kurussi, S., Zhao, B.M., Dyas, B.K., Austin, B.P., Burke Jr., T.R., Ulrich, R.G., Waugh, D.S.
登録日2018-04-18
公開日2018-10-17
実験手法X-RAY DIFFRACTION (1.909 Å)
主引用文献High-resolution crystal structures of the D1 and D2 domains of protein tyrosine phosphatase epsilon for structure-based drug design.
Acta Crystallogr D Struct Biol, 74, 2018
1BZC
  • Download 1bzc
  • View 1bzc
Molmil generated image of 1bzc
HUMAN PTP1B CATALYTIC DOMAIN COMPLEXED WITH TPI
分子名称:PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE), 4-CARBAMOYL-4-{[6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBONYL]-AMINO}-BUTYRIC ACID
著者Groves, M.R., Yao, Z.J., Jr Burke, T.R., Barford, D.
登録日1998-10-27
公開日1999-02-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics.
Biochemistry, 37, 1998
3RQ7
  • Download 3rq7
  • View 3rq7
Molmil generated image of 3rq7
POLO-LIKE KINASE 1 POLO BOX DOMAIN IN COMPLEX WITH A C6H5(CH2)8-DERIVATIZED PEPTIDE INHIBITOR
分子名称:Serine/threonine-protein kinase PLK1, C6H5(CH2)8-derivatized peptide inhibitor
著者Liu, F., Park, J.-E., Qian, W.-J., Lim, D.C., Graber, M., Berg, T., Yaffe, M.B., Lee, K.S., Burke Jr., T.R.
登録日2011-04-27
公開日2011-07-20
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel.
Nat.Chem.Biol., 7, 2011
4DFW
  • Download 4dfw
  • View 4dfw
Molmil generated image of 4dfw
OXIME-BASED POST SOLID-PHASE PEPTIDE DIVERSIFICATION: IDENTIFICATION OF HIGH AFFINITY POLO-LIKE KINASE 1 (PLK1) POLO-BOX DOMAIN BINDING PEPTIDES
分子名称:Serine/threonine-protein kinase PLK1, Peptide, CHLORIDE ION
著者Liu, F., Park, J.-E., Qian, W.-J., Lim, D., Gr ber, M., Berg, T., Yaffe, M.B., Lee, K.S., Burke Jr., T.R.
登録日2012-01-24
公開日2012-03-28
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Oxime-based Post Solid-phase Peptide Diversification: Identification of High Affinity Polo-like Kinase 1 (Plk1) Polo-box Domain Binding Peptides
Chem.Biol., 2012
6AX4
  • Download 6ax4
  • View 6ax4
Molmil generated image of 6ax4
PLK-1 POLO-BOX DOMAIN IN COMPLEX WITH HISTIDINE N(TAU)-CYCLIZED MACROCYCLE 5B.
分子名称:Serine/threonine-protein kinase PLK1, histidine N(tau)-cyclized Macrocycle 5b, AMYLAMINE
著者Grant, R.A., Hymel, D., Yaffe, M.B., Burke, T.R.
登録日2017-09-06
公開日2018-09-12
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Histidine N( tau )-cyclized macrocycles as a new genre of polo-like kinase 1 polo-box domain-binding inhibitors.
Bioorg. Med. Chem. Lett., 28, 2018
1BZJ
  • Download 1bzj
  • View 1bzj
Molmil generated image of 1bzj
HUMAN PTP1B COMPLEXED WITH TPICOOH
分子名称:PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE), 6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBOXYLIC ACID
著者Groves, M.R., Yao, Z.-J., Barford Jr., D.T.B.
登録日1998-10-29
公開日1999-02-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics.
Biochemistry, 37, 1998
1A5V
  • Download 1a5v
  • View 1a5v
Molmil generated image of 1a5v
ASV INTEGRASE CORE DOMAIN WITH HIV-1 INTEGRASE INHIBITOR Y3 AND MN CATION
分子名称:INTEGRASE, MANGANESE (II) ION, 4-ACETYLAMINO-5-HYDROXYNAPHTHALENE-2,7-DISULFONIC ACID
著者Lubkowski, J., Yang, F., Alexandratos, J., Wlodawer, A.
登録日1998-02-18
公開日1998-05-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure of the catalytic domain of avian sarcoma virus integrase with a bound HIV-1 integrase-targeted inhibitor.
Proc.Natl.Acad.Sci.USA, 95, 1998
1A5W
  • Download 1a5w
  • View 1a5w
Molmil generated image of 1a5w
ASV INTEGRASE CORE DOMAIN WITH HIV-1 INTEGRASE INHIBITOR Y3
分子名称:INTEGRASE, 4-ACETYLAMINO-5-HYDROXYNAPHTHALENE-2,7-DISULFONIC ACID
著者Lubkowski, J., Yang, F., Alexandratos, J., Wlodawer, A.
登録日1998-02-18
公開日1998-05-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of the catalytic domain of avian sarcoma virus integrase with a bound HIV-1 integrase-targeted inhibitor.
Proc.Natl.Acad.Sci.USA, 95, 1998
1A5X
  • Download 1a5x
  • View 1a5x
Molmil generated image of 1a5x
ASV INTEGRASE CORE DOMAIN WITH HIV-1 INTEGRASE INHIBITOR Y3
分子名称:INTEGRASE, 4-ACETYLAMINO-5-HYDROXYNAPHTHALENE-2,7-DISULFONIC ACID
著者Lubkowski, J., Yang, F., Alexandratos, J., Wlodawer, A.
登録日1998-02-18
公開日1998-05-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure of the catalytic domain of avian sarcoma virus integrase with a bound HIV-1 integrase-targeted inhibitor.
Proc.Natl.Acad.Sci.USA, 95, 1998