Author results

2LK3
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U2/U6 HELIX I
Descriptor:RNA (5'-R(*GP*GP*CP*UP*UP*AP*GP*AP*UP*CP*AP*GP*AP*AP*AP*UP*GP*AP*UP*CP*AP*GP*CP*C)-3')
Authors:Burke, J.E., Sashital, D.G., Zuo, X.E., Wang, Y., Butcher, S.E.
Deposit date:2011-10-03
Release date:2012-02-22
Last modified:2012-04-04
Method:SOLUTION NMR
Cite:Structure of the yeast U2/U6 snRNA complex.
Rna, 18, 2012
2LKR
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YEAST U2/U6 COMPLEX
Descriptor:RNA (111-MER)
Authors:Burke, J.E., Sashital, D.G., Zuo, X., Wang, Y., Butcher, S.E.
Deposit date:2011-10-19
Release date:2012-02-22
Last modified:2012-04-04
Method:SOLUTION NMR
Cite:Structure of the yeast U2/U6 snRNA complex.
Rna, 18, 2012
4D0L
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PHOSPHATIDYLINOSITOL 4-KINASE III BETA-PIK93 IN A COMPLEX WITH RAB11A- GTP GAMMAS
Descriptor:PHOSPHATIDYLINOSITOL 4-KINASE BETA, RAS-RELATED PROTEIN RAB-11A, N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)- PHENYLTHIAZOLE-2-YL)-ACETAMIDE, ...
Authors:Burke, J.E., Inglis, A.J., Perisic, O., Masson, G.R., McLaughin, S.H., Rutaganira, F., Shokat, K.M., Williams, R.L.
Deposit date:2014-04-29
Release date:2014-05-28
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.94 Å)
Cite:Structures of Pi4Kiiibeta Complexes Show Simultaneous Recruitment of Rab11 and its Effectors.
Science, 344, 2014
4D0M
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PHOSPHATIDYLINOSITOL 4-KINASE III BETA IN A COMPLEX WITH RAB11A-GTP- GAMMA-S AND THE RAB-BINDING DOMAIN OF FIP3
Descriptor:PHOSPHATIDYLINOSITOL 4-KINASE BETA, RAS-RELATED PROTEIN RAB-11A, RAB11 FAMILY-INTERACTING PROTEIN 3, ...
Authors:Burke, J.E., Inglis, A.J., Perisic, O., Masson, G.R., McLaughlin, S.H., Rutaganira, F., Shokat, K.M., Williams, R.L.
Deposit date:2014-04-29
Release date:2014-05-28
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (6 Å)
Cite:Structures of Pi4Kiiibeta Complexes Show Simultaneous Recruitment of Rab11 and its Effectors.
Science, 344, 2014
5C46
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CRYSTAL STRUCTURE OF AN ENGINEERED CONSTRUCT OF PHOSPHATIDYLINOSITOL 4 KINASE III BETA IN COMPLEX WITH GTP GAMMA S LOADED RAB11
Descriptor:Phosphatidylinositol 4-kinase beta, Ras-related protein Rab-11A, SULFATE ION, ...
Authors:Burke, J.E., Fowler, M.L.
Deposit date:2015-06-17
Release date:2016-01-20
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIII beta with Rab11.
Protein Sci., 25, 2016
5C4G
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CRYSTAL STRUCTURE OF AN ENGINEERED CONSTRUCT OF PHOSPHATIDYLINOSITOL 4 KINASE III BETA WITH THE INHIBITOR BQR695 IN COMPLEX WITH GDP LOADED RAB11
Descriptor:Ras-related protein Rab-11A, Phosphatidylinositol 4-kinase beta, MAGNESIUM ION, ...
Authors:Burke, J.E., Fowler, M.L.
Deposit date:2015-06-18
Release date:2016-01-20
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIII beta with Rab11.
Protein Sci., 25, 2016
5EUQ
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CRYSTAL STRUCTURE OF AN ENGINEERED CONSTRUCT OF PHOSPHATIDYLINOSITOL 4 KINASE III BETA WITH A POTENT AND SELECTIVE INHIBITOR IN COMPLEX WITH GDP LOADED RAB11
Descriptor:Ras-related protein Rab-11A, Phosphatidylinositol 4-kinase beta, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Burke, J.E., Fowler, M.L.
Deposit date:2015-11-19
Release date:2016-02-24
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase III beta.
J.Med.Chem., 59, 2016
5JHA
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STRUCTURE OF PHOSPHOINOSITIDE 3-KINASE GAMMA (PI3K) BOUND TO THE POTENT INHIBITOR PIKIN2
Descriptor:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, [1-{4-[6-amino-4-(trifluoromethyl)pyridin-3-yl]-6-(morpholin-4-yl)pyrimidin-2-yl}-3-(chloromethyl)azetidin-3-yl]methanol, SULFATE ION
Authors:Burke, J.E., Inglis, A.J., Williams, R.L.
Deposit date:2016-04-20
Release date:2017-03-15
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention.
Nat Commun, 8, 2017
5JHB
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STRUCTURE OF PHOSPHOINOSITIDE 3-KINASE GAMMA (PI3K) BOUND TO THE POTENT INHIBITOR PIKIN3
Descriptor:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, [1-{4-[6-amino-4-(trifluoromethyl)pyridin-3-yl]-6-(morpholin-4-yl)-1,3,5-triazin-2-yl}-3-(chloromethyl)azetidin-3-yl]methanol, SULFATE ION
Authors:Burke, J.E., Inglis, A.J., Williams, R.L.
Deposit date:2016-04-20
Release date:2017-03-15
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention.
Nat Commun, 8, 2017
6DJL
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CRYSTAL STRUCTURE OF THE RAB11 GEF SH3BP5 BOUND TO NUCLEOTIDE FREE RAB11A
Descriptor:Ras-related protein Rab-11A, SH3 domain-binding protein 5
Authors:Burke, J.E., Jenkins, M.L., Boulanger, M.J.
Deposit date:2018-05-25
Release date:2018-09-26
Method:X-RAY DIFFRACTION (3.100012 Å)
Cite:Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5.
Nat Commun, 9, 2018
2N7M
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NMR-SAXS/WAXS STRUCTURE OF THE CORE OF THE U4/U6 DI-SNRNA
Descriptor:RNA (92-MER)
Authors:Cornilescu, G., Didychuk, A.L., Rodgers, M.L., Michael, L.A., Burke, J.E., Montemayor, E.J., Hoskins, A.A., Butcher, S.E., Tonelli, M.
Deposit date:2015-09-14
Release date:2015-12-30
Last modified:2016-03-30
Method:SOLUTION NMR
Cite:Structural Analysis of Multi-Helical RNAs by NMR-SAXS/WAXS: Application to the U4/U6 di-snRNA.
J.Mol.Biol., 428, 2016
2N8V
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AN NMR/SAXS STRUCTURE OF THE PKI DOMAIN OF THE HONEYBEE DICISTROVIRUS, ISRAELI ACUTE PARALYSIS VIRUS (IAPV) IRES
Descriptor:RNA (70-MER)
Authors:Au, H.H., Cornilescu, G., Mouzakis, K.D., Burke, J.E., Ren, Q., Lee, S., Butcher, S.E., Jan, E.
Deposit date:2015-10-27
Release date:2015-11-11
Last modified:2016-01-20
Method:SOLUTION NMR
Cite:Global shape mimicry of tRNA within a viral internal ribosome entry site mediates translational reading frame selection.
Proc.Natl.Acad.Sci.USA, 112, 2015
5LRU
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STRUCTURE OF CEZANNE/OTUD7B OTU DOMAIN
Descriptor:OTU domain-containing protein 7B
Authors:Mevissen, T.E.T., Kulathu, Y., Mulder, M.P.C., Geurink, P.P., Maslen, S.L., Gersch, M., Elliott, P.R., Burke, J.E., van Tol, B.D.M., Akutsu, M., El Oualid, F., Kawasaki, M., Freund, S.M.V., Ovaa, H., Komander, D.
Deposit date:2016-08-22
Release date:2016-10-19
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.
Nature, 538, 2016
5LRV
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STRUCTURE OF CEZANNE/OTUD7B OTU DOMAIN BOUND TO LYS11-LINKED DIUBIQUITIN
Descriptor:OTU domain-containing protein 7B, Polyubiquitin-B, PHOSPHATE ION, ...
Authors:Mevissen, T.E.T., Kulathu, Y., Mulder, M.P.C., Geurink, P.P., Maslen, S.L., Gersch, M., Elliott, P.R., Burke, J.E., van Tol, B.D.M., Akutsu, M., El Oualid, F., Kawasaki, M., Freund, S.M.V., Ovaa, H., Komander, D.
Deposit date:2016-08-22
Release date:2016-10-19
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.
Nature, 538, 2016
5LRW
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STRUCTURE OF CEZANNE/OTUD7B OTU DOMAIN BOUND TO UBIQUITIN
Descriptor:OTU domain-containing protein 7B, Polyubiquitin-B, GLYCEROL
Authors:Mevissen, T.E.T., Kulathu, Y., Mulder, M.P.C., Geurink, P.P., Maslen, S.L., Gersch, M., Elliott, P.R., Burke, J.E., van Tol, B.D.M., Akutsu, M., El Oualid, F., Kawasaki, M., Freund, S.M.V., Ovaa, H., Komander, D.
Deposit date:2016-08-22
Release date:2016-10-19
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.
Nature, 538, 2016
5LRX
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STRUCTURE OF A20 OTU DOMAIN BOUND TO UBIQUITIN
Descriptor:Tumor necrosis factor alpha-induced protein 3, Polyubiquitin-B
Authors:Mevissen, T.E.T., Kulathu, Y., Mulder, M.P.C., Geurink, P.P., Maslen, S.L., Gersch, M., Elliott, P.R., Burke, J.E., van Tol, B.D.M., Akutsu, M., El Oualid, F., Kawasaki, M., Freund, S.M.V., Ovaa, H., Komander, D.
Deposit date:2016-08-22
Release date:2016-10-19
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.
Nature, 538, 2016
5TDQ
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CRYSTAL STRUCTURE OF THE GOLD DOMAIN OF ACBD3
Descriptor:Golgi resident protein GCP60
Authors:McPhail, J.A., Burke, J.E.
Deposit date:2016-09-19
Release date:2016-11-23
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.493 Å)
Cite:The Molecular Basis of Aichi Virus 3A Protein Activation of Phosphatidylinositol 4 Kinase III beta , PI4KB, through ACBD3.
Structure, 25, 2017
5V6S
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CRYSTAL STRUCTURE OF SMALL MOLECULE ACRYLAMIDE 1 COVALENTLY BOUND TO K-RAS G12C
Descriptor:GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:McGregor, L.M., Jenkins, M., Kerwin, C., Burke, J.E., Shokat, K.M.
Deposit date:2017-03-17
Release date:2017-06-28
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Expanding the Scope of Electrophiles Capable of Targeting K-Ras Oncogenes.
Biochemistry, 56, 2017
5V6V
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CRYSTAL STRUCTURE OF SMALL MOLECULE AZIRIDINE 3 COVALENTLY BOUND TO K-RAS G12C
Descriptor:GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, CALCIUM ION, ...
Authors:McGregor, L.M., Jenkins, M., Kerwin, C., Burke, J.E., Shokat, K.M.
Deposit date:2017-03-17
Release date:2017-06-28
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Expanding the Scope of Electrophiles Capable of Targeting K-Ras Oncogenes.
Biochemistry, 56, 2017
5VBE
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CRYSTAL STRUCTURE OF SMALL MOLECULE DISULFIDE 2C07 BOUND TO H-RAS M72C GDP
Descriptor:GTPase HRas, GUANOSINE-5'-DIPHOSPHATE, 1-(4-methoxyphenyl)-N-(3-sulfanylpropyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide, ...
Authors:Gentile, D.R., Jenkins, M.L., Moss, S.M., Burke, J.E., Shokat, K.M.
Deposit date:2017-03-29
Release date:2017-10-25
Last modified:2018-01-03
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States.
Cell Chem Biol, 24, 2017
5VBM
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CRYSTAL STRUCTURE OF SMALL MOLECULE DISULFIDE 2C07 BOUND TO K-RAS CYS LIGHT M72C GDP
Descriptor:GTPase KRas, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Gentile, D.R., Jenkins, M.L., Moss, S.M., Burke, J.E., Shokat, K.M.
Deposit date:2017-03-29
Release date:2017-10-25
Last modified:2018-01-03
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States.
Cell Chem Biol, 24, 2017
5VBZ
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CRYSTAL STRUCTURE OF SMALL MOLECULE DISULFIDE 2C07 BOUND TO H-RAS M72C GPPNHP
Descriptor:GTPase HRas, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION, ...
Authors:Gentile, D.R., Jenkins, M.L., Moss, S.M., Burke, J.E., Shokat, K.M.
Deposit date:2017-03-30
Release date:2017-10-25
Last modified:2018-01-03
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States.
Cell Chem Biol, 24, 2017
6ARK
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CRYSTAL STRUCTURE OF COMPOUND 10 COVALENTLY BOUND TO K-RAS G12C
Descriptor:GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Nnadi, C.I., Jenkins, M.L., Gentile, D.R., Bateman, L.A., Zaidman, D., Balius, T.E., Nomura, D.K., Burke, J.E., Shokat, K.M., London, N.
Deposit date:2017-08-22
Release date:2018-01-31
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Novel K-Ras G12C Switch-II Covalent Binders Destabilize Ras and Accelerate Nucleotide Exchange.
J Chem Inf Model, 58, 2018
4TMU
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CRYSTAL STRUCTURE OF RECQ CATALYTIC CORE FROM C. SAKAZAKII BOUND TO DNA
Descriptor:RecQ, DNA (29-MER), ZINC ION
Authors:Manthei, K.A., Keck, J.L.
Deposit date:2014-06-02
Release date:2015-03-11
Last modified:2015-04-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural mechanisms of DNA binding and unwinding in bacterial RecQ helicases.
Proc.Natl.Acad.Sci.USA, 112, 2015
5DFZ
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STRUCTURE OF VPS34 COMPLEX II FROM S. CEREVISIAE.
Descriptor:Vacuolar protein sorting-associated protein 38, Phosphatidylinositol 3-kinase VPS34, Serine/threonine-protein kinase VPS15, ...
Authors:Rostislavleva, K., Soler, N., Ohashi, Y., Zhang, L., Williams, R.L.
Deposit date:2015-08-27
Release date:2015-10-07
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (4.4 Å)
Cite:Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes.
Science, 350, 2015
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