Author results

4V8A
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THE STRUCTURE OF THERMORUBIN IN COMPLEX WITH THE 70S RIBOSOME FROM THERMUS THERMOPHILUS.
Descriptor:23S ribosomal RNA, 5S ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Bulkley, D., Johnson, F.A., Steitz, T.A.
Deposit date:2011-12-05
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The antibiotic thermorubin inhibits protein synthesis by binding to inter-subunit bridge b2a of the ribosome.
J.Mol.Biol., 416, 2012
4PLX
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CRYSTAL STRUCTURE OF THE TRIPLE-HELICAL STABILITY ELEMENT AT THE 3' END OF MALAT1
Descriptor:Core ENE hairpin and A-rich tract from MALAT1
Authors:Brown, J.A., Bulkley, D., Wang, J., Valenstein, M.L., Yario, T.A., Steitz, T.A., Steitz, J.A.
Deposit date:2014-05-19
Release date:2014-06-25
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural insights into the stabilization of MALAT1 noncoding RNA by a bipartite triple helix.
Nat.Struct.Mol.Biol., 21, 2014
4W2F
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH AMICOUMACIN, MRNA AND THREE DEACYLATED TRNAS IN THE A, P AND E SITES
Descriptor:16S Ribosomal RNA, 30S Ribosomal Protein S2, 30S Ribosomal Protein S3, ...
Authors:Polikanov, Y.S., Osterman, I.A., Szal, T., Tashlitsky, V.N., Serebryakova, M.V., Kusochek, P., Bulkley, D., Malanicheva, I.A., Efimenko, T.A., Efremenkova, O.V., Konevega, A.L., Shaw, K.J., Bogdanov, A.A., Rodnina, M.V., Dontsova, O.A., Mankin, A.S., Steitz, T.A., Sergiev, P.V.
Deposit date:2014-09-12
Release date:2014-10-15
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome.
Mol.Cell, 56, 2014
4W2G
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH PACTAMYCIN (SOAKED), MRNA AND THREE DEACYLATED TRNAS IN THE A, P AND E SITES
Descriptor:16S Ribosomal RNA, 30S Ribosomal Protein S2, 30S Ribosomal Protein S3, ...
Authors:Polikanov, Y.S., Osterman, I.A., Szal, T., Tashlitsky, V.N., Serebryakova, M.V., Kusochek, P., Bulkley, D., Malanicheva, I.A., Efimenko, T.A., Efremenkova, O.V., Konevega, A.L., Shaw, K.J., Bogdanov, A.A., Rodnina, M.V., Dontsova, O.A., Mankin, A.S., Steitz, T.A., Sergiev, P.V.
Deposit date:2014-09-12
Release date:2014-10-15
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome.
Mol.Cell, 56, 2014
4W2H
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH PACTAMYCIN (CO-CRYSTALLIZED), MRNA AND DEACYLATED TRNA IN THE P SITE
Descriptor:16S Ribosomal RNA, 30S Ribosomal Protein S2, 30S Ribosomal Protein S3, ...
Authors:Polikanov, Y.S., Osterman, I.A., Szal, T., Tashlitsky, V.N., Serebryakova, M.V., Kusochek, P., Bulkley, D., Malanicheva, I.A., Efimenko, T.A., Efremenkova, O.V., Konevega, A.L., Shaw, K.J., Bogdanov, A.A., Rodnina, M.V., Dontsova, O.A., Mankin, A.S., Steitz, T.A., Sergiev, P.V.
Deposit date:2014-09-12
Release date:2014-10-15
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome.
Mol.Cell, 56, 2014
5T4D
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CRYO-EM STRUCTURE OF POLYCYSTIC KIDNEY DISEASE PROTEIN 2 (PKD2), RESIDUES 198-703
Descriptor:hPKD:198-703, Polycystin-2, N-ACETYL-D-GLUCOSAMINE
Authors:Shen, P.S., Yang, X., DeCaen, P.G., Liu, X., Bulkley, D., Clapham, D.E., Cao, E.
Deposit date:2016-08-29
Release date:2016-11-02
Last modified:2017-11-08
Method:ELECTRON MICROSCOPY (3 Å)
Cite:The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs.
Cell, 167, 2016
5VKQ
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STRUCTURE OF A MECHANOTRANSDUCTION ION CHANNEL DROSOPHILA NOMPC IN NANODISC
Descriptor:No mechanoreceptor potential C isoform L, 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE
Authors:Jin, P., Bulkley, D., Guo, Y., Zhang, W., Guo, Z., Huynh, W., Wu, S., Meltzer, S., Chen, T., Jan, L.Y., Jan, Y.-N., Cheng, Y.
Deposit date:2017-04-22
Release date:2017-06-28
Last modified:2017-09-20
Method:ELECTRON MICROSCOPY (3.55 Å)
Cite:Electron cryo-microscopy structure of the mechanotransduction channel NOMPC.
Nature, 547, 2017
6BGI
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CRYO-EM STRUCTURE OF THE TMEM16A CALCIUM-ACTIVATED CHLORIDE CHANNEL IN NANODISC
Descriptor:Anoctamin-1, CALCIUM ION
Authors:Dang, S., Feng, S., Tien, J., Peters, C.J., Bulkley, D., Lolicato, M., Zhao, J., Zuberbuhler, K., Ye, W., Qi, J., Chen, T., Craik, C.S., Jan, Y.N., Minor Jr., D.L., Cheng, Y., Jan, L.Y.
Deposit date:2017-10-28
Release date:2017-12-27
Last modified:2018-01-17
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryo-EM structures of the TMEM16A calcium-activated chloride channel.
Nature, 552, 2017
6BGJ
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CRYO-EM STRUCTURE OF THE TMEM16A CALCIUM-ACTIVATED CHLORIDE CHANNEL IN LMNG
Descriptor:Anoctamin-1, CALCIUM ION
Authors:Dang, S., Feng, S., Tien, J., Peters, C.J., Bulkley, D., Lolicato, M., Zhao, J., Zuberbuhler, K., Ye, W., Qi, L., Chen, T., Craik, C.S., Jan, Y.N., Minor Jr., D.L., Cheng, Y., Jan, L.Y.
Deposit date:2017-10-28
Release date:2017-12-27
Last modified:2018-04-11
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryo-EM structures of the TMEM16A calcium-activated chloride channel.
Nature, 552, 2017
4V7W
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STRUCTURE OF THE THERMUS THERMOPHILUS RIBOSOME COMPLEXED WITH CHLORAMPHENICOL.
Descriptor:16S rRNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Bulkley, D.P., Innis, C.A., Blaha, G., Steitz, T.A.
Deposit date:2010-08-16
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:Revisiting the structures of several antibiotics bound to the bacterial ribosome.
Proc.Natl.Acad.Sci.USA, 107, 2010
4V7X
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STRUCTURE OF THE THERMUS THERMOPHILUS RIBOSOME COMPLEXED WITH ERYTHROMYCIN.
Descriptor:16S rRNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Bulkley, D.P., Innis, C.A., Blaha, G., Steitz, T.A.
Deposit date:2010-08-17
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:Revisiting the structures of several antibiotics bound to the bacterial ribosome.
Proc.Natl.Acad.Sci.USA, 107, 2010
4V7Y
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STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME COMPLEXED WITH AZITHROMYCIN.
Descriptor:16S rRNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Bulkley, D.P., Innis, C.A., Blaha, G., Steitz, T.A.
Deposit date:2010-08-18
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:Revisiting the structures of several antibiotics bound to the bacterial ribosome.
Proc.Natl.Acad.Sci.USA, 107, 2010
4V7Z
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STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME COMPLEXED WITH TELITHROMYCIN.
Descriptor:16S rRNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Bulkley, D.P., Innis, C.A., Blaha, G., Steitz, T.A.
Deposit date:2010-08-18
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Revisiting the structures of several antibiotics bound to the bacterial ribosome.
Proc.Natl.Acad.Sci.USA, 107, 2010
4V9R
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CRYSTAL STRUCTURE OF ANTIBIOTIC DITYROMYCIN BOUND TO 70S RIBOSOME
Descriptor:16S Ribosomal RNA, 30S Ribosomal Protein S2, 30S Ribosomal Protein S3, ...
Authors:Bulkley, D.P., Brandi, L., Polikanov, Y.S., Fabbretti, A., O'Connor, M., Gualerzi, C.O., Steitz, T.A.
Deposit date:2013-12-05
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:The antibiotics dityromycin and GE82832 bind protein S12 and block EF-G-catalyzed translocation.
Cell Rep, 6, 2014
4V9S
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CRYSTAL STRUCTURE OF ANTIBIOTIC GE82832 BOUND TO 70S RIBOSOME
Descriptor:16S Ribosomal RNA, 30S Ribosomal Protein S2, 30S Ribosomal Protein S3, ...
Authors:Bulkley, D.P., Brandi, L., Polikanov, Y.S., Fabbretti, A., O'Connor, M., Gualerzi, C.O., Steitz, T.A.
Deposit date:2013-12-05
Release date:2014-07-09
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The antibiotics dityromycin and GE82832 bind protein S12 and block EF-G-catalyzed translocation.
Cell Rep, 6, 2014
4V95
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CRYSTAL STRUCTURE OF YAEJ BOUND TO THE 70S RIBOSOME
Descriptor:16S Ribosomal RNA, 30S Ribosomal Protein S2, 30S Ribosomal Protein S3, ...
Authors:Gagnon, M.G., Seetharaman, S.V., Bulkley, D.P., Steitz, T.A.
Deposit date:2012-01-27
Release date:2014-07-09
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis for the rescue of stalled ribosomes: structure of YaeJ bound to the ribosome.
Science, 335, 2012
6MG8
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STRUCTURAL BASIS FOR CHOLESTEROL TRANSPORT-LIKE ACTIVITY OF THE HEDGEHOG RECEPTOR PATCHED
Descriptor:Protein patched homolog 1, UNKNOWN LIGAND
Authors:Zhang, Y., Bulkley, D., Xin, Y., Roberts, K.J., Asarnow, D.E., Sharma, A., Myers, B.R., Cho, W., Cheng, Y., Beachy, P.A.
Deposit date:2018-09-13
Release date:2018-11-28
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched.
Cell, 175, 2018
6D1W
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HUMAN PKD2 F604P MUTANT
Descriptor:Polycystin-2, N-ACETYL-D-GLUCOSAMINE
Authors:Zheng, W., Yang, X., Bulkley, D., Chen, X.Z., Cao, E.
Deposit date:2018-04-12
Release date:2018-06-27
Method:ELECTRON MICROSCOPY (3.54 Å)
Cite:Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels.
Nat Commun, 9, 2018
4DTJ
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RB69 DNA POLYMERASE TERNARY COMPLEX WITH DTTP OPPOSITE AN ABASIC SITE AND DDT/DA AS THE PENULTIMATE BASE-PAIR
Descriptor:DNA polymerase, DNA template, DNA primer, ...
Authors:Xia, S., Wang, J., Konigsberg, W.H.
Deposit date:2012-02-21
Release date:2012-06-06
Last modified:2012-09-05
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Contribution of Partial Charge Interactions and Base Stacking to the Efficiency of Primer Extension at and beyond Abasic Sites in DNA.
Biochemistry, 51, 2012
4DTM
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RB69 DNA POLYMERASE TERNARY COMPLEX WITH DCTP OPPOSITE AN ABASIC SITE AND DDG/DC AS THE PENULTIMATE BASE-PAIR
Descriptor:DNA polymerase, DNA template, DNA primer, ...
Authors:Xia, S., Wang, J., Konigsberg, W.H.
Deposit date:2012-02-21
Release date:2012-06-06
Last modified:2012-09-05
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Contribution of Partial Charge Interactions and Base Stacking to the Efficiency of Primer Extension at and beyond Abasic Sites in DNA.
Biochemistry, 51, 2012
4DTN
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RB69 DNA POLYMERASE TERNARY COMPLEX WITH DATP OPPOSITE AN ABASIC SITE AND DDA/DT AS THE PENULTIMATE BASE-PAIR
Descriptor:DNA polymerase, DNA template, DNA primer, ...
Authors:Xia, S., Wang, J., Konigsberg, W.H.
Deposit date:2012-02-21
Release date:2012-06-06
Last modified:2012-09-05
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Contribution of Partial Charge Interactions and Base Stacking to the Efficiency of Primer Extension at and beyond Abasic Sites in DNA.
Biochemistry, 51, 2012
4DTO
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RB69 DNA POLYMERASE TERNARY COMPLEX WITH DCTP OPPOSITE AN ABASIC SITE AND DDA/DT AS THE PENULTIMATE BASE-PAIR
Descriptor:DNA polymerase, DNA template, DNA primer, ...
Authors:Xia, S., Wang, J., Konigsberg, W.H.
Deposit date:2012-02-21
Release date:2012-06-06
Last modified:2012-09-05
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Contribution of Partial Charge Interactions and Base Stacking to the Efficiency of Primer Extension at and beyond Abasic Sites in DNA.
Biochemistry, 51, 2012
4DTP
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RB69 DNA POLYMERASE TERNARY COMPLEX WITH DGTP OPPOSITE AN ABASIC SITE AND DDA/DT AS THE PENULTIMATE BASE-PAIR
Descriptor:DNA polymerase, DNA template, DNA primer, ...
Authors:Xia, S., Wang, J., Konigsberg, W.H.
Deposit date:2012-02-21
Release date:2012-06-06
Last modified:2012-09-05
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Contribution of Partial Charge Interactions and Base Stacking to the Efficiency of Primer Extension at and beyond Abasic Sites in DNA.
Biochemistry, 51, 2012
4DTR
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RB69 DNA POLYMERASE TERNARY COMPLEX WITH DATP OPPOSITE AN ABASIC SITE AND DDC/DG AS THE PENULTIMATE BASE-PAIR
Descriptor:DNA polymerase, DNA template, DNA primer, ...
Authors:Xia, S., Wang, J., Konigsberg, W.H.
Deposit date:2012-02-21
Release date:2012-06-06
Last modified:2012-09-05
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Contribution of Partial Charge Interactions and Base Stacking to the Efficiency of Primer Extension at and beyond Abasic Sites in DNA.
Biochemistry, 51, 2012
4DTS
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RB69 DNA POLYMERASE TERNARY COMPLEX WITH DCTP OPPOSITE AN ABASIC SITE AND DDC/DG AS THE PENULTIMATE BASE-PAIR
Descriptor:DNA polymerase, DNA template, DNA primer, ...
Authors:Xia, S., Wang, J., Konigsberg, W.H.
Deposit date:2012-02-21
Release date:2012-06-06
Last modified:2012-09-05
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Contribution of Partial Charge Interactions and Base Stacking to the Efficiency of Primer Extension at and beyond Abasic Sites in DNA.
Biochemistry, 51, 2012
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