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4JE5
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BU of 4je5 by Molmil
Crystal structure of the aromatic aminotransferase Aro8, a putative alpha-aminoadipate aminotransferase in Saccharomyces cerevisiae
Descriptor: 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Aromatic/aminoadipate aminotransferase 1, ...
Authors:Bulfer, S.L, Brunzelle, J.S, Trievel, R.C.
Deposit date:2013-02-26
Release date:2013-09-11
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.909 Å)
Cite:Crystal structure of Saccharomyces cerevisiae Aro8, a putative alpha-aminoadipate aminotransferase.
Protein Sci., 22, 2013
3TY3
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BU of 3ty3 by Molmil
Crystal structure of homoisocitrate dehydrogenase from Schizosaccharomyces pombe bound to glycyl-glycyl-glycine
Descriptor: GLYCEROL, Probable homoisocitrate dehydrogenase, glycylglycylglycine
Authors:Bulfer, S.L, Hendershot, J.M, Trievel, R.C.
Deposit date:2011-09-23
Release date:2011-11-09
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of homoisocitrate dehydrogenase from Schizosaccharomyces pombe.
Proteins, 80, 2012
3TY4
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BU of 3ty4 by Molmil
Crystal structure of homoisocitrate dehydrogenase from Schizosaccharomyces pombe
Descriptor: GLYCEROL, Probable homoisocitrate dehydrogenase
Authors:Bulfer, S.L, Hendershot, J.M, Trievel, R.C.
Deposit date:2011-09-23
Release date:2011-11-09
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structure of homoisocitrate dehydrogenase from Schizosaccharomyces pombe.
Proteins, 80, 2012
3MI3
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BU of 3mi3 by Molmil
Homocitrate Synthase Lys4 bound to Lysine
Descriptor: Homocitrate synthase, mitochondrial, LYSINE, ...
Authors:Bulfer, S.L, Scott, E.M, Pillus, L, Trievel, R.C.
Deposit date:2010-04-09
Release date:2010-04-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Structural Basis for L-lysine Feedback Inhibition of Homocitrate Synthase
J.Biol.Chem., 285, 2010
3IVS
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BU of 3ivs by Molmil
Homocitrate Synthase Lys4
Descriptor: COBALT (II) ION, Homocitrate synthase, mitochondrial, ...
Authors:Bulfer, S.L, Scott, E.M, Couture, J.-F, Pillus, L, Trievel, R.C.
Deposit date:2009-09-01
Release date:2009-09-22
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis.
J.Biol.Chem., 284, 2009
3IVU
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BU of 3ivu by Molmil
Homocitrate Synthase Lys4 bound to 2-OG
Descriptor: 2-OXOGLUTARIC ACID, COBALT (II) ION, Homocitrate synthase, ...
Authors:Bulfer, S.L, Scott, E.M, Couture, J.-F, Pillus, L, Trievel, R.C.
Deposit date:2009-09-01
Release date:2009-09-22
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis.
J.Biol.Chem., 284, 2009
3IVT
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BU of 3ivt by Molmil
Homocitrate Synthase Lys4 bound to 2-OG
Descriptor: 2-OXOGLUTARIC ACID, Homocitrate synthase, mitochondrial, ...
Authors:Bulfer, S.L, Scott, E.M, Couture, J.-F, Pillus, L, Trievel, R.C.
Deposit date:2009-09-01
Release date:2009-09-22
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis.
J.Biol.Chem., 284, 2009
5FTM
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BU of 5ftm by Molmil
Cryo-EM structure of human p97 bound to ATPgS (Conformation II)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
Authors:Banerjee, S, Bartesaghi, A, Merk, A, Rao, P, Bulfer, S.L, Yan, Y, Green, N, Mroczkowski, B, Neitz, R.J, Wipf, P, Falconieri, V, Deshaies, R.J, Milne, J.L.S, Huryn, D, Arkin, M, Subramaniam, S.
Deposit date:2016-01-14
Release date:2016-01-27
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:2.3 A Resolution Cryo-Em Structure of Human P97 and Mechanism of Allosteric Inhibition
Science, 351, 2016
5FTK
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BU of 5ftk by Molmil
Cryo-EM structure of human p97 bound to ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE
Authors:Banerjee, S, Bartesaghi, A, Merk, A, Rao, P, Bulfer, S.L, Yan, Y, Green, N, Mroczkowski, B, Neitz, R.J, Wipf, P, Falconieri, V, Deshaies, R.J, Milne, J.L.S, Huryn, D, Arkin, M, Subramaniam, S.
Deposit date:2016-01-14
Release date:2016-01-27
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:2.3 A Resolution Cryo-Em Structure of Human P97 and Mechanism of Allosteric Inhibition
Science, 351, 2016
5FTL
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BU of 5ftl by Molmil
Cryo-EM structure of human p97 bound to ATPgS (Conformation I)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE
Authors:Banerjee, S, Bartesaghi, A, Merk, A, Rao, P, Bulfer, S.L, Yan, Y, Green, N, Mroczkowski, B, Neitz, R.J, Wipf, P, Falconieri, V, Deshaies, R.J, Milne, J.L.S, Huryn, D, Arkin, M, Subramaniam, S.
Deposit date:2016-01-14
Release date:2016-01-27
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:2.3 A Resolution Cryo-Em Structure of Human P97 and Mechanism of Allosteric Inhibition
Science, 351, 2016
5FTJ
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BU of 5ftj by Molmil
Cryo-EM structure of human p97 bound to UPCDC30245 inhibitor
Descriptor: 1-(3-(5-FLUORO-1H-INDOL-2-YL)PHENYL)PIPERIDIN-4-YL)(2-(4-ISOPROPYL-PIPERAZIN1-YL)ETHYL)-CARBAMATE, ADENOSINE-5'-DIPHOSPHATE, TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE
Authors:Banerjee, S, Bartesaghi, A, Merk, A, Rao, P, Bulfer, S.L, Yan, Y, Green, N, Mroczkowski, B, Neitz, R.J, Wipf, P, Falconieri, V, Deshaies, R.J, Milne, J.L.S, Huryn, D, Arkin, M, Subramaniam, S.
Deposit date:2016-01-14
Release date:2016-01-27
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (2.3 Å)
Cite:2.3 A Resolution Cryo-Em Structure of Human P97 and Mechanism of Allosteric Inhibition
Science, 351, 2016
5FTN
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BU of 5ftn by Molmil
Cryo-EM structure of human p97 bound to ATPgS (Conformation III)
Descriptor: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE
Authors:Banerjee, S, Bartesaghi, A, Merk, A, Rao, P, Bulfer, S.L, Yan, Y, Green, N, Mroczkowski, B, Neitz, R.J, Wipf, P, Falconieri, V, Deshaies, R.J, Milne, J.L.S, Huryn, D, Arkin, M, Subramaniam, S.
Deposit date:2016-01-14
Release date:2016-01-27
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:2.3 A Resolution Cryo-Em Structure of Human P97 and Mechanism of Allosteric Inhibition
Science, 351, 2016
7TNH
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BU of 7tnh by Molmil
Crystal structure of CSF1R kinase domain in complex with DP-6233
Descriptor: 2,2-dimethyl-N-[(6-methyl-5-{[2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl]oxy}pyridin-2-yl)carbamoyl]propanamide, CHLORIDE ION, Macrophage colony-stimulating factor 1 receptor,Fibroblast growth factor receptor 1 chimera, ...
Authors:Edwards, T.E, Arakaki, T.L, Chun, L, Flynn, D.L.
Deposit date:2022-01-21
Release date:2022-08-24
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Discovery of acyl ureas as highly selective small molecule CSF1R kinase inhibitors.
Bioorg.Med.Chem.Lett., 74, 2022
6MOB
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BU of 6mob by Molmil
Crystal structure of KIT1 in complex with DP2976 via co-crystallization
Descriptor: Mast/stem cell growth factor receptor Kit, N-{4-chloro-5-[1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl]-2-fluorophenyl}-N'-phenylurea, NITRATE ION
Authors:Edwards, T.E, Abendroth, J, Safford, K, Chun, L.
Deposit date:2018-10-04
Release date:2019-07-31
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Ripretinib (DCC-2618) Is a Switch Control Kinase Inhibitor of a Broad Spectrum of Oncogenic and Drug-Resistant KIT and PDGFRA Variants.
Cancer Cell, 35, 2019

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