Author results

5AGR
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CRYSTAL STRUCTURE OF THE LEURS EDITING DOMAIN OF MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH THE ADDUCT (S)-3-(AMINOMETHYL)-7-ETHOXYBENZO[C][1,2]OXABOROL-1(3H)-OL-AMP
Descriptor:LEUCINE--TRNA LIGASE, METHIONINE, LEUCINE, ...
Authors:Palencia, A., Li, X., Alley, M.R.K., Ding, C., Easom, E.E., Hernandez, V., Meewan, M., Mohan, M., Rock, F.L., Franzblau, S.G., Wang, Y., Lenaerts, A.J., Parish, T., Cooper, C.B., Waters, M.G., Ma, Z., Mendoza, A., Barros, D., Cusack, S., Plattner, J.J.
Deposit date:2015-02-03
Release date:2016-03-02
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium Tuberculosis that Target Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
5AGT
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CRYSTAL STRUCTURE OF THE LEURS EDITING DOMAIN OF MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH THE ADDUCT (S)-3-(AMINOMETHYL)-4-CHLORO-7-ETHOXYBENZO[C][1,2]OXABOROL-1(3H)-OL-AMP
Descriptor:LEUCINE--TRNA LIGASE, METHIONINE, 4-Chloro-3-aminomethyl-7-[ethoxy]-3H-benzo[C][1,2]oxaborol-1-ol modified adenosine, ...
Authors:Palencia, A., Li, X., Alley, M.R.K., Ding, C., Easom, E.E., Hernandez, V., Meewan, M., Mohan, M., Rock, F.L., Franzblau, S.G., Wang, Y., Lenaerts, A.J., Parish, T., Cooper, C.B., Waters, M.G., Ma, Z., Mendoza, A., Barros, D., Cusack, S., Plattner, J.J.
Deposit date:2015-02-03
Release date:2016-03-02
Last modified:2016-10-05
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium Tuberculosis that Target Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
5AGS
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CRYSTAL STRUCTURE OF THE LEURS EDITING DOMAIN OF MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH THE ADDUCT 3-(AMINOMETHYL)-4-BROMO-7-ETHOXYBENZO[C][1,2]OXABOROL-1(3H)-OL-AMP
Descriptor:LEUCYL-TRNA SYNTHETASE, METHIONINE, 3-(AMINOMETHYL)-4-BROMO-7-ETHOXYBENZO[C][1,2]OXABOROL-1(3H)-OL-MODIFIED ADENOSINE
Authors:Palencia, A., Li, X., Alley, M.R.K., Ding, C., Easom, E.E., Hernandez, V., Meewan, M., Mohan, M., Rock, F.L., Franzblau, S.G., Wang, Y., Lenaerts, A.J., Parish, T., Cooper, C.B., Waters, M.G., Ma, Z., Mendoza, A., Barros, D., Cusack, S., Plattner, J.J.
Deposit date:2015-02-03
Release date:2016-03-09
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium Tuberculosis that Target Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
3KVV
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TRAPPING OF AN OXOCARBENIUM ION INTERMEDIATE IN UP CRYSTALS
Descriptor:Uridine phosphorylase, 5-FLUOROURACIL, SULFATE ION, ...
Authors:Paul, D., O'Leary, S., Rajashankar, K., Bu, W., Toms, A., Settembre, E., Sanders, J., Begley, T.P., Ealick, S.E.
Deposit date:2009-11-30
Release date:2010-04-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Glycal formation in crystals of uridine phosphorylase.
Biochemistry, 49, 2010
3U90
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APOFERRITIN: COMPLEX WITH SDS
Descriptor:Ferritin light chain, DODECYL SULFATE, CADMIUM ION
Authors:Liu, R., Bu, W., Xi, J., Mortazavi, S.R., Cheung-Lau, J.C., Dmochowski, I.J., Loll, P.J.
Deposit date:2011-10-17
Release date:2012-04-25
Last modified:2013-01-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Beyond the detergent effect: a binding site for sodium dodecyl sulfate (SDS) in mammalian apoferritin.
Acta Crystallogr.,Sect.D, 68, 2012
1U1G
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STRUCTURE OF E. COLI URIDINE PHOSPHORYLASE COMPLEXED TO 5-(M-(BENZYLOXY)BENZYL)BARBITURIC ACID (BBBA)
Descriptor:Uridine phosphorylase, POTASSIUM ION, 1-((2-HYDROXYETHOXY)METHYL)-5-(3-(BENZYLOXY)BENZYL)-6-HYDROXYPYRIMIDINE-2,4(1H,3H)-DIONE
Authors:Bu, W., Settembre, E.C., Ealick, S.E.
Deposit date:2004-07-15
Release date:2005-07-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural basis for inhibition of Escherichia coli uridine phosphorylase by 5-substituted acyclouridines.
Acta Crystallogr.,Sect.D, 61, 2005
1U1D
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STRUCTURE OF E. COLI URIDINE PHOSPHORYLASE COMPLEXED TO 5-(PHENYLTHIO)ACYCLOURIDINE (PTAU)
Descriptor:Uridine phosphorylase, PHOSPHATE ION, POTASSIUM ION, ...
Authors:Bu, W., Settembre, E.C., Ealick, S.E.
Deposit date:2004-07-15
Release date:2005-07-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Structural basis for inhibition of Escherichia coli uridine phosphorylase by 5-substituted acyclouridines.
Acta Crystallogr.,Sect.D, 61, 2005
1U1E
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STRUCTURE OF E. COLI URIDINE PHOSPHORYLASE COMPLEXED TO 5(PHENYLSELENO)ACYCLOURIDINE (PSAU)
Descriptor:Uridine phosphorylase, PHOSPHATE ION, POTASSIUM ION, ...
Authors:Bu, W., Settembre, E.C., Ealick, S.E.
Deposit date:2004-07-15
Release date:2005-07-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Structural basis for inhibition of Escherichia coli uridine phosphorylase by 5-substituted acyclouridines.
Acta Crystallogr.,Sect.D, 61, 2005
3KU4
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TRAPPING OF AN OXOCARBENIUM ION INTERMEDIATE IN UP CRYSTALS
Descriptor:Uridine phosphorylase, SULFATE ION
Authors:Paul, D., O'Leary, S., Rajashankar, K., Bu, W., Toms, A., Settembre, E., Sanders, J., Begley, T.P., Ealick, S.E.
Deposit date:2009-11-26
Release date:2010-04-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:Glycal formation in crystals of uridine phosphorylase.
Biochemistry, 49, 2010
4DE6
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HORSE SPLEEN APO-FERRITIN COMPLEX WITH ARACHIDONIC ACID
Descriptor:Ferritin light chain, ARACHIDONIC ACID, CADMIUM ION, ...
Authors:Bu, W., Liu, R., Dmochowski, I.J., Loll, P.J., Eckenhoff, R.G.
Deposit date:2012-01-19
Release date:2012-03-07
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Ferritin couples iron and fatty acid metabolism.
Faseb J., 26, 2012
1TGV
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STRUCTURE OF E. COLI URIDINE PHOSPHORYLASE COMPLEXED WITH 5-FLUOROURIDINE AND SULFATE
Descriptor:uridine phosphorylase, SULFATE ION, POTASSIUM ION, ...
Authors:Bu, W., Settembre, E.C., Sanders, J.M., Begley, T.P., Ealick, S.E.
Deposit date:2004-05-31
Release date:2005-06-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structures of E. coli Uridine Phosphorylase
To be Published, 2004
1TGY
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STRUCTURE OF E. COLI URIDINE PHOSPHORYLASE COMPLEXED WITH URACIL AND RIBOSE 1-PHOSPHATE
Descriptor:uridine phosphorylase, RIBOSE-1-PHOSPHATE, POTASSIUM ION, ...
Authors:Bu, W., Settembre, E.C., Sanders, J.M., Begley, T.P., Ealick, S.E.
Deposit date:2004-05-31
Release date:2005-06-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structures of E. coli Uridine Phosphorylase
To be Published, 2004
1U1C
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STRUCTURE OF E. COLI URIDINE PHOSPHORYLASE COMPLEXED TO 5-BENZYLACYCLOURIDINE (BAU)
Descriptor:Uridine phosphorylase, PHOSPHATE ION, POTASSIUM ION, ...
Authors:Bu, W., Settembre, E.C., Ealick, S.E.
Deposit date:2004-07-15
Release date:2005-07-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for inhibition of Escherichia coli uridine phosphorylase by 5-substituted acyclouridines.
Acta Crystallogr.,Sect.D, 61, 2005
3ZJT
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TERNARY COMPLEX OF E.COLI LEUCYL-TRNA SYNTHETASE, TRNA(LEU)574 AND THE BENZOXABOROLE AN3017 IN THE EDITING CONFORMATION
Descriptor:LEUCYL-TRNA SYNTHETASE, TRNALEU5 UAA ISOACCEPTOR, MAGNESIUM ION
Authors:Cusack, S., Palencia, A., Crepin, T., Hernandez, V., Akama, T., Baker, S.J., Bu, W., Feng, L., Freund, Y.R., Liu, L., Meewan, M., Mohan, M., Mao, W., Rock, F.L., Sexton, H., Sheoran, A., Zhang, Y., Zhang, Y., Zhou, Y., Nieman, J.A., Anugula, M.R., Keramane, E.M., Savariraj, K., Reddy, D.S., Sharma, R., Subedi, R., Singh, R., OLeary, A., Simon, N.L., DeMarsh, P.L., Mushtaq, S., Warner, M., Livermore, D.M., Alley, M.R.K., Plattner, J.J.
Deposit date:2013-01-18
Release date:2013-04-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery of a Novel Class of Boron-Based Antibacterials with Activity Against Gram-Negative Bacteria.
Antimicrob.Agents Chemother., 57, 2013
4D6V
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CRYSTAL STRUCTURE OF SIGNAL TRANSDUCING PROTEIN
Descriptor:G PROTEIN BETA SUBUNIT GIB2
Authors:Ero, R., Dimitrova, V.T., Chen, Y., Bu, W., Feng, S., Liu, T., Wang, P., Xue, C., Tan, S.M., Gao, Y.G.
Deposit date:2014-11-17
Release date:2015-03-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of Gib2, a Signal-Transducing Protein Scaffold Associated with Ribosomes in Cryptococcus Neoformans.
Sci.Rep., 5, 2015
1U1F
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STRUCTURE OF E. COLI URIDINE PHOSPHORYLASE COMPLEXED TO 5-(M-(BENZYLOXY)BENZYL)ACYCLOURIDINE (BBAU)
Descriptor:Uridine phosphorylase, PHOSPHATE ION, POTASSIUM ION, ...
Authors:Bu, W., Settembre, E.C., Ealick, S.E.
Deposit date:2004-07-15
Release date:2005-07-05
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for inhibition of Escherichia coli uridine phosphorylase by 5-substituted acyclouridines.
Acta Crystallogr.,Sect.D, 61, 2005
3D26
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NORWALK P DOMAIN A-TRISACCHARIDE COMPLEX
Descriptor:58 kd capsid protein, N-ACETYL-D-GALACTOSAMINE, BETA-D-GALACTOSE, ...
Authors:Hegde, R., Bu, W.
Deposit date:2008-05-07
Release date:2008-06-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for the receptor binding specificity of Norwalk virus.
J.Virol., 82, 2008
3H0L
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STRUCTURE OF TRNA-DEPENDENT AMIDOTRANSFERASE GATCAB FROM AQUIFEX AEOLICUS
Descriptor:Glutamyl-tRNA(Gln) amidotransferase subunit A, Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Glutamyl-tRNA(Gln) amidotransferase subunit C, ...
Authors:Wu, J., Bu, W., Sheppard, K., Kitabatake, M., Soll, D., Smith, J.L.
Deposit date:2009-04-09
Release date:2009-07-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Insights into tRNA-Dependent Amidotransferase Evolution and Catalysis from the Structure of the Aquifex aeolicus Enzyme
J.Mol.Biol., 391, 2009
3KVY
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TRAPPING OF AN OXOCARBENIUM ION INTERMEDIATE IN UP CRYSTALS
Descriptor:Uridine Phosphorylase, SULFATE ION, URACIL, ...
Authors:Paul, D., O'Leary, S., Rajashankar, K., Bu, W., Toms, A., Settembre, E., Sanders, J., Begley, T.P., Ealick, S.E.
Deposit date:2009-11-30
Release date:2010-04-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Glycal formation in crystals of uridine phosphorylase.
Biochemistry, 49, 2010
3ZJV
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TERNARY COMPLEX OF E .COLI LEUCYL-TRNA SYNTHETASE, TRNA(LEU) AND THE BENZOXABOROLE AN3213 IN THE EDITING CONFORMATION
Descriptor:LEUCINE--TRNA LIGASE, TRNALEU5 UAA ISOACCEPTOR
Authors:Cusack, S., Palencia, A., Crepin, T., Hernandez, V., Akama, T., Baker, S.J., Bu, W., Feng, L., Freund, Y.R., Liu, L., Meewan, M., Mohan, M., Mao, W., Rock, F.L., Sexton, H., Sheoran, A., Zhang, Y., Zhang, Y., Zhou, Y., Nieman, J.A., Anugula, M.R., Keramane, E.M., Savariraj, K., Reddy, D.S., Sharma, R., Subedi, R., Singh, R., OLeary, A., Simon, N.L., DeMarsh, P.L., Mushtaq, S., Warner, M., Livermore, D.M., Alley, M.R.K., Plattner, J.J.
Deposit date:2013-01-18
Release date:2013-04-17
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Discovery of a Novel Class of Boron-Based Antibacterials with Activity Against Gram-Negative Bacteria.
Antimicrob.Agents Chemother., 57, 2013
1LU5
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2.4 ANGSTROM CRYSTAL STRUCTURE OF THE ASYMMETRIC PLATINUM COMPLEX {PT(AMMINE)(CYCLOHEXYLAMINE)}2+ BOUND TO A DODECAMER DNA DUPLEX
Descriptor:5'-D(*CP*CP*TP*CP*TP*GP*GP*TP*CP*TP*CP*C)-3', 5'-D(*GP*GP*AP*GP*AP*CP*CP*AP*GP*AP*GP*G)-3', CIS-(AMMINE)(CYCLOHEXYLAMINE)PLATINUM(II) COMPLEX
Authors:Silverman, A.P., Bu, W., Cohen, S.M., Lippard, S.J.
Deposit date:2002-05-21
Release date:2002-12-20
Last modified:2012-02-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:2.4-A Crystal Structure of the Asymmetric Platinum Complex {Pt(ammine)(cyclohexylamine)}2+ Bound to a Dodecamer DNA Duplex
J.Biol.Chem., 277, 2002
3ZJU
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TERNARY COMPLEX OF E .COLI LEUCYL-TRNA SYNTHETASE, TRNA(LEU) AND THE BENZOXABOROLE AN3016 IN THE EDITING CONFORMATION
Descriptor:LEUCYL-TRNA SYNTHETASE, TRNALEU5 UAA ISOACCEPTOR, MAGNESIUM ION
Authors:Cusack, S., Palencia, A., Crepin, T., Hernandez, V., Akama, T., Baker, S.J., Bu, W., Feng, L., Freund, Y.R., Liu, L., Meewan, M., Mohan, M., Mao, W., Rock, F.L., Sexton, H., Sheoran, A., Zhang, Y., Zhang, Y., Zhou, Y., Nieman, J.A., Anugula, M.R., Keramane, E.M., Savariraj, K., Reddy, D.S., Sharma, R., Subedi, R., Singh, R., OLeary, A., Simon, N.L., DeMarsh, P.L., Mushtaq, S., Warner, M., Livermore, D.M., Alley, M.R.K., Plattner, J.J.
Deposit date:2013-01-18
Release date:2013-04-17
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovery of a Novel Class of Boron-Based Antibacterials with Activity Against Gram-Negative Bacteria.
Antimicrob.Agents Chemother., 57, 2013
4MGJ
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CRYSTAL STRUCTURE OF CYTOCHROME P450 2B4 F429H IN COMPLEX WITH 4-CPI
Descriptor:Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, 4-(4-CHLOROPHENYL)IMIDAZOLE
Authors:Yang, Y., Zhang, H., Usharani, D., Bu, W., Im, S., Tarasev, M., Rwere, F., Meagher, J., Sun, C., Stuckey, J., Shaik, S., Waskell, L.
Deposit date:2013-08-28
Release date:2014-08-13
Last modified:2014-09-24
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Structural and Functional Characterization of a Cytochrome P450 2B4 F429H Mutant with an Axial Thiolate-Histidine Hydrogen Bond.
Biochemistry, 53, 2014
3BY2
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NORWALK P POLYPEPTIDE (228-523)
Descriptor:58 kd capsid protein
Authors:Hegde, R., Bu, W.
Deposit date:2008-01-15
Release date:2008-04-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for the receptor binding specificity of Norwalk virus.
J.Virol., 82, 2008
3KVR
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TRAPPING OF AN OXOCARBENIUM ION INTERMEDIATE IN UP CRYSTALS
Descriptor:Uridine phosphorylase, 5-FLUOROURACIL, SULFATE ION, ...
Authors:Paul, D., O'Leary, S., Rajashankar, K., Bu, W., Toms, A., Settembre, E., Sanders, J., Begley, T.P., Ealick, S.E.
Deposit date:2009-11-30
Release date:2010-04-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Glycal formation in crystals of uridine phosphorylase.
Biochemistry, 49, 2010
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