Author results

5TGL
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A MODEL FOR INTERFACIAL ACTIVATION IN LIPASES FROM THE STRUCTURE OF A FUNGAL LIPASE-INHIBITOR COMPLEX
Descriptor:LIPASE, N-HEXYLPHOSPHONATE ETHYL ESTER
Authors:Brzozowski, A.M., Derewenda, U., Derewenda, Z.S., Dodson, G.G., Lawson, D., Turkenburg, J.P., Bjorkling, F., Huge-Jensen, B., Patkar, S.R., Thim, L.
Deposit date:1991-10-30
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:A model for interfacial activation in lipases from the structure of a fungal lipase-inhibitor complex.
Nature, 351, 1991
1E3X
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NATIVE STRUCTURE OF CHIMAERIC AMYLASE FROM B. AMYLOLIQUEFACIENS AND B. LICHENIFORMIS AT 1.92A
Descriptor:ALPHA-AMYLASE, CALCIUM ION, SODIUM ION
Authors:Brzozowski, A.M., Lawson, D.M., Turkenburg, J.P., Bisgaard-Frantzen, H., Svendsen, A., Borchert, T.V., Dauter, Z., Wilson, K.S., Davies, G.J.
Deposit date:2000-06-26
Release date:2001-06-21
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Analysis of a Chimeric Bacterial Alpha-Amylase. High Resolution Analysis of Native and Ligand Complexes
Biochemistry, 39, 2000
1E3Z
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ACARBOSE COMPLEX OF CHIMAERIC AMYLASE FROM B. AMYLOLIQUEFACIENS AND B. LICHENIFORMIS AT 1.93A
Descriptor:ALPHA-AMYLASE, CALCIUM ION, SODIUM ION, ...
Authors:Brzozowski, A.M., Lawson, D.M., Turkenburg, J.P., Bisgaard-Frantzen, H., Svendsen, A., Borchert, T.V., Dauter, Z., Wilson, K.S., Davies, G.J.
Deposit date:2000-06-27
Release date:2001-06-21
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Structural Analysis of a Chimeric Bacterial Alpha-Amylase. High Resolution Analysis of Native and Ligand Complexes
Biochemistry, 39, 2000
1E40
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TRIS/MALTOTRIOSE COMPLEX OF CHIMAERIC AMYLASE FROM B. AMYLOLIQUEFACIENS AND B. LICHENIFORMIS AT 2.2A
Descriptor:ALPHA-AMYLASE, CALCIUM ION, SODIUM ION, ...
Authors:Brzozowski, A.M., Lawson, D.M., Turkenburg, J.P., Bisgaard-Frantzen, H., Svendsen, A., Borchert, T.V., Dauter, Z., Wilson, K.S., Davies, G.J.
Deposit date:2000-06-27
Release date:2001-06-21
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Analysis of a Chimeric Bacterial Alpha-Amylase. High Resolution Analysis of Native and Ligand Complexes
Biochemistry, 39, 2000
1E43
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NATIVE STRUCTURE OF CHIMAERIC AMYLASE FROM B. AMYLOLIQUEFACIENS AND B. LICHENIFORMIS AT 1.7A
Descriptor:ALPHA-AMYLASE, CALCIUM ION, SODIUM ION
Authors:Brzozowski, A.M., Lawson, D.M., Turkenburg, J.P., Bisgaard-Frantzen, H., Svendsen, A., Borchert, T.V., Dauter, Z., Wilson, K.S., Davies, G.J.
Deposit date:2000-06-27
Release date:2001-06-21
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Analysis of a Chimeric Bacterial Alpha-Amylase. High Resolution Analysis of Native and Ligand Complexes
Biochemistry, 39, 2000
1ERE
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HUMAN ESTROGEN RECEPTOR LIGAND-BINDING DOMAIN IN COMPLEX WITH 17BETA-ESTRADIOL
Descriptor:ESTROGEN RECEPTOR, ESTRADIOL
Authors:Brzozowski, A.M., Pike, A.C.W.
Deposit date:1997-09-08
Release date:1998-09-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Molecular basis of agonism and antagonism in the oestrogen receptor.
Nature, 389, 1997
1ERR
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HUMAN ESTROGEN RECEPTOR LIGAND-BINDING DOMAIN IN COMPLEX WITH RALOXIFENE
Descriptor:ESTROGEN RECEPTOR, RALOXIFENE
Authors:Brzozowski, A.M., Pike, A.C.W.
Deposit date:1997-09-08
Release date:1998-09-16
Last modified:2013-05-15
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular basis of agonism and antagonism in the oestrogen receptor.
Nature, 389, 1997
1GZR
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HUMAN INSULIN-LIKE GROWTH FACTOR; ESRF DATA
Descriptor:INSULIN-LIKE GROWTH FACTOR I, N-DODECYL-N,N-DIMETHYL-3-AMMONIO-1-PROPANESULFONATE
Authors:Brzozowski, A.M., Dodson, E.J., Dodson, G.G., Murshudov, G., Verma, C., Turkenburg, J.P., De Bree, F.M., Dauter, Z.
Deposit date:2002-05-28
Release date:2002-07-25
Last modified:2019-05-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Origins of the Functional Divergence of Human Insulin-Like Growth Factor-I and Insulin
Biochemistry, 41, 2002
1GZY
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HUMAN INSULIN-LIKE GROWTH FACTOR; IN-HOUSE DATA
Descriptor:INSULIN-LIKE GROWTH FACTOR I, N-DODECYL-N,N-DIMETHYL-3-AMMONIO-1-PROPANESULFONATE
Authors:Brzozowski, A.M., Dodson, E.J., Dodson, G.G., Murshudov, G., Verma, C., Turkenburg, J.P., De Bree, F.M., Dauter, Z.
Deposit date:2002-06-10
Release date:2002-07-25
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Structural Origins of the Functional Divergence of Human Insulin-Like Growth Factor-I and Insulin
Biochemistry, 41, 2002
1GZZ
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HUMAN INSULIN-LIKE GROWTH FACTOR; HAMBURG DATA
Descriptor:INSULIN-LIKE GROWTH FACTOR I, N-DODECYL-N,N-DIMETHYL-3-AMMONIO-1-PROPANESULFONATE
Authors:Brzozowski, A.M., Dodson, E.J., Dodson, G.G., Murshudov, G., Verma, C., Turkenburg, J.P., De Bree, F.M., Dauter, Z.
Deposit date:2002-06-10
Release date:2002-07-25
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Origins of the Functional Divergence of Human Insulin-Like Growth Factor-I and Insulin
Biochemistry, 41, 2002
1H02
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HUMAN INSULIN-LIKE GROWTH FACTOR; SRS DARESBURY DATA
Descriptor:INSULIN-LIKE GROWTH FACTOR I, N-DODECYL-N,N-DIMETHYL-3-AMMONIO-1-PROPANESULFONATE
Authors:Brzozowski, A.M., Dodson, E.J., Dodson, G.G., Murshudov, G., Verma, C., Turkenburg, J.P., De Bree, F.M., Dauter, Z.
Deposit date:2002-06-11
Release date:2002-07-25
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Origins of the Functional Divergence of Human Insulin-Like Growth Factor-I and Insulin
Biochemistry, 41, 2002
3TGL
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STRUCTURE AND MOLECULAR MODEL REFINEMENT OF RHIZOMUCOR MIEHEI TRIACYLGLYCERIDE LIPASE: A CASE STUDY OF THE USE OF SIMULATED ANNEALING IN PARTIAL MODEL REFINEMENT
Descriptor:TRIACYL-GLYCEROL ACYLHYDROLASE
Authors:Brady, L., Brzozowski, A.M., Derewenda, Z.S., Dodson, E.J., Dodson, G.G., Tolley, S.P., Turkenburg, J.P., Christiansen, L., Huge-Jensen, B., Norskov, L., Thim, L.
Deposit date:1991-07-29
Release date:1993-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:STRUCTURE AND MOLECULAR-MODEL REFINEMENT OF RHIZOMUCOR-MIEHEI TRIACYLGLYCERIDE LIPASE - A CASE-STUDY OF THE USE OF SIMULATED ANNEALING IN PARTIAL MODEL REFINEMENT.
Acta Crystallogr.,Sect.B, 48, 1992
1GT6
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S146A MUTANT OF THERMOMYCES (HUMICOLA) LANUGINOSA LIPASE COMPLEX WITH OLEIC ACID
Descriptor:Lipase, OLEIC ACID
Authors:Brzozowski, A.M., Yapoudjian, S., Ivanova, M.G., Patkar, S.A., Vind, J., Svendsen, A., Verger, R.
Deposit date:2002-01-11
Release date:2003-01-23
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Binding of Thermomyces (Humicola) lanuginosa lipase to the mixed micelles of cis-parinaric acid/NaTDC.
Eur. J. Biochem., 269, 2002
2WRU
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SEMI-SYNTHETIC HIGHLY ACTIVE ANALOGUE OF HUMAN INSULIN NMEALAB26-DTI- NH2
Descriptor:INSULIN A CHAIN, INSULIN B CHAIN, ACETATE ION
Authors:Brzozowski, A.M., Jiracek, J., Zakova, L., Antolikova, E., Watson, C.J., Turkenburg, J.P., Dodson, G.G.
Deposit date:2009-09-02
Release date:2010-02-09
Last modified:2013-03-20
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues.
Proc.Natl.Acad.Sci.USA, 107, 2010
2WRV
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SEMI-SYNTHETIC HIGHLY ACTIVE ANALOGUE OF HUMAN INSULIN NMEHISB26-DTI- NH2
Descriptor:INSULIN A CHAIN, INSULIN B CHAIN, ACETATE ION
Authors:Brzozowski, A.M., Jiracek, J., Zakova, L., Antolikova, E., Watson, C.J., Turkenburg, J.P., Dodson, G.G.
Deposit date:2009-09-02
Release date:2010-02-09
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues.
Proc.Natl.Acad.Sci.USA, 107, 2010
2WRW
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SEMI-SYNTHETIC HIGHLY ACTIVE ANALOGUE OF HUMAN INSULIN D-PROB26-DTI- NH2
Descriptor:INSULIN A CHAIN, INSULIN B CHAIN
Authors:Brzozowski, A.M., Jiracek, J., Zakova, L., Antolikova, E., Watson, C.J., Turkenburg, J.P., Dodson, G.G.
Deposit date:2009-09-02
Release date:2010-02-09
Last modified:2012-06-06
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues.
Proc.Natl.Acad.Sci.USA, 107, 2010
2WRX
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SEMI-SYNTHETIC ANALOGUE OF HUMAN INSULIN NMEALAB26-INSULIN AT PH 3.0
Descriptor:INSULIN A CHAIN, INSULIN B CHAIN, SODIUM ION
Authors:Brzozowski, A.M., Jiracek, J., Zakova, L., Antolikova, E., Watson, C.J., Turkenburg, J.P., Dodson, G.G.
Deposit date:2009-09-02
Release date:2010-02-09
Last modified:2012-04-04
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues.
Proc.Natl.Acad.Sci.USA, 107, 2010
2WS0
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SEMI-SYNTHETIC ANALOGUE OF HUMAN INSULIN NMEALAB26-INSULIN AT PH 7.5
Descriptor:INSULIN A CHAIN, INSULIN B CHAIN
Authors:Brzozowski, A.M., Jiracek, J., Zakova, L., Antolikova, E., Watson, C.J., Turkenburg, J.P., Dodson, G.G.
Deposit date:2009-09-03
Release date:2010-02-09
Last modified:2012-06-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues.
Proc.Natl.Acad.Sci.USA, 107, 2010
2WS1
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SEMI-SYNTHETIC ANALOGUE OF HUMAN INSULIN NMETYRB26-INSULIN IN MONOMER FORM
Descriptor:INSULIN A CHAIN, INSULIN B CHAIN, ACETATE ION
Authors:Brzozowski, A.M., Jiracek, J., Zakova, L., Antolikova, E., Watson, C.J., Turkenburg, J.P., Dodson, G.G.
Deposit date:2009-09-03
Release date:2010-02-09
Last modified:2012-04-04
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues.
Proc.Natl.Acad.Sci.USA, 107, 2010
2WS4
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SEMI-SYNTHETIC ANALOGUE OF HUMAN INSULIN PROB26-DTI IN MONOMER FORM
Descriptor:INSULIN A CHAIN, INSULIN B CHAIN
Authors:Brzozowski, A.M., Jiracek, J., Zakova, L., Antolikova, E., Watson, C.J., Turkenburg, J.P., Dodson, G.G.
Deposit date:2009-09-03
Release date:2010-02-09
Last modified:2012-04-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues.
Proc.Natl.Acad.Sci.USA, 107, 2010
2WS6
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SEMI-SYNTHETIC ANALOGUE OF HUMAN INSULIN NMETYRB26-INSULIN IN HEXAMER FORM
Descriptor:INSULIN A CHAIN, INSULIN B CHAIN, PHENOL, ...
Authors:Brzozowski, A.M., Jiracek, J., Zakova, L., Antolikova, E., Watson, C.J., Turkenburg, J.P., Dodson, G.G.
Deposit date:2009-09-03
Release date:2010-02-09
Last modified:2012-04-04
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues.
Proc.Natl.Acad.Sci.USA, 107, 2010
2WS7
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SEMI-SYNTHETIC ANALOGUE OF HUMAN INSULIN PROB26-DTI
Descriptor:INSULIN A CHAIN, INSULIN B CHAIN, PHENOL, ...
Authors:Brzozowski, A.M., Jiracek, J., Zakova, L., Antolikova, E., Watson, C.J., Turkenburg, J.P., Dodson, G.G.
Deposit date:2009-09-03
Release date:2010-02-09
Last modified:2012-06-06
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues.
Proc.Natl.Acad.Sci.USA, 107, 2010
5BOQ
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HUMAN INSULIN WITH INTRA-CHAIN CHEMICAL CROSSLINK BETWEEN MODIFIED B24 AND B29
Descriptor:Insulin, SULFATE ION
Authors:Brzozowski, A.M., Turkenburg, J.P., Jiracek, J., Zakova, L.
Deposit date:2015-05-27
Release date:2016-02-03
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Rational steering of insulin binding specificity by intra-chain chemical crosslinking.
Sci Rep, 6, 2016
5BPO
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HUMAN INSULIN WITH INTRA-CHAIN CHEMICAL CROSSLINK BETWEEN MODIFIED B27 AND B29
Descriptor:Insulin
Authors:Brzozowski, A.M., Turkenburg, J.P., Jiracek, J., Zakova, L.
Deposit date:2015-05-28
Release date:2016-02-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Rational steering of insulin binding specificity by intra-chain chemical crosslinking.
Sci Rep, 6, 2016
5BQQ
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HUMAN INSULIN WITH INTRA-CHAIN CHEMICAL CROSSLINK BETWEEN MODIFIED B27 AND B30
Descriptor:Insulin, PHENOL, ZINC ION, ...
Authors:Brzozowski, A.M., Turkenburg, J.P., Jiracek, J., Zakova, L.
Deposit date:2015-05-29
Release date:2016-02-03
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Rational steering of insulin binding specificity by intra-chain chemical crosslinking.
Sci Rep, 6, 2016