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6DDA
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BU of 6dda by Molmil
Nurr1 Covalently Modified by a Dopamine Metabolite
Descriptor: 5-hydroxy-1,2-dihydro-6H-indol-6-one, BROMIDE ION, Nuclear receptor subfamily 4 group A member 2, ...
Authors:Bruning, J.M, Wang, Y, Otrabella, F, Boxue, T, Liu, H, Bhattacharya, P, Guo, S, Holton, J.M, Fletterick, R.J, Jacobson, M.P, England, P.M.
Deposit date:2018-05-09
Release date:2019-03-20
Last modified:2019-11-06
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite.
Cell Chem Biol, 26, 2019
8CYO
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BU of 8cyo by Molmil
Nurr1 Covalently Bound to a Synthetic Ligand, 10.25, via a Disulfide Bond
Descriptor: 2-(3,4-dichlorophenoxy)-N-(2-sulfanylethyl)acetamide, CHLORIDE ION, Nuclear receptor subfamily 4 group A member 2
Authors:Bruning, J.M, Liu, J, England, P.M.
Deposit date:2022-05-24
Release date:2024-01-17
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Nurr1 Covalently Bound to a Synthetic Ligand, 10.25, via a Disulfide Bond
To Be Published
7MDP
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BU of 7mdp by Molmil
KRas G12C in complex with G-2897
Descriptor: 1,2-ETHANEDIOL, 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, 4-(trifluoromethyl)-1,3-benzothiazol-2-amine, ...
Authors:Oh, A, Frank, Y, Wang, W.
Deposit date:2021-04-05
Release date:2022-03-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Conformation-locking antibodies for the discovery and characterization of KRAS inhibitors.
Nat.Biotechnol., 40, 2022
7RA0
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BU of 7ra0 by Molmil
LC3A in complex with Fragment 2-10
Descriptor: (5-ethyl-2-methyl-1H-indol-3-yl)acetic acid, Microtubule-associated proteins 1A/1B light chain 3A
Authors:Rouge, L, Steffek, M, Helgason, E, Dueber, E, Mulvihill, M.
Deposit date:2021-06-29
Release date:2022-01-12
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:A Multifaceted Hit-Finding Approach Reveals Novel LC3 Family Ligands.
Biochemistry, 62, 2023
7R9Z
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BU of 7r9z by Molmil
LC3A in complex with Fragment 2-3
Descriptor: (5-fluoro-1H-indol-3-yl)acetic acid, Microtubule-associated proteins 1A/1B light chain 3A
Authors:Rouge, L, Steffek, M, Helgason, E, Dueber, E, Mulvihill, M.
Deposit date:2021-06-29
Release date:2022-01-12
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:A Multifaceted Hit-Finding Approach Reveals Novel LC3 Family Ligands.
Biochemistry, 62, 2023
7R9W
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BU of 7r9w by Molmil
LC3A in complex with Fragment 1-1
Descriptor: 4-phenoxybenzoic acid, GLYCEROL, Microtubule-associated proteins 1A/1B light chain 3A
Authors:Rouge, L, Steffek, M, Helgason, E, Dueber, E, Mulvihill, M.
Deposit date:2021-06-29
Release date:2022-01-12
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:A Multifaceted Hit-Finding Approach Reveals Novel LC3 Family Ligands.
Biochemistry, 62, 2023
7RP3
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BU of 7rp3 by Molmil
Crystal structure of GNE-1952 alkylated KRAS G12C in complex with 2H11 CLAMP
Descriptor: 1,2-ETHANEDIOL, 1-[4-[6-chloranyl-7-(5-methyl-1~{H}-indazol-4-yl)quinazolin-4-yl]piperazin-1-yl]propan-1-one, GLYCEROL, ...
Authors:Oh, A, Tam, C, Wang, W.
Deposit date:2021-08-03
Release date:2022-03-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Conformation-locking antibodies for the discovery and characterization of KRAS inhibitors.
Nat.Biotechnol., 40, 2022
7RP4
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BU of 7rp4 by Molmil
Crystal structure of KRAS G12C in complex with GNE-1952
Descriptor: 1-[4-[6-chloranyl-7-(5-methyl-1~{H}-indazol-4-yl)quinazolin-4-yl]piperazin-1-yl]propan-1-one, GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Oh, A, Tam, C, Wang, W.
Deposit date:2021-08-03
Release date:2022-03-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Conformation-locking antibodies for the discovery and characterization of KRAS inhibitors.
Nat.Biotechnol., 40, 2022
7RP2
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BU of 7rp2 by Molmil
Crystal structure of Kas G12C in complex with 2H11 CLAMP
Descriptor: 1,2-ETHANEDIOL, CACODYLATE ION, GTPase KRas, ...
Authors:Oh, A, Tam, C, Wang, W.
Deposit date:2021-08-03
Release date:2022-03-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Conformation-locking antibodies for the discovery and characterization of KRAS inhibitors.
Nat.Biotechnol., 40, 2022
7SD1
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BU of 7sd1 by Molmil
Crystal structure of SHOC2
Descriptor: Leucine-rich repeat protein SHOC-2
Authors:Liau, N.P.D, Hymowitz, S.G, Sudhamsu, J.
Deposit date:2021-09-29
Release date:2022-04-20
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:Structural basis for SHOC2 modulation of RAS signalling.
Nature, 609, 2022
7SD0
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BU of 7sd0 by Molmil
Cryo-EM structure of the SHOC2:PP1C:MRAS complex
Descriptor: Leucine-rich repeat protein SHOC-2, MAGNESIUM ION, MANGANESE (II) ION, ...
Authors:Liau, N.P.D, Johnson, M.C, Hymowitz, S.G, Sudhamsu, J.
Deposit date:2021-09-29
Release date:2022-04-20
Last modified:2023-11-29
Method:ELECTRON MICROSCOPY (2.95 Å)
Cite:Structural basis for SHOC2 modulation of RAS signalling.
Nature, 609, 2022

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