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3V5Z
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BU of 3v5z by Molmil
Structure of FBXL5 hemerythrin domain, C2 cell, grown anaerobically
Descriptor: F-box/LRR-repeat protein 5, MU-OXO-DIIRON
Authors:Tomchick, D.R, Bruick, R.K, Thompson, J.W, Brautigam, C.A.
Deposit date:2011-12-17
Release date:2012-01-25
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.1847 Å)
Cite:Structural and Molecular Characterization of Iron-sensing Hemerythrin-like Domain within F-box and Leucine-rich Repeat Protein 5 (FBXL5).
J.Biol.Chem., 287, 2012
3V5Y
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BU of 3v5y by Molmil
Structure of FBXL5 hemerythrin domain, P2(1) cell
Descriptor: F-box/LRR-repeat protein 5, MU-OXO-DIIRON
Authors:Tomchick, D.R, Bruick, R.K, Thompson, J.W, Brautigam, C.A.
Deposit date:2011-12-17
Release date:2012-01-25
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and Molecular Characterization of Iron-sensing Hemerythrin-like Domain within F-box and Leucine-rich Repeat Protein 5 (FBXL5).
J.Biol.Chem., 287, 2012
3V5X
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BU of 3v5x by Molmil
Structure of FBXL5 hemerythrin domain, C2 cell
Descriptor: F-box/LRR-repeat protein 5, MU-OXO-DIIRON
Authors:Tomchick, D.R, Bruick, R.K, Thompson, J.W, Brautigam, C.A.
Deposit date:2011-12-17
Release date:2012-01-25
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural and Molecular Characterization of Iron-sensing Hemerythrin-like Domain within F-box and Leucine-rich Repeat Protein 5 (FBXL5).
J.Biol.Chem., 287, 2012
3F1P
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BU of 3f1p by Molmil
Crystal structure of a high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains
Descriptor: Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1
Authors:Scheuermann, T.H, Tomchick, D.R, Machius, M, Guo, Y, Bruick, R.K, Gardner, K.H.
Deposit date:2008-10-28
Release date:2009-01-20
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.17 Å)
Cite:Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor.
Proc.Natl.Acad.Sci.USA, 106, 2009
3F1O
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BU of 3f1o by Molmil
Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains, with an internally-bound artificial ligand
Descriptor: 1,2-ETHANEDIOL, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, ...
Authors:Scheuermann, T.H, Tomchick, D.R, Machius, M, Guo, Y, Bruick, R.K, Gardner, K.H.
Deposit date:2008-10-28
Release date:2009-01-20
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.598 Å)
Cite:Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor.
Proc.Natl.Acad.Sci.USA, 106, 2009
3F1N
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BU of 3f1n by Molmil
Crystal structure of a high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains, with internally bound ethylene glycol.
Descriptor: 1,2-ETHANEDIOL, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1
Authors:Scheuermann, T.H, Tomchick, D.R, Machius, M, Guo, Y, Bruick, R.K, Gardner, K.H.
Deposit date:2008-10-28
Release date:2009-01-20
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.479 Å)
Cite:Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor.
Proc.Natl.Acad.Sci.USA, 106, 2009
1MZF
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BU of 1mzf by Molmil
Human Factor inhibiting HIF (FIH1) in Complex with 2-oxoglutarate
Descriptor: 2-OXOGLUTARIC ACID, FE (II) ION, factor inhibiting HIF1
Authors:Dann III, C.E, Bruick, R.K, Deisenhofer, J.
Deposit date:2002-10-07
Release date:2002-11-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of Factor-Inhibiting Hypoxia-Inducible Factor 1: An Asparaginyl Hydroxylase Involved in the Hypoxic Response Pathway.
Proc.Natl.Acad.Sci.USA, 99, 2002
1MZE
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BU of 1mze by Molmil
Human Factor Inhibiting HIF (FIH1)
Descriptor: D(-)-TARTARIC ACID, FE (II) ION, factor inhibiting HIF1
Authors:Dann III, C.E, Bruick, R.K, Deisenhofer, J.
Deposit date:2002-10-07
Release date:2002-11-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of Factor-Inhibiting Hypoxia-Inducible Factor 1: An Asparaginyl Hydroxylase Involved in the Hypoxic Response Pathway
Proc.Natl.Acad.Sci.USA, 99, 2002
1P97
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BU of 1p97 by Molmil
NMR structure of the C-terminal PAS domain of HIF2a
Descriptor: Endothelial PAS domain protein 1
Authors:Erbel, P.J, Card, P.B, Karakuzu, O, Bruick, R.K, Gardner, K.H.
Deposit date:2003-05-09
Release date:2004-01-13
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Structural basis for PAS domain heterodimerization in the basic helix-loop-helix-PAS transcription factor hypoxia-inducible factor.
Proc.Natl.Acad.Sci.USA, 100, 2003
4GHI
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BU of 4ghi by Molmil
Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains in complex with a benzoxadiazole antagonist
Descriptor: Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, N-(3-chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine
Authors:Scheuermann, T.H, Key, J, Tambar, U.K, Bruick, R.K, Gardner, K.H.
Deposit date:2012-08-07
Release date:2013-02-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Allosteric inhibition of hypoxia inducible factor-2 with small molecules.
Nat.Chem.Biol., 9, 2013
6MJL
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BU of 6mjl by Molmil
Crystal structure of ChREBP NLS peptide bound to importin alpha.
Descriptor: ChREBP Peptide ASN-TYR-TRP-LYS-ARG-ARG-ILE-GLU-VAL, Importin subunit alpha-1
Authors:Jung, H, Uyeda, K.
Deposit date:2018-09-21
Release date:2019-09-25
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The structure of importin alpha and the nuclear localization peptide of ChREBP, and small compound inhibitors of ChREBP-importin alpha interactions.
Biochem.J., 477, 2020
5UFP
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BU of 5ufp by Molmil
Crystal structure of PT2399 bound to HIF2a-B*:ARNT-B* complex
Descriptor: 3-({(1S)-7-[(difluoromethyl)sulfonyl]-2,2-difluoro-1-hydroxy-2,3-dihydro-1H-inden-4-yl}oxy)-5-fluorobenzonitrile, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1
Authors:Du, X.
Deposit date:2017-01-05
Release date:2017-01-25
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:On-target efficacy of a HIF-2 alpha antagonist in preclinical kidney cancer models.
Nature, 539, 2016
4XT2
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BU of 4xt2 by Molmil
Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains in complex with a tetrazole-containing antagonist
Descriptor: (5S,7R)-5,7-bis(3-bromophenyl)-4,5,6,7-tetrahydrotetrazolo[1,5-a]pyrimidine, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1
Authors:Scheuermann, T.H, Gardner, K.H.
Deposit date:2015-01-22
Release date:2015-12-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.698 Å)
Cite:Isoform-Selective and Stereoselective Inhibition of Hypoxia Inducible Factor-2.
J.Med.Chem., 58, 2015
4EQ1
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BU of 4eq1 by Molmil
Crystal Structure of the ARNT PAS-B homodimer
Descriptor: 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, Aryl hydrocarbon receptor nuclear translocator
Authors:Gardner, K.H, Key, J.M.
Deposit date:2012-04-17
Release date:2013-04-17
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Regulating the ARNT/TACC3 Axis: Multiple Approaches to Manipulating Protein/Protein Interactions with Small Molecules.
Acs Chem.Biol., 8, 2013
4GS9
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BU of 4gs9 by Molmil
Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains in complex with an inactive benzoxadiazole antagonist
Descriptor: 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, ...
Authors:Scheuermann, T.H, Gardner, K.H.
Deposit date:2012-08-27
Release date:2013-04-03
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Development of Inhibitors of the PAS-B Domain of the HIF-2 alpha Transcription Factor
J.Med.Chem., 56, 2013

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PDB entries from 2024-03-27

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