Author results

4BUL
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NOVEL HYDROXYL TRICYCLICS (E.G. GSK966587) AS POTENT INHIBITORS OF BACTERIAL TYPE IIA TOPOISOMERASES
Descriptor:DNA GYRASE SUBUNIT B, DNA GYRASE SUBUNIT A, 5'-D(*TP*GP*TP*GP*CP*GP*GP*TP*GP*TP*AP*CP*CP*TP *AP*CP*GP*GP*CP*T)-3', ...
Authors:Miles, T.J., Hennessy, A.J., Bax, B., Brooks, G., Brown, B.S., Brown, P., Cailleau, N., Chen, D., Dabbs, S., Davies, D.T., Esken, J.M., Giordano, I., Hoover, J.L., Huang, J., Jones, G.E., Sukmar, S.K.K., Spitzfaden, C., Markwell, R.E., Minthorn, E.A., Rittenhouse, S., Gwynn, M.N., Pearson, N.D.
Deposit date:2013-06-20
Release date:2013-08-07
Last modified:2017-03-15
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Novel Hydroxyl Tricyclics (E.G., Gsk966587) as Potent Inhibitors of Bacterial Type Iia Topoisomerases.
Bioorg.Med.Chem.Lett., 23, 2013
2A2K
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CRYSTAL STRUCTURE OF AN ACTIVE SITE MUTANT, C473S, OF CDC25B PHOSPHATASE CATALYTIC DOMAIN
Descriptor:M-phase inducer phosphatase 2, CHLORIDE ION, SULFATE ION
Authors:Sohn, J., Parks, J., Buhrman, G., Brown, P., Kristjansdottir, K., Safi, A., Yang, W., Edelsbrunner, H., Rudolph, J.
Deposit date:2005-06-22
Release date:2006-01-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Experimental Validation of the Docking Orientation of Cdc25 with Its Cdk2-CycA Protein Substrate.
Biochemistry, 44, 2005
1GWX
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MOLECULAR RECOGNITION OF FATTY ACIDS BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS
Descriptor:PROTEIN (PPAR-DELTA), 2-(4-{3-[1-[2-(2-CHLORO-6-FLUORO-PHENYL)-ETHYL]-3-(2,3-DICHLORO-PHENYL)-UREIDO]-PROPYL}-PHENOXY)-2-METHYL-PROPIONIC ACID
Authors:Xu, H.E., Lambert, M.H., Montana, V.G., Park, D.J., Blanchard, S., Brown, P., Sternbach, D., Lehmann, J., Bruce, G.W., Willson, T.M., Kliewer, S.A., Milburn, M.V.
Deposit date:1999-03-17
Release date:2000-03-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular recognition of fatty acids by peroxisome proliferator-activated receptors.
Mol.Cell, 3, 1999
2GWX
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MOLECULAR RECOGNITION OF FATTY ACIDS BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS
Descriptor:PROTEIN (PPAR-DELTA)
Authors:Xu, H.E., Lambert, M.H., Montana, V.G., Park, D.J., Blanchard, S., Brown, P., Sternbach, D., Lehmann, J., Bruce, G.W., Willson, T.M., Kliewer, S.A., Milburn, M.V.
Deposit date:1999-03-11
Release date:2000-03-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular recognition of fatty acids by peroxisome proliferator-activated receptors.
Mol.Cell, 3, 1999
3UR4
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CRYSTAL STRUCTURE OF HUMAN WD REPEAT DOMAIN 5 WITH COMPOUND
Descriptor:WD repeat-containing protein 5, methyl 3-[(3-methoxybenzoyl)amino]-4-(4-methylpiperazin-1-yl)benzoate, 1,2-ETHANEDIOL, ...
Authors:Dong, A., Dombrovski, L., Senisterra, G., Wernimont, A., Wasney, G.A., Allali Hassani, A., Nguyen, K.T., Smil, D., Bolshan, Y., Hajian, T., Poda, G., Chau, I., Al-Awar, R., Bountra, C., Weigelt, J., Edwards, A.M., Arrowsmith, C.H., Brown, P., Schapira, M., Vedadi, M., Wu, H., Structural Genomics Consortium (SGC)
Deposit date:2011-11-21
Release date:2011-12-14
Last modified:2018-05-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5.
Biochem. J., 449, 2013
4HC4
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HUMAN HMT1 HNRNP METHYLTRANSFERASE-LIKE PROTEIN 6 (S. CEREVISIAE)
Descriptor:Protein arginine N-methyltransferase 6, S-ADENOSYL-L-HOMOCYSTEINE, 1,2-ETHANEDIOL, ...
Authors:Dong, A., Zeng, H., He, H., El Bakkouri, M., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Wu, H., Structural Genomics Consortium (SGC)
Deposit date:2012-09-28
Release date:2012-10-17
Last modified:2018-05-16
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Structural basis of arginine asymmetrical dimethylation by PRMT6.
Biochem. J., 473, 2016
4QQK
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HUMAN HMT1 HNRNP METHYLTRANSFERASE-LIKE PROTEIN 6 (S. CEREVISIAE) WITH GMS
Descriptor:Protein arginine N-methyltransferase 6, (5S)-5-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}-N~6~-carbamimidoyl-L-lysine, GLYCEROL, ...
Authors:Dong, A., Zeng, H., He, H., Wernimont, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Min, J., Luo, M., Wu, H., Structural Genomics Consortium (SGC)
Deposit date:2014-06-27
Release date:2014-07-16
Last modified:2018-05-16
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Structural basis of arginine asymmetrical dimethylation by PRMT6.
Biochem. J., 473, 2016
5HZM
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HUMAN HMT1 HNRNP METHYLTRANSFERASE-LIKE PROTEIN 6 (S. CEREVISIAE)
Descriptor:Protein arginine N-methyltransferase 6, S-ADENOSYL-L-HOMOCYSTEINE, UNKNOWN ATOM OR ION
Authors:DONG, A., ZENG, H., WALKER, J.R., Seitova, A., Hutchinson, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., BROWN, P.J., MIN, J., WU, H., Structural Genomics Consortium (SGC)
Deposit date:2016-02-02
Release date:2016-02-17
Last modified:2018-05-16
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Structural basis of arginine asymmetrical dimethylation by PRMT6.
Biochem. J., 473, 2016
5IWI
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1.98A STRUCTURE OF GSK945237 WITH S.AUREUS DNA GYRASE AND SINGLY NICKED DNA
Descriptor:DNA gyrase subunit B,DNA gyrase subunit B, DNA gyrase subunit A, DNA (5'-D(*AP*GP*CP*CP*GP*TP*AP*GP*GP*TP*AP*CP*AP*CP*CP*GP*CP*AP*CP*A)-3'), ...
Authors:Bax, B.D., Miles, T.J.
Deposit date:2016-03-22
Release date:2016-05-25
Last modified:2016-06-29
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Novel tricyclics (e.g., GSK945237) as potent inhibitors of bacterial type IIA topoisomerases.
Bioorg.Med.Chem.Lett., 26, 2016
5IWM
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2.5A STRUCTURE OF GSK945237 WITH S.AUREUS DNA GYRASE AND DNA.
Descriptor:DNA gyrase subunit B,DNA gyrase subunit B, DNA gyrase subunit A, DNA (5'-D(*AP*GP*CP*CP*GP*TP*AP*GP*GP*TP*TP*CP*AP*CP*CP*GP*CP*AP*CP*A)-3'), ...
Authors:Bax, B.D., Miles, T.J.
Deposit date:2016-03-22
Release date:2016-05-25
Last modified:2016-06-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Novel tricyclics (e.g., GSK945237) as potent inhibitors of bacterial type IIA topoisomerases.
Bioorg.Med.Chem.Lett., 26, 2016
2MTF
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SOLUTION STRUCTURE OF THE LA MOTIF OF HUMAN LARP6
Descriptor:La-related protein 6
Authors:Martino, L., Salisbury, N.JH., Atkinson, A.R., Kelly, G., Conte, M.R.
Deposit date:2014-08-18
Release date:2014-12-24
Last modified:2015-01-28
Method:SOLUTION NMR
Cite:Synergic interplay of the La motif, RRM1 and the interdomain linker of LARP6 in the recognition of collagen mRNA expands the RNA binding repertoire of the La module.
Nucleic Acids Res., 43, 2015
2MTG
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SOLUTION STRUCTURE OF THE RRM1 OF HUMAN LARP6
Descriptor:La-related protein 6
Authors:Martino, L., Atkinson, A.R., Kelly, G., Conte, M.R.
Deposit date:2014-08-18
Release date:2014-12-24
Last modified:2015-01-28
Method:SOLUTION NMR
Cite:Synergic interplay of the La motif, RRM1 and the interdomain linker of LARP6 in the recognition of collagen mRNA expands the RNA binding repertoire of the La module.
Nucleic Acids Res., 43, 2015
1JII
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CRYSTAL STRUCTURE OF S. AUREUS TYRRS IN COMPLEX WITH SB-219383
Descriptor:tyrosyl-tRNA synthetase, [2-AMINO-3-(4-HYDROXY-PHENYL)-PROPIONYLAMINO]- (2,4,5,8-TETRAHYDROXY-7-OXA-2-AZA-BICYCLO[3.2.1]OCT-3-YL)- ACETIC ACID
Authors:Qiu, X., Janson, C.A., Smith, W.W., Jarvest, R.L.
Deposit date:2001-07-02
Release date:2001-10-26
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of Staphylococcus aureus tyrosyl-tRNA synthetase in complex with a class of potent and specific inhibitors.
Protein Sci., 10, 2001
1JIJ
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CRYSTAL STRUCTURE OF S. AUREUS TYRRS IN COMPLEX WITH SB-239629
Descriptor:tyrosyl-tRNA synthetase, [2-AMINO-3-(4-HYDROXY-PHENYL)-PROPIONYLAMINO]-(1,3,4,5-TETRAHYDROXY-4-HYDROXYMETHYL-PIPERIDIN-2-YL)- ACETIC ACID
Authors:Qiu, X., Janson, C.A., Smith, W.W., Jarvest, R.L.
Deposit date:2001-07-02
Release date:2001-10-26
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of Staphylococcus aureus tyrosyl-tRNA synthetase in complex with a class of potent and specific inhibitors.
Protein Sci., 10, 2001
1JIK
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CRYSTAL STRUCTURE OF S. AUREUS TYRRS IN COMPLEX WITH SB-243545
Descriptor:tyrosyl-tRNA synthetase, [2-AMINO-3-(4-HYDROXY-PHENYL)-PROPIONYLAMINO]-(1,3,4,5-TETRAHYDROXY-4-HYDROXYMETHYL-PIPERIDIN-2-YL)- ACETIC ACID BUTYL ESTER
Authors:Qiu, X., Janson, C.A., Smith, W.W., Jarvest, R.L.
Deposit date:2001-07-02
Release date:2001-10-26
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of Staphylococcus aureus tyrosyl-tRNA synthetase in complex with a class of potent and specific inhibitors.
Protein Sci., 10, 2001
1JIL
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CRYSTAL STRUCTURE OF S. AUREUS TYRRS IN COMPLEX WITH SB284485
Descriptor:tyrosyl-tRNA synthetase, [2-AMINO-3-(4-HYDROXY-PHENYL)-PROPIONYLAMINO]- (3,4,5-TRIHYDROXY-6-METHYL-TETRAHYDRO-PYRAN-2-YL)- ACETIC ACID
Authors:Qiu, X., Janson, C.A., Smith, W.W., Jarvest, R.L.
Deposit date:2001-07-02
Release date:2001-10-26
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of Staphylococcus aureus tyrosyl-tRNA synthetase in complex with a class of potent and specific inhibitors.
Protein Sci., 10, 2001
4IO2
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CRYSTAL STRUCTURE OF THE AVGLUR1 LIGAND BINDING DOMAIN COMPLEX WITH GLUTAMATE AT 1.37 ANGSTROM RESOLUTION
Descriptor:Glutamate receptor 1, CHLORIDE ION, GLUTAMIC ACID
Authors:Lomash, S., Chittori, S., Mayer, M.L.
Deposit date:2013-01-07
Release date:2013-02-20
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:Anions Mediate Ligand Binding in Adineta vaga Glutamate Receptor Ion Channels.
Structure, 21, 2013
4IO3
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CRYSTAL STRUCTURE OF THE AVGLUR1 LIGAND BINDING DOMAIN COMPLEX WITH ASPARTATE AT 1.66 ANGSTROM RESOLUTION
Descriptor:AvGluR1 ligand binding domain, ASPARTIC ACID, CHLORIDE ION
Authors:Lomash, S., Chittori, S., Mayer, M.L.
Deposit date:2013-01-07
Release date:2013-02-20
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Anions Mediate Ligand Binding in Adineta vaga Glutamate Receptor Ion Channels.
Structure, 21, 2013
4IO4
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CRYSTAL STRUCTURE OF THE AVGLUR1 LIGAND BINDING DOMAIN COMPLEX WITH SERINE AT 1.94 ANGSTROM RESOLUTION
Descriptor:AvGluR1 ligand binding domain, SERINE, CHLORIDE ION, ...
Authors:Lomash, S., Chittori, S., Mayer, M.L.
Deposit date:2013-01-07
Release date:2013-02-20
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (1.941 Å)
Cite:Anions Mediate Ligand Binding in Adineta vaga Glutamate Receptor Ion Channels.
Structure, 21, 2013
4IO5
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CRYSTAL STRUCTURE OF THE AVGLUR1 LIGAND BINDING DOMAIN COMPLEX WITH ALANINE AT 1.72 ANGSTROM RESOLUTION
Descriptor:AvGluR1 ligand binding domain, ALANINE, CHLORIDE ION
Authors:Lomash, S., Chittori, S., Mayer, M.L.
Deposit date:2013-01-07
Release date:2013-02-20
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (1.721 Å)
Cite:Anions Mediate Ligand Binding in Adineta vaga Glutamate Receptor Ion Channels.
Structure, 21, 2013
4IO6
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CRYSTAL STRUCTURE OF THE AVGLUR1 LIGAND BINDING DOMAIN COMPLEX WITH METHIONINE AT 1.6 ANGSTROM RESOLUTION
Descriptor:AvGluR1 ligand binding domain, METHIONINE, CHLORIDE ION
Authors:Lomash, S., Chittori, S., Mayer, M.L.
Deposit date:2013-01-07
Release date:2013-02-20
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Anions Mediate Ligand Binding in Adineta vaga Glutamate Receptor Ion Channels.
Structure, 21, 2013
4IO7
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CRYSTAL STRUCTURE OF THE AVGLUR1 LIGAND BINDING DOMAIN COMPLEX WITH PHENYLALANINE AT 1.9 ANGSTROM RESOLUTION
Descriptor:AvGluR1 ligand binding domain, PHENYLALANINE, CHLORIDE ION
Authors:Lomash, S., Chittori, S., Mayer, M.L.
Deposit date:2013-01-07
Release date:2013-02-20
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Anions Mediate Ligand Binding in Adineta vaga Glutamate Receptor Ion Channels.
Structure, 21, 2013
2UZQ
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PROTEIN PHOSPHATASE, NEW CRYSTAL FORM
Descriptor:M-PHASE INDUCER PHOSPHATASE 2, PHOSPHATE ION
Authors:Hillig, R.C., Eberspaecher, U.
Deposit date:2007-05-01
Release date:2008-06-24
Last modified:2014-02-05
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:New Crystal Form of Protein Phosphatase Cdc25B Triggered by Guanidinium Chloride as an Additive
To be Published