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4PLX
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CRYSTAL STRUCTURE OF THE TRIPLE-HELICAL STABILITY ELEMENT AT THE 3' END OF MALAT1
Descriptor:Core ENE hairpin and A-rich tract from MALAT1
Authors:Brown, J.A., Bulkley, D., Wang, J., Valenstein, M.L., Yario, T.A., Steitz, T.A., Steitz, J.A.
Deposit date:2014-05-19
Release date:2014-06-25
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural insights into the stabilization of MALAT1 noncoding RNA by a bipartite triple helix.
Nat.Struct.Mol.Biol., 21, 2014
6B91
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CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF HUMAN METTL16
Descriptor:U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase, SODIUM ION, 1,2-ETHANEDIOL
Authors:Ruszkowska, A., Ruszkowski, M., Dauter, Z., Brown, J.A.
Deposit date:2017-10-09
Release date:2018-04-04
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Structural insights into the RNA methyltransferase domain of METTL16.
Sci Rep, 8, 2018
6B92
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CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF HUMAN METTL16 IN COMPLEX WITH SAH
Descriptor:U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase, 1,2-ETHANEDIOL, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Ruszkowska, A., Ruszkowski, M., Dauter, Z., Brown, J.A.
Deposit date:2017-10-09
Release date:2018-04-04
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural insights into the RNA methyltransferase domain of METTL16.
Sci Rep, 8, 2018
5FP3
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CELL PENETRANT INHIBITORS OF THE JMJD2 (KDM4) AND JARID1 (KDM5) FAMILIES OF HISTONE LYSINE DEMETHYLASES
Descriptor:HUMAN LYSINE-SPECIFIC DEMETHYLASE 6B, JMJD3, 3-(4-PHENYLBUTANAMIDO)PYRIDINE-4-CARBOXYLIC ACID, ...
Authors:Chung, C.
Deposit date:2015-11-27
Release date:2016-01-27
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Cell Penetrant Inhibitors of the Kdm4 and Kdm5 Families of Histone Lysine Demethylases. 1. 3-Amino-4-Pyridine Carboxylate Derivatives.
J.Med.Chem., 59, 2016
5FP4
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CRYSTAL STRUCTURE OF HUMAN KDM4D IN COMPLEX WITH 3-(4- PHENYLBUTANAMIDO)PYRIDINE-4-CARBOXYLIC ACID
Descriptor:LYSINE-SPECIFIC DEMETHYLASE 4D, ZINC ION, FE (II) ION, ...
Authors:Chung, C.
Deposit date:2015-11-27
Release date:2016-01-27
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Cell Penetrant Inhibitors of the Kdm4 and Kdm5 Families of Histone Lysine Demethylases. 1. 3-Amino-4-Pyridine Carboxylate Derivatives.
J.Med.Chem., 59, 2016
5FP7
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CRYSTAL STRUCTURE OF HUMAN KDM4D IN COMPLEX WITH 3-4-METHYLTHIOPHEN-2- YL METHYLAMINOPYRIDINE-4-CARBOXYLIC ACID
Descriptor:LYSINE-SPECIFIC DEMETHYLASE 4D, ZINC ION, FE (II) ION, ...
Authors:Chung, C.
Deposit date:2015-11-27
Release date:2016-11-09
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives.
J. Med. Chem., 59, 2016
5FP8
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CRYSTAL STRUCTURE OF HUMAN KDM4D IN COMPLEX WITH 3-4-METHYLTHIOPHEN-2- YLMETHYLAMINOPYRIDINE-4-CARBOXYLIC ACID
Descriptor:LYSINE-SPECIFIC DEMETHYLASE 4D, ZINC ION, COBALT (II) ION, ...
Authors:Chung, C.
Deposit date:2015-11-27
Release date:2016-01-27
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Cell Penetrant Inhibitors of the Kdm4 and Kdm5 Families of Histone Lysine Demethylases. 1. 3-Amino-4-Pyridine Carboxylate Derivatives.
J.Med.Chem., 59, 2016
5FP9
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CRYSTAL STRUCTURE OF HUMAN KDM4D IN COMPLEX WITH 3-AMINOPYRIDINE-4- CARBOXYLIC ACID
Descriptor:HUMAN LYSINE-SPECIFIC DEMETHYLASE 4D JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN 3D, JUMONJI DOMAIN-CONTAINING PROTEIN 2D, JMJD2D, ...
Authors:Chung, C.
Deposit date:2015-11-27
Release date:2016-01-27
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Cell Penetrant Inhibitors of the Kdm4 and Kdm5 Families of Histone Lysine Demethylases. 1. 3-Amino-4-Pyridine Carboxylate Derivatives.
J.Med.Chem., 59, 2016
5FPA
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CRYSTAL STRUCTURE OF HUMAN KDM4D IN COMPLEX WITH 3H,4H-PYRIDO-3,4-D- PYRIMIDIN-4-ONE
Descriptor:LYSINE-SPECIFIC DEMETHYLASE 4D, ZINC ION, COBALT (II) ION, ...
Authors:Chung, C.
Deposit date:2015-11-27
Release date:2016-01-27
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Cell Penetrant Inhibitors of the Kdm4 and Kdm5 Families of Histone Lysine Demethylases. 1. 3-Amino-4-Pyridine Carboxylate Derivatives.
J.Med.Chem., 59, 2016
5FPB
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CRYSTAL STRUCTURE OF HUMAN KDM4D IN COMPLEX WITH 2-1H-PYRAZOL-4-YLOXY- 3H,4H-PYRIDO-3,4-D-PYRIMIDIN-4-ONE
Descriptor:LYSINE-SPECIFIC DEMETHYLASE 4D, ZINC ION, COBALT (II) ION, ...
Authors:Chung, C.
Deposit date:2015-11-27
Release date:2016-01-27
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Cell Penetrant Inhibitors of the Kdm4 and Kdm5 Families of Histone Lysine Demethylases. 1. 3-Amino-4-Pyridine Carboxylate Derivatives.
J.Med.Chem., 59, 2016
2IMW
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MECHANISM OF TEMPLATE-INDEPENDENT NUCLEOTIDE INCORPORATION CATALYZED BY A TEMPLATE-DEPENDENT DNA POLYMERASE
Descriptor:5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP*TP*TP*C)-3', 5'-D(*TP*AP*GP*AP*AP*TP*CP*CP*TP*TP*CP*CP*CP*CP*C)-3', DNA polymerase IV, ...
Authors:Ling, H., Yang, W.
Deposit date:2006-10-05
Release date:2007-01-16
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Mechanism of Template-independent Nucleotide Incorporation Catalyzed by a Template-dependent DNA Polymerase.
J.Mol.Biol., 365, 2007
3M9M
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CRYSTAL STRUCTURE OF DPO4 IN COMPLEX WITH DNA CONTAINING THE MAJOR CISPLATIN LESION
Descriptor:DNA polymerase IV, DNA (5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP*AP*AP*G)-3'), DNA (5'-D(*TP*CP*TP*GP*GP*CP*TP*TP*TP*CP*CP*TP*TP*CP*CP*CP*CP*C)-3'), ...
Authors:Wong, J.H.Y., Ling, H.
Deposit date:2010-03-22
Release date:2010-06-16
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural insight into dynamic bypass of the major cisplatin-DNA adduct by Y-family polymerase Dpo4.
Embo J., 29, 2010
3M9N
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CRYSTAL STRUCTURE OF DPO4 IN COMPLEX WITH DNA CONTAINING THE MAJOR CISPLATIN LESION
Descriptor:DNA polymerase IV, DNA (5'-D(*GP*GP*GP*GP*AP*AP*GP*GP*AP*AP*AP*GP*C)-3'), DNA (5'-D(*TP*CP*TP*GP*GP*CP*TP*TP*TP*CP*CP*TP*TP*CP*CP*CP*CP*C)-3'), ...
Authors:Wong, J.H.Y., Ling, H.
Deposit date:2010-03-22
Release date:2010-06-16
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Structural insight into dynamic bypass of the major cisplatin-DNA adduct by Y-family polymerase Dpo4.
Embo J., 29, 2010
3M9O
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CRYSTAL STRUCTURE OF DPO4 IN COMPLEX WITH DNA CONTAINING THE MAJOR CISPLATIN LESION
Descriptor:DNA polymerase IV, DNA (5'-D(*GP*GP*GP*AP*AP*GP*GP*AP*AP*AP*GP*CP*C)-3'), DNA (5'-D(*TP*CP*TP*GP*GP*CP*TP*TP*TP*CP*CP*TP*TP*CP*CP*CP*CP*C)-3'), ...
Authors:Wong, J.H.Y., Ling, H.
Deposit date:2010-03-22
Release date:2010-06-16
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural insight into dynamic bypass of the major cisplatin-DNA adduct by Y-family polymerase Dpo4.
Embo J., 29, 2010
5KQ5
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AMPK BOUND TO ALLOSTERIC ACTIVATOR
Descriptor:5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Calabrese, M.F., Kurumbail, R.G.
Deposit date:2016-07-05
Release date:2016-08-17
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (3.41 Å)
Cite:Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy.
J.Med.Chem., 59, 2016
6E4T
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STRUCTURE OF AMPK BOUND TO ACTIVATOR
Descriptor:5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Calabrese, M.F., Kurumbail, R.G.
Deposit date:2018-07-18
Release date:2018-08-08
Last modified:2018-09-05
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK).
J. Med. Chem., 61, 2018
6E4U
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STRUCTURE OF AMPK BOUND TO ACTIVATOR
Descriptor:5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Calabrese, M.F., Kurumbail, R.G.
Deposit date:2018-07-18
Release date:2018-08-08
Last modified:2018-09-05
Method:X-RAY DIFFRACTION (3.27 Å)
Cite:Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK).
J. Med. Chem., 61, 2018
6E4W
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STRUCTURE OF AMPK BOUND TO ACTIVATOR
Descriptor:5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Calabrese, M.F., Kurumbail, R.G.
Deposit date:2018-07-18
Release date:2018-08-08
Last modified:2018-09-05
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK).
J. Med. Chem., 61, 2018
1R42
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NATIVE HUMAN ANGIOTENSIN CONVERTING ENZYME-RELATED CARBOXYPEPTIDASE (ACE2)
Descriptor:angiotensin I converting enzyme 2, disordered segment of collectrin homology domain, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Towler, P., Staker, B., Prasad, S.G., Menon, S., Ryan, D., Tang, J., Parsons, T., Fisher, M., Williams, D., Dales, N.A., Patane, M.A., Pantoliano, M.W.
Deposit date:2003-10-07
Release date:2004-02-03
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis.
J.Biol.Chem., 279, 2004
1R4L
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INHIBITOR BOUND HUMAN ANGIOTENSIN CONVERTING ENZYME-RELATED CARBOXYPEPTIDASE (ACE2)
Descriptor:angiotensin I converting enzyme 2, disordered segment of collectrin homology domain, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Towler, P., Staker, B., Prasad, S.G., Menon, S., Ryan, D., Tang, J., Parsons, T., Fisher, M., Williams, D., Dales, N.A., Patane, M.A., Pantoliano, M.W.
Deposit date:2003-10-07
Release date:2004-02-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis.
J.Biol.Chem., 279, 2004