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2V8W
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BU of 2v8w by Molmil
Crystallographic and mass spectrometric characterisation of eIF4E with N7-cap derivatives
Descriptor: EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1, [[(2R,3S,4R,5R)-5-(6-AMINO-3-METHYL-4-OXO-5H-IMIDAZO[4,5-C]PYRIDIN-1-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHOXY-HYDROXY-PHOSPHORYL] PHOSPHONO HYDROGEN PHOSPHATE
Authors:Brown, C.J, Mcnae, I, Fischer, P.M, Walkinshaw, M.D.
Deposit date:2007-08-16
Release date:2007-08-28
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystallographic and Mass Spectrometric Characterisation of Eif4E with N(7)-Alkylated CAP Derivatives.
J.Mol.Biol., 372, 2007
2V8Y
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BU of 2v8y by Molmil
Crystallographic and mass spectrometric characterisation of eIF4E with N7-cap derivatives
Descriptor: EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1, P-FLUORO-7-BENZYL GUANINE MONOPHOSPHATE
Authors:Brown, C.J, Mcnae, I, Fischer, P.M, Walkinshaw, M.D.
Deposit date:2007-08-16
Release date:2007-08-28
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystallographic and Mass Spectrometric Characterisation of Eif4E with N(7)-Alkylated CAP Derivatives.
J.Mol.Biol., 372, 2007
2V8X
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BU of 2v8x by Molmil
Crystallographic and mass spectrometric characterisation of eIF4E with N7-cap derivatives
Descriptor: 7-BENZYL GUANINE MONOPHOSPHATE, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1
Authors:Brown, C.J, Mcnae, I, Fischer, P.M, Walkinshaw, M.D.
Deposit date:2007-08-16
Release date:2007-08-28
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystallographic and Mass Spectrometric Characterisation of Eif4E with N(7)-Alkylated CAP Derivatives.
J.Mol.Biol., 372, 2007
2W97
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BU of 2w97 by Molmil
Crystal Structure of eIF4E Bound to Glycerol and eIF4G1 peptide
Descriptor: EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 1, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, GLYCEROL, ...
Authors:Brown, C.J, Verma, C.S, Walkinshaw, M.D, Lane, D.P.
Deposit date:2009-01-22
Release date:2010-03-31
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Crystallization of eIF4E complexed with eIF4GI peptide and glycerol reveals distinct structural differences around the cap-binding site.
Cell Cycle, 8, 2009
7XTP
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BU of 7xtp by Molmil
eIF4E in Complex with a Disulphide-Free Autonomous VH Domain
Descriptor: Eukaryotic translation initiation factor 4E, VH-S4ss, [[(2R,3S,4R,5R)-5-(6-AMINO-3-METHYL-4-OXO-5H-IMIDAZO[4,5-C]PYRIDIN-1-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHOXY-HYDROXY-PHOSPHORYL] PHOSPHONO HYDROGEN PHOSPHATE
Authors:Brown, C.J, Frosi, Y, Jiang, S, Lin, Y.C.
Deposit date:2022-05-17
Release date:2022-07-27
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.828 Å)
Cite:Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex.
Nat Commun, 13, 2022
5GW6
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BU of 5gw6 by Molmil
Water-Bridge Mediates Recognition of mRNA Cap in eIF4E
Descriptor: Eukaryotic translation initiation factor 4E, GLYCEROL
Authors:Brown, C.J.
Deposit date:2016-09-08
Release date:2016-10-19
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Water-Bridge Mediates Recognition of mRNA Cap in eIF4E
Structure, 25, 2017
5XXK
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BU of 5xxk by Molmil
Structure-activity studies of Mdm2/Mdm4-binding stapled peptides comprising non-natural amino acids
Descriptor: E3 ubiquitin-protein ligase Mdm2, Hydrocarbon stapled peptide THC-SER-PHE-0EH-GLU-TYR-6CW-ALA-LEU-LEU-MK8-NH2
Authors:Brown, C.J.
Deposit date:2017-07-04
Release date:2017-12-27
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Structure-activity studies of Mdm2/Mdm4-binding stapled peptides comprising non-natural amino acids.
PLoS ONE, 12, 2017
6AAW
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BU of 6aaw by Molmil
Mdm2 in complex with a D amino Acid Containing Stapled Peptide
Descriptor: ACE-LEU-THR-PHE-STQ-GLU-TYR-DTR-GLN-LEU-CBA-MK8-SER-ALA-ALA, E3 ubiquitin-protein ligase Mdm2
Authors:Brown, C.J, Partridge, A.W.
Deposit date:2018-07-19
Release date:2019-07-24
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:A Model System to Explore Macrocyclic Peptide Structural and Chirality Relationships: Tolerance of helix-breaking residues within the context of a stapled peptide.
To Be Published
7D6Y
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BU of 7d6y by Molmil
eIF4E in Complex with a Disulphide-Free Autonomous VH Domain
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Eukaryotic translation initiation factor 4E, VH Domain (1C5), ...
Authors:Brown, C.J, Frosi, Y, Jiang, S, Lin, Y.C.
Deposit date:2020-10-02
Release date:2021-10-06
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.668 Å)
Cite:Engineering Disulphide-Free Autonomous Antibody VH Domains to modulate intracellular pathways
To Be Published
7EZW
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BU of 7ezw by Molmil
Cyclic Peptide that Interacts with the eIF4E Capped-mRNA Binding Site
Descriptor: ALA-CYS-GLU-MET-GLY-PHE-PHE-GLN-ASP-CYS-GLY, Eukaryotic translation initiation factor 4E, SODIUM ION
Authors:Brown, C.J, Ng, S, Frosi, Y.
Deposit date:2021-06-02
Release date:2022-06-08
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Development of a novel peptide aptamer that interacts with the eIF4E capped-mRNA binding site using peptide epitope linker evolution (PELE).
Rsc Chem Biol, 3, 2022
7F07
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BU of 7f07 by Molmil
Autonomous VH domain that interacts with eIF4E at the Capped mRNA Binding site.
Descriptor: Eukaryotic translation initiation factor 4E, VH domain (VH-DiFCAP-01)
Authors:Brown, C.J, Frosi, Y, Ng, S, Lin, Y.C.
Deposit date:2021-06-03
Release date:2022-06-08
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Development of a novel peptide aptamer that interacts with the eIF4E capped-mRNA binding site using peptide epitope linker evolution (PELE).
Rsc Chem Biol, 3, 2022
8GU0
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BU of 8gu0 by Molmil
Crystal structure of a fungal halogenase RadH
Descriptor: CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, Non-heme halogenase radH, ...
Authors:Jiang, S.M, Brown, C.J.
Deposit date:2022-09-09
Release date:2023-07-26
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Further Characterization of Fungal Halogenase RadH and Its Homologs.
Biomolecules, 13, 2023
6KZU
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BU of 6kzu by Molmil
Macrocyclization of an all-D linear peptide improves target affinity and imparts cellular activity: A novel stapled alpha-helical peptide modality
Descriptor: 2JN-DAL-E03-DTY-2JN-DSG-TDF-DGL-MK8-DLE-DLE-2JN, E3 ubiquitin-protein ligase Mdm2
Authors:Jiang, S, Brown, C.J.
Deposit date:2019-09-25
Release date:2019-10-16
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Macrocyclization of an all-d linear alpha-helical peptide imparts cellular permeability.
Chem Sci, 11, 2020
4UMN
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BU of 4umn by Molmil
Structure of a stapled peptide antagonist bound to Nutlin-resistant Mdm2.
Descriptor: E3 ubiquitin-protein ligase Mdm2, M06
Authors:Chee, S, Wongsantichon, J, Quah, S, Robinson, R.C, Verma, C, Lane, D.P, Brown, C.J, Ghadessy, F.J.
Deposit date:2014-05-20
Release date:2014-05-28
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Structure of a stapled peptide antagonist bound to nutlin-resistant Mdm2.
PLoS ONE, 9, 2014
4UD7
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BU of 4ud7 by Molmil
Structure of the stapled peptide YS-02 bound to MDM2
Descriptor: MDM2, YS-02
Authors:Tan, Y.S, Reeks, J, Brown, C.J, Jennings, C.E, Eapen, R.S, Tng, Q.S, Thean, D, Ying, Y.T, Gago, F.J.F, Lane, D.P, Noble, M.E.M, Verma, C.
Deposit date:2014-12-08
Release date:2016-01-13
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Benzene Probes in Molecular Dynamics Simulations Reveal Novel Binding Sites for Ligand Design.
J Phys Chem Lett, 7, 2016
4UE1
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BU of 4ue1 by Molmil
Structure of the stapled peptide YS-01 bound to MDM2
Descriptor: E3 UBIQUITIN-PROTEIN LIGASE MDM2, YS-01
Authors:Tan, Y.S, Reeks, J, Brown, C.J, Jennings, C.E, Eapen, R.S, Tng, Q.S, Thean, D, Ying, Y.T, Gago, F.J.F, Lane, D.P, Noble, M.E.M, Verma, C.
Deposit date:2014-12-14
Release date:2016-01-13
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Benzene Probes in Molecular Dynamics Simulations Reveal Novel Binding Sites for Ligand Design.
J Phys Chem Lett, 7, 2016
5ZK9
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BU of 5zk9 by Molmil
Stapled-peptides tailored against initiation of translation
Descriptor: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, ACE-ARG-ILE-ILE-TYR-SER-ARG-MK8-GLN-LEU-LEU-MK8-LEU-LYS-NH2, DI(HYDROXYETHYL)ETHER, ...
Authors:Lama, D, Liberator, A, Frosi, Y, Nakhle, J, Tsomia, N, Bashir, T, Lane, D.P, Brown, C.J, Verma, C.S, Auvin, S, Ciesielski, F, Uhring, M.
Deposit date:2018-03-23
Release date:2019-02-20
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein.
Chem Sci, 10, 2019
5ZK7
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BU of 5zk7 by Molmil
Stapled-peptides tailored against initiation of translation
Descriptor: 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, ACE-ARG-TYR-SER-ARG-MK8-GLN-LEU-LEU-MK8-LEU-PHE-ARG-NH2, CHLORIDE ION, ...
Authors:Lama, D, Liberator, A, Frosi, Y, Nakhle, J, Tsomia, N, Bashir, T, Lane, D.P, Brown, C.J, Verma, C.S, Auvin, S, Ciesielski, F, Uhring, M.
Deposit date:2018-03-23
Release date:2019-02-20
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein.
Chem Sci, 10, 2019
5ZML
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BU of 5zml by Molmil
Stapled-peptides tailored against initiation of translation
Descriptor: 1,2-ETHANEDIOL, ACE-LYS-LYS-ARG-TYR-SER-ARG-MK8-GLN-LEU-LEU-MK8-PHE-ARG-ARG, Eukaryotic translation initiation factor 4E, ...
Authors:Lama, D, Liberator, A, Frosi, Y, Nakhle, J, Tsomia, N, Bashir, T, Lane, D.P, Brown, C.J, Verma, C.S, Auvin, S, Yano, J.
Deposit date:2018-04-04
Release date:2019-02-20
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein.
Chem Sci, 10, 2019
5ZJY
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BU of 5zjy by Molmil
Stapled-peptides tailored against initiation of translation
Descriptor: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4E, LYS-LYS-ARG-TYR-SER-ARG-2JN-GLN-LEU-LEU-2JN-PHE
Authors:Lama, D, Liberator, A, Frosi, Y, Nakhle, J, Tsomia, N, Bashir, T, Lane, D.P, Brown, C.J, Verma, C.S, Auvin, S, Ciesielski, B, Uhring, M.
Deposit date:2018-03-22
Release date:2019-03-20
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein.
Chem Sci, 10, 2019
5ZK5
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BU of 5zk5 by Molmil
Stapled-peptides tailored against initiation of translation
Descriptor: 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4E, LYS-ARG-TYR-SER-ARG-GLU-GLN-LEU-LEU-MK8-PHE-GLN-ARG-MK8
Authors:Lama, D, Liberator, A, Frosi, Y, Nakhle, J, Tsomia, N, Bashir, T, Lane, D.P, Brown, C.J, Verma, C.S, Auvin, S, Ciesielski, F, Uhring, M.
Deposit date:2018-03-23
Release date:2019-02-20
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein.
Chem Sci, 10, 2019
5ZJZ
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BU of 5zjz by Molmil
Stapled-peptides tailored against initiation of translation
Descriptor: 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4 gamma 1, Eukaryotic translation initiation factor 4E
Authors:Lama, D, Liberator, A, Frosi, Y, Nakhle, J, Tsomia, N, Bashir, T, Lane, D.P, Brown, C.J, Verma, C.S, Auvin, S, Ciesielski, F, Uhring, M.
Deposit date:2018-03-22
Release date:2019-02-20
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein.
Chem Sci, 10, 2019
4BEA
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BU of 4bea by Molmil
Crystal Structure of eIF4E in Complex with a Stapled Peptide Derivative
Descriptor: Eukaryotic translation initiation factor 4E, STAPLED EIF4E INTERACTING PEPTIDE
Authors:Quah, S.T, Lama, D, Verma, C.S, Lane, D.P, Brown, C.J.
Deposit date:2013-03-07
Release date:2013-12-11
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:Rational Optimization of Conformational Effects Induced by Hydrocarbon Staples in Peptides and Their Binding Interfaces.
Sci.Rep., 3, 2013
4AZA
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BU of 4aza by Molmil
Improved eIF4E binding peptides by phage display guided design.
Descriptor: EIF4G1_D5S PEPTIDE, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, [[(2R,3S,4R,5R)-5-(6-AMINO-3-METHYL-4-OXO-5H-IMIDAZO[4,5-C]PYRIDIN-1-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHOXY-HYDROXY-PHOSPHORYL] PHOSPHONO HYDROGEN PHOSPHATE
Authors:Chew, W.Z, Quah, S.T, Verma, C.S, Liu, Y, Lane, D.P, Brown, C.J.
Deposit date:2012-06-25
Release date:2012-08-08
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Improved Eif4E Binding Peptides by Phage Display Guided Design: Plasticity of Interacting Surfaces Yield Collective Effects.
Plos One, 7, 2012
7D8B
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BU of 7d8b by Molmil
Engineering Disulphide-Free Autonomous Antibody VH Domains to modulate intracellular pathways
Descriptor: Eukaryotic translation initiation factor 4E, VH-S4
Authors:Frosi, Y, Lin, Y.C, Jiang, S, Brown, C.J.
Deposit date:2020-10-07
Release date:2021-08-25
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex.
Nat Commun, 13, 2022

 

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