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3PKY
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BU of 3pky by Molmil
Polymerase Domain from Mycobacterium tuberculosis Ligase D in complex with DNA, UTP and Manganese.
Descriptor: DNA 5'-D(*G*CP*CP*GP*CP*AP*AP*CP*GP*CP*AP*CP*G)-3', DNA 5'-D(P*GP*CP*GP*GP*C)-3', MANGANESE (II) ION, ...
Authors:Brissett, N.C, Fox, G.C, Pitcher, R.S, Doherty, A.J.
Deposit date:2010-11-12
Release date:2011-02-16
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of a Preternary Complex Involving a Prokaryotic NHEJ DNA Polymerase.
Mol.Cell, 41, 2011
2R9L
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BU of 2r9l by Molmil
Polymerase Domain from Mycobacterium tuberculosis Ligase D in complex with DNA
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, DNA (5'-D(*DGP*DCP*DCP*DGP*DCP*DAP*DAP*DCP*DGP*DCP*DA)-3'), ...
Authors:Brissett, N.C, Fox, G.C, Pitcher, R.S, Doherty, A.J.
Deposit date:2007-09-13
Release date:2008-01-08
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of a NHEJ polymerase-mediated DNA synaptic complex
Science, 318, 2007
6SA1
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BU of 6sa1 by Molmil
Post catalytic complex of Prim-PolC from Mycobacterium smegmatis with gapped DNA and 3'-dUTP
Descriptor: 1,2-ETHANEDIOL, 3'-DEOXY-URIDINE 5'-TRIPHOSPHATE, DNA (5'-D(*CP*GP*CP*TP*CP*GP*CP*AP*AP*CP*GP*CP*A)-3'), ...
Authors:Brissett, N.C, Doherty, A.J.
Deposit date:2019-07-15
Release date:2020-11-18
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Molecular basis for DNA repair synthesis on short gaps by mycobacterial Primase-Polymerase C.
Nat Commun, 11, 2020
6SA0
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BU of 6sa0 by Molmil
Ternary complex of Prim-PolC from Mycobacterium smegmatis with 2nt gapped DNA and UpNHpp
Descriptor: 1,2-ETHANEDIOL, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, CACODYLATE ION, ...
Authors:Brissett, N.C, Doherty, A.J.
Deposit date:2019-07-15
Release date:2020-11-18
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.209 Å)
Cite:Molecular basis for DNA repair synthesis on short gaps by mycobacterial Primase-Polymerase C.
Nat Commun, 11, 2020
4MKY
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BU of 4mky by Molmil
Polymerase Domain from Mycobacterium tuberculosis Ligase D in complex with an annealed double-strand DNA break.
Descriptor: 5'-D(*DGP*DCP*DCP*DGP*DCP*DAP*DGP*DTP*DAP*DC)-3', 5'-D(P*DGP*DCP*DGP*DGP*DC)-3', DNA ligase-like protein Rv0938/MT0965
Authors:Brissett, N.C, Doherty, A.J.
Deposit date:2013-09-05
Release date:2013-12-11
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Molecular Basis for DNA Double-Strand Break Annealing and Primer Extension by an NHEJ DNA Polymerase.
Cell Rep, 5, 2013
5OP0
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BU of 5op0 by Molmil
Structure of Prim-PolC from Mycobacterium smegmatis
Descriptor: DNA polymerase LigD, polymerase domain
Authors:Brissett, N.C, Doherty, A.J.
Deposit date:2017-08-09
Release date:2017-11-15
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:DNA Ligase C and Prim-PolC participate in base excision repair in mycobacteria.
Nat Commun, 8, 2017
5N85
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BU of 5n85 by Molmil
Structure of RPA70N in complex with PrimPol (fragment 514-525)
Descriptor: DNA-directed primase/polymerase protein, Replication protein A 70 kDa DNA-binding subunit
Authors:Brissett, N.C, Doherty, A.J.
Deposit date:2017-02-23
Release date:2017-06-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular basis for PrimPol recruitment to replication forks by RPA.
Nat Commun, 8, 2017
5N8A
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BU of 5n8a by Molmil
Structure of RPA70N in complex with PrimPol (fragment 480-560)
Descriptor: DNA-directed primase/polymerase protein, Replication protein A 70 kDa DNA-binding subunit
Authors:Brissett, N.C, Doherty, A.J.
Deposit date:2017-02-23
Release date:2017-06-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:Molecular basis for PrimPol recruitment to replication forks by RPA.
Nat Commun, 8, 2017
2IRX
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BU of 2irx by Molmil
Crystal Structure of the Polymerase Domain from Mycobacterium tuberculosis Ligase D with GTP and Manganese.
Descriptor: DNA ligase-like protein Rv0938/MT0965, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION
Authors:Brissett, N.C, Pitcher, R.S, Doherty, A.J.
Deposit date:2006-10-16
Release date:2007-01-02
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure and function of a mycobacterial NHEJ DNA repair polymerase.
J.Mol.Biol., 366, 2007
2IRU
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BU of 2iru by Molmil
Crystal Structure of the Polymerase Domain from Mycobacterium tuberculosis Ligase D
Descriptor: Putative DNA ligase-like protein Rv0938/MT0965
Authors:Brissett, N.C, Pitcher, R.S, Doherty, A.J.
Deposit date:2006-10-16
Release date:2007-01-02
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure and function of a mycobacterial NHEJ DNA repair polymerase.
J.Mol.Biol., 366, 2007
2IRY
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BU of 2iry by Molmil
Crystal Structure of the Polymerase Domain from Mycobacterium tuberculosis Ligase D with dGTP and Manganese.
Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA ligase-like protein Rv0938/MT0965, MANGANESE (II) ION
Authors:Brissett, N.C, Pitcher, R.S, Doherty, A.J.
Deposit date:2006-10-16
Release date:2007-01-02
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structure and function of a mycobacterial NHEJ DNA repair polymerase.
J.Mol.Biol., 366, 2007
4LIT
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BU of 4lit by Molmil
Structure of YcfD a Ribosomal oxygenase from Escherichia coli in complex with Cobalt and 2-oxoglutarate.
Descriptor: 2-OXOGLUTARIC ACID, 50S ribosomal protein L16 arginine hydroxylase, COBALT (II) ION
Authors:Brissett, N.C, Doherty, A.J.
Deposit date:2013-07-03
Release date:2014-05-14
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 509, 2014
4LIU
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BU of 4liu by Molmil
Structure of YcfD, a Ribosomal oxygenase from Escherichia coli.
Descriptor: 50S ribosomal protein L16 arginine hydroxylase, PHOSPHATE ION, TRIS(HYDROXYETHYL)AMINOMETHANE
Authors:Brissett, N.C, Doherty, A.J, Fox, G.C.
Deposit date:2013-07-03
Release date:2014-05-14
Last modified:2014-07-09
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 509, 2014
4LIV
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BU of 4liv by Molmil
Structure of YcfD, a Ribosomal oxygenase from Escherichia coli in complex with Cobalt and succinic acid.
Descriptor: 50S ribosomal protein L16 arginine hydroxylase, COBALT (II) ION, SUCCINIC ACID
Authors:Brissett, N.C, Doherty, A.J.
Deposit date:2013-07-03
Release date:2014-05-14
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 509, 2014
5DMU
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BU of 5dmu by Molmil
Structure of the NHEJ polymerase from Methanocella paludicola
Descriptor: 1,2-ETHANEDIOL, GLYCEROL, NHEJ Polymerase, ...
Authors:Brissett, N.C, Bartlett, E.J, Doherty, A.J.
Deposit date:2015-09-09
Release date:2015-10-07
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.949 Å)
Cite:Molecular basis for DNA strand displacement by NHEJ repair polymerases.
Nucleic Acids Res., 44, 2016
5DMP
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BU of 5dmp by Molmil
Structure of the Archaeal NHEJ Phosphoesterase from Methanocella paludicola.
Descriptor: 1,2-ETHANEDIOL, MAGNESIUM ION, Uncharacterized protein, ...
Authors:Brissett, N.C, Bartlett, E.J, Doherty, A.J.
Deposit date:2015-09-09
Release date:2015-10-07
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.793 Å)
Cite:Molecular basis for DNA strand displacement by NHEJ repair polymerases.
Nucleic Acids Res., 44, 2016
2XDV
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BU of 2xdv by Molmil
Crystal Structure of the Catalytic Domain of FLJ14393
Descriptor: 1,2-ETHANEDIOL, CADMIUM ION, MANGANESE (II) ION, ...
Authors:Krojer, T, Muniz, J.R.C, Ng, S.S, Pilka, E, Guo, K, Pike, A.C.W, Filippakopoulos, P, Knapp, S, Kavanagh, K.L, Gileadi, O, Bunkoczi, G, Yue, W.W, Niesen, F, Sobott, F, Fedorov, O, Savitsky, P, Kochan, G, Daniel, M, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Oppermann, U.
Deposit date:2010-05-07
Release date:2010-05-26
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 510, 2014
1UZ3
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BU of 1uz3 by Molmil
Crystal structure of novel protein EMSY
Descriptor: EMSY PROTEIN
Authors:Chavali, G.B, Basu, B.P, Doherty, A.J.
Deposit date:2004-03-03
Release date:2005-10-13
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Crystal Structure of the Ent Domain of Human Emsy.
J.Mol.Biol., 350, 2005
5J3S
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BU of 5j3s by Molmil
Crystal structure of the catalytic domain of human tyrosyl DNA phosphodiesterase 2 in complex with a small molecule inhibitor
Descriptor: 2,4-dioxo-10-[3-(1H-tetrazol-5-yl)phenyl]-2,3,4,10-tetrahydropyrimido[4,5-b]quinoline-8-carbonitrile, Tyrosyl-DNA phosphodiesterase 2
Authors:Hornyak, P, Pearl, L.H, Caldecott, K.W, Oliver, A.W.
Deposit date:2016-03-31
Release date:2016-05-04
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2.
Biochem.J., 473, 2016
5J42
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BU of 5j42 by Molmil
Crystal structure of m2hTDP2-CAT in complex with a small molecule inhibitor
Descriptor: 1,2-ETHANEDIOL, 10-(4-hydroxyphenyl)-2,4-dioxo-2,3,4,10-tetrahydropyrimido[4,5-b]quinoline-8-carbonitrile, GLYCEROL, ...
Authors:Hornyak, P, Pearl, L.H, Caldecott, K.W, Oliver, A.W.
Deposit date:2016-03-31
Release date:2016-05-04
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2.
Biochem.J., 473, 2016
5J3P
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BU of 5j3p by Molmil
Crystal structure of the catalytic domain of human tyrosyl DNA phosphodiesterase 2
Descriptor: GLYCEROL, MAGNESIUM ION, Tyrosyl-DNA phosphodiesterase 2
Authors:Hornyak, P, Pearl, L.H, Caldecott, K.W, Oliver, A.W.
Deposit date:2016-03-31
Release date:2016-05-04
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2.
Biochem.J., 473, 2016
5J3Z
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BU of 5j3z by Molmil
Crystal structure of m2hTDP2-CAT in complex with a small molecule inhibitor
Descriptor: 1,2-ETHANEDIOL, 2,4-dioxo-10-[3-(1H-tetrazol-5-yl)phenyl]-2,3,4,10-tetrahydropyrimido[4,5-b]quinoline-8-carbonitrile, ACETATE ION, ...
Authors:Hornyak, P, Pearl, L.H, Caldecott, K.W, Oliver, A.W.
Deposit date:2016-03-31
Release date:2016-05-04
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2.
Biochem.J., 473, 2016
4BU2
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BU of 4bu2 by Molmil
60S ribosomal protein L27A histidine hydroxylase (MINA53) in complex with Ni(II) and 2-oxoglutarate (2OG)
Descriptor: 1,2-ETHANEDIOL, 2-OXOGLUTARIC ACID, BIFUNCTIONAL LYSINE-SPECIFIC DEMETHYLASE AND HISTIDYL-HYDROXYLASE MINA, ...
Authors:Chowdhury, R, Clifton, I.J, McDonough, M.A, Ng, S.S, Pilka, E, Oppermann, U, Schofield, C.J.
Deposit date:2013-06-19
Release date:2014-05-14
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 510, 2014
4CCL
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BU of 4ccl by Molmil
X-Ray structure of E. coli ycfD
Descriptor: 50S RIBOSOMAL PROTEIN L16 ARGININE HYDROXYLASE, MANGANESE (II) ION, SULFATE ION
Authors:McDonough, M.A, Ho, C.H, Kershaw, N.J, Schofield, C.J.
Deposit date:2013-10-23
Release date:2014-04-30
Last modified:2020-06-03
Method:X-RAY DIFFRACTION (2.596 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 510, 2014
4BXF
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BU of 4bxf by Molmil
60S ribosomal protein L27A histidine hydroxylase (MINA53 Y209C) in complex with MN(II), 2-oxoglutarate (2OG) and 60S ribosomal protein L27A (RPL27A G37C) peptide fragment
Descriptor: 2-OXOGLUTARIC ACID, 60S RIBOSOMAL PROTEIN L27A, BIFUNCTIONAL LYSINE-SPECIFIC DEMETHYLASE AND HISTIDYL-HYDROXYLASE MINA, ...
Authors:Chowdhury, R, Schofield, C.J.
Deposit date:2013-07-10
Release date:2014-05-14
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 510, 2014

 

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