Author results

4NXJ
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CRYSTAL STRUCTURE OF PF3D7_1475600, A BROMODOMAIN FROM PLASMODIUM FALCIPARUM
分子名称:Bromodomain protein
著者Wernimont, A.K., Loppnau, P., Knapp, S., Fonseca, M., Brennan, P.E., Dong, A., Walker, J.R., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Hui, R., Hutchinson, A., Structural Genomics Consortium (SGC)
登録日2013-12-09
公開日2014-03-19
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.18 Å)
主引用文献Crystal Structure of PF3D7_1475600, a bromodomain from Plasmodium Falciparum
TO BE PUBLISHED
4PY6
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CRYSTAL STRUCTURE OF BROMODOMAIN OF PFA0510W FROM PLASMODIUM FALCIPARUM
分子名称:Bromodomain protein, putative, 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide, ...
著者Fonseca, M., Tallant, C., Hutchinson, A., Savitsky, P., Krojer, T., Filippakopoulos, P., Loppnau, P., Brennan, P.E., von Delft, F., Dong, A., Josling, G.A., Duffy, M.F., Arrowsmith, C.H., Bountra, C., Hui, R., Knapp, S., Wernimont, A.K., Structural Genomics Consortium (SGC)
登録日2014-03-26
公開日2014-04-30
最終更新日2014-05-07
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal Structure of bromodomain of PFA0510w from Plasmodium Falciparum
To be Published
4URA
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CRYSTAL STRUCTURE OF HUMAN JMJD2A IN COMPLEX WITH COMPOUND 14A
分子名称:LYSINE-SPECIFIC DEMETHYLASE 4A, 1,2-ETHANEDIOL, SULFATE ION, ...
著者Krojer, T., England, K.S., Vollmar, M., Crawley, L., Williams, E., Riesebos, E., Szykowska, A., Burgess-Brown, N., Oppermann, U., Brennan, P.E., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.
登録日2014-06-27
公開日2015-06-17
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.23 Å)
主引用文献Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor.
Medchemcomm, 5, 2014
4XDL
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CRYSTAL STRUCTURE OF HUMAN TWO PORE DOMAIN POTASSIUM ION CHANNEL TREK2 (K2P10.1) IN COMPLEX WITH A BROMINATED FLUOXETINE DERIVATIVE.
分子名称:Potassium channel subfamily K member 10, POTASSIUM ION, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ...
著者Mackenzie, A., Pike, A.C.W., Dong, Y.Y., Mukhopadhyay, S., Ruda, G.F., Brennan, P.E., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Burgess-Brown, N.A., Carpenter, E.P., Structural Genomics Consortium (SGC)
登録日2014-12-19
公開日2015-03-18
最終更新日2018-01-10
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.
Science, 347, 2015
4Z6H
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CRYSTAL STRUCTURE OF BRD9 BROMODOMAIN IN COMPLEX WITH A VALEROLACTAM QUINOLONE LIGAND
分子名称:Bromodomain-containing protein 9, 1,4-dimethyl-7-(2-oxopiperidin-1-yl)quinolin-2(1H)-one
著者Tallant, C., Structural Genomics Consortium (SGC), Clark, P.G.K., Vieira, L.C.C., Krojer, T., Nunez-Alonso, G., Picaud, S., Fedorov, O., Dixon, D.J., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Brennan, P.E., Knapp, S.
登録日2015-04-05
公開日2015-05-20
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor.
Angew.Chem.Int.Ed.Engl., 54, 2015
4Z6I
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CRYSTAL STRUCTURE OF BRD9 BROMODOMAIN IN COMPLEX WITH A SUBSTITUTED VALEROLACTAM QUINOLONE LIGAND
分子名称:Bromodomain-containing protein 9, tert-butyl [(2R,3S)-1-(1,4-dimethyl-2-oxo-1,2-dihydroquinolin-7-yl)-6-oxo-2-phenylpiperidin-3-yl]carbamate
著者Tallant, C., Structural Genomics Consortium (SGC), Clark, P.G.K., Vieira, L.C.C., Newman, J.A., Krojer, T., Nunez-Alonso, G., Picaud, S., Fedorov, O., Dixon, D.J., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Brennan, P.E., Knapp, S.
登録日2015-04-05
公開日2015-05-20
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor.
Angew.Chem.Int.Ed.Engl., 54, 2015
4ZQL
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CRYSTAL STRUCTURE OF TRIM24 WITH 3,4-DIMETHOXY-N-(6-(4-METHOXYPHENOXY)-1,3-DIMETHYL-2-OXO-2,3-DIHYDRO-1H-BENZO[D]IMIDAZOL-5-YL)BENZENESULFONAMIDE INHIBITOR
分子名称:Transcription intermediary factor 1-alpha, ZINC ION, SULFATE ION, ...
著者Tallant, C., Structural Genomics Consortium (SGC), Clark, P.G.K., Vieira, L.C.C., Krojer, T., Nunez-Alonso, G., Picaud, S., Fedorov, O., Dixon, D.J., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Brennan, P.E., Knapp, S.
登録日2015-05-10
公開日2015-06-17
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Crystal structure of TRIM24 with 3,4-dimethoxy-N-(6-(4-methoxyphenoxy)-1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)benzenesulfonamide inhibitor
To Be Published
5BT3
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CRYSTAL STRUCTURE OF EP300 BROMODOMAIN IN COMPLEX WITH SGC-CBP30 CHEMICAL PROBE
分子名称:Histone acetyltransferase p300, 2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(2S)-2-(morpholin-4-yl)propyl]-1H-benzimidazole, ISOPROPYL ALCOHOL
著者Tallant, C., Hay, D., Krojer, T., Nunez-Alonso, G., Picaud, S., Newman, J.A., Fedorov, O., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Brennan, P.E., Knapp, S., Structural Genomics Consortium (SGC)
登録日2015-06-02
公開日2015-07-01
実験手法X-RAY DIFFRACTION (1.05 Å)
主引用文献Crystal structure of EP300 bromodomain in complex with a 3,5-dimethylisoxazol ligand
To Be Published
5BT4
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CRYSTAL STRUCTURE OF BRD4 FIRST BROMODOMAIN IN COMPLEX WITH SGC-CBP30 CHEMICAL PROBE
分子名称:Bromodomain-containing protein 4, 2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(2S)-2-(morpholin-4-yl)propyl]-1H-benzimidazole, 1,2-ETHANEDIOL
著者Tallant, C., Hay, D., Krojer, T., Nunez-Alonso, G., Picaud, S., Newman, J.A., Fedorov, O., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Brennan, P.E., Knapp, S., Structural Genomics Consortium (SGC)
登録日2015-06-02
公開日2015-07-01
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Crystal structure of BRD4 first bromodomain in complex with a 3,5-dimethylisoxazol ligand
To Be Published
5BT5
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CRYSTAL STRUCTURE OF BRD2 SECOND BROMODOMAIN IN COMPLEX WITH SGC-CBP30 CHEMICAL PROBE
分子名称:Bromodomain-containing protein 2, 1,2-ETHANEDIOL, 2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(2S)-2-(morpholin-4-yl)propyl]-1H-benzimidazole
著者Tallant, C., Hay, D., Krojer, T., Nunez-Alonso, G., Picaud, S., Newman, J.A., Fedorov, O., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Brennan, P.E., Knapp, S., Structural Genomics Consortium (SGC)
登録日2015-06-02
公開日2015-07-01
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Crystal structure of BRD2 second bromodomain in complex with a 3,5-dimethylisoxazol ligand
To Be Published
5E9V
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CRYSTAL STRUCTURE OF BRD9 BROMODOMAIN IN COMPLEX WITH AN INDOLIZINE LIGAND
分子名称:Bromodomain-containing protein 9, 1-[1-(imidazo[1,2-a]pyridin-5-yl)-7-(morpholin-4-yl)indolizin-3-yl]ethanone, 1,2-ETHANEDIOL
著者Tallant, C., Hay, D.A., Krojer, T., Nunez-Alonso, G., Picaud, S., Fedorov, O., Schofield, C.J., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Brennan, P.E., Knapp, S.
登録日2015-10-15
公開日2015-10-28
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of BRD9 bromodomain in complex with an indolizine ligand
To Be Published
5FBX
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CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH PNZ5 ISOXAZOLE INHIBITOR
分子名称:Bromodomain-containing protein 4, (3~{S})-5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methyl-3-phenyl-3~{H}-isoindol-1-one
著者Tallant, C., Clark, P.G.K., Siejka, P., Fedorov, O., Nowak, R., Srikannathasan, V., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Muller, S., Brennan, P.E., Dixon, D., Knapp, S.
登録日2015-12-14
公開日2015-12-30
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Crystal structure of the first bromodomain of human BRD4 in complex with PNZ5 isoxazole inhibitor
To Be Published
5FG5
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN BRPF1 IN COMPLEX WITH PFI-4 CHEMICAL PROBE
分子名称:Peregrin, ~{N}-(1,3-dimethyl-2-oxidanylidene-6-pyrrolidin-1-yl-benzimidazol-5-yl)-2-methoxy-benzamide, NITRATE ION
著者Tallant, C., Owen, D.R., Gerstenberger, B.S., Savitsky, P., Chaikuad, A., Fedorov, O., Nunez-Alonso, G., Filippakopoulos, P., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Muller, S., Brennan, P.E., Knapp, S.
登録日2015-12-20
公開日2015-12-30
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Crystal structure of the bromodomain of human BRPF1 in complex with PFI-4 chemical probe
To Be Published
5FH6
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CRYSTAL STRUCTURE OF THE FIFTH BROMODOMAIN OF HUMAN PB1 IN COMPLEX WITH COMPOUND 10
分子名称:Protein polybromo-1, (3~{R})-3-(piperidin-1-ylmethyl)-2,3-dihydro-1~{H}-pyrrolo[1,2-a]quinazolin-5-one
著者Tallant, C., Sutherell, C.L., Siejka, P., Krojer, T., Picaud, S., Fonseca, M., Fedorov, O., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Brennan, P.E., Ley, S.V., Knapp, S.
登録日2015-12-21
公開日2016-06-01
最終更新日2016-06-08
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Identification and Development of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex.
J.Med.Chem., 59, 2016
5FH7
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CRYSTAL STRUCTURE OF THE FIFTH BROMODOMAIN OF HUMAN PB1 IN COMPLEX WITH COMPOUND 18
分子名称:Protein polybromo-1, 1,2-ETHANEDIOL, 6-chloranyl-3-[(dimethylamino)methyl]-4~{H}-pyrrolo[1,2-a]quinazolin-5-one
著者Tallant, C., Sutherell, C.L., Siejka, P., Sorrell, F.J., Krojer, T., Picaud, S., Fedorov, O., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Brennan, P.E., Ley, S.V., Knapp, S.
登録日2015-12-21
公開日2016-06-01
最終更新日2016-06-08
実験手法X-RAY DIFFRACTION (1.47 Å)
主引用文献Identification and Development of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex.
J.Med.Chem., 59, 2016
5FH8
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CRYSTAL STRUCTURE OF THE FIFTH BROMODOMAIN OF HUMAN PB1 IN COMPLEX WITH COMPOUND 28
分子名称:Protein polybromo-1, 6-chloranyl-3-(2-ethylbutyl)-4~{H}-pyrrolo[1,2-a]quinazolin-5-one, DIMETHYL SULFOXIDE, ...
著者Tallant, C., Sutherell, C.L., Siejka, P., Sorrell, F.J., Krojer, T., Picaud, S., Fedorov, O., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Brennan, P.E., Ley, S.V., Knapp, S.
登録日2015-12-21
公開日2016-06-01
最終更新日2016-06-08
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Identification and Development of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex.
J.Med.Chem., 59, 2016
5FZ0
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN JARID1B IN COMPLEX WITH 2,5-DICHLORO-N-(PYRIDIN-3-YL)THIOPHENE-3-CARBOXAMIDE (N08137B) (LIGAND MODELLED BASED ON PANDDA EVENT MAP, SGC - DIAMOND I04-1 FRAGMENT SCREENING)
分子名称:LYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, DIMETHYL SULFOXIDE, ...
著者Nowak, R., Krojer, T., Pearce, N., Johansson, C., Gileadi, C., Kupinska, K., Strain-Damerell, C., Szykowska, A., Burgess-Brown, N.A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., von Delft, F., Brennan, P.E., Oppermann, U.
登録日2016-03-10
公開日2016-04-06
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.42 Å)
主引用文献Crystal Structure of the Catalytic Domain of Human Jarid1B in Complex with N11213A
To be Published
5FZ1
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN JARID1B IN COMPLEX WITH MAYBRIDGE FRAGMENT 2,4-DICHLORO-N-PYRIDIN-3-YLBENZAMIDE (E48115B) (LIGAND MODELLED BASED ON PANDDA EVENT MAP)
分子名称:LYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, DIMETHYL SULFOXIDE, ...
著者Nowak, R., Krojer, T., Johansson, C., Gileadi, C., Kupinska, K., Strain-Damerell, C., Szykowska, A., Burgess-Brown, N.A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., von Delft, F., Brennan, P.E., Oppermann, U.
登録日2016-03-10
公開日2016-05-04
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.39 Å)
主引用文献Crystal Structure of the Catalytic Domain of Human Jarid1B in Complex with E48115B
To be Published
5FZ3
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN JARID1B IN COMPLEX WITH MAYBRIDGE FRAGMENT 3,6-DIHYDROXYBENZONORBORNANE (N08776B) (LIGAND MODELLED BASED ON PANDDA EVENT MAP)
分子名称:LYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, DIMETHYL SULFOXIDE, ...
著者Nowak, R., Krojer, T., Johansson, C., Gileadi, C., Kupinska, K., Strain-Damerell, C., Szykowska, A., Pearce, N., Talon, R., Collins, P., Burgess-Brown, N.A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., von Delft, F., Brennan, P.E., Oppermann, U.
登録日2016-03-10
公開日2016-03-23
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal Structure of the Catalytic Domain of Human Jarid1B in Complex with N08776B
To be Published
5FZ4
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN JARID1B IN COMPLEX WITH 3D FRAGMENT (3R)-1-[(3-PHENYL-1,2,4-OXADIAZOL-5-YL)METHYL]PYRROLIDIN-3-OL (N10057A) (LIGAND MODELLED BASED ON PANDDA EVENT MAP, SGC - DIAMOND I04-1 FRAGMENT SCREENING)
分子名称:LYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, (3S)-1-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]pyrrolidin-3-ol, ...
著者Nowak, R., Krojer, T., Pearce, N., Talon, R., Collins, P., Johansson, C., Gileadi, C., Kupinska, K., Strain-Damerell, C., Szykowska, A., Burgess-Brown, N.A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., von Delft, F., Brennan, P.E., Oppermann, U.
登録日2016-03-10
公開日2016-03-23
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献Crystal Structure of the Catalytic Domain of Human Jarid1B in Complex with N10057A
To be Published
5FZ6
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN JARID1B IN COMPLEX WITH MAYBRIDGE FRAGMENT N05859B (LIGAND MODELLED BASED ON PANDDA EVENT MAP, SGC - DIAMOND I04-1 FRAGMENT SCREENING)
分子名称:LYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, DIMETHYL SULFOXIDE, ...
著者Nowak, R., Krojer, T., Johansson, C., Kupinska, K., Szykowska, A., Pearce, N., Talon, R., Collins, P., Gileadi, C., Strain-Damerell, C., Burgess-Brown, N.A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., von Delft, F., Brennan, P.E., Oppermann, U.
登録日2016-03-11
公開日2016-03-23
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.33 Å)
主引用文献Crystal Structure of the Catalytic Domain of Human Jarid1B in Complex with Maybridge Fragment N05859B (Ligand Modelled Based on Pandda Event Map, Sgc - Diamond I04-1 Fragment Screening)
To be Published
5FZ7
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN JARID1B IN COMPLEX WITH MAYBRIDGE FRAGMENT ETHYL 2-AMINO-4-THIOPHEN-2-YLTHIOPHENE-3- CARBOXYLATE (N06131B) (LIGAND MODELLED BASED ON PANDDA EVENT MAP, SGC - DIAMOND I04-1 FRAGMENT SCREENING)
分子名称:LYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, DIMETHYL SULFOXIDE, ...
著者Nowak, R., Krojer, T., Johansson, C., Kupinska, K., Szykowska, A., Pearce, N., Talon, R., Collins, P., Gileadi, C., Strain-Damerell, C., Burgess-Brown, N.A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., von Delft, F., Brennan, P.E., Oppermann, U.
登録日2016-03-11
公開日2016-03-23
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal Structure of the Catalytic Domain of Human Jarid1B in Complex with Maybridge Fragment Ethyl 2-Amino-4-Thiophen-2-Ylthiophene-3-Carboxylate (N06131B) (Ligand Modelled Based on Pandda Event Map, Sgc - Diamond I04-1 Fragment Screening)
To be Published
5FZ9
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN JARID1B IN COMPLEX WITH MAYBRIDGE FRAGMENT THIENO(3,2-B)THIOPHENE-5-CARBOXYLIC ACID (N06263B) (LIGAND MODELLED BASED ON PANDDA EVENT MAP, SGC - DIAMOND I04-1 FRAGMENT SCREENING)
分子名称:LYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, DIMETHYL SULFOXIDE, ...
著者Nowak, R., Krojer, T., Johansson, C., Kupinska, K., Szykowska, A., Pearce, N., Talon, R., Collins, P., Gileadi, C., Strain-Damerell, C., Burgess-Brown, N.A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., von Delft, F., Brennan, P.E., Oppermann, U.
登録日2016-03-12
公開日2016-03-30
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Crystal Structure of the Catalytic Domain of Human Jarid1B in Complex with Maybridge Fragment Thieno(3,2-B)Thiophene -5-Carboxylic Acid (N06263B) (Ligand Modelled Based on Pandda Event Map, Sgc - Diamond I04-1 Fragment Screening)
To be Published
5FZA
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN JARID1B IN COMPLEX WITH 3D FRAGMENT 2-PIPERIDIN-4-YLOXY-5-(TRIFLUOROMETHYL)PYRIDINE (N10072A) (LIGAND MODELLED BASED ON PANDDA EVENT MAP)
分子名称:LYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, CHLORIDE ION, ...
著者Nowak, R., Krojer, T., Pearce, N., Johansson, C., Gileadi, C., Kupinska, K., Strain-Damerell, C., Szykowska, A., Burgess-Brown, N.A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., von Delft, F., Brennan, P.E., Oppermann, U.
登録日2016-03-12
公開日2016-03-30
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.099 Å)
主引用文献Crystal Structure of the Catalytic Domain of Human Jarid1B in Complex with 3D Fragment 2-Piperidin-4-Yloxy-5-(Trifluoromethyl)Pyridine (N10072A) (Ligand Modelled Based on Pandda Event Map)
To be Published
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN JARID1B IN COMPLEX WITH MAYBRIDGE FRAGMENT 4-PYRIDYLTHIOUREA (N06275B) (LIGAND MODELLED BASED ON PANDDA EVENT MAP, SGC - DIAMOND I04-1 FRAGMENT SCREENING)
分子名称:LYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, DIMETHYL SULFOXIDE, ...
著者Nowak, R., Krojer, T., Johansson, C., Kupinska, K., Szykowska, A., Pearce, N., Talon, R., Collins, P., Gileadi, C., Strain-Damerell, C., Burgess-Brown, N.A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., von Delft, F., Brennan, P.E., Oppermann, U.
登録日2016-03-12
公開日2016-03-30
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.18 Å)
主引用文献Crystal Structure of the Catalytic Domain of Human Jarid1B in Complex with Maybridge Fragment 4-Pyridylthiourea (N06275B) (Ligand Modelled Based on Pandda Event Map, Sgc -Diamond I04-1 Fragment Screening)
To be Published