Author results

5L6Y
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IL13 IN COMPLEX WITH TRALOKINUMAB
分子名称:Interleukin-13, tralokinumab FAb digest VH, tralokiumab FAb digest VL, ...
著者Breed, J.
登録日2016-06-01
公開日2016-12-21
最終更新日2017-01-25
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Structural Characterisation Reveals Mechanism of IL-13-Neutralising Monoclonal Antibody Tralokinumab as Inhibition of Binding to IL-13R alpha 1 and IL-13R alpha 2.
J. Mol. Biol., 429, 2017
2YER
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SYNTHESIS AND EVALUATION OF TRIAZOLONES AS CHECKPOINT KINASE 1 INHIBITORS
分子名称:SERINE/THREONINE-PROTEIN KINASE CHK1, 5-(HYDROXYMETHYL)-8-(1H-PYRROL-2-YL)-2H-[1,2,4]TRIAZOLO[4,3-A]QUINOLIN-1-ONE, SULFATE ION, ...
著者Read, J.A., Breed, J., Haye, H., McCall, E., Vallentine, A., White, A., Otterbein, L.
登録日2011-03-30
公開日2012-03-14
最終更新日2018-04-04
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献Synthesis and Evaluation of Triazolones as Checkpoint Kinase 1 Inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
2YEX
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SYNTHESIS AND EVALUATION OF TRIAZOLONES AS CHECKPOINT KINASE 1 INHIBITORS
分子名称:SERINE/THREONINE-PROTEIN KINASE CHK1, GLYCEROL, 5-METHYL-8-(1H-PYRROL-2-YL)[1,2,4]TRIAZOLO[4,3-A]QUINOLIN-1(2H)-ONE, ...
著者Read, J.A., Breed, J., Haye, H., McCall, E., Vallentine, A., White, A.
登録日2011-03-31
公開日2012-03-14
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Synthesis and Evaluation of Triazolones as Checkpoint Kinase 1 Inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
1G29
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MALK
分子名称:MALTOSE TRANSPORT PROTEIN MALK, AMMONIUM ION, CHLORIDE ION, ...
著者Diederichs, K., Diez, J., Greller, G., Mueller, C., Breed, J., Schnell, C., Vonrhein, C., Boos, W., Welte, W.
登録日2000-10-18
公開日2000-12-06
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of MalK, the ATPase subunit of the trehalose/maltose ABC transporter of the archaeon Thermococcus litoralis.
EMBO J., 19, 2000
2BAL
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P38ALPHA MAP KINASE BOUND TO PYRAZOLOAMINE
分子名称:Mitogen-activated protein kinase 14, [5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL][3-(PIPERIDIN-4-YLOXY)PHENYL]METHANONE
著者Gerhardt, S., Pauptit, R.A., Read, J., Tucker, J., Norman, R.A., Breed, J.
登録日2005-10-14
公開日2005-12-06
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Prevention of MKK6-Dependent Activation by Binding to p38alpha MAP Kinase.
Biochemistry, 44, 2005
2BAQ
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P38ALPHA BOUND TO RO3201195
分子名称:Mitogen-activated protein kinase 14, [5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL](3-{[(2R)-2,3-DIHYDROXYPROPYL]OXY}PHENYL)METHANONE
著者Gerhardt, S., Pauptit, R.A., Breed, J., Read, J., Tucker, J., Norman, R.A.
登録日2005-10-14
公開日2005-12-06
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Prevention of MKK6-Dependent Activation by Binding to p38alpha MAP Kinase.
Biochemistry, 44, 2005
2BGD
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STRUCTURE-BASED DESIGN OF PROTEIN TYROSINE PHOSPHATASE-1B INHIBITORS
分子名称:PROTEIN-TYROSINE PHOSPHATASE NON-RECEPTOR TYPE 1, 5-(4-METHOXYBIPHENYL-3-YL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE, CHLORIDE ION, ...
著者Black, E., Breed, J., Breeze, A.L., Embrey, K., Garcia, R., Gero, T.W., Godfrey, L., Kenny, P.W., Morley, A.D., Minshull, C.A., Pannifer, A.D., Read, J., Rees, A., Russell, D.J., Toader, D., Tucker, J.
登録日2004-12-21
公開日2005-05-04
最終更新日2015-09-16
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure-Based Design of Protein Tyrosine Phosphatase-1B Inhibitors
Bioorg.Med.Chem.Lett., 15, 2005
2BGE
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STRUCTURE-BASED DESIGN OF PROTEIN TYROSINE PHOSPHATASE-1B INHIBITORS
分子名称:PROTEIN-TYROSINE PHOSPHATASE NON-RECEPTOR TYPE 1, 1,2,5-THIADIAZOLIDIN-3-ONE-1,1-DIOXIDE
著者Black, E., Breed, J., Breeze, A.L., Embrey, K., Garcia, R., Gero, T.W., Godfrey, L., Kenny, P.W., Morley, A.D., Minshull, C.A., Pannifer, A.D., Read, J., Rees, A., Russell, D.J., Toader, D., Tucker, J.
登録日2004-12-21
公開日2005-05-04
最終更新日2015-10-07
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure-Based Design of Protein Tyrosine Phosphatase-1B Inhibitors
Bioorg.Med.Chem.Lett., 15, 2005
5ANS
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POTENT AND SELECTIVE INHIBITORS OF MTH1 PROBE ITS ROLE IN CANCER CELL SURVIVAL
分子名称:7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE, 1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol
著者Kettle, J.G., Alwan, H., Bista, M., Breed, J., Kack, H., Eckersley, K., Foote, K.M., Fillery, S., Goodwin, L., Jones, D., Lau, A., Nissink, J.W.M., Read, J., Scott, J., Taylor, B., Walker, G., Wissler, L.
登録日2015-09-08
公開日2016-03-02
最終更新日2016-04-06
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Potent and Selective Inhibitors of Mth1 Probe its Role in Cancer Cell Survival.
J.Med.Chem., 59, 2016
5ANT
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POTENT AND SELECTIVE INHIBITORS OF MTH1 PROBE ITS ROLE IN CANCER CELL SURVIVAL
分子名称:7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE, 2-(2-methoxyethoxy)-6-(methylamino)-9-(phenylmethyl)-7H-purin-8-one
著者Kettle, J.G., Alwan, H., Bista, M., Breed, J., Kack, H., Eckersley, K., Foote, K.M., Fillery, S., Goodwin, L., Jones, D., Lau, A., Nissink, J.W.M., Read, J., Scott, J., Taylor, B., Walker, G., Wissler, L.
登録日2015-09-08
公開日2016-03-02
最終更新日2017-08-30
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Potent and Selective Inhibitors of Mth1 Probe its Role in Cancer Cell Survival.
J.Med.Chem., 59, 2016
5MLA
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CRYSTAL STRUCTURE OF HUMAN RAS IN COMPLEX WITH DARPIN K55
分子名称:GTPase KRas, darpin k55, MAGNESIUM ION, ...
著者Debreczeni, J.E., Guillard, S., Kolasinska-Zwierz, P., Breed, J., Zhang, J., Bery, N., Marwood, R., Tart, J., Overman, R., Stocki, P., Mistry, B., Phillips, C., Rabbitts, T., Jackson, R., Minter, R.
登録日2016-12-06
公開日2017-12-20
実験手法X-RAY DIFFRACTION (2.19 Å)
主引用文献Inhibition of RAS nucleotide exchange by a DARPin: structural characterisation and effects on downstream signalling by active RAS
To Be Published
5MLB
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CRYSTAL STRUCTURE OF HUMAN RAS IN COMPLEX WITH DARPIN K27
分子名称:GTPase KRas, DARPin K27, GUANOSINE-5'-DIPHOSPHATE, ...
著者Debreczeni, J.E., Guillard, S., Kolasinska-Zwierz, P., Breed, J., Zhang, J., Bery, N., Marwood, R., Tart, J., Overman, R., Stocki, P., Mistry, B., Phillips, C., Rabbitts, T., Jackson, R., Minter, R.
登録日2016-12-06
公開日2017-12-20
実験手法X-RAY DIFFRACTION (3.22 Å)
主引用文献INhibition of RAS nucleotide exchange by a DARPin: structural characterisation and effects on downstream signalling by active RAS
To Be Published
5O2S
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HUMAN KRAS IN COMPLEX WITH DARPIN K27
分子名称:GTPase KRas, darpin K27, GUANOSINE-5'-DIPHOSPHATE, ...
著者Debreczeni, J.E., Guillard, S., Kolasinska-Zwierz, P., Breed, J., Zhang, J., Bery, N., Marwood, R., Tart, J., Stocki, P., Mistry, B., Phillips, C., Rabbitts, T., Jackson, R., Minter, R.
登録日2017-05-22
公開日2017-07-26
実験手法X-RAY DIFFRACTION (3.22 Å)
主引用文献Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange.
Nat Commun, 8, 2017
5O2T
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HUMAN KRAS IN COMPLEX WITH DARPIN K27
分子名称:GTPase KRas, darpin 55, MAGNESIUM ION, ...
著者Debreczeni, J.E., Guillard, S., Kolasinska-Zwierz, P., Breed, J., Zhang, J., Bery, N., Marwood, R., Tart, J., Stocki, P., Mistry, B., Phillips, C., Rabbitts, T., Jackson, R., Minter, R.
登録日2017-05-22
公開日2017-07-26
実験手法X-RAY DIFFRACTION (2.19 Å)
主引用文献Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange.
Nat Commun, 8, 2017
1R9L
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STRUCTURE ANALYSIS OF PROX IN COMPLEX WITH GLYCINE BETAINE
分子名称:Glycine betaine-binding periplasmic protein, UNKNOWN ATOM OR ION, TRIMETHYL GLYCINE
著者Schiefner, A., Breed, J., Bosser, L., Kneip, S., Gade, J., Holtmann, G., Diederichs, K., Welte, W., Bremer, E.
登録日2003-10-30
公開日2004-02-24
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献Cation-pi Interactions as Determinants for Binding of the Compatible Solutes Glycine Betaine and Proline Betaine by the Periplasmic Ligand-binding Protein ProX from Escherichia coli
J.BIOL.CHEM., 279, 2004
1R9Q
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STRUCTURE ANALYSIS OF PROX IN COMPLEX WITH PROLINE BETAINE
分子名称:Glycine betaine-binding periplasmic protein, UNKNOWN ATOM OR ION, 1,1-DIMETHYL-PROLINIUM
著者Schiefner, A., Breed, J., Bosser, L., Kneip, S., Gade, J., Holtmann, G., Diederichs, K., Welte, W., Bremer, E.
登録日2003-10-30
公開日2004-02-24
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Cation-pi Interactions as Determinants for Binding of the Compatible Solutes Glycine Betaine and Proline Betaine by the Periplasmic Ligand-binding Protein ProX from Escherichia coli
J.BIOL.CHEM., 279, 2004
2BAJ
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P38ALPHA BOUND TO PYRAZOLOUREA
分子名称:Mitogen-activated protein kinase 14, 1-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2,3-dichlorophenyl)urea
著者Gerhardt, S., Pauptit, R.A., Read, J., Breed, J., Norman, R.A., Ward, W.H.
登録日2005-10-14
公開日2005-12-06
最終更新日2012-12-05
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Prevention of MKK6-Dependent Activation by Binding to p38alpha MAP Kinase
Biochemistry, 44, 2005
2BAK
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P38ALPHA MAP KINASE BOUND TO MPAQ
分子名称:Mitogen-activated protein kinase 14, N-(3-{[7-METHOXY-6-(2-PYRROLIDIN-1-YLETHOXY)QUINAZOLIN-4-YL]AMINO}-4-METHYLPHENYL)-2-MORPHOLIN-4-YLISONICOTINAMIDE
著者Gerhardt, S., Breed, J., Pauptit, R.A., Read, J., Norman, R.A., Ward, W.H.
登録日2005-10-14
公開日2005-12-06
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Prevention of MKK6-Dependent Activation by Binding to p38alpha MAP Kinase
Biochemistry, 44, 2005
2C6D
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AURORA A KINASE ACTIVATED MUTANT (T287D) IN COMPLEX WITH ADPNP
分子名称:SERINE/THREONINE-PROTEIN KINASE 6, GLYCEROL, PHOSPHATE ION, ...
著者Pauptit, R.A., Pannifer, A.D., Breed, J., McMiken, H.H.J., Rowsell, S., Anderson, M.
登録日2005-11-09
公開日2006-01-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Sar and Inhibitor Complex Structure Determination of a Novel Class of Potent and Specific Aurora Kinase Inhibitors.
Bioorg.Med.Chem.Lett., 16, 2006
2C6E
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AURORA A KINASE ACTIVATED MUTANT (T287D) IN COMPLEX WITH A 5- AMINOPYRIMIDINYL QUINAZOLINE INHIBITOR
分子名称:SERINE/THREONINE-PROTEIN KINASE 6, N-{5-[(7-{[(2S)-2-HYDROXY-3-PIPERIDIN-1-YLPROPYL]OXY}-6-METHOXYQUINAZOLIN-4-YL)AMINO]PYRIMIDIN-2-YL}BENZAMIDE
著者Pauptit, R.A., Pannifer, A.D., Breed, J., McMiken, H.H.J., Rowsell, S., Anderson, M.
登録日2005-11-09
公開日2006-01-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Sar and Inhibitor Complex Structure Determination of a Novel Class of Potent and Specific Aurora Kinase Inhibitors.
Bioorg.Med.Chem.Lett., 16, 2006
2H8H
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SRC KINASE IN COMPLEX WITH A QUINAZOLINE INHIBITOR
分子名称:Proto-oncogene tyrosine-protein kinase Src, N-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-7-[2-(4-METHYLPIPERAZIN-1-YL)ETHOXY]-5-(TETRAHYDRO-2H-PYRAN-4-YLOXY)QUINAZOLIN-4-AMINE
著者Otterbein, L.R., Norman, R., Pauptit, R.A., Rowsell, S., Breed, J.
登録日2006-06-07
公開日2006-11-21
最終更新日2015-07-01
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor.
J.Med.Chem., 49, 2006
2X8D
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DISCOVERY OF A NOVEL CLASS OF TRIAZOLONES AS CHECKPOINT KINASE INHIBITORS - HIT TO LEAD EXPLORATION
分子名称:SERINE/THREONINE-PROTEIN KINASE CHK1, 5-METHYL[1,2,4]TRIAZOLO[4,3-A]QUINOLIN-1(2H)-ONE, SULFATE ION
著者Read, J.A., Breed, J., Haye, H., McCall, E., Rowsell, S., Vallentine, A., White, A.
登録日2010-03-08
公開日2010-08-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Discovery of a Novel Class of Triazolones as Checkpoint Kinase Inhibitors-Hit to Lead Exploration.
Bioorg.Med.Chem., 20, 2010
2X8E
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DISCOVERY OF A NOVEL CLASS OF TRIAZOLONES AS CHECKPOINT KINASE INHIBITORS - HIT TO LEAD EXPLORATION
分子名称:SERINE/THREONINE-PROTEIN KINASE CHK1, 5-METHYL-8-PYRIDIN-4-YL[1,2,4]TRIAZOLO[4,3-A]QUINOLIN-1(2H)-ONE, SULFATE ION
著者Read, J.A., Breed, J., Haye, H., McCall, E., Rowsell, S., Vallentine, A., White, A.
登録日2010-03-09
公開日2010-08-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Discovery of a Novel Class of Triazolones as Checkpoint Kinase Inhibitors-Hit to Lead Exploration.
Bioorg.Med.Chem., 20, 2010
2X8I
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DISCOVERY OF A NOVEL CLASS OF TRIAZOLONES AS CHECKPOINT KINASE INHIBITORS - HIT TO LEAD EXPLORATION
分子名称:SERINE/THREONINE-PROTEIN KINASE CHK1, 7-(3-hydroxyphenyl)-5-methyl[1,2,4]triazolo[4,3-a]quinolin-1(2H)-one, SULFATE ION, ...
著者Read, J.A., Breed, J., Haye, H., McCall, E., Otterbein, L., Vallentine, A., White, A.
登録日2010-03-09
公開日2010-08-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Discovery of a Novel Class of Triazolones as Checkpoint Kinase Inhibitors-Hit to Lead Exploration.
Bioorg.Med.Chem., 20, 2010
2YDI
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DISCOVERY OF CHECKPOINT KINASE INHIBITOR AZD7762 BY STRUCTURE BASED DESIGN AND OPTIMIZATION OF THIOPHENE CARBOXAMIDE UREAS
分子名称:SERINE/THREONINE-PROTEIN KINASE CHK1, SULFATE ION, 5-[4-(2-DIMETHYLAMINOETHYLOXY)PHENYL]-2-UREIDO-THIOPHENE-3-CARBOXAMIDE
著者Read, J.A., Breed, J., Haye, H., McCall, E., Rowsell, S., Vallentine, A., White, A.
登録日2011-03-21
公開日2012-04-04
最終更新日2019-04-03
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Discovery of Checkpoint Kinase Inhibitor (S)-5-(3-Fluorophenyl)-N-(Piperidin-3-Yl)-3-Ureidothiophene-2-Carboxamide (Azd7762) by Structure-Based Design and Optimization of Thiophenecarboxamide Ureas.
J.Med.Chem., 55, 2012