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2GN5
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BU of 2gn5 by Molmil
REFINED STRUCTURE OF THE GENE 5 DNA BINDING PROTEIN FROM BACTERIOPHAGE FD
Descriptor: GENE V PROTEIN
Authors:Brayer, G.D, McPherson, A.
Deposit date:1986-01-13
Release date:1986-01-21
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Refined structure of the gene 5 DNA binding protein from bacteriophage fd.
J.Mol.Biol., 169, 1983
2CPU
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BU of 2cpu by Molmil
SUBSITE MAPPING OF THE ACTIVE SITE OF HUMAN PANCREATIC ALPHA-AMYLASE USING SUBSTRATES, THE PHARMACOLOGICAL INHIBITOR ACARBOSE, AND AN ACTIVE SITE VARIANT
Descriptor: ALPHA-AMYLASE, CALCIUM ION, CHLORIDE ION
Authors:Brayer, G.D, Sidhu, G, Maurus, R, Rydberg, E.H, Braun, C, Wang, Y, Nguyen, N.T, Overall, C.M, Withers, S.G.
Deposit date:1999-06-08
Release date:2001-06-30
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Subsite mapping of the human pancreatic alpha-amylase active site through structural, kinetic, and mutagenesis techniques.
Biochemistry, 39, 2000
3CPU
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BU of 3cpu by Molmil
SUBSITE MAPPING OF THE ACTIVE SITE OF HUMAN PANCREATIC ALPHA-AMYLASE USING SUBSTRATES, THE PHARMACOLOGICAL INHIBITOR ACARBOSE, AND AN ACTIVE SITE VARIANT
Descriptor: CALCIUM ION, CHLORIDE ION, Pancreatic alpha-amylase, ...
Authors:Brayer, G.D, Sidhu, G, Maurus, R, Rydberg, E.H, Braun, C, Wang, Y, Nguyen, N.T, Overall, C.M, Withers, S.G.
Deposit date:1999-06-08
Release date:2001-06-30
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Subsite mapping of the human pancreatic alpha-amylase active site through structural, kinetic, and mutagenesis techniques.
Biochemistry, 39, 2000
1CPU
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BU of 1cpu by Molmil
SUBSITE MAPPING OF THE ACTIVE SITE OF HUMAN PANCREATIC ALPHA-AMYLASE USING SUBSTRATES, THE PHARMACOLOGICAL INHIBITOR ACARBOSE, AND AN ACTIVE SITE VARIANT
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-amino-4,6-dideoxy-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, 5-HYDROXYMETHYL-CHONDURITOL, ...
Authors:Brayer, G.D, Sidhu, G, Maurus, R, Rydberg, E.H, Braun, C, Wang, Y, Nguyen, N.T, Overall, C.M, Withers, S.G.
Deposit date:1999-06-07
Release date:1999-06-14
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Subsite mapping of the human pancreatic alpha-amylase active site through structural, kinetic, and mutagenesis techniques.
Biochemistry, 39, 2000
1HNY
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BU of 1hny by Molmil
The structure of human pancreatic alpha-amylase at 1.8 angstroms resolution and comparisons with related enzymes
Descriptor: CALCIUM ION, CHLORIDE ION, HUMAN PANCREATIC ALPHA-AMYLASE
Authors:Luo, Y, Brayer, G.D.
Deposit date:1995-06-28
Release date:1996-03-08
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The structure of human pancreatic alpha-amylase at 1.8 A resolution and comparisons with related enzymes.
Protein Sci., 4, 1995
2YCC
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BU of 2ycc by Molmil
OXIDATION STATE-DEPENDENT CONFORMATIONAL CHANGES IN CYTOCHROME C
Descriptor: CYTOCHROME C, HEME C, SULFATE ION
Authors:Berghuis, A.M, Brayer, G.D.
Deposit date:1991-01-29
Release date:1992-07-15
Last modified:2021-03-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Oxidation state-dependent conformational changes in cytochrome c.
J.Mol.Biol., 223, 1992
1AZI
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BU of 1azi by Molmil
MYOGLOBIN (HORSE HEART) RECOMBINANT WILD-TYPE COMPLEXED WITH AZIDE
Descriptor: AZIDE ION, MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Maurus, R, Brayer, G.D.
Deposit date:1997-10-11
Release date:1998-02-25
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and spectroscopic studies of azide complexes of horse heart myoglobin and the His-64-->Thr variant.
Biochem.J., 332, 1998
1BJE
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BU of 1bje by Molmil
H64T VARIANT OF MYOGLOBIN (HORSE HEART) RECOMBINANT WILD-TYPE COMPLEXED WITH AZIDE
Descriptor: AZIDE ION, MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Maurus, R, Brayer, G.D.
Deposit date:1997-10-18
Release date:1998-01-28
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and spectroscopic studies of azide complexes of horse heart myoglobin and the His-64-->Thr variant.
Biochem.J., 332, 1998
6PXF
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BU of 6pxf by Molmil
Structure of human Cathepsin K with an ectosteric inhibitor at 1.85 Angstrom resolution
Descriptor: 1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-2-sulfonic acid, Cathepsin K
Authors:Law, S, Aguda, A.H, Nguyen, N.T, Brayer, G.D, Bromme, D.
Deposit date:2019-07-25
Release date:2020-07-29
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure of human Cathepsin K with an ectosteric inhibitor at 1.85 Angstrom resolution
To Be Published
6DV5
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BU of 6dv5 by Molmil
Oligomeric complex of a Hsp27 24-mer at 3.6 A resolution
Descriptor: Heat shock protein beta-1
Authors:Aguda, A.H, Brayer, G.D.
Deposit date:2018-06-22
Release date:2019-06-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.58 Å)
Cite:Structure-Guided Discovery of Ivermectin as an Inhibitor of Heat Shock Protein-27 Phosphorylation and Depolymerization.
To Be Published
2ALP
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BU of 2alp by Molmil
REFINED STRUCTURE OF ALPHA-LYTIC PROTEASE AT 1.7 ANGSTROMS RESOLUTION. ANALYSIS OF HYDROGEN BONDING AND SOLVENT STRUCTURE
Descriptor: ALPHA-LYTIC PROTEASE, SULFATE ION
Authors:Fujinaga, M, Delbaere, L.T.J, Brayer, G.D, James, M.N.G.
Deposit date:1985-03-07
Release date:1985-07-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Refined structure of alpha-lytic protease at 1.7 A resolution. Analysis of hydrogen bonding and solvent structure.
J.Mol.Biol., 184, 1985
1YMA
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BU of 1yma by Molmil
STRUCTURAL CHARACTERIZATION OF HEME LIGATION IN THE HIS64-->TYR VARIANT OF MYOGLOBIN
Descriptor: MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION
Authors:Maurus, R, Brayer, G.D.
Deposit date:1993-09-27
Release date:1994-01-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural characterization of heme ligation in the His64-->Tyr variant of myoglobin.
J.Biol.Chem., 269, 1994
1YTC
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BU of 1ytc by Molmil
THERMODYNAMIC CYCLES AS PROBES OF STRUCTURE-FUNCTION RELATIONSHIPS IN UNFOLDED PROTEINS
Descriptor: HEME C, SULFATE ION, YEAST ISO-2 CYTOCHROME C
Authors:Luo, Y, Brayer, G.D.
Deposit date:1995-07-03
Release date:1996-03-08
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Thermodynamic cycles as probes of structure in unfolded proteins.
Biochemistry, 35, 1996
1HSY
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BU of 1hsy by Molmil
ORIGIN OF THE PH-DEPENDENT SPECTROSCOPIC PROPERTIES OF PENTACOORDINATE METMYOGLOBIN VARIANTS
Descriptor: MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION
Authors:Maurus, R, Brayer, G.D.
Deposit date:1994-12-12
Release date:1995-02-27
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Origin of the pH-dependent spectroscopic properties of pentacoordinate metmyoglobin variants.
Biochemistry, 34, 1995
4W93
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BU of 4w93 by Molmil
Human pancreatic alpha-amylase in complex with montbretin A
Descriptor: CALCIUM ION, CHLORIDE ION, Montbretin A, ...
Authors:Williams, L.K, Caner, S, Brayer, G.D.
Deposit date:2014-08-27
Release date:2015-07-15
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.352 Å)
Cite:The amylase inhibitor montbretin A reveals a new glycosidase inhibition motif.
Nat.Chem.Biol., 11, 2015
5KEZ
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BU of 5kez by Molmil
Selective and potent inhibition of the glycosidase human amylase by the short and extremely compact peptide piHA from mRNA display
Descriptor: ACE-DTY-PRO-TYR-SER-CYS-TRP-VAL-ARG-HIS-NH2, CALCIUM ION, CHLORIDE ION, ...
Authors:Caner, S, Brayer, G.D.
Deposit date:2016-06-10
Release date:2017-03-29
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Rapid Discovery of Potent and Selective Glycosidase-Inhibiting De Novo Peptides.
Cell Chem Biol, 24, 2017
1A8E
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BU of 1a8e by Molmil
HUMAN SERUM TRANSFERRIN, RECOMBINANT N-TERMINAL LOBE
Descriptor: CARBONATE ION, FE (III) ION, SERUM TRANSFERRIN
Authors:Macgillivray, R.T.A, Moore, S.A, Chen, J, Anderson, B.F, Baker, H, Luo, Y, Bewley, M, Smith, C.A, Murphy, M.E.P, Wang, Y, Mason, A.B, Woodworth, R.C, Brayer, G.D, Baker, E.N.
Deposit date:1998-03-24
Release date:1998-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Two high-resolution crystal structures of the recombinant N-lobe of human transferrin reveal a structural change implicated in iron release.
Biochemistry, 37, 1998
1A8F
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BU of 1a8f by Molmil
HUMAN SERUM TRANSFERRIN, RECOMBINANT N-TERMINAL LOBE
Descriptor: CARBONATE ION, FE (III) ION, SERUM TRANSFERRIN
Authors:Macgillivray, R.T.A, Moore, S.A, Chen, J, Anderson, B.F, Baker, H, Luo, Y, Bewley, M, Smith, C.A, Murphy, M.E.P, Wang, Y, Mason, A.B, Woodworth, R.C, Brayer, G.D, Baker, E.N.
Deposit date:1998-03-25
Release date:1998-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Two high-resolution crystal structures of the recombinant N-lobe of human transferrin reveal a structural change implicated in iron release.
Biochemistry, 37, 1998
1HRM
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BU of 1hrm by Molmil
THE PROXIMAL LIGAND VARIANT HIS93TYR OF HORSE HEART MYOGLOBIN
Descriptor: MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION
Authors:Burk, D.L, Brayer, G.D.
Deposit date:1994-09-21
Release date:1995-01-26
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The proximal ligand variant His93Tyr of horse heart myoglobin.
Biochemistry, 34, 1995
4N8W
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BU of 4n8w by Molmil
cathepsin K - chondroitin sulfate complex
Descriptor: 2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid, Cathepsin K
Authors:Aguda, A.H, Nguyen, N.T, Bromme, D, Brayer, G.D.
Deposit date:2013-10-18
Release date:2014-11-26
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Structural basis of collagen fiber degradation by cathepsin K.
Proc.Natl.Acad.Sci.USA, 111, 2014
4N79
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BU of 4n79 by Molmil
Structure of Cathepsin K-dermatan sulfate complex
Descriptor: Cathepsin K, alpha-L-idopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-alpha-L-idopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-alpha-L-idopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose
Authors:Aguda, A.H, Nguyen, N.T, Bromme, D, Brayer, G.D.
Deposit date:2013-10-15
Release date:2014-11-26
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Structural basis of collagen fiber degradation by cathepsin K.
Proc.Natl.Acad.Sci.USA, 111, 2014
3ZOA
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BU of 3zoa by Molmil
The structure of Trehalose Synthase (TreS) of Mycobacterium smegmatis in complex with acarbose
Descriptor: 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
Authors:Caner, S, Nguyen, N, Aguda, A, Zhang, R, Pan, Y.T, Withers, S.G, Brayer, G.D.
Deposit date:2013-02-21
Release date:2013-07-17
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:The Structure of the Mycobacterium Smegmatis Trehalose Synthase Reveals an Unusual Active Site Configuration and Acarbose-Binding Mode.
Glycobiology, 23, 2013
3ZO9
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BU of 3zo9 by Molmil
The structure of Trehalose Synthase (TreS) of Mycobacterium smegmatis
Descriptor: CALCIUM ION, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Caner, S, Nguyen, N, Aguda, A, Zhang, R, Pan, Y.T, Withers, S.G, Brayer, G.D.
Deposit date:2013-02-21
Release date:2013-07-17
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:The Structure of the Mycobacterium Smegmatis Trehalose Synthase Reveals an Unusual Active Site Configuration and Acarbose-Binding Mode.
Glycobiology, 23, 2013
1IRV
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BU of 1irv by Molmil
CYTOCHROME C ISOZYME 1, REDUCED, MUTANT WITH ILE 75 REPLACED BY MET AND CYS 102 REPLACED BY THR
Descriptor: CYTOCHROME C, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION
Authors:Berghuis, A.M, Brayer, G.D.
Deposit date:1996-06-27
Release date:1997-01-11
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mechanistic and structural contributions of critical surface and internal residues to cytochrome c electron transfer reactivity.
Biochemistry, 35, 1996
1IRW
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BU of 1irw by Molmil
CYTOCHROME C ISOZYME 1, REDUCED, MUTANT WITH ASN 52 REPLACED BY ALA AND CYS 102 REPLACED BY THR
Descriptor: CYTOCHROME C, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION
Authors:Berghuis, A.M, Brayer, G.D.
Deposit date:1996-06-27
Release date:1997-01-11
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:Mechanistic and structural contributions of critical surface and internal residues to cytochrome c electron transfer reactivity.
Biochemistry, 35, 1996

217705

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