Author results

1QSL
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KLENOW FRAGMENT COMPLEXED WITH SINGLE-STRANDED SUBSTRATE AND EUROPIUM (III) ION
Descriptor:5'-D(*GP*CP*TP*TP*AP*CP*GP*C)-3', DNA POLYMERASE I, EUROPIUM ION
Authors:Brautigam, C.A., Aschheim, K., Steitz, T.A.
Deposit date:1999-06-22
Release date:1999-06-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural elucidation of the binding and inhibitory properties of lanthanide (III) ions at the 3'-5' exonucleolytic active site of the Klenow fragment
Chem.Biol., 6, 1999
2KFN
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KLENOW FRAGMENT WITH BRIDGING-SULFUR SUBSTRATE AND MANGANESE
Descriptor:5'-D(*GP*CP*TP*TP*AP*(US1)P*G)-3', KLENOW FRAGMENT OF DNA POLYMERASE I, MANGANESE (II) ION, ...
Authors:Brautigam, C.A., Sun, S., Piccirilli, J.A., Steitz, T.A.
Deposit date:1998-07-01
Release date:1998-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Structures of normal single-stranded DNA and deoxyribo-3'-S-phosphorothiolates bound to the 3'-5' exonucleolytic active site of DNA polymerase I from Escherichia coli.
Biochemistry, 38, 1999
2KFZ
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KLENOW FRAGMENT WITH BRIDGING-SULFUR SUBSTRATE AND ZINC ONLY
Descriptor:5'-D(*GP*CP*TP*TP*AP*(US1)P*G)-3', KLENOW FRAGMENT OF DNA POLYMERASE I, ZINC ION, ...
Authors:Brautigam, C.A., Sun, S., Piccirilli, J.A., Steitz, T.A.
Deposit date:1998-07-02
Release date:1998-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Structures of normal single-stranded DNA and deoxyribo-3'-S-phosphorothiolates bound to the 3'-5' exonucleolytic active site of DNA polymerase I from Escherichia coli.
Biochemistry, 38, 1999
2KZM
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KLENOW FRAGMENT WITH NORMAL SUBSTRATE AND ZINC AND MANGANESE
Descriptor:DNA (5'-D(*GP*CP*TP*TP*A*CP*GP*C)-3'), PROTEIN (DNA POLYMERASE I), MANGANESE (II) ION, ...
Authors:Brautigam, C.A., Sun, S., Piccirilli, J.A., Steitz, T.A.
Deposit date:1998-07-03
Release date:1999-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structures of normal single-stranded DNA and deoxyribo-3'-S-phosphorothiolates bound to the 3'-5' exonucleolytic active site of DNA polymerase I from Escherichia coli.
Biochemistry, 38, 1999
2KZZ
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KLENOW FRAGMENT WITH NORMAL SUBSTRATE AND ZINC ONLY
Descriptor:DNA (5'-D(*GP*CP*TP*T*AP*CP*G)-3'), PROTEIN (DNA POLYMERASE I), ZINC ION
Authors:Brautigam, C.A., Sun, S., Piccirilli, J.A., Steitz, T.A.
Deposit date:1998-07-07
Release date:1999-12-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structures of normal single-stranded DNA and deoxyribo-3'-S-phosphorothiolates bound to the 3'-5' exonucleolytic active site of DNA polymerase I from Escherichia coli.
Biochemistry, 38, 1999
4U3Q
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CRYSTAL STRUCTURE OF RECOMBINANT TP0435 FROM TREPONEMA PALLIDUM
Descriptor:17 kDa lipoprotein
Authors:Brautigam, C.A., Deka, R.K., Norgard, M.V.
Deposit date:2014-07-22
Release date:2014-10-22
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Insights into the potential function and membrane organization of the TP0435 (Tp17) lipoprotein from Treponema pallidum derived from structural and biophysical analyses.
Protein Sci., 24, 2015
1KFS
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DNA POLYMERASE I KLENOW FRAGMENT (E.C.2.7.7.7) MUTANT/DNA COMPLEX
Descriptor:DNA (5'-D(*GP*CP*TP*TP*AP*CP*G)-3'), PROTEIN (DNA POLYMERASE I KLENOW FRAGMENT (E.C.2.7.7.7)), MAGNESIUM ION, ...
Authors:Brautigam, C.A., Steitz, T.A.
Deposit date:1997-08-18
Release date:1998-02-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural principles for the inhibition of the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I by phosphorothioates.
J.Mol.Biol., 277, 1998
1KRP
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DNA POLYMERASE I KLENOW FRAGMENT (E.C.2.7.7.7) MUTANT/DNA COMPLEX
Descriptor:DNA (5'-D(P*TP*TP*PST)-3'), PROTEIN (DNA POLYMERASE I KLENOW FRAGMENT (E.C.2.7.7.7)), ZINC ION
Authors:Brautigam, C.A., Steitz, T.A.
Deposit date:1997-08-19
Release date:1998-02-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural principles for the inhibition of the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I by phosphorothioates.
J.Mol.Biol., 277, 1998
1KSP
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DNA POLYMERASE I KLENOW FRAGMENT (E.C.2.7.7.7) MUTANT/DNA COMPLEX
Descriptor:DNA (5'-D(P*TP*TP*PST)-3'), PROTEIN (DNA POLYMERASE I-KLENOW FRAGMENT (E.C.2.7.7.7)), ZINC ION
Authors:Brautigam, C.A., Steitz, T.A.
Deposit date:1997-08-19
Release date:1998-02-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural principles for the inhibition of the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I by phosphorothioates.
J.Mol.Biol., 277, 1998
1PK8
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CRYSTAL STRUCTURE OF RAT SYNAPSIN I C DOMAIN COMPLEXED TO CA.ATP
Descriptor:rat synapsin I, CALCIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Brautigam, C.A., Chelliah, Y., Deisenhofer, J.
Deposit date:2003-06-05
Release date:2004-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Tetramerization and ATP binding by a protein comprising the A, B, and C domains of rat synapsin I.
J.Biol.Chem., 279, 2004
1PX2
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CRYSTAL STRUCTURE OF RAT SYNAPSIN I C DOMAIN COMPLEXED TO CA.ATP (FORM 1)
Descriptor:Synapsin I, CALCIUM ION, ADENOSINE-5'-TRIPHOSPHATE
Authors:Brautigam, C.A., Chelliah, Y., Deisenhofer, J.
Deposit date:2003-07-02
Release date:2004-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Tetramerization and ATP binding by a protein comprising the A, B, and C domains of rat synapsin I.
J.Biol.Chem., 279, 2004
1U3C
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CRYSTAL STRUCTURE OF THE PHR DOMAIN OF CRYPTOCHROME 1 FROM ARABIDOPSIS THALIANA
Descriptor:Cryptochrome 1 apoprotein, MAGNESIUM ION, CHLORIDE ION, ...
Authors:Brautigam, C.A., Smith, B.S., Ma, Z., Palnitkar, M., Tomchick, D.R., Machius, M., Deisenhofer, J.
Deposit date:2004-07-21
Release date:2004-08-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of the photolyase-like domain of cryptochrome 1 from Arabidopsis thaliana.
Proc.Natl.Acad.Sci.USA, 101, 2004
1U3D
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CRYSTAL STRUCTURE OF THE PHR DOMAIN OF CRYPTOCHROME 1 FROM ARABIDOPSIS THALIANA WITH AMPPNP BOUND
Descriptor:Cryptochrome 1 apoprotein, MAGNESIUM ION, CHLORIDE ION, ...
Authors:Brautigam, C.A., Smith, B.S., Ma, Z., Palnitkar, M., Tomchick, D.R., Machius, M., Deisenhofer, J.
Deposit date:2004-07-21
Release date:2004-08-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structure of the photolyase-like domain of cryptochrome 1 from Arabidopsis thaliana.
Proc.Natl.Acad.Sci.USA, 101, 2004
1ZMC
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CRYSTAL STRUCTURE OF HUMAN DIHYDROLIPOAMIDE DEHYDROGENASE COMPLEXED TO NAD+
Descriptor:Dihydrolipoyl dehydrogenase, mitochondrial, SULFATE ION, ...
Authors:Brautigam, C.A., Chuang, J.L., Tomchick, D.R., Machius, M., Chuang, D.T.
Deposit date:2005-05-10
Release date:2005-06-28
Last modified:2019-11-13
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Crystal Structure of Human Dihydrolipoamide Dehydrogenase: NAD(+)/NADH Binding and the Structural Basis of Disease-causing Mutations
J.Mol.Biol., 350, 2005
1ZMD
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CRYSTAL STRUCTURE OF HUMAN DIHYDROLIPOAMIDE DEHYDROGENASE COMPLEXED TO NADH
Descriptor:Dihydrolipoyl dehydrogenase, SULFATE ION, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Brautigam, C.A., Chuang, J.L., Tomchick, D.R., Machius, M., Chuang, D.T.
Deposit date:2005-05-10
Release date:2005-06-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Crystal Structure of Human Dihydrolipoamide Dehydrogenase: NAD+/NADH Binding and the Structural Basis of Disease-causing Mutations
J.Mol.Biol., 350, 2005
2F5Z
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CRYSTAL STRUCTURE OF HUMAN DIHYDROLIPOAMIDE DEHYDROGENASE (E3) COMPLEXED TO THE E3-BINDING DOMAIN OF HUMAN E3-BINDING PROTEIN
Descriptor:Dihydrolipoyl dehydrogenase, Pyruvate dehydrogenase protein X component, SULFATE ION, ...
Authors:Brautigam, C.A., Chuang, J.L., Wynn, R.M., Tomchick, D.R., Machius, M., Chuang, D.T.
Deposit date:2005-11-28
Release date:2006-01-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Structural Insight into Interactions between Dihydrolipoamide Dehydrogenase (E3) and E3 Binding Protein of Human Pyruvate Dehydrogenase Complex.
Structure, 14, 2006
2F60
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CRYSTAL STRUCTURE OF THE DIHYDROLIPOAMIDE DEHYDROGENASE (E3)-BINDING DOMAIN OF HUMAN E3-BINDING PROTEIN
Descriptor:Pyruvate dehydrogenase protein X component, GLYCEROL
Authors:Brautigam, C.A., Chuang, J.L., Wynn, R.M., Tomchick, D.R., Machius, M., Chuang, D.T.
Deposit date:2005-11-28
Release date:2006-01-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural Insight into Interactions between Dihydrolipoamide Dehydrogenase (E3) and E3 Binding Protein of Human Pyruvate Dehydrogenase Complex.
Structure, 14, 2006
3PJL
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THE CRYSTAL STRUCTURE OF TP34 BOUND TO CO (II) ION AT PH 7.5
Descriptor:34 kDa membrane antigen, COBALT (II) ION, SULFATE ION, ...
Authors:Brautigam, C.A., Deka, R.K., Tomchick, D.R., Machius, M., Norgard, M.V.
Deposit date:2010-11-10
Release date:2011-11-02
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Characterization of the Tp34 lipoprotein from Treponema pallidum suggests a role in transition metal homeostasis
To be Published
3PJN
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THE CRYSTAL STRUCTURE OF TP34 BOUND TO ZN(II) ION AT PH 7.5
Descriptor:34 kDa membrane antigen, ZINC ION, SULFATE ION, ...
Authors:Brautigam, C.A., Deka, R.K., Tomchick, D.R., Machius, M., Norgard, M.V.
Deposit date:2010-11-10
Release date:2011-11-02
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Characterization of the Tp34 lipoprotein from Treponema pallidum suggests a role in transition metal homeostasis
To be Published
3RNM
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THE CRYSTAL STRUCTURE OF THE SUBUNIT BINDING OF HUMAN DIHYDROLIPOAMIDE TRANSACYLASE (E2B) BOUND TO HUMAN DIHYDROLIPOAMIDE DEHYDROGENASE (E3)
Descriptor:Dihydrolipoyl dehydrogenase, mitochondrial, Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, ...
Authors:Brautigam, C.A., Wynn, R.M., Chuang, J.C., Young, B.B., Chuang, D.T.
Deposit date:2011-04-22
Release date:2011-05-04
Last modified:2011-07-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural and Thermodynamic Basis for Weak Interactions between Dihydrolipoamide Dehydrogenase and Subunit-binding Domain of the Branched-chain {alpha}-Ketoacid Dehydrogenase Complex.
J.Biol.Chem., 286, 2011
4DI3
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CRYSTAL STRUCTURE OF A 2:1 COMPLEX OF TREPONEMA PALLIDUM TATP(T) (TP0957) BOUND TO TATT (TP0956)
Descriptor:TatP(T) (Tp0957), TatT (Tp0956)
Authors:Brautigam, C.A., Deka, R.K., Norgard, M.V.
Deposit date:2012-01-30
Release date:2012-05-23
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Structural and Thermodynamic Characterization of the Interaction between Two Periplasmic Treponema pallidum Lipoproteins that are Components of a TPR-Protein-Associated TRAP Transporter (TPAT).
J.Mol.Biol., 420, 2012
4DI4
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CRYSTAL STRUCTURE OF A 3:1 COMPLEX OF TREPONEMA PALLIDUM TATP(T) (TP0957) BOUND TO TATT (TP0956)
Descriptor:TatT (Tp0956), TatP(T) (Tp0957), TRIETHYLENE GLYCOL, ...
Authors:Brautigam, C.A., Deka, R.K., Norgard, M.V.
Deposit date:2012-01-30
Release date:2012-05-23
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.714 Å)
Cite:Structural and Thermodynamic Characterization of the Interaction between Two Periplasmic Treponema pallidum Lipoproteins that are Components of a TPR-Protein-Associated TRAP Transporter (TPAT).
J.Mol.Biol., 420, 2012
4N13
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CRYSTAL STRUCTURE OF PSTS (BB_0215) FROM BORRELIA BURGDORFERI
Descriptor:Phosphate ABC transporter, periplasmic phosphate-binding protein, SULFATE ION, ...
Authors:Brautigam, C.A., Deka, R.K., Norgard, M.V.
Deposit date:2013-10-03
Release date:2014-01-22
Last modified:2014-02-12
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Sequence, biophysical, and structural analyses of the PstS lipoprotein (BB0215) from Borrelia burgdorferi reveal a likely binding component of an ABC-type phosphate transporter.
Protein Sci., 23, 2014
5JX2
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CRYSTAL STRUCTURE OF MGLB-2 (TP0684) FROM TREPONEMA PALLIDUM
Descriptor:Glucose/galactose-binding lipoprotein, CALCIUM ION, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Brautigam, C.A., Deka, R.K., Norgard, M.V.
Deposit date:2016-05-12
Release date:2016-08-31
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (2.0504 Å)
Cite:The Tp0684 (MglB-2) Lipoprotein of Treponema pallidum: A Glucose-Binding Protein with Divergent Topology.
Plos One, 11, 2016
5U2P
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THE CRYSTAL STRUCTURE OF TP0737 FROM TREPONEMA PALLIDUM
Descriptor:Sugar ABC transporter substrate-binding protein, BROMIDE ION, CHLORIDE ION, ...
Authors:Brautigam, C.A., Deka, R.K., Tomchick, D.R., Norgard, M.V.
Deposit date:2016-11-30
Release date:2017-02-22
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Functional clues from the crystal structure of an orphan periplasmic ligand-binding protein from Treponema pallidum.
Protein Sci., 26, 2017