Author results

1FAX
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COAGULATION FACTOR XA INHIBITOR COMPLEX
Descriptor:FACTOR XA, CALCIUM ION, (2S)-3-(7-carbamimidoylnaphthalen-2-yl)-2-[4-({(3R)-1-[(1Z)-ethanimidoyl]pyrrolidin-3-yl}oxy)phenyl]propanoic acid
Authors:Brandstetter, H., Engh, R.A.
Deposit date:1996-08-23
Release date:1997-10-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:X-ray structure of active site-inhibited clotting factor Xa. Implications for drug design and substrate recognition.
J.Biol.Chem., 271, 1996
1A85
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MMP8 WITH MALONIC AND ASPARAGINE BASED INHIBITOR
Descriptor:MMP-8, CALCIUM ION, ZINC ION, ...
Authors:Brandstetter, H., Roedern, E.G.V., Grams, F., Engh, R.A.
Deposit date:1998-04-03
Release date:1999-04-27
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of malonic acid-based inhibitors bound to human neutrophil collagenase. A new binding mode explains apparently anomalous data.
Protein Sci., 7, 1998
1A86
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MMP8 WITH MALONIC AND ASPARTIC ACID BASED INHIBITOR
Descriptor:MMP-8, N-benzyl-N~2~-[(2R)-2-(hydroxycarbamoyl)-4-methylpentanoyl]-L-alpha-asparagine, CALCIUM ION, ...
Authors:Brandstetter, H., Roedern, E.G.V., Grams, F., Engh, R.A.
Deposit date:1998-04-03
Release date:1999-05-04
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of malonic acid-based inhibitors bound to human neutrophil collagenase. A new binding mode explains apparently anomalous data.
Protein Sci., 7, 1998
1JJ9
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CRYSTAL STRUCTURE OF MMP8-BARBITURATE COMPLEX REVEALS MECHANISM FOR COLLAGEN SUBSTRATE RECOGNITION
Descriptor:Matrix Metalloproteinase 8, CALCIUM ION, ZINC ION, ...
Authors:Brandstetter, H., Grams, F., Glitz, D., Lang, A., Huber, R., Bode, W., Krell, H.-W., Engh, R.A.
Deposit date:2001-07-04
Release date:2001-08-01
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:The 1.8-A crystal structure of a matrix metalloproteinase 8-barbiturate inhibitor complex reveals a previously unobserved mechanism for collagenase substrate recognition.
J.Biol.Chem., 276, 2001
1K32
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CRYSTAL STRUCTURE OF THE TRICORN PROTEASE
Descriptor:tricorn protease
Authors:Brandstetter, H., Kim, J.-S., Groll, M., Huber, R.
Deposit date:2001-10-01
Release date:2001-12-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the tricorn protease reveals a protein disassembly line.
Nature, 414, 2001
1PFX
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PORCINE FACTOR IXA
Descriptor:FACTOR IXA, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide
Authors:Brandstetter, H., Bauer, M., Huber, R., Lollar, P., Bode, W.
Deposit date:1995-07-19
Release date:1996-08-17
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:X-ray structure of clotting factor IXa: active site and module structure related to Xase activity and hemophilia B.
Proc.Natl.Acad.Sci.USA, 92, 1995
1ETR
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REFINED 2.3 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF BOVINE THROMBIN COMPLEXES FORMED WITH THE BENZAMIDINE AND ARGININE-BASED THROMBIN INHIBITORS NAPAP, 4-TAPAP AND MQPA: A STARTING POINT FOR IMPROVING ANTITHROMBOTICS
Descriptor:EPSILON-THROMBIN, amino{[(4S)-5-[(2R,4R)-2-carboxy-4-methylpiperidin-1-yl]-4-({[(3R)-3-methyl-1,2,3,4-tetrahydroquinolin-8-yl]sulfonyl}amino)-5-oxopentyl]amino}methaniminium
Authors:Bode, W., Brandstetter, H.
Deposit date:1992-07-06
Release date:1994-01-31
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics.
J.Mol.Biol., 226, 1992
1ETS
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REFINED 2.3 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF BOVINE THROMBIN COMPLEXES FORMED WITH THE BENZAMIDINE AND ARGININE-BASED THROMBIN INHIBITORS NAPAP, 4-TAPAP AND MQPA: A STARTING POINT FOR IMPROVING ANTITHROMBOTICS
Descriptor:EPSILON-THROMBIN, 1-[N-(naphthalen-2-ylsulfonyl)glycyl-4-carbamimidoyl-D-phenylalanyl]piperidine
Authors:Bode, W., Brandstetter, H.
Deposit date:1992-07-06
Release date:1994-01-31
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics.
J.Mol.Biol., 226, 1992
1ETT
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REFINED 2.3 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF BOVINE THROMBIN COMPLEXES FORMED WITH THE BENZAMIDINE AND ARGININE-BASED THROMBIN INHIBITORS NAPAP, 4-TAPAP AND MQPA: A STARTING POINT FOR IMPROVING ANTITHROMBOTICS
Descriptor:EPSILON-THROMBIN, 4-[(2S)-2-{[(4-methylphenyl)sulfonyl]amino}-3-oxo-3-(piperidin-1-yl)propyl]benzene-1-carboximidamide
Authors:Bode, W., Brandstetter, H.
Deposit date:1992-07-06
Release date:1994-01-31
Last modified:2018-09-12
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics.
J.Mol.Biol., 226, 1992
2Y72
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CRYSTAL STRUCTURE OF THE PKD DOMAIN OF COLLAGENASE G FROM CLOSTRIDIUM HISTOLYTICUM AT 1.18 ANGSTROM RESOLUTION.
Descriptor:COLLAGENASE
Authors:Eckhard, U., Brandstetter, H.
Deposit date:2011-01-27
Release date:2011-09-28
Last modified:2011-10-19
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:Structure of Collagenase G Reveals a Chew-and -Digest Mechanism of Bacterial Collagenolysis
Nat.Struct.Mol.Biol., 18, 2011
4ARE
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CRYSTAL STRUCTURE OF THE COLLAGENASE UNIT OF COLLAGENASE G FROM CLOSTRIDIUM HISTOLYTICUM AT 2.19 ANGSTROM RESOLUTION.
Descriptor:COLLAGENASE G, ZINC ION, HEXAETHYLENE GLYCOL, ...
Authors:Eckhard, U., Brandstetter, H.
Deposit date:2012-04-23
Release date:2013-06-05
Last modified:2013-07-31
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Structural Basis for Activity Regulation and Substrate Preference of Clostridial Collagenases G, H, and T.
J.Biol.Chem., 288, 2013
1JH1
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CRYSTAL STRUCTURE OF MMP-8 COMPLEXED WITH A 6H-1,3,4-THIADIAZINE DERIVED INHIBITOR
Descriptor:Matrix Metalloproteinase 8, CALCIUM ION, ZINC ION, ...
Authors:Schroder, J., Henke, A., Wenzel, H., Brandstetter, H., Stammler, H.G., Stammler, A., Pfeiffer, W.D., Tschesche, H.
Deposit date:2001-06-27
Release date:2001-12-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure-based design and synthesis of potent matrix metalloproteinase inhibitors derived from a 6H-1,3,4-thiadiazine scaffold.
J.Med.Chem., 44, 2001
1ITV
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DIMERIC FORM OF THE HAEMOPEXIN DOMAIN OF MMP9
Descriptor:MMP9, SULFATE ION
Authors:Cha, H., Kopetzki, E., Huber, R., Lanzendoerfer, M., Brandstetter, H.
Deposit date:2002-02-11
Release date:2002-09-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural basis of the adaptive molecular recognition by MMP9.
J.Mol.Biol., 320, 2002
1J2P
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ALPHA-RING FROM THE PROTEASOME FROM ARCHAEOGLOBUS FULGIDUS
Descriptor:Proteasome alpha subunit
Authors:Groll, M., Brandstetter, H., Bartunik, H., Bourenkow, G., Huber, R.
Deposit date:2003-01-08
Release date:2003-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Investigations on the Maturation and Regulation of Archaebacterial Proteasomes
J.MOL.BIOL., 327, 2003
1J2Q
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20S PROTEASOME IN COMPLEX WITH CALPAIN-INHIBITOR I FROM ARCHAEOGLOBUS FULGIDUS
Descriptor:Proteasome alpha subunit, Proteasome beta subunit, 2-ACETYLAMINO-4-METHYL-PENTANOIC ACID [1-(1-FORMYL-PENTYLCARBAMOYL)-3-METHYL-BUTYL]-AMIDE
Authors:Groll, M., Brandstetter, H., Bartunik, H., Bourenkow, G., Huber, R.
Deposit date:2003-01-08
Release date:2003-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.83 Å)
Cite:Investigations on the Maturation and Regulation of Archaebacterial Proteasomes
J.MOL.BIOL., 327, 2003
4BQD
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KD1 OF HUMAN TFPI IN COMPLEX WITH A SYNTHETIC PEPTIDE
Descriptor:TISSUE FACTOR PATHWAY INHIBITOR (LIPOPROTEIN-ASSOCIATED COAGULATION INHIBITOR) VARIANT, PEPTIDE, GLYCEROL
Authors:Griessner, A., Brandstetter, H.
Deposit date:2013-05-30
Release date:2013-12-04
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Small Peptides Blocking Inhibition of Factor Xa and Tissue Factor-Factor Viia by Tissue Factor Pathway Inhibitor (Tfpi)
J.Biol.Chem., 289, 2014
5LU8
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CRYSTAL STRUCTURE OF YVAD-CMK BOUND HUMAN LEGUMAIN (AEP) IN COMPLEX WITH COMPOUND 11B
Descriptor:AC-TYR-VAL-ALA-ASP-CHLOROMETHYLKETONE, Legumain, SULFATE ION, ...
Authors:Dall, E., Ye, K., Brandstetter, H.
Deposit date:2016-09-08
Release date:2017-03-29
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.
Nat Commun, 8, 2017
5LU9
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CRYSTAL STRUCTURE OF YVAD-CMK BOUND HUMAN LEGUMAIN (AEP) IN COMPLEX WITH COMPOUND 11
Descriptor:AC-TYR-VAL-ALA-ASP-CHLOROMETHYLKETONE, Legumain, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Dall, E., Ye, K., Brandstetter, H.
Deposit date:2016-09-08
Release date:2017-03-29
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.
Nat Commun, 8, 2017
5LUA
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CRYSTAL STRUCTURE OF HUMAN LEGUMAIN (AEP) IN COMPLEX WITH COMPOUND 11B
Descriptor:Legumain, N-ACETYL-D-GLUCOSAMINE, 2,4-di(morpholin-4-yl)aniline
Authors:Dall, E., Ye, K., Brandstetter, H.
Deposit date:2016-09-08
Release date:2017-03-29
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (2 Å)
Cite:Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.
Nat Commun, 8, 2017
5LUB
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CRYSTAL STRUCTURE OF HUMAN LEGUMAIN (AEP) IN COMPLEX WITH COMPOUND 11
Descriptor:Legumain, N-ACETYL-D-GLUCOSAMINE, 7-(morpholin-4-yl)-2,1,3-benzoxadiazol-4-amine
Authors:Dall, E., Ye, K., Brandstetter, H.
Deposit date:2016-09-08
Release date:2017-03-29
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.
Nat Commun, 8, 2017
6FK0
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XRAY STRUCTURE OF DOMAIN-SWAPPED CYSTATIN E DIMER
Descriptor:Cystatin-M
Authors:Dall, E., Brandstetter, H.
Deposit date:2018-01-23
Release date:2018-07-11
Last modified:2018-09-05
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural and functional analysis of cystatin E reveals enzymologically relevant dimer and amyloid fibril states.
J. Biol. Chem., 293, 2018
1KLI
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COFACTOR-AND SUBSTRATE-ASSISTED ACTIVATION OF FACTOR VIIA
Descriptor:factor VIIa, SULFATE ION, CALCIUM ION, ...
Authors:Sichler, K., Banner, D.W., D'Arcy, A., Hopfner, K.P., Huber, R., Bode, W., Kresse, G.B., Kopetzki, E., Brandstetter, H.
Deposit date:2001-12-12
Release date:2002-09-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Crystal Structure of Uninhibited Factor VIIa Link its Cofactor and Substrate-assisted Activation to Specific Interactions
J.Mol.Biol., 322, 2002
1KLJ
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CRYSTAL STRUCTURE OF UNINHIBITED FACTOR VIIA
Descriptor:factor VIIa, CALCIUM ION, 1,2-ETHANEDIOL
Authors:Sichler, K., Banner, D., D'Arcy, A., Hopfner, K.P., Huber, R., Bode, W., Kresse, G.B., Kopetzki, E., Brandstetter, H.
Deposit date:2001-12-12
Release date:2002-10-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Crystal structures of uninhibited factor VIIa link its cofactor and substrate-assisted activation to specific interactions.
J.Mol.Biol., 322, 2002
1MT3
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CRYSTAL STRUCTURE OF THE TRICORN INTERACTING FACTOR SELENOMETHIONINE-F1
Descriptor:Proline iminopeptidase, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Goettig, P., Groll, M., Kim, J.-S., Huber, R., Brandstetter, H.
Deposit date:2002-09-20
Release date:2002-11-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of the tricorn-interacting aminopeptidase F1 with different ligands explain its catalytic mechanism
Embo J., 21, 2002
1MTZ
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CRYSTAL STRUCTURE OF THE TRICORN INTERACTING FACTOR F1
Descriptor:Proline iminopeptidase
Authors:Goettig, P., Groll, M., Kim, J.-S., Huber, R., Brandstetter, H.
Deposit date:2002-09-23
Release date:2002-11-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structures of the tricorn-interacting aminopeptidase F1 with different ligands explain its catalytic mechanism
Embo J., 21, 2002