Author results

4CI7
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THE CRYSTAL STRUCTURE OF THE CYSTEINE PROTEASE AND LECTIN-LIKE DOMAINS OF CWP84, A SURFACE LAYER ASSOCIATED PROTEIN OF CLOSTRIDIUM DIFFICILE
Descriptor:CELL SURFACE PROTEIN (PUTATIVE CELL SURFACE-ASSOCIATED CYSTEINE PROTEASE), SULFATE ION, GLYCEROL, ...
Authors:Bradshaw, W.J., Kirby, J.M., Thiyagarajan, N., Chambers, C.J., Davies, A.H., Roberts, A.K., Shone, C.C., Acharya, K.R.
Deposit date:2013-12-06
Release date:2014-05-14
Last modified:2014-07-23
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The Structure of the Cysteine Protease and Lectin-Like Domains of Cwp84, a Surface Layer-Associated Protein from Clostridium Difficile
Acta Crystallogr.,Sect.D, 70, 2014
4D59
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CLOSTRIDIAL CYSTEINE PROTEASE CWP84 C116A AFTER PROPEPTIDE CLEAVAGE
Descriptor:CELL SURFACE PROTEIN (PUTATIVE CELL SURFACE-ASSOCIATED CYSTEINE PROTEASE), CALCIUM ION, O-(O-(2-AMINOPROPYL)-O'-(2-METHOXYETHYL)POLYPROPYLENE GLYCOL 500)
Authors:Bradshaw, W.J., Roberts, A.K., Shone, C.C., Acharya, K.R.
Deposit date:2014-11-03
Release date:2015-03-04
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Cwp84, a Clostridium Difficile Cysteine Protease, Exhibits Conformational Flexibility in the Absence of its Propeptide
Acta Crystallogr.,Sect.F, 71, 2015
4D5A
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CLOSTRIDIAL CYSTEINE PROTEASE CWP84 C116A AFTER PROPEPTIDE CLEAVAGE
Descriptor:CELL SURFACE PROTEIN (PUTATIVE CELL SURFACE-ASSOCIATED CYSTEINE PROTEASE), CALCIUM ION, TRIETHYLENE GLYCOL, ...
Authors:Bradshaw, W.J., Roberts, A.K., Shone, C.C., Acharya, K.R.
Deposit date:2014-11-03
Release date:2015-03-04
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Cwp84, a Clostridium Difficile Cysteine Protease, Exhibits Conformational Flexibility in the Absence of its Propeptide
Acta Crystallogr.,Sect.F, 71, 2015
5M9A
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HUMAN ANGIOGENIN PD VARIANT H13R
Descriptor:Angiogenin, D(-)-TARTARIC ACID
Authors:Bradshaw, W.J., Rehman, S., Pham, T.T.K., Thiyagarajan, N., Lee, R.L., Subramanian, V., Acharya, K.R.
Deposit date:2016-11-01
Release date:2017-02-22
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural insights into human angiogenin variants implicated in Parkinson's disease and Amyotrophic Lateral Sclerosis.
Sci Rep, 7, 2017
5M9C
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HUMAN ANGIOGENIN ALS VARIANT K40R
Descriptor:Angiogenin, D(-)-TARTARIC ACID, DI(HYDROXYETHYL)ETHER
Authors:Bradshaw, W.J., Rehman, S., Pham, T.T.K., Thiyagarajan, N., Lee, R.L., Subramanian, V., Acharya, K.R.
Deposit date:2016-11-01
Release date:2017-02-22
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural insights into human angiogenin variants implicated in Parkinson's disease and Amyotrophic Lateral Sclerosis.
Sci Rep, 7, 2017
5M9G
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HUMAN ANGIOGENIN PD VARIANT K54R
Descriptor:Angiogenin, D(-)-TARTARIC ACID, DI(HYDROXYETHYL)ETHER
Authors:Bradshaw, W.J., Rehman, S., Pham, T.T.K., Thiyagarajan, N., Lee, R.L., Subramanian, V., Acharya, K.R.
Deposit date:2016-11-01
Release date:2017-02-22
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Structural insights into human angiogenin variants implicated in Parkinson's disease and Amyotrophic Lateral Sclerosis.
Sci Rep, 7, 2017
5M9J
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HUMAN ANGIOGENIN PD VARIANT K60E
Descriptor:Angiogenin, L(+)-TARTARIC ACID
Authors:Bradshaw, W.J., Rehman, S., Pham, T.T.K., Thiyagarajan, N., Lee, R.L., Subramanian, V., Acharya, K.R.
Deposit date:2016-11-01
Release date:2017-02-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural insights into human angiogenin variants implicated in Parkinson's disease and Amyotrophic Lateral Sclerosis.
Sci Rep, 7, 2017
5M9M
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HUMAN ANGIOGENIN PD VARIANT Q77P
Descriptor:Angiogenin, SULFATE ION, TRIETHYLENE GLYCOL, ...
Authors:Bradshaw, W.J., Rehman, S., Pham, T.T.K., Thiyagarajan, N., Lee, R.L., Subramanian, V., Acharya, K.R.
Deposit date:2016-11-01
Release date:2017-02-22
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural insights into human angiogenin variants implicated in Parkinson's disease and Amyotrophic Lateral Sclerosis.
Sci Rep, 7, 2017
5M9P
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HUMAN ANGIOGENIN ALS VARIANT T80S
Descriptor:Angiogenin, SULFATE ION
Authors:Bradshaw, W.J., Rehman, S., Pham, T.T.K., Thiyagarajan, N., Lee, R.L., Subramanian, V., Acharya, K.R.
Deposit date:2016-11-02
Release date:2017-02-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural insights into human angiogenin variants implicated in Parkinson's disease and Amyotrophic Lateral Sclerosis.
Sci Rep, 7, 2017
5M9Q
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HUMAN ANGIOGENIN PD VARIANT R95Q
Descriptor:Angiogenin, SULFATE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Bradshaw, W.J., Rehman, S., Pham, T.T.K., Thiyagarajan, N., Lee, R.L., Subramanian, V., Acharya, K.R.
Deposit date:2016-11-02
Release date:2017-02-22
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structural insights into human angiogenin variants implicated in Parkinson's disease and Amyotrophic Lateral Sclerosis.
Sci Rep, 7, 2017
5M9R
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HUMAN ANGIOGENIN ALS VARIANT F100I
Descriptor:Angiogenin, D(-)-TARTARIC ACID, L(+)-TARTARIC ACID, ...
Authors:Bradshaw, W.J., Rehman, S., Pham, T.T.K., Thiyagarajan, N., Lee, R.L., Subramanian, V., Acharya, K.R.
Deposit date:2016-11-02
Release date:2017-02-22
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:Structural insights into human angiogenin variants implicated in Parkinson's disease and Amyotrophic Lateral Sclerosis.
Sci Rep, 7, 2017
5M9S
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HUMAN ANGIOGENIN ALS VARIANT V103I
Descriptor:Angiogenin, D(-)-TARTARIC ACID
Authors:Bradshaw, W.J., Rehman, S., Pham, T.T.K., Thiyagarajan, N., Lee, R.L., Subramanian, V., Acharya, K.R.
Deposit date:2016-11-02
Release date:2017-02-22
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural insights into human angiogenin variants implicated in Parkinson's disease and Amyotrophic Lateral Sclerosis.
Sci Rep, 7, 2017
5M9T
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HUMAN ANGIOGENIN ALS VARIANT H114R
Descriptor:Angiogenin, GLYCEROL, BORATE ION
Authors:Bradshaw, W.J., Rehman, S., Pham, T.T.K., Thiyagarajan, N., Lee, R.L., Subramanian, V., Acharya, K.R.
Deposit date:2016-11-02
Release date:2017-02-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural insights into human angiogenin variants implicated in Parkinson's disease and Amyotrophic Lateral Sclerosis.
Sci Rep, 7, 2017
5M9V
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HUMAN ANGIOGENIN PD/ALS VARIANT R121C
Descriptor:Angiogenin, L(+)-TARTARIC ACID, GLUTATHIONE
Authors:Bradshaw, W.J., Rehman, S., Pham, T.T.K., Thiyagarajan, N., Lee, R.L., Subramanian, V., Acharya, K.R.
Deposit date:2016-11-02
Release date:2017-02-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural insights into human angiogenin variants implicated in Parkinson's disease and Amyotrophic Lateral Sclerosis.
Sci Rep, 7, 2017
5NJL
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CWP2 FROM CLOSTRIDIUM DIFFICILE
Descriptor:Cell surface protein (Putative S-layer protein), SULFATE ION
Authors:Bradshaw, W.J., Kirby, J.M., Roberts, A.K., Shone, C.C., Acharya, K.R.
Deposit date:2017-03-29
Release date:2017-07-05
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Cwp2 from Clostridium difficile exhibits an extended three domain fold and cell adhesion in vitro.
FEBS J., 284, 2017
5OQ2
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SE-SAD STRUCTURE OF THE FUNCTIONAL REGION OF CWP19 FROM CLOSTRIDIUM DIFFICILE
Descriptor:Cwp19, PHOSPHATE ION, 1,2-ETHANEDIOL
Authors:Bradshaw, W.J., Kirby, J.M., Roberts, A.K., Shone, C.C., Acharya, K.R.
Deposit date:2017-08-10
Release date:2017-11-01
Last modified:2017-12-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The molecular structure of the glycoside hydrolase domain of Cwp19 from Clostridium difficile.
FEBS J., 284, 2017
5OQ3
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HIGH RESOLUTION STRUCTURE OF THE FUNCTIONAL REGION OF CWP19 FROM CLOSTRIDIUM DIFFICILE
Descriptor:Cwp19, CHLORIDE ION, 1,2-ETHANEDIOL, ...
Authors:Bradshaw, W.J., Kirby, J.M., Roberts, A.K., Shone, C.C., Acharya, K.R.
Deposit date:2017-08-10
Release date:2017-11-01
Last modified:2017-12-27
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:The molecular structure of the glycoside hydrolase domain of Cwp19 from Clostridium difficile.
FEBS J., 284, 2017
6HNI
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THE LIGAND-BOUND, CLOSED STRUCTURE OF CD0873, A SUBSTRATE BINDING PROTEIN WITH ADHESIVE PROPERTIES FROM CLOSTRIDIUM DIFFICILE.
Descriptor:ABC-type transport system, sugar-family extracellular solute-binding protein, TYROSINE, ...
Authors:Bradshaw, W.J., Kovacs-Simon, A., Harmer, N.J., Michell, S.L., Acharya, K.R.
Deposit date:2018-09-15
Release date:2019-08-28
Last modified:2019-11-06
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Molecular features of lipoprotein CD0873: A potential vaccine against the human pathogenClostridioides difficile.
J.Biol.Chem., 294, 2019
6HNJ
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THE LIGAND-BOUND, OPEN STRUCTURE OF CD0873, A SUBSTRATE BINDING PROTEIN WITH ADHESIVE PROPERTIES FROM CLOSTRIDIUM DIFFICILE.
Descriptor:ABC-type transport system, sugar-family extracellular solute-binding protein, 1,2-ETHANEDIOL, ...
Authors:Bradshaw, W.J., Kovacs-Simon, A., Harmer, N.J., Michell, S.L., Acharya, K.R.
Deposit date:2018-09-15
Release date:2019-08-28
Last modified:2019-11-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Molecular features of lipoprotein CD0873: A potential vaccine against the human pathogenClostridioides difficile.
J.Biol.Chem., 294, 2019
6HNK
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THE LIGAND-FREE, OPEN STRUCTURE OF CD0873, A SUBSTRATE BINDING PROTEIN WITH ADHESIVE PROPERTIES FROM CLOSTRIDIUM DIFFICILE.
Descriptor:ABC-type transport system, sugar-family extracellular solute-binding protein
Authors:Bradshaw, W.J., Kovacs-Simon, A., Harmer, N.J., Michell, S.L., Acharya, K.R.
Deposit date:2018-09-15
Release date:2019-08-28
Last modified:2019-11-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular features of lipoprotein CD0873: A potential vaccine against the human pathogenClostridioides difficile.
J.Biol.Chem., 294, 2019
6IBD
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THE PHOSPHATASE AND C2 DOMAINS OF HUMAN SHIP1
Descriptor:Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
Authors:Bradshaw, W.J., Williams, E.P., Fernandez-Cid, A., Burgess-Brown, N., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.
Deposit date:2018-11-29
Release date:2019-01-16
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:The Phosphatase and C2 domains of Human SHIP1
To Be Published
6IBE
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THE FERM DOMAIN OF HUMAN EPB41L3
Descriptor:Band 4.1-like protein 3, 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Bradshaw, W.J., Katis, V.L., Newman, J.A., Fernandez-Cid, A., Burgess-Brown, N., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.
Deposit date:2018-11-29
Release date:2018-12-19
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:The FERM domain of Human EPB41L3
To Be Published
6TXQ
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THE HIGH RESOLUTION STRUCTURE OF THE FERM DOMAIN AND HELICAL LINKER OF HUMAN MOESIN
Descriptor:Moesin, ACETATE ION
Authors:Bradshaw, W.J., Katis, V.L., Kelly, J.J., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.
Deposit date:2020-01-14
Release date:2020-01-29
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:The high resolution structure of the FERM domain and helical linker of human moesin
To Be Published
6TXS
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THE STRUCTURE OF THE FERM DOMAIN AND HELICAL LINKER OF HUMAN MOESIN BOUND TO A CD44 PEPTIDE
Descriptor:Moesin, CD44 antigen
Authors:Bradshaw, W.J., Katis, V.L., Kelly, J.J., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.
Deposit date:2020-01-14
Release date:2020-01-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The structure of the FERM domain and helical linker of human moesin bound to a CD44 peptide
To Be Published
6XTJ
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THE HIGH RESOLUTION STRUCTURE OF THE FERM DOMAIN OF HUMAN FERMT2
Descriptor:Fermitin family homolog 2,Fermitin family homolog 2,Fermitin family homolog 2, CITRIC ACID
Authors:Bradshaw, W.J., Katis, V.L., Newman, J.A., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.
Deposit date:2020-01-16
Release date:2020-02-12
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The high resolution structure of the FERM domain of human FERMT2
To Be Published
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