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Structure of thymidylate synthase ThyX complexed to a new inhibitor
Descriptor:	2-hydroxy-3-(4-methoxybenzyl)naphthalene-1,4-dione, DIMETHYL SULFOXIDE, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:	Basta, T, Boum, Y, Briffotaux, J, Becker, H.F, Lamarre-Jouenne, I, Lambry, J.C, Skouloubris, S, Liebl, U, van Tilbeurgh, H, Graille, M, Myllylkallio, H.
Deposit date:	2012-07-06
Release date:	2013-05-22
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (2.59 Å)
Cite:	Mechanistic and structural basis for inhibition of thymidylate synthase ThyX. Open Biology, 2, 2012

Crystal structure of His-tagged human thymidylate synthase R175A mutant
Descriptor:	1,2-ETHANEDIOL, SULFATE ION, Thymidylate synthase
Authors:	Pozzi, C, Mangani, S.
Deposit date:	2013-05-14
Release date:	2014-05-14
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (2.03 Å)
Cite:	Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase. J.Med.Chem., 58, 2015

Crystal structure of human thymidylate synthase Y202A in inactive conformation.
Descriptor:	SULFATE ION, Thymidylate synthase
Authors:	Tochowicz, A, Stroud, R.M, Wade, R.C.
Deposit date:	2013-02-26
Release date:	2014-08-20
Last modified:	2015-05-06
Method:	X-RAY DIFFRACTION (2.311 Å)
Cite:	Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase. J.Med.Chem., 58, 2015