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8FZZ
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BU of 8fzz by Molmil
Phocaeicola vulgatus type VI secretion system Ntox15 effector and immunity Tde2/Tdi2
Descriptor: DUF1851 domain-containing protein, Ntox15 domain-containing protein
Authors:Bosch, D.E, Mougous, J.D.
Deposit date:2023-01-30
Release date:2023-07-05
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Structural disruption of Ntox15 nuclease effector domains by immunity proteins protects against type VI secretion system intoxication in Bacteroidales.
Mbio, 14, 2023
8G0K
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BU of 8g0k by Molmil
Bacteroides multispecies type VI secretion system Ntox15 domain effector and immunity Tde1/Tdi1
Descriptor: DUF1851 domain-containing protein, Ntox15 domain-containing protein
Authors:Bosch, D.E, Mougous, J.D.
Deposit date:2023-01-31
Release date:2023-07-05
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural disruption of Ntox15 nuclease effector domains by immunity proteins protects against type VI secretion system intoxication in Bacteroidales.
Mbio, 14, 2023
8FZY
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BU of 8fzy by Molmil
Bacteroides spp. Ntox15 domain type VI secretion system effector Tde1
Descriptor: 1,2-ETHANEDIOL, Ntox15 domain-containing protein, SULFATE ION
Authors:Bosch, D.E, Mougous, J.D.
Deposit date:2023-01-30
Release date:2023-07-05
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural disruption of Ntox15 nuclease effector domains by immunity proteins protects against type VI secretion system intoxication in Bacteroidales.
Mbio, 14, 2023
4MIT
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BU of 4mit by Molmil
Crystal structure of E. histolytica RacC bound to the EhPAK4 PBD
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Rho family GTPase, ...
Authors:Bosch, D.E, Siderovski, D.P.
Deposit date:2013-09-02
Release date:2014-09-03
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Entamoeba histolytica RacC Selectively Engages p21-Activated Kinase Effectors.
Biochemistry, 54, 2015
3REF
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BU of 3ref by Molmil
Crystal structure of EhRho1 bound to GDP and Magnesium
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Rho-like small GTPase, ...
Authors:Bosch, D.E, Qiu, C, Siderovski, D.P.
Deposit date:2011-04-04
Release date:2011-09-28
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Unique structural and nucleotide exchange features of the Rho1 GTPase of Entamoeba histolytica.
J.Biol.Chem., 286, 2011
4DVG
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BU of 4dvg by Molmil
Crystal structure of E. histolytica Formin1 bound to EhRho1-GTPgammaS
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Diaphanous protein, MAGNESIUM ION, ...
Authors:Bosch, D.E, Siderovski, D.P.
Deposit date:2012-02-23
Release date:2012-11-14
Last modified:2012-11-28
Method:X-RAY DIFFRACTION (2.604 Å)
Cite:Entamoeba histolytica Rho1 Regulates Actin Polymerization through a Divergent, Diaphanous-Related Formin.
Biochemistry, 51, 2012
4FID
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BU of 4fid by Molmil
Crystal structure of a heterotrimeric G-Protein subunit from entamoeba histolytica, EHG-ALPHA-1
Descriptor: G protein alpha subunit, GUANOSINE-5'-DIPHOSPHATE
Authors:Bosch, D.E, Kimple, A.J, Muller, R.E, Gigure, P.M, Willard, F.S, Machius, M, Temple, B.R, Siderovski, D.P.
Deposit date:2012-06-08
Release date:2012-11-28
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Heterotrimeric G-protein Signaling Is Critical to Pathogenic Processes in Entamoeba histolytica.
Plos Pathog., 8, 2012
4GPR
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BU of 4gpr by Molmil
Crystal structure of EhUbc5, a ubiquitin conjugating enzyme from Entamoeba histolytica
Descriptor: COBALT (II) ION, Ubiquitin-conjugating enzyme family protein
Authors:Bosch, D.E, Siderovski, D.P.
Deposit date:2012-08-21
Release date:2012-12-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural Determinants of Ubiquitin Conjugation in Entamoeba histolytica.
J.Biol.Chem., 288, 2013
4GU2
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BU of 4gu2 by Molmil
Crystal structure of ubiquitin from Entamoeba histolytica to 1.35 Angstrom
Descriptor: Ubiquitin
Authors:Bosch, D.E, Siderovski, D.P.
Deposit date:2012-08-29
Release date:2012-12-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structural Determinants of Ubiquitin Conjugation in Entamoeba histolytica.
J.Biol.Chem., 288, 2013
4GOU
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BU of 4gou by Molmil
Crystal structure of an RGS-RhoGEF from Entamoeba histolytica
Descriptor: EhRGS-RhoGEF
Authors:Bosch, D.E, Kimple, A.J, Muller, R.E, Willard, F.S, Machius, M, Siderovski, D.P.
Deposit date:2012-08-20
Release date:2013-01-09
Last modified:2013-01-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Determinants of RGS-RhoGEF Signaling Critical to Entamoeba histolytica Pathogenesis.
Structure, 21, 2013
4GSW
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BU of 4gsw by Molmil
Crystal structure of ubiquitin from Entamoeba histolytica to 2.15 Angstrom
Descriptor: SULFATE ION, Ubiquitin
Authors:Bosch, D.E, Siderovski, D.P.
Deposit date:2012-08-28
Release date:2012-12-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural Determinants of Ubiquitin Conjugation in Entamoeba histolytica.
J.Biol.Chem., 288, 2013
3QI2
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BU of 3qi2 by Molmil
A Galpha P-loop mutation prevents transition to the activated state: G42R bound to RGS14 GoLoco
Descriptor: GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Bosch, D.E, Willard, F.S, Kimple, A.J, Miley, M.J, Siderovski, D.P.
Deposit date:2011-01-26
Release date:2012-02-01
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.797 Å)
Cite:A P-loop Mutation in Galpha Subunits Prevents Transition to the Active State: Implications for G-protein Signaling in Fungal Pathogenesis
Plos Pathog., 8, 2012
3QE0
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BU of 3qe0 by Molmil
A Galpha-i1 P-loop mutation prevents transition to the activated state
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1, KB752 peptide, ...
Authors:Bosch, D.E, Willard, F.S, Kimple, A.J, Miley, M.J, Siderovski, D.P.
Deposit date:2011-01-19
Release date:2012-01-25
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:A P-loop Mutation in Galpha Subunits Prevents Transition to the Active State: Implications for G-protein Signaling in Fungal Pathogenesis
Plos Pathog., 8, 2012
3REG
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BU of 3reg by Molmil
Crystal structure of EhRho1 bound to a GTP analog and Magnesium
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, Rho-like small GTPase
Authors:Bosch, D.E, Qiu, C, Siderovski, D.P.
Deposit date:2011-04-04
Release date:2011-09-28
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.801 Å)
Cite:Unique structural and nucleotide exchange features of the Rho1 GTPase of Entamoeba histolytica.
J.Biol.Chem., 286, 2011
7JTU
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BU of 7jtu by Molmil
Cytidine deaminase T6S toxin from Pseudomonas syringae
Descriptor: SsdA, SsdAI
Authors:Bosch, D.E, Hsu, F, de Moraes, M.H, Mougous, J.D.
Deposit date:2020-08-18
Release date:2021-03-31
Last modified:2021-04-07
Method:X-RAY DIFFRACTION (3 Å)
Cite:An interbacterial DNA deaminase toxin directly mutagenizes surviving target populations.
Elife, 10, 2021
6U08
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BU of 6u08 by Molmil
Double-stranded DNA-specific cytidine deaminase type VI secretion system effector and cognate immunity complex from Burkholderia cenocepacia
Descriptor: DddI, Double-stranded DNA-specific cytidine deaminase, ZINC ION
Authors:Bosch, D.E, de Moraes, M.M.H, Mougous, J.D.
Deposit date:2019-08-13
Release date:2020-07-15
Last modified:2020-08-05
Method:X-RAY DIFFRACTION (2.491 Å)
Cite:A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing.
Nature, 583, 2020
6DRH
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BU of 6drh by Molmil
ADP-ribosyltransferase toxin/immunity pair
Descriptor: ADP-ribosyl-(Dinitrogen reductase) hydrolase, MAGNESIUM ION, PAAR repeat-containing protein, ...
Authors:Bosch, D.E, Ting, S, Allaire, M, Mougous, J.D.
Deposit date:2018-06-11
Release date:2018-10-31
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.299 Å)
Cite:Bifunctional Immunity Proteins Protect Bacteria against FtsZ-Targeting ADP-Ribosylating Toxins.
Cell, 175, 2018
6DRE
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BU of 6dre by Molmil
ADP-ribosyltransferase toxin/immunity pair
Descriptor: ADP-ribosyl-(Dinitrogen reductase) hydrolase, MAGNESIUM ION, PAAR repeat-containing protein
Authors:Bosch, D.E, Ting, S, Allaire, M, Mougous, J.D.
Deposit date:2018-06-11
Release date:2018-10-31
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Bifunctional Immunity Proteins Protect Bacteria against FtsZ-Targeting ADP-Ribosylating Toxins.
Cell, 175, 2018
3ONW
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BU of 3onw by Molmil
Structure of a G-alpha-i1 mutant with enhanced affinity for the RGS14 GoLoco motif.
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1, Regulator of G-protein signaling 14, ...
Authors:Bosch, D, Kimple, A.J, Sammond, D.W, Miley, M.J, Machius, M, Kuhlman, B, Willard, F.S, Siderovski, D.P.
Deposit date:2010-08-30
Release date:2010-11-24
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Structural Determinants of Affinity Enhancement between GoLoco Motifs and G-Protein {alpha} Subunit Mutants.
J.Biol.Chem., 286, 2011
2XNS
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BU of 2xns by Molmil
Crystal Structure Of Human G alpha i1 Bound To A Designed Helical Peptide Derived From The Goloco Motif Of RGS14
Descriptor: GUANINE NUCLEOTIDE-BINDING PROTEIN G(I) SUBUNIT ALPHA-1, GUANOSINE-5'-DIPHOSPHATE, REGULATOR OF G-PROTEIN SIGNALING 14, ...
Authors:Bosch, D, Sammond, D.W, Butterfoss, G.L, Machius, M, Siderovski, D.P, Kuhlman, B.
Deposit date:2010-08-05
Release date:2011-06-08
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.41 Å)
Cite:Computational Design of the Sequence and Structure of a Protein-Binding Peptide.
J.Am.Chem.Soc., 133, 2011

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