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2IEN
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CRYSTAL STRUCTURE ANALYSIS OF HIV-1 PROTEASE WITH A POTENT NON-PEPTIDE INHIBITOR (UIC-94017)
Descriptor:Protease, SODIUM ION, CHLORIDE ION, ...
Authors:Tie, Y., Boross, P.I., Wang, Y.F., Gaddis, L., Manna, D., Hussain, A.K., Leshchenko, S., Ghosh, A.K., Louis, J.M., Harrison, R.W., Weber, I.T.
Deposit date:2006-09-19
Release date:2006-10-03
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:High Resolution Crystal Structures of HIV-1 Protease with a Potent Non-Peptide Inhibitor (Uic-94017) Active Against Multi-Drug-Resistant Clinical Strains.
J.Mol.Biol., 338, 2004
1SDT
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CRYSTAL STRUCTURES OF HIV PROTEASE V82A AND L90M MUTANTS REVEAL CHANGES IN INDINAVIR BINDING SITE.
Descriptor:protease RETROPEPSIN, CHLORIDE ION, N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE
Authors:Mahalingam, B., Wang, Y.-F., Boross, P.I., Tozser, J., Louis, J.M., Harrison, R.W., Weber, I.T.
Deposit date:2004-02-14
Release date:2004-05-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Crystal structures of HIV protease V82A and L90M mutants reveal changes in the indinavir-binding site
Eur.J.Biochem., 271, 2004
1SDU
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CRYSTAL STRUCTURES OF HIV PROTEASE V82A AND L90M MUTANTS REVEAL CHANGES IN INDINAVIR BINDING SITE.
Descriptor:protease RETROPEPSIN, SULFATE ION, ACETATE ION, ...
Authors:Mahalingam, B., Wang, Y.-F., Boross, P.I., Tozser, J., Louis, J.M., Harrison, R.W., Weber, I.T.
Deposit date:2004-02-14
Release date:2004-05-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Crystal structures of HIV protease V82A and L90M mutants reveal changes in the indinavir-binding site
Eur.J.Biochem., 271, 2004
1SDV
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CRYSTAL STRUCTURES OF HIV PROTEASE V82A AND L90M MUTANTS REVEAL CHANGES IN INDINAVIR BINDING SITE.
Descriptor:protease RETROPEPSIN, CHLORIDE ION, N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE
Authors:Mahalingam, B., Wang, Y.-F., Boross, P.I., Tozser, J., Louis, J.M., Harrison, R.W., Weber, I.T.
Deposit date:2004-02-14
Release date:2004-05-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structures of HIV protease V82A and L90M mutants reveal changes in the indinavir-binding site
Eur.J.Biochem., 271, 2004
2AOC
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CRYSTAL STRUCTURE ANALYSIS OF HIV-1 PROTEASE MUTANT I84V WITH A SUBSTRATE ANALOG P2-NC
Descriptor:HIV-1 PROTEASE, UNKNOWN ATOM OR ION, SODIUM ION, ...
Authors:Tie, Y., Boross, P.I., Wang, Y.F., Gaddis, L., Liu, F., Chen, X., Tozser, J., Harrison, R.W., Weber, I.T.
Deposit date:2005-08-12
Release date:2006-01-17
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs.
Febs J., 272, 2005
2AOD
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CRYSTAL STRUCTURE ANALYSIS OF HIV-1 PROTEASE WITH A SUBSTRATE ANALOG P2-NC
Descriptor:HIV-1 PROTEASE, DIMETHYL SULFOXIDE, UNKNOWN ATOM OR ION, ...
Authors:Tie, Y., Boross, P.I., Wang, Y.F., Gaddis, L., Liu, F., Chen, X., Tozser, J., Harrison, R.W., Weber, I.T.
Deposit date:2005-08-12
Release date:2006-01-17
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs.
Febs J., 272, 2005
2AOE
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CRYSTAL STRUCTURE ANALYSIS OF HIV-1 PROTEASE MUTANT V82A WITH A SUBSTRATE ANALOG CA-P2
Descriptor:POL POLYPROTEIN, SODIUM ION, CHLORIDE ION, ...
Authors:Tie, Y., Boross, P.I., Wang, Y.F., Gaddis, L., Liu, F., Chen, X., Tozser, J., Harrison, R.W., Weber, I.T.
Deposit date:2005-08-12
Release date:2006-01-17
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs.
Febs J., 272, 2005
2AOF
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CRYSTAL STRUCTURE ANALYSIS OF HIV-1 PROTEASE MUTANT V82A WITH A SUBSTRATE ANALOG P1-P6
Descriptor:POL POLYPROTEIN, PEPTIDE INHIBITOR, SODIUM ION, ...
Authors:Tie, Y., Boross, P.I., Wang, Y.F., Gaddis, L., Liu, F., Chen, X., Tozser, J., Harrison, R.W., Weber, I.T.
Deposit date:2005-08-12
Release date:2006-01-17
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs.
Febs J., 272, 2005
2AOG
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CRYSTAL STRUCTURE ANALYSIS OF HIV-1 PROTEASE MUTANT V82A WITH A SUBSTRATE ANALOG P2-NC
Descriptor:HIV-1 PROTEASE (RETROPEPSIN), N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide, UNKNOWN ATOM OR ION, ...
Authors:Tie, Y., Boross, P.I., Wang, Y.F., Gaddis, L., Liu, F., Chen, X., Tozser, J., Harrison, R.W., Weber, I.T.
Deposit date:2005-08-12
Release date:2006-01-17
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs.
Febs J., 272, 2005
2AOH
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CRYSTAL STRUCTURE ANALYSIS OF HIV-1 PROTEASE MUTANT V82A WITH A SUBSTRATE ANALOG P6-PR
Descriptor:POL POLYPROTEIN, PEPTIDE INHIBITOR, SODIUM ION, ...
Authors:Tie, Y., Boross, P.I., Wang, Y.F., Gaddis, L., Liu, F., Chen, X., Tozser, J., Harrison, R.W., Weber, I.T.
Deposit date:2005-08-12
Release date:2006-01-17
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs.
Febs J., 272, 2005
2AOI
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CRYSTAL STRUCTURE ANALYSIS OF HIV-1 PROTEASE WITH A SUBSTRATE ANALOG P1-P6
Descriptor:POL POLYPROTEIN, PEPTIDE INHIBITOR, SULFATE ION
Authors:Tie, Y., Boross, P.I., Wang, Y.F., Gaddis, L., Liu, F., Chen, X., Tozser, J., Harrison, R.W., Weber, I.T.
Deposit date:2005-08-12
Release date:2006-01-17
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs.
Febs J., 272, 2005
2AOJ
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CRYSTAL STRUCTURE ANALYSIS OF HIV-1 PROTEASE WITH A SUBSTRATE ANALOG P6-PR
Descriptor:POL POLYPROTEIN, PEPTIDE INHIBITOR, DIMETHYL SULFOXIDE, ...
Authors:Tie, Y., Boross, P.I., Wang, Y.F., Gaddis, L., Liu, F., Chen, X., Tozser, J., Harrison, R.W., Weber, I.T.
Deposit date:2005-08-12
Release date:2006-01-17
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs.
Febs J., 272, 2005
2AVM
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KINETICS, STABILITY, AND STRUCTURAL CHANGES IN HIGH RESOLUTION CRYSTAL STRUCTURES OF HIV-1 PROTEASE WITH DRUG RESISTANT MUTATIONS L24I, I50V, AND G73S
Descriptor:HIV-1 protease, GLYCEROL, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide, ...
Authors:Liu, F., Boross, P.I., Wang, Y.F., Tozser, J., Louis, J.M., Harrison, R.W., Weber, I.T.
Deposit date:2005-08-30
Release date:2006-01-24
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S.
J.Mol.Biol., 354, 2005
2AVO
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KINETICS, STABILITY, AND STRUCTURAL CHANGES IN HIGH RESOLUTION CRYSTAL STRUCTURES OF HIV-1 PROTEASE WITH DRUG RESISTANT MUTATIONS L24I, I50V, AND G73S
Descriptor:Pol polyprotein, SULFATE ION, DIMETHYL SULFOXIDE, ...
Authors:Liu, F., Boross, P.I., Wang, Y.F., Tozser, J., Louis, J.M., Harrison, R.W., Weber, I.T.
Deposit date:2005-08-30
Release date:2006-01-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S.
J.Mol.Biol., 354, 2005
2AVQ
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KINETICS, STABILITY, AND STRUCTURAL CHANGES IN HIGH RESOLUTION CRYSTAL STRUCTURES OF HIV-1 PROTEASE WITH DRUG RESISTANT MUTATIONS L24I, I50V, AND G73S
Descriptor:Pol polyprotein, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:Liu, F., Boross, P.I., Wang, Y.F., Tozser, J., Louis, J.M., Harrison, R.W., Weber, I.T.
Deposit date:2005-08-30
Release date:2006-01-24
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S.
J.Mol.Biol., 354, 2005
2AVS
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KINETICS, STABILITY, AND STRUCTURAL CHANGES IN HIGH RESOLUTION CRYSTAL STRUCTURES OF HIV-1 PROTEASE WITH DRUG RESISTANT MUTATIONS L24I, I50V, AND G73S
Descriptor:Pol polyprotein, PHOSPHATE ION, SULFATE ION, ...
Authors:Liu, F., Boross, P.I., Wang, Y.F., Tozser, J., Louis, J.M., Harrison, R.W., Weber, I.T.
Deposit date:2005-08-30
Release date:2006-01-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S.
J.Mol.Biol., 354, 2005
2AVV
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KINETICS, STABILITY, AND STRUCTURAL CHANGES IN HIGH RESOLUTION CRYSTAL STRUCTURES OF HIV-1 PROTEASE WITH DRUG RESISTANT MUTATIONS L24I, I50V, AND G73S
Descriptor:Pol polyprotein, N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE, ACETIC ACID, ...
Authors:Liu, F., Boross, P.I., Wang, Y.F., Tozser, J., Louis, J.M., Harrison, R.W., Weber, I.T.
Deposit date:2005-08-30
Release date:2006-01-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S.
J.Mol.Biol., 354, 2005
2H5I
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CRYSTAL STRUCTURE OF CASPASE-3 WITH INHIBITOR AC-DEVD-CHO
Descriptor:caspase-3, p17 subunit, p12 subunit, ...
Authors:Fang, B., Boross, P.I., Tozser, J., Weber, I.T.
Deposit date:2006-05-26
Release date:2006-09-19
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Structural and kinetic analysis of caspase-3 reveals role for s5 binding site in substrate recognition
J.Mol.Biol., 360, 2006
2H5J
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CRYSTAL STRUSTURE OF CASPASE-3 WITH INHIBITOR AC-DMQD-CHO
Descriptor:caspase-3, p17 subunit, p12 subunit, ...
Authors:Fang, B., Boross, P.I., Tozser, J., Weber, I.T.
Deposit date:2006-05-26
Release date:2006-09-19
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and kinetic analysis of caspase-3 reveals role for s5 binding site in substrate recognition
J.Mol.Biol., 360, 2006
2H65
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CRYSTAL STRUSTURE OF CASPASE-3 WITH INHIBITOR AC-VDVAD-CHO
Descriptor:caspase-3, p17 subunit, p12 subunit, ...
Authors:Fang, B., Boross, P.I., Tozser, J., Weber, I.T.
Deposit date:2006-05-30
Release date:2006-09-19
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and kinetic analysis of caspase-3 reveals role for s5 binding site in substrate recognition
J.Mol.Biol., 360, 2006
2IDW
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CRYSTAL STRUCTURE ANALYSIS OF HIV-1 PROTEASE MUTANT V82A WITH A POTENT NON-PEPTIDE INHIBITOR (UIC-94017)
Descriptor:Protease, CHLORIDE ION, PHOSPHATE ION, ...
Authors:Tie, Y., Boross, P.I., Wang, Y.F., Gaddis, L., Manna, D., Hussain, A.K., Leshchenko, S., Ghosh, A.K., Louis, J.M., Harrison, R.W., Weber, I.T.
Deposit date:2006-09-15
Release date:2006-10-03
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:High Resolution Crystal Structures of HIV-1 Protease with a Potent Non-Peptide Inhibitor (Uic-94017) Active Against Multi-Drug-Resistant Clinical Strains.
J.Mol.Biol., 338, 2004
2IEO
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CRYSTAL STRUCTURE ANALYSIS OF HIV-1 PROTEASE MUTANT I84V WITH A POTENT NON-PEPTIDE INHIBITOR (UIC-94017)
Descriptor:Protease, CHLORIDE ION, SODIUM ION, ...
Authors:Tie, Y., Boross, P.I., Wang, Y.F., Gaddis, L., Manna, D., Hussain, A.K., Leshchenko, S., Ghosh, A.K., Louis, J.M., Harrison, R.W., Weber, I.T.
Deposit date:2006-09-19
Release date:2006-10-03
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:High Resolution Crystal Structures of HIV-1 Protease with a Potent Non-Peptide Inhibitor (Uic-94017) Active Against Multi-Drug-Resistant Clinical Strains.
J.Mol.Biol., 338, 2004
2QCI
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HIV-1 PROTEASE MUTANT D30N WITH POTENT ANTIVIRAL INHIBITOR GRL-98065
Descriptor:Protease, SODIUM ION, CHLORIDE ION, ...
Authors:Wang, Y.F., Tie, Y., Boross, P.I., Tozser, J., Ghosh, A.K., Harrison, R.W., Weber, I.T.
Deposit date:2007-06-19
Release date:2008-04-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Potent new antiviral compound shows similar inhibition and structural interactions with drug resistant mutants and wild type HIV-1 protease.
J.Med.Chem., 50, 2007
2QD6
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HIV-1 PROTEASE MUTANT I50V WITH POTENT ANTIVIRAL INHIBITOR GRL-98065
Descriptor:Protease, SODIUM ION, CHLORIDE ION, ...
Authors:Wang, Y.F., Tie, Y., Boross, P.I., Tozser, J., Ghosh, A.K., Harrison, R.W., Weber, I.T.
Deposit date:2007-06-20
Release date:2008-04-22
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:Potent new antiviral compound shows similar inhibition and structural interactions with drug resistant mutants and wild type HIV-1 protease.
J.Med.Chem., 50, 2007
2QD7
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HIV-1 PROTEASE MUTANT V82A WITH POTENT ANTIVIRAL INHIBITOR GRL-98065
Descriptor:Protease, PHOSPHATE ION, DIMETHYL SULFOXIDE, ...
Authors:Wang, Y.F., Tie, Y., Boross, P.I., Tozser, J., Ghosh, A.K., Harrison, R.W., Weber, I.T.
Deposit date:2007-06-20
Release date:2008-04-22
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.11 Å)
Cite:Potent new antiviral compound shows similar inhibition and structural interactions with drug resistant mutants and wild type HIV-1 protease.
J.Med.Chem., 50, 2007
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