Author results

4HBA
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STRUCTURAL AND CATALYTIC CHARACTERIZATION OF A THERMAL AND ACID STABLE VARIANT OF HUMAN CARBONIC ANHYDRASE II CONTAINING AN ENGINEERED DISULFIDE BOND
分子名称:Carbonic anhydrase 2, ZINC ION, GLYCEROL
著者Boone, C.D., Habibzadegan, A., McKenna, R.
登録日2012-09-27
公開日2013-07-31
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (1.762 Å)
主引用文献Structural and catalytic characterization of a thermally stable and acid-stable variant of human carbonic anhydrase II containing an engineered disulfide bond.
Acta Crystallogr.,Sect.D, 69, 2013
4L5U
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THE STRUCTURAL IMPLICATIONS OF THE SECONDARY CO2 BINDING POCKET IN HUMAN CARBONIC ANHYDRASE II
分子名称:Carbonic anhydrase 2, ZINC ION, GLYCEROL
著者Boone, C.D., Gill, S., McKenna, R.
登録日2013-06-11
公開日2014-04-30
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Structural, catalytic and stabilizing consequences of aromatic cluster variants in human carbonic anhydrase II.
Arch.Biochem.Biophys., 539, 2013
4L5V
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THE STRUCTURAL IMPLICATIONS OF THE SECONDARY CO2 BINDING POCKET IN HUMAN CARBONIC ANHYDRASE II
分子名称:Carbonic anhydrase 2, ZINC ION, GLYCEROL
著者Boone, C.D., Gill, S., McKenna, R.
登録日2013-06-11
公開日2014-04-30
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献Structural, catalytic and stabilizing consequences of aromatic cluster variants in human carbonic anhydrase II.
Arch.Biochem.Biophys., 539, 2013
4L5W
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STRUCTURAL IMPLICATIONS OF THE SECONDARY CO2 BINDING POCKET IN HUMAN CARBONIC ANHYDRASE II
分子名称:Carbonic anhydrase 2, ZINC ION, GLYCEROL
著者Boone, C.D., Gill, S., McKenna, R.
登録日2013-06-11
公開日2014-04-30
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural, catalytic and stabilizing consequences of aromatic cluster variants in human carbonic anhydrase II.
Arch.Biochem.Biophys., 539, 2013
4N16
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STRUCTURE OF CHOLATE BOUND TO HUMAN CARBONIC ANHYDRASE II
分子名称:Carbonic anhydrase 2, CHOLIC ACID, GLYCEROL, ...
著者Boone, C.D., McKenna, R.
登録日2013-10-03
公開日2014-06-18
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (1.54 Å)
主引用文献Structural elucidation of the hormonal inhibition mechanism of the bile acid cholate on human carbonic anhydrase II.
Acta Crystallogr.,Sect.D, 70, 2014
4PXX
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CRYSTAL STRUCTURE OF A HIGHLY THERMAL STABILIZED VARIANT OF HUMAN CARBONIC ANHYDRASE II
分子名称:Carbonic anhydrase 2, ZINC ION, CHOLIC ACID, ...
著者Boone, C.D., Habibzadegan, A., McKenna, R.
登録日2014-03-25
公開日2015-06-10
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.851 Å)
主引用文献Crystal structure of a highly thermal stabilized variant of Human Carbonic Anhydrase II
TO BE PUBLISHED
4QK1
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STRUCTURAL AND CATALYTIC EFFECTS OF PROLINE SUBSTITUTION AND SURFACE LOOP DELETION IN THE EXTENDED ACTIVE SITE OF HUMAN CARBONIC ANHYDRASE II - K170P
分子名称:Carbonic anhydrase 2, ZINC ION
著者Boone, C.D., Rasi, V., McKenna, R.
登録日2014-06-05
公開日2015-03-04
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.599 Å)
主引用文献Structural and catalytic effects of proline substitution and surface loop deletion in the extended active site of human carbonic anhydrase II.
Febs J., 282, 2015
4QK2
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STRUCTURAL AND CATALYTIC EFFECTS OF PROLINE SUBSTITUTION AND SURFACE LOOP DELETION IN THE EXTENDED ACTIVE SITE OF HUMAN CARBONIC ANHYDRASE II - E234P
分子名称:Carbonic anhydrase 2, ZINC ION, GLYCEROL
著者Boone, C.D., Rasi, V., McKenna, R.
登録日2014-06-05
公開日2015-03-04
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.519 Å)
主引用文献Structural and catalytic effects of proline substitution and surface loop deletion in the extended active site of human carbonic anhydrase II.
Febs J., 282, 2015
4QK3
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STRUCTURAL AND CATALYTIC EFFECTS OF PROLINE SUBSTITUTION AND SURFACE LOOP DELETION IN THE EXTENDED ACTIVE SITE OF HUMAN CARBONIC ANHYDRASE II - [DELTA]230-240
分子名称:Carbonic anhydrase 2, ZINC ION
著者Boone, C.D., Rasi, V., McKenna, R.
登録日2014-06-05
公開日2015-03-04
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.345 Å)
主引用文献Structural and catalytic effects of proline substitution and surface loop deletion in the extended active site of human carbonic anhydrase II.
Febs J., 282, 2015
6E0U
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STAPHYLOCOCCUS PSEUDINTERMEDIUS EXFOLIATIVE TOXIN EXI
分子名称:Serine protease
著者Boone, C.D., Laganowsky, A.
登録日2018-07-06
公開日2019-07-10
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Crystal structure of the Exfoliative toxin Exi from Staphylococcus pseudintermedius
To be Published
3V3F
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KINETIC AND STRUCTURAL STUDIES OF THERMOSTABILIZED MUTANTS OF HCA II.
分子名称:Carbonic anhydrase 2, ZINC ION, CHLORIDE ION
著者Boone, C.D., Fisher, S.Z., McKenna, R.
登録日2011-12-13
公開日2012-06-20
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Kinetic and structural characterization of thermostabilized mutants of human carbonic anhydrase II.
Protein Eng.Des.Sel., 25, 2012
3V3G
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KINETIC AND STRUCTURAL STUDIES OF THERMOSTABILIZED MUTANTS OF HCA II.
分子名称:Carbonic anhydrase 2, ZINC ION, CHLORIDE ION
著者Boone, C.D., Fisher, S.Z., McKenna, R.
登録日2011-12-13
公開日2012-06-20
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.5581 Å)
主引用文献Kinetic and structural characterization of thermostabilized mutants of human carbonic anhydrase II.
Protein Eng.Des.Sel., 25, 2012
3V3H
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KINETIC AND STRUCTURAL STUDIES OF THERMOSTABILIZED MUTANTS OF HCA II.
分子名称:Carbonic anhydrase 2, ZINC ION, CHLORIDE ION
著者Boone, C.D., Fisher, S.Z., McKenna, R.
登録日2011-12-13
公開日2012-06-20
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Kinetic and structural characterization of thermostabilized mutants of human carbonic anhydrase II.
Protein Eng.Des.Sel., 25, 2012
3V3I
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KINETIC AND STRUCTURAL STUDIES OF THERMOSTABILIZED MUTANTS OF HCA II.
分子名称:Carbonic anhydrase 2, ZINC ION, CHLORIDE ION
著者Boone, C.D., Fisher, S.Z., McKenna, R.
登録日2011-12-13
公開日2012-06-20
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献Kinetic and structural characterization of thermostabilized mutants of human carbonic anhydrase II.
Protein Eng.Des.Sel., 25, 2012
3V3J
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KINETIC AND STRUCTURAL STUDIES OF THERMOSTABILIZED MUTANTS OF HCA II.
分子名称:Carbonic anhydrase 2, ZINC ION
著者Boone, C.D., Fisher, S.Z., McKenna, R.
登録日2011-12-13
公開日2012-06-20
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献Kinetic and structural characterization of thermostabilized mutants of human carbonic anhydrase II.
Protein Eng.Des.Sel., 25, 2012
6B21
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CRYSTAL STRUCTURE OF AMTB FROM E. COLI BOUND TO TOPFLUOR CARDIOLIPIN
分子名称:Ammonia channel, [(2R,5R,11R,14S,24E)-14-[(acetyloxy)methyl]-8-{[5-(3,5-dimethyl-1H-pyrrol-2-yl-kappaN)-5-(3,5-dimethyl-2H-pyrrol-2-ylidene-kappaN)pentanoyl]oxy}-5,11-dihydroxy-2-{[(9E)-octadec-9-enoyl]oxy}-5,11,16-trioxo-4,6,10,12,15-pentaoxa-5lambda~5~,11lambda~5~-diphosphatritriacont-24-en-1-yl (9E)-octadec-9-enoatato](difluoro)boron
著者Boone, C.D., Laganowsky, A.
登録日2017-09-19
公開日2018-03-07
最終更新日2018-03-28
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Allostery revealed within lipid binding events to membrane proteins.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
4M2R
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HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH BRINZOLAMIDE
分子名称:Carbonic anhydrase 2, ZINC ION, (+)-4-ETHYLAMINO-3,4-DIHYDRO-2-(METHOXY)PROPYL-2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE-1,1-DIOXIDE
著者Pinard, M.P., Boone, C.D., Rife, B.D., Supuran, C.T., Mckenna, R.
登録日2013-08-05
公開日2013-11-06
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (1.993 Å)
主引用文献Structural study of interaction between brinzolamide and dorzolamide inhibition of human carbonic anhydrases.
Bioorg.Med.Chem., 21, 2013
4M2U
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CARBONIC ANHYDRASE II IN COMPLEX WITH DORZOLAMIDE
分子名称:Carbonic anhydrase 2, ZINC ION, (4S-TRANS)-4-(ETHYLAMINO)-5,6-DIHYDRO-6-METHYL-4H-THIENO(2,3-B)THIOPYRAN-2-SULFONAMIDE-7,7-DIOXIDE
著者Pinard, M.P., Boone, C.D., Rife, B.D., Supuran, C.T., Mckenna, R.
登録日2013-08-05
公開日2013-11-06
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (1.999 Å)
主引用文献Structural study of interaction between brinzolamide and dorzolamide inhibition of human carbonic anhydrases.
Bioorg.Med.Chem., 21, 2013
4M2V
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GENETICALLY ENGINEERED CARBONIC ANHYDRASE IX IN COMPLEX WITH BRINZOLAMIDE
分子名称:Carbonic anhydrase 2, ZINC ION, (+)-4-ETHYLAMINO-3,4-DIHYDRO-2-(METHOXY)PROPYL-2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE-1,1-DIOXIDE
著者Pinard, M.P., Boone, C.D., Rife, B.D., Supuran, C.T., Mckenna, R.
登録日2013-08-05
公開日2013-11-06
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (1.718 Å)
主引用文献Structural study of interaction between brinzolamide and dorzolamide inhibition of human carbonic anhydrases.
Bioorg.Med.Chem., 21, 2013
4M2W
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GENETICALLY ENGINEERED CARBONIC ANHYDRASE IX IN COMPLEX WITH DORZOLAMIDE
分子名称:Carbonic anhydrase 2, ZINC ION, (4S-TRANS)-4-(ETHYLAMINO)-5,6-DIHYDRO-6-METHYL-4H-THIENO(2,3-B)THIOPYRAN-2-SULFONAMIDE-7,7-DIOXIDE
著者Pinard, M.P., Boone, C.D., Rife, B.D., Supuran, C.T., McKenna, R.
登録日2013-08-05
公開日2013-11-06
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (1.658 Å)
主引用文献Structural study of interaction between brinzolamide and dorzolamide inhibition of human carbonic anhydrases.
Bioorg.Med.Chem., 21, 2013
4RXY
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CRYSTAL STRUCTURE OF THE BETA CARBONIC ANHYDRASE PSCA3 ISOLATED FROM PSEUDOMONAS AERUGINOSA
分子名称:Carbonic anhydrase, ZINC ION, GLYCEROL
著者Pinard, M.A., Mckenna, R.
登録日2014-12-12
公開日2015-06-24
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.901 Å)
主引用文献Structure and inhibition studies of a type II beta-carbonic anhydrase psCA3 from Pseudomonas aeruginosa.
Bioorg.Med.Chem., 23, 2015
4XZ5
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STRUCTURE OF THE THERMOSTABLE ALPHA-CARBONIC ANYDRASE FROM THIOMICROSPIRA CRUNOGENA XCL-2 GAMMAPROTEOBACTERIUM
分子名称:Carbonic anhydrase, alpha family, ZINC ION, ...
著者Mahon, B.P., Diaz-Torres, N.A., Pinard, M.A., McKenna, R.
登録日2015-02-03
公開日2015-07-29
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (2.596 Å)
主引用文献Structural and biophysical characterization of the alpha-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2: insights into engineering thermostable enzymes for CO2 sequestration.
Acta Crystallogr.,Sect.D, 71, 2015