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1PNJ
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BU of 1pnj by Molmil
SOLUTION STRUCTURE AND LIGAND-BINDING SITE OF THE SH3 DOMAIN OF THE P85ALPHA SUBUNIT OF PHOSPHATIDYLINOSITOL 3-KINASE
Descriptor: PHOSPHATIDYLINOSITOL 3-KINASE P85-ALPHA SUBUNIT SH3 DOMAIN
Authors:Booker, G.W, Gout, I, Downing, A.K, Driscoll, P.C, Boyd, J, Waterfield, M.D, Campbell, I.D.
Deposit date:1993-07-19
Release date:1993-10-31
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Solution structure and ligand-binding site of the SH3 domain of the p85 alpha subunit of phosphatidylinositol 3-kinase.
Cell(Cambridge,Mass.), 73, 1993
2PNB
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BU of 2pnb by Molmil
STRUCTURE OF AN SH2 DOMAIN OF THE P85 ALPHA SUBUNIT OF PHOSPHATIDYLINOSITOL-3-OH KINASE
Descriptor: PHOSPHATIDYLINOSITOL 3-KINASE P85-ALPHA SUBUNIT N-TERMINAL SH2 DOMAIN
Authors:Booker, G.W, Breeze, A.L, Downing, A.K, Panayotou, G, Gout, I, Waterfield, M.D, Campbell, I.D.
Deposit date:1992-06-30
Release date:1994-01-31
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Structure of an SH2 domain of the p85 alpha subunit of phosphatidylinositol-3-OH kinase.
Nature, 358, 1992
2PNI
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BU of 2pni by Molmil
SOLUTION STRUCTURE AND LIGAND-BINDING SITE OF THE SH3 DOMAIN OF THE P85ALPHA SUBUNIT OF PHOSPHATIDYLINOSITOL 3-KINASE
Descriptor: PHOSPHATIDYLINOSITOL 3-KINASE P85-ALPHA SUBUNIT SH3 DOMAIN
Authors:Booker, G.W, Gout, I, Downing, A.K, Driscoll, P.C, Boyd, J, Waterfield, M.D, Campbell, I.D.
Deposit date:1993-07-19
Release date:1993-10-31
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Solution structure and ligand-binding site of the SH3 domain of the p85 alpha subunit of phosphatidylinositol 3-kinase.
Cell(Cambridge,Mass.), 73, 1993
2PNA
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BU of 2pna by Molmil
STRUCTURE OF AN SH2 DOMAIN OF THE P85 ALPHA SUBUNIT OF PHOSPHATIDYLINOSITOL-3-OH KINASE
Descriptor: PHOSPHATIDYLINOSITOL 3-KINASE P85-ALPHA SUBUNIT N-TERMINAL SH2 DOMAIN
Authors:Booker, G.W, Breeze, A.L, Downing, A.K, Panayotou, G, Gout, I, Waterfield, M.D, Campbell, I.D.
Deposit date:1992-06-30
Release date:1994-01-31
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Structure of an SH2 domain of the p85 alpha subunit of phosphatidylinositol-3-OH kinase.
Nature, 358, 1992
4WOP
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BU of 4wop by Molmil
Nucleotide Triphosphate Promiscuity in Mycobacterium tuberculosis Dethiobiotin Synthetase
Descriptor: ATP-dependent dethiobiotin synthetase BioD, CYTIDINE-5'-TRIPHOSPHATE, SULFATE ION
Authors:Salaemae, W, Yap, M.Y, Wegener, K.L, Booker, G.W, Wilce, M.C.J, Polyak, S.W.
Deposit date:2014-10-16
Release date:2015-04-08
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.393 Å)
Cite:Nucleotide triphosphate promiscuity in Mycobacterium tuberculosis dethiobiotin synthetase.
Tuberculosis (Edinb), 95, 2015
1C8P
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BU of 1c8p by Molmil
NMR STRUCTURE OF THE LIGAND BINDING DOMAIN OF THE COMMON BETA-CHAIN IN THE GM-CSF, IL-3 AND IL-5 RECEPTORS
Descriptor: CYTOKINE RECEPTOR COMMON BETA CHAIN
Authors:Mulhern, T.D, D'Andrea, R.J, Gaunt, C, Vandeleur, L, Vadas, M.A, Lopez, A.F, Booker, G.W, Bagley, C.J.
Deposit date:1999-10-05
Release date:2000-06-15
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:The solution structure of the cytokine-binding domain of the common beta-chain of the receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3 and interleukin-5.
J.Mol.Biol., 297, 2000
1GL5
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BU of 1gl5 by Molmil
NMR structure of the SH3 domain from the Tec protein tyrosine kinase
Descriptor: TYROSINE-PROTEIN KINASE TEC
Authors:Mulhern, T.D, Pursglove, S.E, Booker, G.W.
Deposit date:2001-08-28
Release date:2001-11-28
Last modified:2018-02-28
Method:SOLUTION NMR
Cite:The solution structure and intramolecular associations of the Tec kinase SRC homology 3 domain.
J. Biol. Chem., 277, 2002
1WLX
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BU of 1wlx by Molmil
Solution structure of the third spectrin repeat of alpha-actinin-4
Descriptor: Alpha-actinin 4
Authors:Kowalski, K, Merkel, A.L, Booker, G.W.
Deposit date:2004-06-30
Release date:2005-08-09
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Solution structure of the third spectrin repeat of alpha-actinin-4
To be Published
1WR4
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BU of 1wr4 by Molmil
Solution structure of the second WW domain of Nedd4-2
Descriptor: ubiquitin-protein ligase Nedd4-2
Authors:Kowalski, K, Merkel, A.L, Booker, G.W.
Deposit date:2004-10-11
Release date:2005-10-18
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Solution structures of the WW domains of Nedd4-2
To be Published
1WR7
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BU of 1wr7 by Molmil
Solution structure of the third WW domain of Nedd4-2
Descriptor: Nedd4-2
Authors:Kowalski, K, Merkel, A.L, Booker, G.W.
Deposit date:2004-10-13
Release date:2005-10-25
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Solution structures of the WW domains of Nedd4-2
To be Published
1WMV
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BU of 1wmv by Molmil
Solution structure of the second WW domain of WWOX
Descriptor: WW domain containing oxidoreductase
Authors:Kowalski, K, Merkel, A.L, Colella, A, Richards, R.I, Booker, G.W.
Deposit date:2004-07-21
Release date:2005-08-09
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Solution structure of the second WW domain of WWOX
To be Published
1WR3
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BU of 1wr3 by Molmil
Solution structure of the first WW domain of Nedd4-2
Descriptor: ubiquitin-protein ligase Nedd4-2
Authors:Kowalski, K, Merkel, A.L, Booker, G.W.
Deposit date:2004-10-11
Release date:2005-10-18
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Solution structures of WW domains of Nedd4-2
To be Published
8ENI
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BU of 8eni by Molmil
Crystal structure of Staphylococcus aureus biotin protein ligase in complex with inhibitor
Descriptor: 3-[4-(5-fluoro-4-{5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentyl}-1H-1,2,3-triazol-1-yl)butyl]-5-methyl-1,3-benzoxazol-2(3H)-one, Bifunctional ligase/repressor BirA
Authors:Wilce, M.C.J, Cini, D.A.
Deposit date:2022-09-30
Release date:2022-11-30
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Halogenation of Biotin Protein Ligase Inhibitors Improves Whole Cell Activity against Staphylococcus aureus.
ACS Infect Dis, 4, 2018
4DQ2
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BU of 4dq2 by Molmil
Structure of staphylococcus aureus biotin protein ligase in complex with biotinol-5'-amp
Descriptor: ((2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXY-TETRAHYDROFURAN-2-YL)METHYL 5-((3AS,4S,6AR)-2-OXO-HEXAHYDRO-1H-THIENO[3,4-D]IMIDAZOL-4-YL)PENTYL HYDROGEN PHOSPHATE, Biotin-[acetyl-CoA-carboxylase] ligase
Authors:Wilce, M, Yap, M, Pendini, N, Soares de Costa, T, Polyak, S, Tieu, W, Booker, G, Wallace, J.
Deposit date:2012-02-14
Release date:2012-04-18
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Selective inhibition of biotin protein ligase from Staphylococcus aureus.
J.Biol.Chem., 287, 2012
7JT6
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BU of 7jt6 by Molmil
Mycobacterium tuberculosis dethiobiotin synthetase in complex with Tetrazole 2
Descriptor: ATP-dependent dethiobiotin synthetase BioD, GLYCEROL, SULFATE ION, ...
Authors:Pederick, J.P, Bean, J.H, Bruning, J.B.
Deposit date:2020-08-17
Release date:2021-09-08
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Inhibition of Mycobacterium tuberculosis Dethiobiotin Synthase ( Mt DTBS): Toward Next-Generation Antituberculosis Agents.
Acs Chem.Biol., 16, 2021
7JT5
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BU of 7jt5 by Molmil
Mycobacterium tuberculosis dethiobiotin synthetase in complex with fragment analogue 9
Descriptor: ATP-dependent dethiobiotin synthetase BioD, GLYCEROL, SULFATE ION, ...
Authors:Pederick, J.P, Bruning, J.B.
Deposit date:2020-08-17
Release date:2021-09-08
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Inhibition of Mycobacterium tuberculosis Dethiobiotin Synthase ( Mt DTBS): Toward Next-Generation Antituberculosis Agents.
Acs Chem.Biol., 16, 2021
6APW
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BU of 6apw by Molmil
Crystal structure of Staphylococcus aureus biotin protein ligase in complex with inhibitor
Descriptor: 4-[(4-{5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentyl}-1H-1,2,3-triazol-1-yl)methyl]benzoic acid, Bifunctional ligase/repressor BirA
Authors:Cini, D.A, Wilce, M.C.J.
Deposit date:2017-08-18
Release date:2018-02-07
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.614 Å)
Cite:Halogenation of Biotin Protein Ligase Inhibitors Improves Whole Cell Activity against Staphylococcus aureus.
ACS Infect Dis, 4, 2018
6AQQ
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BU of 6aqq by Molmil
Crystal structure of Staphylococcus aureus biotin protein ligase in complex with inhibitor
Descriptor: (3aS,4S,6aR)-4-(5-{1-[(3-fluorophenyl)methyl]-1H-1,2,3-triazol-4-yl}pentyl)tetrahydro-1H-thieno[3,4-d]imidazol-2(3H)-one, Bifunctional ligase/repressor BirA
Authors:Cini, D.A, Wilce, M.C.J.
Deposit date:2017-08-21
Release date:2018-02-07
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Halogenation of Biotin Protein Ligase Inhibitors Improves Whole Cell Activity against Staphylococcus aureus.
ACS Infect Dis, 4, 2018
6CZD
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BU of 6czd by Molmil
Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with adenosine diphosphate
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent dethiobiotin synthetase BioD, MAGNESIUM ION
Authors:Thompson, A.P, Wegener, K.L, Bruning, J.B, Polyak, S.W.
Deposit date:2018-04-09
Release date:2018-10-24
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Precipitant-ligand exchange technique reveals the ADP binding mode in Mycobacterium tuberculosis dethiobiotin synthetase.
Acta Crystallogr D Struct Biol, 74, 2018
7L1J
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BU of 7l1j by Molmil
Mycobacterium tuberculosis dethiobiotin synthetase in complex with Tetrazole 1
Descriptor: ATP-dependent dethiobiotin synthetase BioD, GLYCEROL, SULFATE ION, ...
Authors:Pederick, J.L, Bruning, J.B.
Deposit date:2020-12-14
Release date:2021-10-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Inhibition of Mycobacterium tuberculosis Dethiobiotin Synthase ( Mt DTBS): Toward Next-Generation Antituberculosis Agents.
Acs Chem.Biol., 16, 2021
6NDL
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BU of 6ndl by Molmil
Crystal structure of Staphylococcus aureus biotin protein ligase in complex with a sulfonamide inhibitor
Descriptor: 1-[4-(6-aminopurin-9-yl)butylsulfamoyl]-3-[4-[(4~{S})-2-oxidanylidene-1,3,3~{a},4,6,6~{a}-hexahydrothieno[3,4-d]imidazol-4-yl]butyl]urea, Biotin Protein Ligase, GLYCEROL
Authors:Marshall, A.C, Polyak, S.W, Bruning, J.B, Lee, K.
Deposit date:2018-12-13
Release date:2019-12-18
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Sulfonamide-Based Inhibitors of Biotin Protein Ligase as New Antibiotic Leads.
Acs Chem.Biol., 14, 2019
6CVF
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BU of 6cvf by Molmil
Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with cytidine diphosphate
Descriptor: ATP-dependent dethiobiotin synthetase BioD, CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Thompson, A.P, Bruning, J.B, Wegener, K.L, Polyak, S.W.
Deposit date:2018-03-28
Release date:2018-11-21
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Mycobacterium tuberculosis Dethiobiotin Synthetase Facilitates Nucleoside Triphosphate Promiscuity through Alternate Binding Modes
Acs Catalysis, 8(11), 2018
6CZB
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BU of 6czb by Molmil
Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with uridine triphosphate (UTP) - promiscuous binding mode with disordered nucleoside
Descriptor: ATP-dependent dethiobiotin synthetase BioD, MAGNESIUM ION, URIDINE 5'-TRIPHOSPHATE
Authors:Thompson, A.P, Wegener, K.L, Bruning, J.B, Polyak, S.W.
Deposit date:2018-04-09
Release date:2018-11-21
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Mycobacterium tuberculosis Dethiobiotin Synthetase Facilitates Nucleoside Triphosphate Promiscuity through Alternate Binding Modes
Acs Catalysis, 8(11), 2018
6CVE
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BU of 6cve by Molmil
Crystal structure of Mycobacterium tuberculosis dethiobiotin Synthetase in complex with cytidine triphosphate and 7,8-diaminopelargonic acid
Descriptor: 7-(CARBOXYAMINO)-8-AMINO-NONANOIC ACID, ATP-dependent dethiobiotin synthetase BioD, CITRATE ANION, ...
Authors:Thompson, A.P, Bruning, J.B, Wegener, K.L, Polyak, S.W.
Deposit date:2018-03-28
Release date:2018-11-21
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Mycobacterium tuberculosis Dethiobiotin Synthetase Facilitates Nucleoside Triphosphate Promiscuity through Alternate Binding Modes
Acs Catalysis, 8(11), 2018
6CVV
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BU of 6cvv by Molmil
Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with adenosine triphosphate (ATP) - promiscuous binding mode with disordered nucleoside
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent dethiobiotin synthetase BioD, MAGNESIUM ION
Authors:Thompson, A.P, Wegener, K.L, Bruning, J.B, Polyak, S.W.
Deposit date:2018-03-29
Release date:2018-11-21
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Mycobacterium tuberculosis Dethiobiotin Synthetase Facilitates Nucleoside Triphosphate Promiscuity through Alternate Binding Modes
Acs Catalysis, 8(11), 2018

 

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