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2H5D
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0.9A RESOLUTION CRYSTAL STRUCTURE OF ALPHA-LYTIC PROTEASE COMPLEXED WITH A TRANSITION STATE ANALOGUE, MEOSUC-ALA-ALA-PRO-VAL BORONIC ACID
分子名称:ALPHA-LYTIC PROTEASE, MEOSUC-ALA-ALA-PRO-ALA BORONIC ACID INHIBITOR, SULFATE ION, ...
著者Fuhrmann, C.N., Agard, D.A.
登録日2006-05-25
公開日2006-09-26
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (0.9 Å)
主引用文献Subangstrom crystallography reveals that short ionic hydrogen bonds, and not a His-Asp low-barrier hydrogen bond, stabilize the transition state in serine protease catalysis
J.Am.Chem.Soc., 128, 2006
1TAL
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ALPHA-LYTIC PROTEASE AT 120 K (SINGLE STRUCTURE MODEL)
分子名称:ALPHA-LYTIC PROTEASE, SULFATE ION, TRIS(HYDROXYETHYL)AMINOMETHANE
著者Rader, S.D., Agard, D.A.
登録日1996-10-30
公開日1997-04-01
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Conformational substates in enzyme mechanism: the 120 K structure of alpha-lytic protease at 1.5 A resolution.
Protein Sci., 6, 1997
2ULL
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MULTIPLE CONFORMATION STRUCTURE OF ALPHA-LYTIC PROTEASE AT 120 K
分子名称:ALPHA-LYTIC PROTEASE, SULFATE ION, TRIS(HYDROXYETHYL)AMINOMETHANE
著者Rader, S.D., Agard, D.A.
登録日1996-11-26
公開日1997-07-07
最終更新日2015-09-09
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Conformational substates in enzyme mechanism: the 120 K structure of alpha-lytic protease at 1.5 A resolution.
Protein Sci., 6, 1997
1QBV
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CRYSTAL STRUCTURE OF THROMBIN COMPLEXED WITH AN GUANIDINE-MIMETIC INHIBITOR
分子名称:THROMBIN (LIGHT CHAIN), THROMBIN (HEAVY CHAIN), Hirudin, ...
著者Bone, R., Lu, T., Illig, C.R., Soll, R.M., Spurlino, J.C.
登録日1999-04-27
公開日1999-10-27
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural analysis of thrombin complexed with potent inhibitors incorporating a phenyl group as a peptide mimetic and aminopyridines as guanidine substitutes.
J.Med.Chem., 41, 1998
1P12
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CRYSTAL STRUCTURES OF ALPHA-LYTIC PROTEASE COMPLEXES WITH IRREVERSIBLY BOUND PHOSPHONATE ESTERS
分子名称:ALPHA-LYTIC PROTEASE, PHOSPHONATE ESTER INHIBITOR, SULFATE ION
著者Bone, R., Agard, D.A.
登録日1990-10-26
公開日1993-01-15
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structures of alpha-lytic protease complexes with irreversibly bound phosphonate esters.
Biochemistry, 30, 1991
1P11
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CRYSTAL STRUCTURES OF ALPHA-LYTIC PROTEASE COMPLEXES WITH IRREVERSIBLY BOUND PHOSPHONATE ESTERS
分子名称:ALPHA-LYTIC PROTEASE, PHOSPHONATE ESTER INHIBITOR A, PHOSPHONATE ESTER INHIBITOR B(TRANSITION STATE), ...
著者Bone, R., Agard, D.A.
登録日1990-10-26
公開日1993-01-15
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Crystal structures of alpha-lytic protease complexes with irreversibly bound phosphonate esters.
Biochemistry, 30, 1991
1GBJ
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ALPHA-LYTIC PROTEASE WITH MET 190 REPLACED BY ALA
分子名称:ALPHA-LYTIC PROTEASE, SULFATE ION
著者Mace, J.E., Agard, D.A.
登録日1995-09-06
公開日1996-01-29
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Kinetic and structural characterization of mutations of glycine 216 in alpha-lytic protease: a new target for engineering substrate specificity.
J.Mol.Biol., 254, 1995
1P01
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SERINE PROTEASE MECHANISM. STRUCTURE OF AN INHIBITORY COMPLEX OF ALPHA-LYTIC PROTEASE AND A TIGHTLY BOUND PEPTIDE BORONIC ACID
分子名称:ALPHA-LYTIC PROTEASE, N-(tert-butoxycarbonyl)-L-alanyl-N-[(1R)-1-(dihydroxyboranyl)-2-methylpropyl]-L-prolinamide, SULFATE ION
著者Bone, R., Agard, D.A.
登録日1989-04-24
公開日1990-04-15
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Serine protease mechanism: structure of an inhibitory complex of alpha-lytic protease and a tightly bound peptide boronic acid.
Biochemistry, 26, 1987
1P02
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STRUCTURE ANALYSIS OF SPECIFICITY. ALPHA-LYTIC PROTEASE COMPLEXES WITH ANALOGUES OF REACTION INTERMEDIATES
分子名称:ALPHA-LYTIC PROTEASE, METHOXYSUCCINYL-ALA-ALA-PRO-ALANINE BORONIC ACID INHIBITOR, SULFATE ION
著者Bone, R., Agard, D.A.
登録日1989-04-24
公開日1990-04-15
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural analysis of specificity: alpha-lytic protease complexes with analogues of reaction intermediates.
Biochemistry, 28, 1989
1T4U
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CRYSTAL STRUCTURE ANALYSIS OF A NOVEL OXYGUANIDINE BOUND TO THROMBIN
分子名称:Prothrombin, Hirudin IIIA, 2-METHANESULFONYL-BENZENESULFONIC ACID 3-METHYL-5-((1-AMIDINOAMINOOXYMETHYL-CYCLOPROPYL)METHYLOXY)-PHENYLESTER
著者Spurlino, J.
登録日2004-04-30
公開日2005-03-22
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Oxyguanidines. Part 2: Discovery of a novel orally active thrombin inhibitor through structure-based drug design and parallel synthesis
BIOORG.MED.CHEM.LETT., 14, 2004
1T4V
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CRYSTAL STRUCTURE ANALYSIS OF A NOVEL OXYGUANIDINE BOUND TO THROMBIN
分子名称:Prothrombin, Hirudin IIIA, N-ALLYL-5-AMIDINOAMINOOXY-PROPYLOXY-3-CHLORO-N-CYCLOPENTYLBENZAMIDE
著者Spurlino, J.
登録日2004-04-30
公開日2005-03-22
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Oxyguanidines. Part 2: Discovery of a novel orally active thrombin inhibitor through structure-based drug design and parallel synthesis
BIOORG.MED.CHEM.LETT., 14, 2004
7LPR
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STRUCTURAL BASIS FOR BROAD SPECIFICITY IN ALPHA-LYTIC PROTEASE MUTANTS
分子名称:ALPHA-LYTIC PROTEASE, METHOXYSUCCINYL-ALA-ALA-PRO-LEUCINE BORONIC ACID INHIBITOR, SULFATE ION
著者Fujishige, A., Bone, R., Agard, D.A.
登録日1991-08-05
公開日1993-01-15
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Structural basis for broad specificity in alpha-lytic protease mutants.
Biochemistry, 30, 1991
1BOQ
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PRO REGION C-TERMINUS: PROTEASE ACTIVE SITE INTERACTIONS ARE CRITICAL IN CATALYZING THE FOLDING OF ALPHA-LYTIC PROTEASE
分子名称:PROTEIN (ALPHA-LYTIC PROTEASE), SULFATE ION
著者Peters, R.J., Shiau, A.K., Sohl, J.L., Anderson, D.E., Tang, G., Silen, J.L., Agard, D.A.
登録日1998-08-05
公開日1998-08-12
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Pro region C-terminus:protease active site interactions are critical in catalyzing the folding of alpha-lytic protease.
Biochemistry, 37, 1998
1P05
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STRUCTURE ANALYSIS OF SPECIFICITY. ALPHA-LYTIC PROTEASE COMPLEXES WITH ANALOGUES OF REACTION INTERMEDIATES
分子名称:ALPHA-LYTIC PROTEASE, METHOXYSUCCINYL-ALA-ALA-PRO-NORLEUCINE BORONIC ACID INHIBITOR, SULFATE ION
著者Bone, R., Agard, D.A.
登録日1989-04-24
公開日1990-04-15
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural analysis of specificity: alpha-lytic protease complexes with analogues of reaction intermediates.
Biochemistry, 28, 1989
2HHM
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STRUCTURE OF INOSITOL MONOPHOSPHATASE, THE PUTATIVE TARGET OF LITHIUM THERAPY
分子名称:INOSITOL MONOPHOSPHATASE, SULFATE ION, GADOLINIUM ATOM
著者Bone, R.
登録日1992-10-20
公開日1993-10-31
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure of inositol monophosphatase, the putative target of lithium therapy.
Proc.Natl.Acad.Sci.USA, 89, 1992
4PHV
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X-RAY CRYSTAL STRUCTURE OF THE HIV PROTEASE COMPLEX WITH L-700,417, AN INHIBITOR WITH PSEUDO C2 SYMMETRY
分子名称:HIV-1 PROTEASE, N,N-BIS(2-HYDROXY-1-INDANYL)-2,6- DIPHENYLMETHYL-4-HYDROXY-1,7-HEPTANDIAMIDE
著者Bone, R.
登録日1991-10-04
公開日1993-10-31
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献X-Ray Crystal Structure of the HIV Protease Complex with L-700,417, an Inhibitor with Pseudo C2 Symmetry
J.Am.Chem.Soc., 113, 1991
6LPR
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STRUCTURAL BASIS FOR BROAD SPECIFICITY IN ALPHA-LYTIC PROTEASE MUTANTS
分子名称:ALPHA-LYTIC PROTEASE, METHOXYSUCCINYL-ALA-ALA-PRO-NORLEUCINE BORONIC ACID INHIBITOR, SULFATE ION
著者Bone, R., Agard, D.A.
登録日1991-08-05
公開日1993-01-15
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural basis for broad specificity in alpha-lytic protease mutants.
Biochemistry, 30, 1991
1GBK
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ALPHA-LYTIC PROTEASE WITH MET 190 REPLACED BY ALA COMPLEX WITH METHOXYSUCCINYL-ALA-ALA-PRO-ALANINE BORONIC ACID
分子名称:ALPHA-LYTIC PROTEASE, METHOXYSUCCINYL-ALA-ALA-PRO-ALANINE BORONIC ACID INHIBITOR, SULFATE ION
著者Mace, J.E., Agard, D.A.
登録日1995-09-06
公開日1996-01-29
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (2.13 Å)
主引用文献Kinetic and structural characterization of mutations of glycine 216 in alpha-lytic protease: a new target for engineering substrate specificity.
J.Mol.Biol., 254, 1995
5LPR
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STRUCTURAL BASIS FOR BROAD SPECIFICITY IN ALPHA-LYTIC PROTEASE MUTANTS
分子名称:ALPHA-LYTIC PROTEASE, METHOXYSUCCINYL-ALA-ALA-PRO-ALANINE BORONIC ACID INHIBITOR, SULFATE ION
著者Fujishige, A., Bone, R., Agard, D.A.
登録日1991-08-05
公開日1993-01-15
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (2.13 Å)
主引用文献Structural basis for broad specificity in alpha-lytic protease mutants.
Biochemistry, 30, 1991
1GBA
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ALPHA-LYTIC PROTEASE WITH MET 190 REPLACED BY ALA AND GLY 216 REPLACED BY ALA
分子名称:ALPHA-LYTIC PROTEASE, SULFATE ION
著者Mace, J.E., Agard, D.A.
登録日1995-09-06
公開日1996-01-29
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Kinetic and structural characterization of mutations of glycine 216 in alpha-lytic protease: a new target for engineering substrate specificity.
J.Mol.Biol., 254, 1995
1GBB
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ALPHA-LYTIC PROTEASE WITH MET 190 REPLACED BY ALA AND GLY 216 REPLACED BY ALA COMPLEX WITH METHOXYSUCCINYL-ALA-ALA-PRO-ALANINE BORONIC ACID
分子名称:ALPHA-LYTIC PROTEASE, METHOXYSUCCINYL-ALA-ALA-PRO-ALANINE BORONIC ACID INHIBITOR, SULFATE ION
著者Mace, J.E., Agard, D.A.
登録日1995-09-06
公開日1996-01-29
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Kinetic and structural characterization of mutations of glycine 216 in alpha-lytic protease: a new target for engineering substrate specificity.
J.Mol.Biol., 254, 1995
1GBF
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ALPHA-LYTIC PROTEASE WITH MET 190 REPLACED BY ALA AND GLY 216 REPLACED BY LEU COMPLEX WITH METHOXYSUCCINYL-ALA-ALA-PRO-ALANINE BORONIC ACID
分子名称:ALPHA-LYTIC PROTEASE, METHOXYSUCCINYL-ALA-ALA-PRO-ALANINE BORONIC ACID INHIBITOR, SULFATE ION
著者Mace, J.E., Agard, D.A.
登録日1995-09-06
公開日1996-01-29
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Kinetic and structural characterization of mutations of glycine 216 in alpha-lytic protease: a new target for engineering substrate specificity.
J.Mol.Biol., 254, 1995
1GBL
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ALPHA-LYTIC PROTEASE WITH MET 190 REPLACED BY ALA COMPLEX WITH METHOXYSUCCINYL-ALA-ALA-PRO-LEUCINE BORONIC ACID
分子名称:ALPHA-LYTIC PROTEASE, METHOXYSUCCINYL-ALA-ALA-PRO-LEUCINE BORONIC ACID INHIBITOR, SULFATE ION
著者Mace, J.E., Agard, D.A.
登録日1995-09-06
公開日1996-01-29
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Kinetic and structural characterization of mutations of glycine 216 in alpha-lytic protease: a new target for engineering substrate specificity.
J.Mol.Biol., 254, 1995
1P03
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STRUCTURE ANALYSIS OF SPECIFICITY. ALPHA-LYTIC PROTEASE COMPLEXES WITH ANALOGUES OF REACTION INTERMEDIATES
分子名称:ALPHA-LYTIC PROTEASE, METHOXYSUCCINYL-ALA-ALA-PRO-VALINE BORONIC ACID INHIBITOR, SULFATE ION
著者Bone, R., Agard, D.A.
登録日1989-04-24
公開日1990-04-15
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural analysis of specificity: alpha-lytic protease complexes with analogues of reaction intermediates.
Biochemistry, 28, 1989
3LPR
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STRUCTURAL BASIS FOR BROAD SPECIFICITY IN ALPHA-LYTIC PROTEASE MUTANTS
分子名称:ALPHA-LYTIC PROTEASE, METHOXYSUCCINYL-ALA-ALA-PRO-NORLEUCINE BORONIC ACID INHIBITOR, SULFATE ION
著者Bone, R., Agard, D.A.
登録日1991-08-05
公開日1993-01-15
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural basis for broad specificity in alpha-lytic protease mutants.
Biochemistry, 30, 1991
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