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2XD0
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BU of 2xd0 by Molmil
A processed non-coding RNA regulates a bacterial antiviral system
Descriptor: TOXI, TOXN
Authors:Blower, T.R, Pei, X.Y, Short, F.L, Fineran, P.C, Humphreys, D.P, Luisi, B.F, Salmond, G.P.C.
Deposit date:2010-04-28
Release date:2011-01-12
Last modified:2020-06-03
Method:X-RAY DIFFRACTION (3 Å)
Cite:A processed noncoding RNA regulates an altruistic bacterial antiviral system.
Nat. Struct. Mol. Biol., 18, 2011
2XDB
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BU of 2xdb by Molmil
A processed non-coding RNA regulates a bacterial antiviral system
Descriptor: COBALT (II) ION, SULFATE ION, TOXI, ...
Authors:Blower, T.R, Pei, X.Y, Short, F.L, Fineran, P.C, Humphreys, D.P, Luisi, B.F, Salmond, G.P.C.
Deposit date:2010-04-30
Release date:2011-01-12
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:A Processed Noncoding RNA Regulates an Altruistic Bacterial Antiviral System.
Nat.Struct.Mol.Biol., 18, 2011
5BTN
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BU of 5btn by Molmil
Crystal structure of a topoisomerase II complex
Descriptor: 1-cyclopropyl-6-fluoro-8-methyl-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, DNA gyrase subunit A, DNA gyrase subunit B, ...
Authors:Blower, T.R, Williamson, B.H, Kerns, R.J, Berger, J.M.
Deposit date:2015-06-03
Release date:2016-03-02
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure and stability of gyrase-fluoroquinolone cleaved complexes from Mycobacterium tuberculosis.
Proc.Natl.Acad.Sci.USA, 113, 2016
5BTA
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BU of 5bta by Molmil
Crystal structure of a topoisomerase II complex
Descriptor: 1-cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, DNA gyrase subunit A, DNA gyrase subunit B, ...
Authors:Blower, T.R, Williamson, B.H, Kerns, R.J, Berger, J.M.
Deposit date:2015-06-02
Release date:2016-03-02
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal structure and stability of gyrase-fluoroquinolone cleaved complexes from Mycobacterium tuberculosis.
Proc.Natl.Acad.Sci.USA, 113, 2016
5BTG
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BU of 5btg by Molmil
Crystal structure of a topoisomerase II complex
Descriptor: (3S)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid, DNA gyrase subunit A, DNA gyrase subunit B, ...
Authors:Blower, T.R, Williamson, B.H, Kerns, R.J, Berger, J.M.
Deposit date:2015-06-03
Release date:2016-03-02
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure and stability of gyrase-fluoroquinolone cleaved complexes from Mycobacterium tuberculosis.
Proc.Natl.Acad.Sci.USA, 113, 2016
5BTL
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BU of 5btl by Molmil
Crystal structure of a topoisomerase II complex
Descriptor: 1-cyclopropyl-6-fluoro-8-methyl-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, DNA gyrase subunit A, DNA gyrase subunit B, ...
Authors:Blower, T.R, Williamson, B.H, Kerns, R.J, Berger, J.M.
Deposit date:2015-06-03
Release date:2016-03-02
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure and stability of gyrase-fluoroquinolone cleaved complexes from Mycobacterium tuberculosis.
Proc.Natl.Acad.Sci.USA, 113, 2016
5BTC
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BU of 5btc by Molmil
Crystal structure of a topoisomerase II complex
Descriptor: 1-CYCLOPROPYL-6-FLUORO-4-OXO-7-PIPERAZIN-1-YL-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID, DNA gyrase subunit A, DNA gyrase subunit B, ...
Authors:Blower, T.R, Williamson, B.H, Kerns, R.J, Berger, J.M.
Deposit date:2015-06-02
Release date:2016-03-02
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal structure and stability of gyrase-fluoroquinolone cleaved complexes from Mycobacterium tuberculosis.
Proc.Natl.Acad.Sci.USA, 113, 2016
5BTF
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BU of 5btf by Molmil
Crystal structure of a topoisomerase II complex
Descriptor: 1-cyclopropyl-6-fluoro-8-methoxy-7-[(3S)-3-methylpiperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, DNA gyrase subunit A, DNA gyrase subunit B, ...
Authors:Blower, T.R, Williamson, B.H, Kerns, R.J, Berger, J.M.
Deposit date:2015-06-03
Release date:2016-03-02
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Crystal structure and stability of gyrase-fluoroquinolone cleaved complexes from Mycobacterium tuberculosis.
Proc.Natl.Acad.Sci.USA, 113, 2016
5BS8
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BU of 5bs8 by Molmil
Crystal structure of a topoisomerase II complex
Descriptor: 1-cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, DNA gyrase subunit A, DNA gyrase subunit B, ...
Authors:Blower, T.R, Williamson, B.H, Kerns, R.J, Berger, J.M.
Deposit date:2015-06-01
Release date:2016-03-02
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.399 Å)
Cite:Crystal structure and stability of gyrase-fluoroquinolone cleaved complexes from Mycobacterium tuberculosis.
Proc.Natl.Acad.Sci.USA, 113, 2016
5BTI
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BU of 5bti by Molmil
Crystal structure of a topoisomerase II complex
Descriptor: (3S)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid, DNA gyrase subunit A, DNA gyrase subunit B, ...
Authors:Blower, T.R, Williamson, B.H, Kerns, R.J, Berger, J.M.
Deposit date:2015-06-03
Release date:2016-03-02
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.501 Å)
Cite:Crystal structure and stability of gyrase-fluoroquinolone cleaved complexes from Mycobacterium tuberculosis.
Proc.Natl.Acad.Sci.USA, 113, 2016
5BTD
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BU of 5btd by Molmil
Crystal structure of a topoisomerase II complex
Descriptor: 1-cyclopropyl-6-fluoro-8-methoxy-7-[(3S)-3-methylpiperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, DNA gyrase subunit A, DNA gyrase subunit B, ...
Authors:Blower, T.R, Williamson, B.H, Kerns, R.J, Berger, J.M.
Deposit date:2015-06-03
Release date:2016-03-02
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.497 Å)
Cite:Crystal structure and stability of gyrase-fluoroquinolone cleaved complexes from Mycobacterium tuberculosis.
Proc.Natl.Acad.Sci.USA, 113, 2016
6Y8Q
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BU of 6y8q by Molmil
AbiEi antitoxin from Streptococcus agalactiae
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Abortive phage infection protein
Authors:Blower, T.R, Beck, I.N.
Deposit date:2020-03-05
Release date:2020-12-16
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Antitoxin autoregulation of M. tuberculosis toxin-antitoxin expression through negative cooperativity arising from multiple inverted repeat sequences.
Biochem.J., 477, 2020
6Y5U
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BU of 6y5u by Molmil
MenT3 (aka TglT), nucleotidyltransferase toxin Rv1045 from Mycobacterium tuberculosis
Descriptor: Rv1045
Authors:Blower, T.R, Usher, B.
Deposit date:2020-02-25
Release date:2020-09-16
Last modified:2021-01-20
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:A nucleotidyltransferase toxin inhibits growth of Mycobacterium tuberculosis through inactivation of tRNA acceptor stems.
Sci Adv, 6, 2020
2XDD
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BU of 2xdd by Molmil
A processed non-coding RNA regulates a bacterial antiviral system
Descriptor: TOXI, TOXN, ZINC ION
Authors:Blower, T.R, Pei, X.Y, Short, F.L, Fineran, P.C, Humphreys, D.P, Luisi, B.F, Salmond, G.P.C.
Deposit date:2010-04-30
Release date:2011-01-12
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The Phage Abortive Infection System, Toxin, Functions as a Protein-RNA Toxin-Antitoxin Pair.
Proc.Natl.Acad.Sci.USA, 106, 2009
7ZGE
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BU of 7zge by Molmil
BrxA, BREX phage defence protein
Descriptor: BrxA, BREX phage defence protein
Authors:Picton, D.M, Beck, I.N, Blower, T.R.
Deposit date:2022-04-03
Release date:2022-06-22
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Crystal structure of the anti-CRISPR repressor Aca2.
J.Struct.Biol., 213, 2021
7QFZ
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BU of 7qfz by Molmil
BrxR, a WYL-domain containing transcriptional regulator
Descriptor: SULFATE ION, WYL domain-containing protein
Authors:Picton, D.M, Blower, T.R.
Deposit date:2021-12-07
Release date:2022-05-18
Last modified:2022-06-01
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:A widespread family of WYL-domain transcriptional regulators co-localizes with diverse phage defence systems and islands.
Nucleic Acids Res., 50, 2022
8AN4
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BU of 8an4 by Molmil
MenT1 toxin (rv0078a) from Mycobacterium tuberculosis H37Rv
Descriptor: Bacterial toxin
Authors:Xu, X, Usher, B, Gutierrez, C, Barriot, R, Arrowsmith, T.J, Han, X, Redder, P, Neyrolles, O, Blower, T.R, Genevaux, P.
Deposit date:2022-08-04
Release date:2023-08-02
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:MenT nucleotidyltransferase toxins extend tRNA acceptor stems and can be inhibited by asymmetrical antitoxin binding.
Nat Commun, 14, 2023
8AN5
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BU of 8an5 by Molmil
MenAT1 toxin-antitoxin complex (rv0078a-rv0078b) from Mycobacterium tuberculosis H37Rv
Descriptor: Bacterial toxin, Conserved protein
Authors:Xu, X, Usher, B, Gutierrez, C, Barriot, R, Arrowsmith, T.J, Han, X, Redder, P, Neyrolles, O, Blower, T.R, Genevaux, P.
Deposit date:2022-08-04
Release date:2023-08-02
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:MenT nucleotidyltransferase toxins extend tRNA acceptor stems and can be inhibited by asymmetrical antitoxin binding.
Nat Commun, 14, 2023
8C24
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BU of 8c24 by Molmil
ParDE1 toxin-antitoxin complex from Mycobacterium tuberculosis (rv1960c-rv1959c)
Descriptor: Antitoxin ParD1, Toxin ParE1
Authors:Beck, I.N, Blower, T.R.
Deposit date:2022-12-21
Release date:2023-12-20
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Toxin release by conditional remodelling of ParDE1 from Mycobacterium tuberculosis leads to gyrase inhibition.
Nucleic Acids Res., 52, 2024
8C26
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BU of 8c26 by Molmil
ParDE2 toxin-antitoxin complex from Mycobacterium tuberculosis (rv2142A-rv2142c)
Descriptor: Antitoxin ParD2, CHLORIDE ION, Toxin ParE2
Authors:Beck, I.N, Blower, T.R.
Deposit date:2022-12-21
Release date:2023-12-20
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Toxin release by conditional remodelling of ParDE1 from Mycobacterium tuberculosis leads to gyrase inhibition.
Nucleic Acids Res., 52, 2024
4ATO
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BU of 4ato by Molmil
New insights into the mechanism of bacterial Type III toxin-antitoxin systems: selective toxin inhibition by a non-coding RNA pseudoknot
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, TOXI, TOXN
Authors:Short, F.L, Pei, X.Y, Blower, T.R, Ong, S.L, Luisi, B.F, Salmond, G.P.C.
Deposit date:2012-05-09
Release date:2012-12-26
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Selectivity and Self-Assembly in the Control of a Bacterial Toxin by an Antitoxic Noncoding RNA Pseudoknot.
Proc.Natl.Acad.Sci.USA, 110, 2013
7ZBG
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BU of 7zbg by Molmil
Human Topoisomerase II Beta ATPase ADP
Descriptor: 4-[(2S,3R)-3-[3,5-bis(oxidanylidene)piperazin-1-ium-1-yl]butan-2-yl]piperazin-4-ium-2,6-dione, ADENOSINE-5'-DIPHOSPHATE, DNA topoisomerase 2-beta, ...
Authors:Ling, E.M, Basle, A, Cowell, I.G, Blower, T.R, Austin, C.A.
Deposit date:2022-03-23
Release date:2022-05-25
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A comprehensive structural analysis of the ATPase domain of human DNA topoisomerase II beta bound to AMPPNP, ADP, and the bisdioxopiperazine, ICRF193.
Structure, 30, 2022
7B5J
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BU of 7b5j by Molmil
Anti-CRISPR associated (Aca) protein, Aca2
Descriptor: Anti-CRISPR associated (Aca) protein, Aca2, GLYCEROL
Authors:Usher, B, Birkholz, N, Fineran, P.C, Blower, T.R.
Deposit date:2020-12-03
Release date:2021-06-23
Last modified:2021-08-25
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:Crystal structure of the anti-CRISPR repressor Aca2.
J.Struct.Biol., 213, 2021
7P9K
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BU of 7p9k by Molmil
BrxU, GmrSD-family Type IV restriction enzyme
Descriptor: CHLORIDE ION, DUF262 domain-containing protein, GLYCEROL, ...
Authors:Picton, D.M, Luyten, Y, Morgan, R.D, Nelson, A, Smith, D.L, Dryden, D.T.F, Hinton, J.C.D, Blower, T.R.
Deposit date:2021-07-27
Release date:2021-12-08
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:The phage defence island of a multidrug resistant plasmid uses both BREX and type IV restriction for complementary protection from viruses.
Nucleic Acids Res., 49, 2021
7P9M
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BU of 7p9m by Molmil
BrxU, GmrSD-family Type IV restriction enzyme
Descriptor: CHLORIDE ION, DUF262 domain-containing protein, SULFATE ION
Authors:Picton, D.M, Luyten, Y, Morgan, R.D, Nelson, A, Smith, D.L, Dryden, D.T.F, Hinton, J.C.D, Blower, T.R.
Deposit date:2021-07-27
Release date:2021-12-08
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:The phage defence island of a multidrug resistant plasmid uses both BREX and type IV restriction for complementary protection from viruses.
Nucleic Acids Res., 49, 2021

 

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